LOCUS       NM_001107931            4016 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus caveolae associated protein 4 (Cavin4), mRNA.
ACCESSION   NM_001107931 XM_001055709 XM_232981
VERSION     NM_001107931.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Malette,J., Degrandmaison,J., Giguere,H., Berthiaume,J.,
            Frappier,M., Parent,J.L., Auger-Messier,M. and Boulay,G.
  TITLE     MURC/CAVIN-4 facilitates store-operated calcium entry in neonatal
            cardiomyocytes
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (8), 1249-1259 (2019)
   PUBMED   30951783
  REMARK    GeneRIF: study provides novel evidence that MURC regulates SOCE by
            interacting with STIM1 in cardiomyocytes. In addition, we
            identified a first potential mechanism by which the R140W mutation
            of MURC may contribute to calcium mishandling and the development
            of cardiomyopathies.
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Naito,D., Ogata,T., Hamaoka,T., Nakanishi,N., Miyagawa,K.,
            Maruyama,N., Kasahara,T., Taniguchi,T., Nishi,M., Matoba,S. and
            Ueyama,T.
  TITLE     The coiled-coil domain of MURC/cavin-4 is involved in membrane
            trafficking of caveolin-3 in cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 309 (12), H2127-H2136 (2015)
   PUBMED   26497963
  REMARK    GeneRIF: MURC/cavin-4 requires its coiled-coil domain to target the
            plasma membrane and to stabilize Cav3 at the plasma membrane of
            cardiomyocytes
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Ogata,T., Naito,D., Nakanishi,N., Hayashi,Y.K., Taniguchi,T.,
            Miyagawa,K., Hamaoka,T., Maruyama,N., Matoba,S., Ikeda,K.,
            Yamada,H., Oh,H. and Ueyama,T.
  TITLE     MURC/Cavin-4 facilitates recruitment of ERK to caveolae and
            concentric cardiac hypertrophy induced by alpha1-adrenergic
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 111 (10), 3811-3816 (2014)
   PUBMED   24567387
REFERENCE   4  (bases 1 to 4016)
  AUTHORS   Rodriguez,G., Ueyama,T., Ogata,T., Czernuszewicz,G., Tan,Y.,
            Dorn,G.W. 2nd, Bogaev,R., Amano,K., Oh,H., Matsubara,H.,
            Willerson,J.T. and Marian,A.J.
  TITLE     Molecular genetic and functional characterization implicate
            muscle-restricted coiled-coil gene (MURC) as a causal gene for
            familial dilated cardiomyopathy
  JOURNAL   Circ Cardiovasc Genet 4 (4), 349-358 (2011)
   PUBMED   21642240
REFERENCE   5  (bases 1 to 4016)
  AUTHORS   Hansen,C.G., Bright,N.A., Howard,G. and Nichols,B.J.
  TITLE     SDPR induces membrane curvature and functions in the formation of
            caveolae
  JOURNAL   Nat Cell Biol 11 (7), 807-814 (2009)
   PUBMED   19525939
REFERENCE   6  (bases 1 to 4016)
  AUTHORS   Ogata,T., Ueyama,T., Isodono,K., Tagawa,M., Takehara,N.,
            Kawashima,T., Harada,K., Takahashi,T., Shioi,T., Matsubara,H. and
            Oh,H.
  TITLE     MURC, a muscle-restricted coiled-coil protein that modulates the
            Rho/ROCK pathway, induces cardiac dysfunction and conduction
            disturbance
  JOURNAL   Mol Cell Biol 28 (10), 3424-3436 (2008)
   PUBMED   18332105
  REMARK    GeneRIF: MURC modulates RhoA signaling, and MURC plays an important
            role in the development of cardiac dysfunction and conduction
            disturbance with increased vulnerability to atrial arrhythmias.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 30, 2022 this sequence version replaced NM_001107931.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.15183.1,
                                           SRR26643295.21275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               JAXUCZ010000005.1  67792432-67792908
            478-4016            JAXUCZ010000005.1  67799665-67803203
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4016
                     /gene="Cavin4"
                     /gene_synonym="RGD1310395"
                     /note="caveolae associated protein 4"
                     /db_xref="GeneID:313225"
                     /db_xref="RGD:1310395"
     exon            1..477
                     /gene="Cavin4"
                     /gene_synonym="RGD1310395"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1158
                     /gene="Cavin4"
                     /gene_synonym="RGD1310395"
                     /note="muscle-related coiled-coil protein;
                     muscle-restricted coiled-coil protein"
                     /codon_start=1
                     /product="caveolae-associated protein 4"
                     /protein_id="NP_001101401.1"
                     /db_xref="GeneID:313225"
                     /db_xref="RGD:1310395"
                     /translation="MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVATVV
                     DSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKD
                     VKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDVPCPASLSVVKDRSLPENEEEA
                     EEVFDPPIDLSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSKENMQKTRQNFDKKVS
                     GIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNATPSKEAFKIRSLRKP
                     KDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDGFSETEKEVTKVGYIPQEGGDPPT
                     PEPLKVTFKPQVRVEDDESLLLELKQSS"
     exon            478..4016
                     /gene="Cavin4"
                     /gene_synonym="RGD1310395"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgactttt ggctccgagt gtaggagccg atcgctgtag gacatcttct gctgagaaaa
       61 aaaagtaaaa tggaacacaa tggatctgct tcaaatgctg gtaaaatcca ccagaaccga
      121 ttgtcaagtg tgactgaaga tgaagaccag gacgcagctc tcacaattgt gactgtgctg
      181 gacagggtgg ccaccgtcgt ggacagcgtg caggcaagcc agaagagaat cgaggagaga
      241 cacagagaga tggggaacgc catcaagtct gtccagatag acctgctgaa gctctcacaa
      301 tcacacagca acacgggcta cgttgttaac aagctgtttg agaagacccg gaaagtcagc
      361 gctcacatta aagatgtgaa ggcccgggta gagaagcaac aggttcgagt aaccaaagtc
      421 gaaaccaagc aagaagaaat aatgaagaag aacaagttcc gcgtggtaat cttccaggag
      481 gatgttccct gccccgcatc cctgtctgtt gttaaagaca gaagcctgcc ggagaacgag
      541 gaggaagctg aggaagtctt cgatcccccg atcgatctct catcggatga agaatactat
      601 gttgaagaaa gcagatctgc caggcttaga aagtcaggca aagagcacat cgatcatatt
      661 aagaaggcat tttccaaaga aaacatgcag aagacgcggc agaattttga taagaaagtg
      721 agtggaatta gaaccaggat agttacacct gagagaagag agaggctgag gcagtcagga
      781 gagaggctga ggcagtcggg ggagaggctg aggcagtcgg gggaaagatt taagaaatcg
      841 atctcaaatg ccaccccctc caaggaagct tttaagatcc ggagccttag aaaaccgaag
      901 gaccccaagg cggaaggcca ggaggtagac agggggatgg gggtggacat catctcaggt
      961 agcctggctc tggggcccat ccatgagttc cactctgatg ggttcagtga aacagaaaag
     1021 gaggtgacca aagtagggta cattccccaa gagggagggg accccccaac gcctgagcct
     1081 ttgaaggtga cctttaaacc tcaggtgaga gtagaggatg acgagtcact cctgttggaa
     1141 ttaaagcagt cctcatagag gacttgagtg tgagcatcag tcacttcgaa tcatgtggtc
     1201 gtagtttgaa gggtacagta atttacattc atgcacagtg ggaaggcaaa tggtataaaa
     1261 gcttcatttc ttacctttaa aatcctagag atgatggaaa tattatatac agttttctta
     1321 taatttcctt gggaattcta tttcccctga gaatatatga ctctgacagc ttccccctca
     1381 tccccgctta tgtcatgcct ttccatggga ggtcttggcc aatgagaaaa tagtcggatg
     1441 gctcaggtca cttagatgct tggtcatttg taacacggga acgacacatc tgtgcccatt
     1501 ggtcaccaac aaagcataca ttagggtcag gattaacact tccagtttca aaggggagta
     1561 gctaatgtgt acattgtgtt atccagatgt ttacatctgg agattcatta gtgaatcagt
     1621 agccttatga agctcctgaa gtccttgtgt gagggaaagg aaatagaagt ttggggcctg
     1681 aacgtttagc tgtggcaacg taactttatt actagtgaga cacttggctg gctgcccctc
     1741 gttctcaata ggaaaaatgg tgaggcttcg tacttctcag aggacttgag atctgagggt
     1801 atgtcacaga gtgtgggaga acaagacaca caaccagtgg agaagcgtga accacactgg
     1861 ccttccctaa accagaactg aacagttaca tctctgcaga agcccttggc acaggctctg
     1921 aggccagagt tgagcagaaa ctgagtttgt tcttcacaag tcttcactgc acgcacagtg
     1981 aaaaatgaac gcttggatgg gtgctttctc attgaaggct gagaccaaac cttgggtttt
     2041 agccgtgtcc taacatgttc cttggaagac tggctccatt tgccggtaga tttggatgtg
     2101 gggtagacaa gtacaggtct tgtttgccca gcacgaggta gaagtctgga acacggttgt
     2161 caagtggctt ttccacggtc cgccctggtg tgccgctggg cacagaaaca accccgacac
     2221 ttctgtttgc cagagcggac tgagaacagt gcccataagc tttcgtcagg gccacgcgga
     2281 gggcgtccaa ttccagttag ctcttagatc tagatctggg tagtcaagag gtaactattg
     2341 ctgcttccag cacacggaaa tcttgggggc attttcttga tatggaagag atggtagaat
     2401 ttttgataag ttcgtttaaa ctcacattta gtttaatttt tgaataatca tgtagtactt
     2461 aaatatatgc aggcttgggg gtgcgtgcct gctgccccag cactagcaag gctgaaacag
     2521 gatcgcagtg aagctgagtg agcctgggct ccctttatat acacagttca gtatactttc
     2581 cttttctctt ggcctgaata cgtgttcatc ttgctatctc ttttttattt gtttgttttc
     2641 tttcctcctc ctccttctct tctttggttt gtttgtttgc ttgcttgttt gtgttttcaa
     2701 gatggggttt ctctgtgtag tcctggaact tgctctgtgg accaggctgg cctcttaact
     2761 cacagagacc cgcttgcccc ccctcccgag ggctgggttt aaaggggtgt aacaccatca
     2821 cacggcatcc tgctaccttt tttatactgc aaactaaagc atgtgtagca ttgaataaca
     2881 ctttaagaga ataattccaa acacattttt tttataacag cttagaagga ggttaacggt
     2941 gtctaagaat aagtttgaat gtgaaatgat gttgttgcaa aatgcgaggc cggtgttgtg
     3001 gttgttaatc ttttaaccag tgatgagtgg taactgcaat atgcaaatgg agaaagagtt
     3061 aaccaatggt aaatcaaggc tcgagggaat acagagaagt tacagacgtg gtacgtcgag
     3121 ggcaggagga atgtcgagaa gttacagttg ttgttttcag tttatttcat ttggtctaaa
     3181 atacttttct gcaaatgtct agggctttgt ccactagtca ttaatgtccg gctctgacag
     3241 cttagaaagc attgcacctg tagccatatt agagtctgac tgggaaggag ttacgacctg
     3301 gccagccagc tctttgtctt gctagagttt gacaccagaa ccaccggatg tttcctgttg
     3361 ctgaccgctc atgtaatccc atgcttcctt ctcaccgtca gggtttcccc tccatgttgt
     3421 gaacatgtgt cctttcatgt ttaggacatt cctgaattcc acattcacag tctcttgtac
     3481 ctcctacctg ctttcatggc tcggagatga tgggctgcaa aagtcactca ctctcttaac
     3541 acaagggcac aagggacgtt ctagtcagtg ttcatcagtt taaaagtctc gggaaatgcc
     3601 cggttgcttg ctgatctgta atgcagcatt acgcatcagg ctttagataa tttacccaag
     3661 gcaaaccttc agcaggattt gcccccttct agtaatgaga tggagcagag cagctgcccc
     3721 agaggccagg ggtggggacg ctggtgttga ggcttttcca ggggacacag tgaagtgaaa
     3781 gcctgtctcc tgtgtgtggt gatccagcta tcctgagtgg ccagtggctt ggcccctgct
     3841 tacaggttat agagaaatga actcgggtgt tccgcttgcc gacagtggac ttgtgtgtgt
     3901 tcccccaaaa gcaagttttc atgagtgaaa agtacaagct gccaaagtaa aaagccaacc
     3961 atattgcctt ccttctttgc ctttcatatt cattaaagat gtcagtttgg aacagg
//
