LOCUS       NM_001419955           10835 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Cbl proto-oncogene (Cbl), mRNA.
ACCESSION   NM_001419955 XM_576396
VERSION     NM_001419955.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10835)
  AUTHORS   Sun,F., An,C., Liu,C., Hu,Y., Su,Y., Guo,Z., Che,H. and Ge,S.
  TITLE     FTO represses NLRP3-mediated pyroptosis and alleviates myocardial
            ischemia-reperfusion injury via inhibiting CBL-mediated
            ubiquitination and degradation of beta-catenin
  JOURNAL   FASEB J 37 (6), e22964 (2023)
   PUBMED   37199660
  REMARK    GeneRIF: FTO represses NLRP3-mediated pyroptosis and alleviates
            myocardial ischemia-reperfusion injury via inhibiting CBL-mediated
            ubiquitination and degradation of beta-catenin.
REFERENCE   2  (bases 1 to 10835)
  AUTHORS   Kiefer,K.C., Cremer,S., Pardali,E., Assmus,B., Abou-El-Ardat,K.,
            Kirschbaum,K., Dorsheimer,L., Rasper,T., Berkowitsch,A., Serve,H.,
            Dimmeler,S., Zeiher,A.M. and Rieger,M.A.
  TITLE     Full spectrum of clonal haematopoiesis-driver mutations in chronic
            heart failure and their associations with mortality
  JOURNAL   ESC Heart Fail 8 (3), 1873-1884 (2021)
   PUBMED   33779075
REFERENCE   3  (bases 1 to 10835)
  AUTHORS   Chen,C., Hui,Y., Chen,Y., Qian,C. and Sun,M.
  TITLE     Loss of c-Cbl expression correlates with de-differentiation status
            and lymphatic metastasis in gastric cancer
  JOURNAL   Indian J Pathol Microbiol 62 (4), 549-555 (2019)
   PUBMED   31611438
REFERENCE   4  (bases 1 to 10835)
  AUTHORS   Kumaradevan,S., Lee,S.Y., Richards,S., Lyle,C., Zhao,Q., Tapan,U.,
            Jiangliu,Y., Ghumman,S., Walker,J., Belghasem,M., Arinze,N.,
            Kuhnen,A., Weinberg,J., Francis,J., Hartshorn,K., Kolachalama,V.B.,
            Cifuentes,D., Rahimi,N. and Chitalia,V.C.
  TITLE     c-Cbl Expression Correlates with Human Colorectal Cancer Survival
            and Its Wnt/beta-Catenin Suppressor Function Is Regulated by Tyr371
            Phosphorylation
  JOURNAL   Am J Pathol 188 (8), 1921-1933 (2018)
   PUBMED   30029779
REFERENCE   5  (bases 1 to 10835)
  AUTHORS   Jeong,J.S., Kim,H.Y., Shin,B.S., Lee,A.R., Yoon,J.H., Hahm,T.S. and
            Lee,J.E.
  TITLE     Increased expression of the Cbl family of E3 ubiquitin ligases
            decreases Interleukin-2 production in a rat model of peripheral
            neuropathy
  JOURNAL   BMC Anesthesiol 18 (1), 87 (2018)
   PUBMED   30021515
  REMARK    GeneRIF: results suggest that ubiquitin and the E3 ubiquitin
            ligases c-Cbl and Cbl-b function as neuroimmune modulators in the
            subacute phase of neuropathic pain after nerve injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10835)
  AUTHORS   Baumann,C.A., Ribon,V., Kanzaki,M., Thurmond,D.C., Mora,S.,
            Shigematsu,S., Bickel,P.E., Pessin,J.E. and Saltiel,A.R.
  TITLE     CAP defines a second signalling pathway required for
            insulin-stimulated glucose transport
  JOURNAL   Nature 407 (6801), 202-207 (2000)
   PUBMED   11001060
REFERENCE   7  (bases 1 to 10835)
  AUTHORS   Ribon,V., Printen,J.A., Hoffman,N.G., Kay,B.K. and Saltiel,A.R.
  TITLE     A novel, multifuntional c-Cbl binding protein in insulin receptor
            signaling in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 18 (2), 872-879 (1998)
   PUBMED   9447983
REFERENCE   8  (bases 1 to 10835)
  AUTHORS   Ishiki,M., Sasaoka,T., Ishihara,H., Imamura,T., Usui,I., Takata,Y.
            and Kobayashi,M.
  TITLE     Evidence for functional roles of Crk-II in insulin and epidermal
            growth factor signaling in Rat-1 fibroblasts overexpressing insulin
            receptors
  JOURNAL   Endocrinology 138 (11), 4950-4958 (1997)
   PUBMED   9348226
REFERENCE   9  (bases 1 to 10835)
  AUTHORS   Hunter,S., Koch,B.L. and Anderson,S.M.
  TITLE     Phosphorylation of cbl after stimulation of Nb2 cells with
            prolactin and its association with phosphatidylinositol 3-kinase
  JOURNAL   Mol Endocrinol 11 (9), 1213-1222 (1997)
   PUBMED   9259313
REFERENCE   10 (bases 1 to 10835)
  AUTHORS   Ota,Y., Beitz,L.O., Scharenberg,A.M., Donovan,J.A., Kinet,J.P. and
            Samelson,L.E.
  TITLE     Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk
            complex in RBL-2H3 cells
  JOURNAL   J Exp Med 184 (5), 1713-1723 (1996)
   PUBMED   8920860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 24, 2023 this sequence version replaced XM_576396.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.29869.1,
                                           SRR26643295.31329.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               JAXUCZ010000008.1  53467768-53468067   c
            301-548             JAXUCZ010000008.1  53441599-53441846   c
            549-695             JAXUCZ010000008.1  53414799-53414945   c
            696-852             JAXUCZ010000008.1  53411705-53411861   c
            853-974             JAXUCZ010000008.1  53409518-53409639   c
            975-1112            JAXUCZ010000008.1  53408539-53408676   c
            1113-1200           JAXUCZ010000008.1  53406852-53406939   c
            1201-1332           JAXUCZ010000008.1  53406183-53406314   c
            1333-1536           JAXUCZ010000008.1  53405358-53405561   c
            1537-1668           JAXUCZ010000008.1  53400187-53400318   c
            1669-2046           JAXUCZ010000008.1  53399722-53400099   c
            2047-2141           JAXUCZ010000008.1  53397746-53397840   c
            2142-2282           JAXUCZ010000008.1  53395290-53395430   c
            2283-2380           JAXUCZ010000008.1  53394853-53394950   c
            2381-2560           JAXUCZ010000008.1  53393888-53394067   c
            2561-10835          JAXUCZ010000008.1  53384656-53392930   c
FEATURES             Location/Qualifiers
     source          1..10835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..10835
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /note="Cbl proto-oncogene"
                     /db_xref="GeneID:500985"
                     /db_xref="RGD:1561386"
     exon            1..300
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2853
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /EC_number="6.3.2.-"
                     /note="Casitas B-lineage lymphoma; Cas-Br-M (murine)
                     ecotropic retroviral transforming sequence; Cbl
                     proto-oncogene, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL"
                     /protein_id="NP_001406884.1"
                     /db_xref="GeneID:500985"
                     /db_xref="RGD:1561386"
                     /translation="MAGNVKKSSGAGGSGSGGSGAGGLIGLMKDAFQPHHHHHHHLSP
                     HPPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYE
                     GKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHM
                     LAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGL
                     EAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEV
                     KARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREG
                     FYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKI
                     EPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAP
                     SPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPV
                     PASTSVLGTASKASSSSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGTETRPQRRPLPC
                     TPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLP
                     SQMEPRADVPRLGSTFSLDTSTTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPV
                     PKLPPGEQGDSEEDTEYMTPTSRPVGVQKPEPKRPAETAQSSRACDCDQQIDSCTYEA
                     MYNIQSQALSVAENSACGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLS
                     DISNASSSFGWLSLDGEPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGAMANP
                     AAAAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT
                     "
     exon            301..548
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            549..695
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            696..852
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            853..974
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1112
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1200
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1332
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1536
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1668
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..2046
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2141
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2282
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2380
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2560
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..10835
                     /gene="Cbl"
                     /gene_synonym="c-Cbl; RGD1561386"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccctcgg ctgtgagcgc cggcggtggc tgccggagag gcccctcctt ctcgccccgc
       61 tccattccct cgctcgcggc cgagcgggct cccgaccctc cgctggccat ggccggcaac
      121 gtgaagaaga gctcgggcgc cggcggcagc ggctctgggg gctccggagc gggcggcctg
      181 atcgggctca tgaaggacgc cttccagccg caccaccacc accaccacca cctcagcccg
      241 caccctccct gcacggtgga caagaagatg gtggagaagt gctggaagct catggacaag
      301 gtggtgcggt tgtgtcaaaa cccaaagctg gctctcaaga acagcccacc gtatatctta
      361 gacctgctgc ctgacaccta ccagcacctc cgcactgtcc tgtcgagata tgaggggaag
      421 atggagacgc ttggagagaa tgagtatttc agggtgttca tggagaattt gatgaagaaa
      481 actaagcaga ccatcagcct cttcaaggag ggaaaagaaa ggatgtatga ggagaattcc
      541 cagcctaggc gaaacctaac caagttatcc ctgatcttca gccacatgct ggcagaactg
      601 aaaggcatct ttccaagcgg actcttccaa ggagacactt ttcggatcac taaagcagac
      661 gctgcagagt tctggagaaa agcttttggg gaaaagacga tagtcccttg gaagagcttt
      721 cgacaggccc tgcatgaagt gcatcccatc agttctgggc tggaggccat ggctttgaag
      781 tccactattg atctgacctg caatgattat atttctgttt ttgaatttga tatttttaca
      841 cggctgtttc agccctggtc ctctttgctc agaaattgga acagccttgc tgtaactcac
      901 cctggctaca tggctttcct gacgtatgat gaagtgaaag ctcggctcca gaagttcatc
      961 cacaaacccg gcagttacat ctttcggctg agctgtactc gtttgggtca gtgggctatt
     1021 gggtacgtta cagctgatgg gaacatcctg cagacaatcc cacacaataa accgctcttc
     1081 caagcactga ttgatggctt cagggaaggc ttctatttgt ttcctgatgg aagaaatcaa
     1141 aatcctgacc tgacaggttt atgtgaacca acccctcaag atcatatcaa agtcacccag
     1201 gaacaatatg aactatactg tgaaatgggc tccacatttc aactatgtaa gatatgtgct
     1261 gagaatgata aggatgtgaa gattgagccc tgtggacacc tcatgtgcac gtcctgcctc
     1321 acatcgtggc aggaatcaga aggtcaaggc tgtccttttt gccgatgtga aatcaaaggt
     1381 actgagccca tcgtggtgga tccatttgac cccagaggca gtggcagtct attaaggcaa
     1441 ggagcggaag gtgctccttc cccaaattat gatgatgatg atgatgaacg agctgatgat
     1501 tctctcttca tgatgaagga gttggcaggt gccaaggtgg aaaggccttc ctctccattc
     1561 tccatggccc cacaagcttc ccttcctcca gtgccaccaa gacttgacct tctacagcag
     1621 cgagcacctg ttcctgccag cacctctgtt ctggggactg cttccaaggc ttcttctagc
     1681 tcccttcata aggacaaacc attgccaata cctcctacgc ttcgagatct tcctccacca
     1741 ccccctccag accggcctta ctctgttgga acagaaacaa ggcctcagag acgccccctg
     1801 ccttgtactc caggcgactg tccatctaga gacaaactgc cccctgtccc ctctagccgc
     1861 ccaggggact catggttgtc tcggccaatc cctaaagtac cagtagcgac tccaaaccct
     1921 ggtgatcctt ggaatgggag agaattgacc aatcggcact cacttccatt ctcattgccc
     1981 tcacaaatgg aacccagagc agatgttcca aggcttggaa gcacatttag tctggatacc
     2041 tccacgacta tgaatagcag cccagtagca ggtccagaga gtgagcaccc aaaaatcaag
     2101 ccttcctcat ccgccaatgc catttactct ctggctgcca ggcctcttcc tgtgccaaaa
     2161 ctgccacctg gggagcaagg ggacagtgaa gaagacacgg aatatatgac tcccacgtct
     2221 aggcctgtag gggttcagaa gccagagccc aaacggcctg cagagacagc gcagagttca
     2281 cgagcctgtg actgtgacca gcagattgac agctgcacat acgaagcaat gtataacatt
     2341 cagtcccaag cactctccgt agcagagaac agtgcctgtg gagaagggaa tttggccaca
     2401 gcccacacca gtactggccc ggaggagtca gaaaacgagg atgatggcta tgatgtaccg
     2461 aagcctcctg tgccagctgt actggcccgc cggaccctgt ctgacatctc caatgccagc
     2521 tcctcctttg gctggttatc tttggatggc gaacccacaa acttcaatga gggttcccaa
     2581 gttcctgagc ggccccccaa accattccct cggagaatca actcagaacg aaaagcaagt
     2641 agctatcaac aaggcggagg tgccatggct aaccctgcag ccgccgcccc ctcaccgcag
     2701 ctctcaagcg agattgaacg cctcatgagt cagggctatt cctaccagga cattcagaaa
     2761 gcgttggtca ttgcccacaa caacattgag atggccaaaa acatcctccg ggaattcgtt
     2821 tctatttctt ctcctgccca tgtagccacc tagcacatct ccgtgccatg gcttcagagg
     2881 acccatgagc caggctctta ctcaaggagc acctaggaaa gcagtggctt cttttgggat
     2941 atcacagtga ggtcttgcct tttctgtggg gatcgacaca tatggttcca agatttcaaa
     3001 gcagtgggat gaaaatggag cagctaatgt gtttcattct tgtattggtc ttaagagtgt
     3061 gttcgtagtc ctgcagtctc cattaggaga gagtgggttt ttattaaatg gtaacctacc
     3121 cgaggagcag cacagaaagc agtagaaatg ctgtgctgta gccctagtta aagacataag
     3181 attttcctgc taagggtgtg tgtctctgtg tctgtgtgtc ctgtcattat aagattatcc
     3241 tgctgtgtgt gaatccaggc agggagttag cacaagagct tcaggaagga gactctgaag
     3301 actcccatct actgtggtat tgcacctagc cctgctggat attacaacct cagtccttcc
     3361 cgttggctta gattatcatg gctatggttt atattgttag aatacccact gtcctttccc
     3421 ttggaaactc cttactccac ctcctcctca ttgctgttct gtaggcttgc tgtgaccagt
     3481 cttactgaaa ccaagcagcg tataggatgg cctttctact gtgtgatggt gttggtttgt
     3541 ttggtagaat aggtgggaag gaaagtactg ttctgtggtt acagttataa ttgatgctag
     3601 cacctaacac tggtcacgcc aaagtgctgt ttctatagga atattgaatt tgtattaaaa
     3661 aaagaaaagt aagttttaat tctcgtagtt acctagtgac tggtttgaga tagaggcctt
     3721 catatacatt ccgtgtcctc cccaggaaat agcctgtgga gtctgttgcc ttgatgccag
     3781 gtgtgtgttt ctgatgtagg tcatgagtct gtctacctaa caggaacaga acatttgttt
     3841 ccacagtggc tttccagccc aaaaccatag agcttttagg aagcgtccat catatactat
     3901 ttagatttac aagataaaca gtaaggactt atctgtttag tctctcttgc cagtggttaa
     3961 catcagctta gggatttccc ccttgaatag gagccaggtt agcctttcag aaatgatttt
     4021 tttctttgcc ctctaaggaa tggagataac accagtgagc gcacagcatt tactgatggc
     4081 tagcaccttc tctagactag tgcacccagc gactttactg ttcacgtgcc tagcttgtgc
     4141 tttgggtcct agatataatc actgcgttat ccattcacat tatttagaca tcattcattg
     4201 acattcttta atcaaagaca attgggacgg atgccgtagg ttcagcaaga tctagcgttg
     4261 ttttggagac ctgtttctca gtccttggag agtgaccgct tgggttcatt ttgttctctg
     4321 actggagtct ttgctgcctt ctcttgcagc gttgcccttt ctcatcggag ctggctttca
     4381 catgaattct gtctgttctc taggtccaga aaagaaatga cccaccaaaa atctttccag
     4441 tcttaacatc tttacaactc aaatcttttg aacttttttt tttagtttct agatgtttca
     4501 aggtctagat tttatcctct tgctgtagta ctttatattg gcttggcttg ctatggttac
     4561 ccagtgtctc tacatagcaa tgagtagaaa acatagctta tcatccacaa aaagcttgtg
     4621 acatccaatt ttgcattcat ttgagtattg aaagtctaag ccaggcttgg cggcatctca
     4681 gtacttgggg gatggtggca agatgatcag gagttcagca ccagctcaaa gctcctcaaa
     4741 accgtgtctc aaaaataacg ggtttaaaga gatgactctt tgcctaagag cagctgttct
     4801 cacagaggac ctaggtttgg ttcctaagca cccatacaaa aactttctca gatgtataag
     4861 caactcacaa cataagactc tgatgccctc ttctgtcctc tatgggcacc agccacatga
     4921 tgtgcacata tacatgcgca cagagcatga aataagtact tattaagaaa ttaaaaaata
     4981 aaaattaaag gccttaaaag agaactaggg aaaagccaca gcctctagtc tatctatatt
     5041 ggagtgtctt ctttccttgt agatattgcc cagaatctga agatcaatca agaaaacaaa
     5101 gcattttcct ttttttgagt gtccaagtct tctatggagg ctaaggatat agctcagttg
     5161 gtagagtgct tgtctagcat tcacaaagcc atggctcagt ccccacacta cacagaacag
     5221 tgtgctaagg cacctctgat ccttaacact caagaggtgg agacagtatc agaagctcaa
     5281 agccactctt gcctacatag caagttgaaa actggcctgg gctacatgac accctgcctc
     5341 caaaagaaaa caaaaaccaa acctgtggga ttgctgctca tgctgtctag ggaaccagtt
     5401 ttatcctctg ctgagcactg tgtgagctct gaatgcggca tgggtagggt aggtgggtat
     5461 tcagtccctg tagcagacag gcacatcttg attgacttgg gtgttggttt atcagatgtt
     5521 atctgcaggc attaaggttt gaggccactg cgtgtaagcc tttccttggc tcccaggaca
     5581 ctgaacccat acctggtatt attaggtatc cttaggatgg tttcttacca ctcattttgg
     5641 atagtttcca aaatttgaat ttctttttcc agtgagggca aatatcctat ttatcatttt
     5701 ccatttgtat ggcaaatttt aattctttag ctctccctct gagtttacct aaaactgctt
     5761 tttcataaac aagctttatt tttggcaagc ccatccattt tccctgctct gtgttacaat
     5821 taggtaaacc actttaacgg ttctcctttt tcctcaactt cattagctta ttttattcag
     5881 cacagggcct tgttctccgt gtctctgtgg attgctttac gtgccacctt attgacgggt
     5941 cactatcttg ccaaaacccc aggcaaagct tttctagtct agtcccagaa ctggatgttc
     6001 tagctgtcct ccccactgtc cttccaaagt gaatagtttc taacatggtt ttaaaaacct
     6061 gtgggttctg aagtatacct ctttctagtt aacagaaggc agctcatcat ctcagctttt
     6121 gcatgttaat atttatttaa gcagcgaact gaccttggct ggccattttc cttgtccgtc
     6181 tttctcctcc cagccctccc accatactct gccattttgt ctttctcttt taattctcag
     6241 acatgcctat cactggacca caatgtgtgg tggaaatcct ggcatcggtc agctggtctt
     6301 tggtcttttt tttttttttt ttaattcagg aggtagtctg agatggatag aaggcactat
     6361 tcttcatatt taaaatattt atttcctctg taggaaagta agatatgttt tatggttcaa
     6421 gtaacaaacc tacaagttaa tttttgtaac acaacttgct tacagaccaa accagggacc
     6481 agctgtgtat tcctttcatg gcaccattaa caagatctag tcttctgtga gagtagctag
     6541 gacactaatg ctggatgttc tcttacctca catcatgaga accagagggc tactggcctt
     6601 ctcagacctt cctttttttc tgttggcctt tctgagtctg gaacgatcac tccattgaat
     6661 agagtatcca accagtgtcc tggctacaaa tgtctgagtg attcctgtgt gttgggaacg
     6721 tcagccatct catctttcct gccaccatgt ggcagtttgc tggtgctggg aggttaagct
     6781 tgggctaccc tttcaactct ttcgcatttg actgtgcatg tgtttattca cagctctctt
     6841 atgtagactt atcttcctta cagaactgtt ccacttaaaa ctggtccaac acttccccac
     6901 tagcccctgt tgtcttcctg tggctttgat aatatttggg agattctgtt gtgtatacct
     6961 cattgagtat ccatttttgc tacaaaattt agtgccatct cttgagtggg tgtcgagccc
     7021 actggctgag ttgcacagta gagcactaaa tatttaagct gaacttgctg tagtcccctt
     7081 tccagtccag tgcctttcta tctttactga gctgcttctg tccccagtcc ttgttgggaa
     7141 gattttgttt tacctttctg ggactgtcac catctcccat acagtttgga gtttcttttt
     7201 ctattattca gcaatctgtt ttagaagggg tgaaagggtt ggaaagggta aagacctaat
     7261 tctcagtcta ctcttgtagg aactgctcag gaactgagac tggattctgt ccagaacagc
     7321 ttactagaag taccagagcc tcactgtcag tgatatcctc tggcacttga agtttcaaaa
     7381 tacaacagaa gtactctaac ttcacagagc atctgaatgc aactttgacc tcagcataca
     7441 cacactttta tatgtgacaa aaaaagttcc ctagtccttg agttcatgtg atcttatgat
     7501 gaatgcagtt ctttagaaaa gctcgagaat ttctagaaag acgaggagaa aagttaaccc
     7561 tgtttattaa ttccatgggc cagactggac atcatgaggg agatggtctt gacctgtatc
     7621 ccctgaggct atctgcacac caacctggaa atcatgaaac gagcctgtct tatcagctct
     7681 tgggaagtag aagtaagagg attatgaatt ttaggccagc cttggatccg ttacaagctg
     7741 aagaccagac tggattctgt gagtgtcttg cctgtccctg gagaatgttt tctctttttg
     7801 tttccagcag caggggaagc cacagcacca tctggcacgt gagtggaggt gatctcgtca
     7861 cgtgcagatc actgatggag tggtttcact gccagtggga ctcttggctc ttccactgta
     7921 gttttcttta agtctgatag tttgaaggtg cagtctttca tggtggagca atctcaaggc
     7981 aggagcatga ggtaactact ggtcacattg cacctgcagt caagggacag aagacagtaa
     8041 tgcactccac aagaatagtg atttgagggc cattccccac tgaaccttat aggaagaaca
     8101 gagaaattat gctgaactgg gaacttagaa gagatatgca aaagaacttc cacaatagaa
     8161 atacagttgc tgttctagtc atccctattt ttaagttaga gtcactatca cctttgctgc
     8221 tgctttcctt cttaggagcc ttggcaccca aggccactct tccttgggtg gcatttcttg
     8281 tctccattca acctttttga tgttacttag agtgcagatc atggcttcca ctgtaactcc
     8341 ttttagactt ggctgtcttc tggttttagt gctgaataca ggttcattct gtgggctctt
     8401 gaactgtctc ctgcatccct atcctctttg tcttcctgta ggagagccta cagtgatgtt
     8461 agctttactt tcctaggtgc cactgggacc tttgctagaa tagggatatt ttcagtgtca
     8521 aatagagctt gttctgtgtg cttcttaaat aggcaagcta cctgtatctt ccctgtctgg
     8581 ttgctttttc tctagtcctg taacaagtat ggtggttttg gaagcttttg tttgttttgt
     8641 tttaagttgg ggaagtaaag ctatgcttct gcttgtctga atcattggaa tcccaactta
     8701 gagcctgtcc tgagttttaa ggcatatcaa acatactacc ctgcttttaa cttctaaata
     8761 ttcaagtcat ttggtataca cagaagtaac ctactaatcc aaagatacac attgaggcac
     8821 ataggaaggg caagagcagg tcatcagatt ctgcatttga tgtctagttc aaactcctga
     8881 atgaagaagc agagggatag tagtgccatg tgccttcgta gtgtccagga aatctgggtt
     8941 ggttacagga gaaagtacca gtatttcttg gttccagtaa gtagcacaag agttgagatg
     9001 gagaactagg gacagggaga ggcctgcaca ttgttttgtg cctgatgaag agcaccatgg
     9061 ggagggccag ctgctgacca acagctgctt gcagatcttg cagcctcttc cctgttttag
     9121 ttcttgagaa aaatgtggct gaccgaccac tccttgtgat gtacagagcc ccggctaagt
     9181 gccagcctca gatctcctac cgatctggca gctggacaag tcagccagag ttctgatcac
     9241 ctggccctgc attcctgttt cagtgctaca acagaatgtg agaggcaaat ctccacattg
     9301 ccttgatttt cctttcctct aacccagaac agaggccagt ggagaggatt gcccaatgca
     9361 tgctgtgcac aactcatcag actcacactg cctcaccaca tacgccctga agtggggtgt
     9421 gtggactgtg ttactcctcc ccactacctc ttacccagta gtggagaggg tggccttgtt
     9481 ttggctgtat ttaagtggca agtgaatccg gggccctgca ctctctcccc tgctttctgg
     9541 gctcatgagc ctgccttgca gtgcatgaga ggagccacct cctgacctcc ttagtaccct
     9601 tcagtgggaa gtctgacctc tgctgaaaca tgctgagcat ggcagctgtg aggaacctcc
     9661 tacatctgct ttctggctgt gctgacttgg gatttttaac cttatatatc tttttccttt
     9721 attcaaaaca aaacaatttt tagcacactg aaaaaaaaaa aaagccaaat gttttgtgcc
     9781 tttctaaggc agcgctgtac cccaggctgc atcttaggac ttaatatgga aataccagag
     9841 tctgagctcc tctgccttga atatctttag ccctggagtt ttggggacaa ggatgattgg
     9901 ctggaaaggt ggcacactag gtgcctagag tctcctttct ctgccacgag gcttcactgc
     9961 aagagagcag catttcattc cggcctcccg tggttggttc caggcagcag ttagtgctca
    10021 ggtgactgcc ctgggtgcca cactcaccca cctccgagag cagtgccctg cagagcagag
    10081 ctgtagggtg ggctcttctg ggaagaggag atggttcatt tgttgtcttt ttgttttgct
    10141 ggatcttgag ccagcttcaa cctcctgcct ctccttagac ttggctgtcc tttcagttga
    10201 aggcttcaac cataaagcat taagtggctg gtgcccatca cagggtcagc ttgcacccag
    10261 ggaggggcca cggcaccctg aggcctgtca gtcatactgt cgtaggtttc aaccacaagt
    10321 ttttaccctc ccttctccct ggttctcccc tgcctgtggc taacaaagag tgggggtgga
    10381 aacagttctt tttaagatct gcctcattcg agatttttaa attcttgatt tgggtgggac
    10441 aagagagaac ttgatatttt ccccagaata gagtcccaat ttgtatatca gtgttaagaa
    10501 aacaaaacac acacttaggt gagattctca tggactattt ttaaatgtca ttaatataag
    10561 aaaatttcta ttagcagtat ttacactctc ctgtagaaag caggcagagg taaatgctcc
    10621 tgcagagtag tggagcttta agactcgttc tcttcagtcc atgttgtttt gccagtgtac
    10681 tgatgtgtag aggtctgtta gactaattag aggtctgtta tactaatgtt atttattaat
    10741 ttttttcatt tccatacagt taactaaaga gctttttcaa gcacccatgt ctgtaaaaaa
    10801 atatttttaa ataaaatttc ttttgttgta gcaca
//
