LOCUS       NM_001168542            2599 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus CBFA2/RUNX1 partner transcriptional co-repressor
            2 (Cbfa2t2), mRNA.
ACCESSION   NM_001168542 XM_001064983 XM_215882
VERSION     NM_001168542.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Parang,B., Rosenblatt,D., Williams,A.D., Washington,M.K.,
            Revetta,F., Short,S.P., Reddy,V.K., Hunt,A., Shroyer,N.F.,
            Engel,M.E., Hiebert,S.W. and Williams,C.S.
  TITLE     The transcriptional corepressor MTGR1 regulates intestinal
            secretory lineage allocation
  JOURNAL   FASEB J 29 (3), 786-795 (2015)
   PUBMED   25398765
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   Cai,Y., Xu,Z., Xie,J., Ham,A.J., Koury,M.J., Hiebert,S.W. and
            Brandt,S.J.
  TITLE     Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL
            transcription factor in murine erythroid progenitors
  JOURNAL   Biochem Biophys Res Commun 390 (2), 295-301 (2009)
   PUBMED   19799863
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Ossovskaya,V.S., Dolganov,G. and Basbaum,A.I.
  TITLE     Loss of function genetic screens reveal MTGR1 as an intracellular
            repressor of beta1 integrin-dependent neurite outgrowth
  JOURNAL   J Neurosci Methods 177 (2), 322-333 (2009)
   PUBMED   19026687
REFERENCE   5  (bases 1 to 2599)
  AUTHORS   Amann,J.M., Chyla,B.J., Ellis,T.C., Martinez,A., Moore,A.C.,
            Franklin,J.L., McGhee,L., Meyers,S., Ohm,J.E., Luce,K.S.,
            Ouelette,A.J., Washington,M.K., Thompson,M.A., King,D., Gautam,S.,
            Coffey,R.J., Whitehead,R.H. and Hiebert,S.W.
  TITLE     Mtgr1 is a transcriptional corepressor that is required for
            maintenance of the secretory cell lineage in the small intestine
  JOURNAL   Mol Cell Biol 25 (21), 9576-9585 (2005)
   PUBMED   16227606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 12, 2009 this sequence version replaced
            XM_215882.3, XM_001064983.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222452.1, SRR26643296.11763.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000003.1  163397220-163397371
            153-296             JAXUCZ010000003.1  163467863-163468006
            297-538             JAXUCZ010000003.1  163472474-163472715
            539-628             JAXUCZ010000003.1  163476354-163476443
            629-810             JAXUCZ010000003.1  163481232-163481413
            811-1064            JAXUCZ010000003.1  163483058-163483311
            1065-1150           JAXUCZ010000003.1  163486326-163486411
            1151-1346           JAXUCZ010000003.1  163489356-163489551
            1347-1415           JAXUCZ010000003.1  163492921-163492989
            1416-1606           JAXUCZ010000003.1  163495624-163495814
            1607-2599           JAXUCZ010000003.1  163499122-163500114
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2599
                     /gene="Cbfa2t2"
                     /note="CBFA2/RUNX1 partner transcriptional co-repressor 2"
                     /db_xref="GeneID:296293"
                     /db_xref="RGD:1309088"
     exon            1..152
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1903
                     /gene="Cbfa2t2"
                     /note="translocated to, 2; core-binding factor, runt
                     domain, alpha subunit 2; translocated to, 2; CBFA2/RUNX1
                     translocation partner 2"
                     /codon_start=1
                     /product="protein CBFA2T2"
                     /protein_id="NP_001162014.1"
                     /db_xref="GeneID:296293"
                     /db_xref="RGD:1309088"
                     /translation="MVGVPGAAAFQLGCEKRVPAMPGSPVEVKIQSRASPPIMPPLPP
                     INPGGPRPVSFTPTALSNGISHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATC
                     GARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFP
                     LRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLM
                     EVHGNGKRPSPERRDENNFERDTVPPEPTAKRVCTISPAPRHSPALTVPLLSAGGQFH
                     PTPPPLQHYTLEDIATSHLYREPNKMLEHREVRERHHNLSLNGGYQDELVDHRLTERE
                     WADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRCNENTELRKTGT
                     ELVSRQHSPGSTDSLSNDSQREFTSRPAAGYVPVEFWKKTEEAVNKVKIQAMSEVQKA
                     VAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASET
                     CSGCNIARYCGSFCQHKDWERHHRLCGQSLHGHSPHSQSRSLLPGGRGSARSADCSVP
                     SPALDKTSATTSRSSTPASVTAIDANGL"
     exon            153..296
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..538
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..628
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..810
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1064
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1150
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1346
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1415
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1606
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..2599
                     /gene="Cbfa2t2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcagcgg cggcgctggt gcgggcgagt tcggcgggtg caggtcccgg cctgcgcctg
       61 cggagggctc aggcggaggg tcgaagcggg cggcgctcgc gacagactgc gctccgcgat
      121 ggtgggcgtc cctggagcgg ccgccttcca gcttggttgt gagaaaaggg tgccagcaat
      181 gcctggatcg cctgtggaag tgaagataca gtcaagagcc tcacctccca tcatgccacc
      241 cctcccacca ataaatcctg gaggaccgag gccagtgtcc tttactccta cagcattaag
      301 caatggcatc agccattccc ctcctaccct gaatggtgcc ccatcgccac cacagagatt
      361 cagcaacggg cctgcctcct ccacgtcctc agcgctaaca aatcagcagt tgccagctac
      421 ttgtggtgct cggcaactca gcaagttgaa acgctttctc actactctac aacagtttgg
      481 caatgacatc tcacctgaga ttggcgagaa ggttcggacg cttgttctag ccttggtgaa
      541 ctcaacagtg acaattgaag aattccattg caagctccag gaggctacaa acttcccact
      601 tcgtccattt gtaattccgt ttctcaaggc caacctgccc ctgctgcagc gagaactgct
      661 gcactgtgcc cgggctgcca agcagacccc atcccagtac ctggcccagc atgagcacct
      721 tctgctcaac accagtatcg catctcctgc tgactcttct gaactgctta tggaggttca
      781 tggaaatgga aagaggccca gtcccgaaag gagggatgag aataattttg aaagagacac
      841 agttcctcct gaaccgactg ccaagagagt gtgcactatc agccctgctc ctcggcacag
      901 tcctgccctc actgttcccc tcctgagtgc cgggggccag ttccatccta ctccaccacc
      961 tcttcagcac tataccttag aagacatcgc aacttctcac ctgtatcggg aaccaaacaa
     1021 gatgctagaa caccgagaag ttcgtgagag gcaccacaat cttagtctca atggaggcta
     1081 tcaagatgag ttggtagacc accgtttgac agaaagggag tgggccgatg aatggaaaca
     1141 tcttgaccat gccctgaatt gcatcatgga aatggtggaa aaaacgaggc gctccatggc
     1201 tgtcctgagg cgctgtcagg aatctgaccg tgaagagctt aactattgga aaagacgatg
     1261 taatgaaaat acagagttga ggaagactgg gaccgagttg gtctctaggc agcacagccc
     1321 tgggagtaca gattctctca gcaacgattc tcagcgggaa ttcaccagta ggccagcagc
     1381 aggatacgtg cctgtagagt tttggaagaa aactgaagaa gctgtgaaca aggtgaaaat
     1441 tcaggccatg tcagaggtac aaaaggctgt agctgaggca gagcaaaaag cctttgaagt
     1501 gattgcaact gagagagctc gaatggagca aaccatagcg gatgtcaaaa ggcaggcggc
     1561 agaagatgct ttcctggtca tcaatgagca agaagagtcc acagagaact gctggaactg
     1621 tggccgaaaa gccagtgaga cgtgcagtgg ctgcaatatt gctcgctact gtggctcctt
     1681 ctgccagcat aaggactggg agcggcacca ccgcctctgt ggccagagtc tacatggcca
     1741 cagtccccac agccagagcc ggtcactgct ccctggaggg cggggctcag ccaggtctgc
     1801 tgactgcagt gtgcccagcc cagccctgga caagacctca gctaccacct cacggtcctc
     1861 aacacctgcc tctgtgacag ccattgatgc caacgggctc tgagctacag actccacctc
     1921 ccctggtgac ccctccacat ggcagaatgc ttgcagcagt gagctggcaa tgcgaacaag
     1981 tagctctgtt gggtcatcag caggaaatga agtggcagga agcatcagag gttccacagc
     2041 ttccccgggg tttgccacat gtccttggaa gaactaatgg atcattctgt gcacacagga
     2101 aggagcttga gctgcctcct ccatggcttt cctgaggttt ctcttccagc taaagctggc
     2161 ataaccagcc ccttctcagt gtatacacca gctccctccg gctccctgca tcagcagatt
     2221 gtcagtagtg tcccagcagg caccagtgtc ccacagtgtc catagtagag gcctgaagac
     2281 tggtagcagg gttaggagga ggcccttcct tcccctgcct tcaaacagtt ctttgagccc
     2341 catatccacc ctcaggtgac acggattggc ctaaaagaga cttgggtagc acaaaagcag
     2401 taagtactca gaactccttc ctgagccact cagagctgtt aagaggctca aaaatggaag
     2461 aaagaagtca ctatttcagt aaaatctcta gtaatgatta aaaaaattaa attagtcttc
     2521 ccaagcatca tgggtcattt tggacaagat tttccaacct ggccatcttc gttagtttgg
     2581 aacccactca ccccctacc
//
