LOCUS       NM_001013191            2927 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus core-binding factor subunit beta (Cbfb), mRNA.
ACCESSION   NM_001013191 XM_341670
VERSION     NM_001013191.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2927)
  AUTHORS   Zhang W, Du J, Evans SL, Yu Y and Yu XF.
  TITLE     T-cell differentiation factor CBF-beta regulates HIV-1 Vif-mediated
            evasion of host restriction
  JOURNAL   Nature 481 (7381), 376-379 (2011)
   PUBMED   22190036
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2927)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2927)
  AUTHORS   Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C,
            Okuda T and Taniuchi I.
  TITLE     Repression of the transcription factor Th-POK by Runx complexes in
            cytotoxic T cell development
  JOURNAL   Science 319 (5864), 822-825 (2008)
   PUBMED   18258917
REFERENCE   4  (bases 1 to 2927)
  AUTHORS   Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Kin S, Nakase Y,
            Ito K, Yamagishi H, Ida H, Yazumi S, Chiba T, Ito Y and Hagiwara A.
  TITLE     Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular
            carcinomas in an early stage of hepatocarcinogenesis
  JOURNAL   Anticancer Res 26 (5B), 3633-3643 (2006)
   PUBMED   17094378
REFERENCE   5  (bases 1 to 2927)
  AUTHORS   Yamamoto CM, Banaiee N, Yount NY, Patel B and Selsted ME.
  TITLE     Alpha-defensin expression during myelopoiesis: identification of
            cis and trans elements that regulate expression of NP-3 in rat
            promyelocytes
  JOURNAL   J Leukoc Biol 75 (2), 332-341 (2004)
   PUBMED   14634060
  REMARK    GeneRIF: demonstrated that proximity of the CAAT box and a putative
            polyoma enhancer-binding protein 2/core-binding factor PEBP2/CBF
            site was important for defensin NP-3 promoter activity.
REFERENCE   6  (bases 1 to 2927)
  AUTHORS   Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M,
            Lian JB, Yang Y, Nuckolls GH, Stein GS and Liu PP.
  TITLE     Cbfbeta interacts with Runx2 and has a critical role in bone
            development
  JOURNAL   Nat Genet 32 (4), 639-644 (2002)
   PUBMED   12434156
REFERENCE   7  (bases 1 to 2927)
  AUTHORS   Miller J, Horner A, Stacy T, Lowrey C, Lian JB, Stein G, Nuckolls
            GH and Speck NA.
  TITLE     The core-binding factor beta subunit is required for bone formation
            and hematopoietic maturation
  JOURNAL   Nat Genet 32 (4), 645-649 (2002)
   PUBMED   12434155
REFERENCE   8  (bases 1 to 2927)
  AUTHORS   Chen G, Zeng WZ, Yuan PX, Huang LD, Jiang YM, Zhao ZH and Manji HK.
  TITLE     The mood-stabilizing agents lithium and valproate robustly increase
            the levels of the neuroprotective protein bcl-2 in the CNS
  JOURNAL   J Neurochem 72 (2), 879-882 (1999)
   PUBMED   9930766
REFERENCE   9  (bases 1 to 2927)
  AUTHORS   Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, Asano S, Ito
            Y, Satake M and Noda T.
  TITLE     Hematopoiesis in the fetal liver is impaired by targeted
            mutagenesis of a gene encoding a non-DNA binding subunit of the
            transcription factor, polyomavirus enhancer binding protein 2/core
            binding factor
  JOURNAL   Proc Natl Acad Sci U S A 94 (11), 5697-5702 (1997)
   PUBMED   9159135
REFERENCE   10 (bases 1 to 2927)
  AUTHORS   Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M,
            Siciliano MJ and Collins FS.
  TITLE     Fusion between transcription factor CBF beta/PEBP2 beta and a
            myosin heavy chain in acute myeloid leukemia
  JOURNAL   Science 261 (5124), 1041-1044 (1993)
   PUBMED   8351518
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081946.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341670.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081946.1, EV770149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2927
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /note="core-binding factor subunit beta"
                     /db_xref="GeneID:361391"
                     /db_xref="RGD:620493"
     exon            1..357
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..828
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /note="core binding factor beta; core-binding factor, beta
                     subunit"
                     /codon_start=1
                     /product="core-binding factor subunit beta"
                     /protein_id="NP_001013209.1"
                     /db_xref="GeneID:361391"
                     /db_xref="RGD:620493"
                     /translation="MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRF
                     QNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMI
                     LNGVCVIWKGWIDLHRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSH
                     REEMEVRVSQLLAVTGKKTARP"
     exon            358..444
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..561
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..678
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..805
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..2906
                     /gene="Cbfb"
                     /gene_synonym="Pebp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagaggaa gtggcggctg cggccggggg aggctagagc tgtgtctgcg cgggcggcag
       61 gcaacggctg aggcggtggt agcgtgggtt gggctcaagc agacggccgc acctcagact
      121 ccctggagcg ggagcccacg cgggcgggct cctgaaacaa agagaagcgg gaatccggac
      181 gccgcgagtg ggcgatcagc ccgtcagcac tagggcccgc cagcgggtgc ccgcgctagc
      241 ttggagcgcg gccggccggc gcggcctgag ggcgggaaga tgccgcgcgt cgtaccggac
      301 cagaggagca agttcgagaa cgaggagttc ttcaggaagc tgagccgcga gtgtgagatt
      361 aagtacacgg gcttcaggga ccggccccac gaggagcgcc agacacgctt ccagaacgct
      421 tgccgcgacg gccgctcgga gatcgctttt gtggctacag gaaccaatct gtctctccag
      481 ttttttccgg ccagctggca gggagagcaa cgacaaacac ctagccggga atatgtcgac
      541 ttagaaagag aagcaggcaa ggtatacttg aaagccccca tgattctgaa tggagtatgt
      601 gttatatgga agggctggat tgatctccac agattggatg gtatgggttg cctggagttt
      661 gatgaggagc gagcccagca ggaagatgca ttagcacaac aggcctttga agaggctcga
      721 agaagaactc gagaatttga ggatagagac aggtctcacc gggaggaaat ggaggtgaga
      781 gtttcacagc tgctggcagt aactggcaag aagacagcaa gaccctagtc ctggttctaa
      841 tttaggtggt gatgatctca agcttcgtta ataggagcac agcacatgtg ccccccatct
      901 ctacatacac actgcttcta gttggtataa ataactcatt gtgcgaccag aaactgtgat
      961 aactggaggt actacagtat atttcatgac ctgaggcaga aaagacacca ttagctgcca
     1021 tggttttgca ctataatacc tgcatttctg atttttaaaa catgtagcca gtaataattt
     1081 gaaatttttt tctatgcaag cttatcttgt tggcattatt ttagttgggt tgaaagtatc
     1141 tactttcttc attttaactt aaaagttcat gtcatttaga aacaagataa gaaattaaaa
     1201 tttatatcag ggttgcttaa aattcttttg tactttcaga ctagttggtt atacagcttt
     1261 tcttcttaga taagggttct tggtttttgt ttgttttctc tatatcattt tgtgtttttg
     1321 tattctgcac cattttacaa attaaaatgt gttttctggt tttttttttt tttacaagct
     1381 aagaacctag aatagagctg tctgccgcag cctcctaaaa caaaagttta caattgttaa
     1441 agccacagta tccttttaat tgctaataat caacctttct ttccctttta aacataaaaa
     1501 tttaaattag tattaatttt tgtctcagat cttgtttcaa gttatattct gtaatcataa
     1561 gttaggtaga gatattcttc ataggtgata atgttctaca gaaatgccca aagaagtcac
     1621 agactggctt ctgttttatt cagggatttt ttttttttaa tcagtcagaa aaaggatact
     1681 ggaacttctt gtatgtaaca gcatattaaa ctggaggcag tgataaatca gctacagaag
     1741 taagtaaatt gtattaaaat aatgtttaag atagctgctt tcatgtgtat tttgtattgc
     1801 atgcttttgt agaaacaaaa ttgatgatgg agattagtct tagaaaatat tcatctgtgc
     1861 agaagataca ttttcttcca ttaattctgg gcaaaacatt cacagttata tatgatggta
     1921 ttttacaaaa ggactattaa tagtgccttt tgagatgaat cagtataaca atatttttaa
     1981 aacaggctta gtgtcaaatt acaatttttt taactataaa aactggaaaa aagtgctaag
     2041 tcattggcac atgcttacag atacttttcg tggtcatatt cattaaatgt tactacattt
     2101 ctgaattttt gcaaaaatgt attttatcat aaaatggcat tattttagag aattttaaaa
     2161 actgacatgg tcaattcaga aaagtctgaa taaggtcatt gcatttaaaa agcatataaa
     2221 gatacttgat tgtggaggtg tgactcattg tatataggtc ttataattca taaacaagta
     2281 ccctgtatct caaaataaag atatttgtta tatatttgaa gtcgtgcatg ataagcattg
     2341 tgtttgaatt attataaaca atgtgttaca aaagaccatg ctgaccttgt attgttacca
     2401 agcactatga atggatttgg ttggtatttg gtgtgcggtt cacatgttta cactctgtgc
     2461 cgtaattcct ttggggaatt acctttttaa agtgatcctt cattttttaa aataacatgt
     2521 tgatggtaca ttttctctgt tgcttctggc caagagcttt cagtccagca gtaaaaagat
     2581 cacatggtac tcctgttgtt gccatccctc tgtaaatagt gaatgtttct tactagttct
     2641 gcactgcttc tgtctgtctt aatgctggcg ttaagatcat atactccttt tctccggtag
     2701 tgcaggtttt gaaaattact tttaagttat tgatgcaatt tcatgttttt tcataatcta
     2761 tatttaagat gacatcattg catcattttt ttctaaattc atctccatta aaacttgcct
     2821 taagctacca gattgctttg ctattagctt tactgtacat ctgtatgttt tatttacttt
     2881 cacattaaaa ttctgtgtag tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
