LOCUS       NM_133601               3373 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Cbl proto-oncogene B (Cblb), mRNA.
ACCESSION   NM_133601
VERSION     NM_133601.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Zhang,Z.Y., Bai,H.H., Guo,Z., Li,H.L., Diao,X.T., Zhang,T.Y.,
            Yao,L., Ma,J.J., Cao,Z., Li,Y.X., Bai,X., Chen,H.K., Suo,Z.W.,
            Yang,X. and Hu,X.D.
  TITLE     Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn
  JOURNAL   Sci Signal 13 (638) (2020)
   PUBMED   32606037
  REMARK    GeneRIF: Ubiquitination and functional modification of GluN2B
            subunit-containing NMDA receptors by Cbl-b in the spinal cord
            dorsal horn.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Jeong,J.S., Kim,H.Y., Shin,B.S., Lee,A.R., Yoon,J.H., Hahm,T.S. and
            Lee,J.E.
  TITLE     Increased expression of the Cbl family of E3 ubiquitin ligases
            decreases Interleukin-2 production in a rat model of peripheral
            neuropathy
  JOURNAL   BMC Anesthesiol 18 (1), 87 (2018)
   PUBMED   30021515
  REMARK    GeneRIF: results suggest that ubiquitin and the E3 ubiquitin
            ligases c-Cbl and Cbl-b function as neuroimmune modulators in the
            subacute phase of neuropathic pain after nerve injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3373)
  AUTHORS   Uchida,T., Sakashita,Y., Kitahata,K., Yamashita,Y., Tomida,C.,
            Kimori,Y., Komatsu,A., Hirasaka,K., Ohno,A., Nakao,R.,
            Higashitani,A., Higashibata,A., Ishioka,N., Shimazu,T.,
            Kobayashi,T., Okumura,Y., Choi,I., Oarada,M., Mills,E.M.,
            Teshima-Kondo,S., Takeda,S., Tanaka,E., Tanaka,K., Sokabe,M. and
            Nikawa,T.
  TITLE     Reactive oxygen species upregulate expression of muscle
            atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle
            cells
  JOURNAL   Am J Physiol Cell Physiol 314 (6), C721-C731 (2018)
   PUBMED   29513566
  REMARK    GeneRIF: Under microgravity conditions, elevated ROS may be a
            crucial mechanotransducer in skeletal muscle cells, regulating
            muscle mass through Cbl-b expression activated by the ERK-Egr
            signaling pathway.
REFERENCE   4  (bases 1 to 3373)
  AUTHORS   Li,P., Liu,H.L., Zhang,Z.Q., Lv,X.D., Chang,Y.X., Wang,H.J., Ma,J.,
            Ma,Z.Y., Qu,X.J. and Teng,Y.E.
  TITLE     Single nucleotide polymorphisms of casitas B-lineage lymphoma
            proto-oncogene-b predict outcomes of patients with advanced
            non-small cell lung cancer after first-line platinum based doublet
            chemotherapy
  JOURNAL   J Thorac Dis 10 (3), 1635-1647 (2018)
   PUBMED   29707316
REFERENCE   5  (bases 1 to 3373)
  AUTHORS   Li,P., Liu,H., Zhang,Z., Lv,X., Wang,H., Ma,J., Ma,Z., Qu,X. and
            Teng,Y.E.
  TITLE     Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma
            and Adenocarcinoma
  JOURNAL   Med Sci Monit 24, 623-635 (2018)
   PUBMED   29384143
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3373)
  AUTHORS   Thirone,A.C., Carvalheira,J.B., Hirata,A.E., Velloso,L.A. and
            Saad,M.J.
  TITLE     Regulation of Cbl-associated protein/Cbl pathway in muscle and
            adipose tissues of two animal models of insulin resistance
  JOURNAL   Endocrinology 145 (1), 281-293 (2004)
   PUBMED   14525909
  REMARK    GeneRIF: CAP-Cbl pathway may have a role in the modulation of
            adiposity in fasting and in monosodium glutamate treated rats.
REFERENCE   7  (bases 1 to 3373)
  AUTHORS   Zhang,W., Shao,Y., Fang,D., Huang,J., Jeon,M.S. and Liu,Y.C.
  TITLE     Negative regulation of T cell antigen receptor-mediated Crk-L-C3G
            signaling and cell adhesion by Cbl-b
  JOURNAL   J Biol Chem 278 (26), 23978-23983 (2003)
   PUBMED   12697763
REFERENCE   8  (bases 1 to 3373)
  AUTHORS   Nishio,H., Otsuka,M., Kinoshita,S., Tokuoka,T., Nakajima,M.,
            Noda,Y., Fukuyama,Y. and Suzuki,K.
  TITLE     Phosphorylation of c-Cbl protooncogene product following ethanol
            administration in rat cerebellum: possible involvement of Fyn
            kinase
  JOURNAL   Brain Res 950 (1-2), 203-209 (2002)
   PUBMED   12231245
  REMARK    GeneRIF: c-Cbl protooncogene product is tyrosine- phosphorylated in
            rat cerebellum in response to ethanol administration.
REFERENCE   9  (bases 1 to 3373)
  AUTHORS   Yokoi,N., Komeda,K., Wang,H.Y., Yano,H., Kitada,K., Saitoh,Y.,
            Seino,Y., Yasuda,K., Serikawa,T. and Seino,S.
  TITLE     Cblb is a major susceptibility gene for rat type 1 diabetes
            mellitus
  JOURNAL   Nat Genet 31 (4), 391-394 (2002)
   PUBMED   12118252
  REMARK    GeneRIF: we report the positional cloning of Iddm/kdp1 and identify
            a nonsense mutation in Cblb, a member of the Cbl/Sli family of
            ubiquitin-protein ligases.Cblb is a major susceptibility gene for
            rat type 1 diabetes mellitus
REFERENCE   10 (bases 1 to 3373)
  AUTHORS   Krawczyk,C., Bachmaier,K., Sasaki,T., Jones,R.G., Snapper,S.B.,
            Bouchard,D., Kozieradzki,I., Ohashi,P.S., Alt,F.W. and
            Penninger,J.M.
  TITLE     Cbl-b is a negative regulator of receptor clustering and raft
            aggregation in T cells
  JOURNAL   Immunity 13 (4), 463-473 (2000)
   PUBMED   11070165
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB071283.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB071283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3373
                     /gene="Cblb"
                     /note="Cbl proto-oncogene B"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
     exon            1..26
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            27..212
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2861
                     /gene="Cblb"
                     /EC_number="2.3.2.27"
                     /note="SH3-binding protein CBL-B; signal transduction
                     protein CBL-B; casitas B-lineage lymphoma proto-oncogene
                     b; Cas-Br-M (murine) ectropic retroviral transforming
                     sequence b; RING-type E3 ubiquitin transferase CBL-B;
                     Casitas B-lineage lymphoma b; Cas-Br-M (murine) ecotropic
                     retroviral transforming sequence b; Cbl proto-oncogene B,
                     E3 ubiquitin protein ligase; Cbl proto-oncogene, E3
                     ubiquitin protein ligase B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL-B"
                     /protein_id="NP_598285.1"
                     /db_xref="GeneID:171136"
                     /db_xref="RGD:620535"
                     /translation="MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRR
                     TVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLS
                     ENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAI
                     FPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKS
                     TIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKY
                     STKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDG
                     RSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM
                     CTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLD
                     DDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVP
                     PRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPERPPPIPP
                     DSRLSRHFHHGESVPSRDQPMPLEAWCPRDAFGTNQVMGCRILGDGSPKPGVTANSNL
                     NGRHSRMGSDQVLMRKHRRHDLPSEGAKVFSNGHLAPEEYDVPPRLSPPPPVTALLPS
                     IKCTGPIANCLSEKTRDTVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHC
                     ILNGTHGTPSEMKKSNIPDLGIYLKGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSS
                     SRPSSGQDLFLLPSDPFFDPASGQVPLPPARRAPGDGVKSNRASQDYDQLPSSSDGSQ
                     APARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQN
                     NLEVARSILREFAFPPPVSPRLNL"
     exon            213..463
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            464..610
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            611..767
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            768..889
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1027
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1115
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1247
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1451
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1637
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..2000
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2095
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2242
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2340
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2481
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2601
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..3373
                     /gene="Cblb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcgggcg tggagctgtc tgcacgaaag gactaagatt ccagatggca aattctatga
       61 atggcagaaa tcctggtggt cgaggaggaa acccccgcaa aggtcgaatt ttggggatta
      121 ttgatgccat tcaggatgca gttggacccc caaagcaagc tgcagctgac cgcaggacag
      181 tggagaagac ttggaaactc atggacaaag tggtaagact gtgccaaaat ccgaaacttc
      241 agttgaaaaa cagcccacca tatatcctcg acattttacc tgatacgtat cagcatttgc
      301 ggcttatatt gagtaagtat gacgacaacc agaagctggc tcaactgagc gagaatgagt
      361 actttaaaat ctacatcgac agtctcatga agaagtcaaa gcgagcgatc cggctcttca
      421 aagaaggcaa ggagaggatg tacgaggagc agtcgcagga cagacggaat ctcacaaagc
      481 tgtcccttat cttcagtcac atgctggcag aaatcaaggc gatctttccc aatggccagt
      541 tccagggaga taacttccgg atcaccaaag cagatgctgc cgaattctgg aggaagtttt
      601 ttggagacaa aactatcgta ccatggaaag tcttcagaca gtgcctgcat gaggtccatc
      661 agatcagctc tggcctggag gccatggctc tgaagtcaac cattgactta acttgtaatg
      721 attacatctc cgtgtttgaa tttgatattt ttaccaggct atttcagccc tggggctcta
      781 ttttacggaa ttggaacttc ttagctgtga cacacccggg gtacatggca tttctcacat
      841 atgatgaagt taaagctcga ctacagaaat acagcaccaa gcctggaagc tacattttcc
      901 ggttaagctg cactcggctg ggacaatggg ccattggcta tgtgactggg gacggcaata
      961 tcctacagac catacctcat aacaagcccc tgttccaagc cctgattgat ggtagcaggg
     1021 aaggctttta cctttatcca gatggacgaa gctataaccc tgatttaacc ggattatgtg
     1081 aacctacacc tcatgatcat ataaaagtta cacaggagca atatgaactg tattgtgaaa
     1141 tgggctccac ttttcagctg tgcaagatct gtgcagagaa tgacaaagat gtcaagatcg
     1201 agccttgtgg gcatctcatg tgcacttcgt gccttaccgc gtggcaggag tctgatggcc
     1261 aaggctgccc cttctgtcgc tgtgagataa aaggaaccga acctatcatc gtggatccct
     1321 ttgaccccag agacgaaggc tccaggtgct gcagcatcat cgaccctttc agcatcccca
     1381 tgctcgactt ggatgatgac gatgatcgag aggagtctct gatgatgaac cggctggcga
     1441 gtgttcgcaa gtgcacagac aggcagaact cgccagtcac atcgccagga tcctcacccc
     1501 ttgcccagag aagaaagcct cagccagacc ctctccagat cccccacctc agcctgccac
     1561 cagtgcctcc ccgcctggac ctcattcaga aaggcatcgt gcgctctccc tgtggcagcc
     1621 ccacgggctc cccgaagtct tctccatgca tggttagaaa acaagacaaa ccactcccag
     1681 caccccctcc tcccttgcga gatcctccgc ctccaccaga gcggcctccg ccaatcccgc
     1741 ctgacagtag actgagcaga cacttccacc acggagagag tgtgccttcc agggaccagc
     1801 caatgcctct tgaagcctgg tgccctcggg atgccttcgg gactaatcag gtgatgggat
     1861 gtcgcatcct aggggatggc tctccaaagc ctggcgtcac agcaaactcc aacttaaatg
     1921 gacgtcacag tcgaatgggc tctgaccagg ttcttatgag gaaacacaga cgccacgatt
     1981 tgccttcaga aggcgccaag gtcttttcca atggacacct tgcccctgaa gaatacgacg
     2041 ttcctcctcg gctttcccct cctcctccag tcactgccct tctccctagc ataaagtgta
     2101 ctggtccaat agcaaattgt ctctccgaga aaacaagaga cacagtagaa gaagatgatg
     2161 atgaatacaa gattccttca tcccatcctg tttccctgaa ttcacaacca tctcattgtc
     2221 ataatgtcaa acctcctgtt cggtcttgtg ataatggtca ctgtatactg aatggaactc
     2281 atggtacgcc ttcagagatg aagaaatcaa acatcccaga tttaggcatc tatttgaagg
     2341 gtgaagatgc ttttgatgcc ctccccccat cccttcctcc tcccccacct cctgcaagac
     2401 atagtctcat cgagcattca aaacctccag gctccagtag ccggccttcc tcaggacagg
     2461 accttttcct tcttccttca gatccctttt ttgacccagc aagtggccaa gttccattgc
     2521 ctccggccag gagagcacca ggagatggtg tcaaatccaa cagagcctcc caggactatg
     2581 accagctccc ttcatcttcc gatggttcgc aagcaccagc tagacccccc aaaccacgac
     2641 cccgaaggac tgcaccagaa attcatcaca gaaagcccca tgggcccgag gcggcactgg
     2701 aaaatgtgga tgcgaaaatt gcaaaactca tgggagaggg gtatgccttt gaagaggtga
     2761 agagagcctt agagatcgcc cagaataacc tggaagtggc caggagcata cttcgagaat
     2821 tcgccttccc tcctcccgtc tcgccacgtc tcaatctata gcagcccaga ctgcaaacac
     2881 caaagggtaa aacagttaac aaatattcca ggagtatggg acagaaggac tgagagggaa
     2941 tgcaggagcc atggtgtctt ttcatgtggc gtctccagaa ggcagccttg agtccagctt
     3001 ctctggtacc acagctccct gaggatgccc acgctgcagc ttctgtgttt gtgctagcca
     3061 tacttttaaa tcagggttga actgagaaaa taatttaaag acgtttactc ccccttgaac
     3121 tttgaatctg tgaaatgctt tccttgttta cacgttggca gaattgcagt ttgtctctgt
     3181 ttttgattcc tgtactgtgt tcctgacagg cccttggcag agttggtcag gtctgctgta
     3241 agtttgtcca tgcccaccct gctgcccaca ttggcagcta aagcatctct tcgtgttgct
     3301 gtctatccgg gccccacctc atgtgtccac gtccagttca tttctctcat tcacacagca
     3361 tgctagtctg agg
//
