LOCUS       NM_001105841            1393 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus caveolae associated protein 1 (Cavin1), mRNA.
ACCESSION   NM_001105841 XM_001081467 XM_220982
VERSION     NM_001105841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Wei,Z., Liu,T., Lei,J., Wu,Y., Wang,S. and Liao,K.
  TITLE     Fam198a, a member of secreted kinase, secrets through caveolae
            biogenesis pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 50 (10), 968-975 (2018)
   PUBMED   30188967
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Zhou,L.J., Chen,X.Y., Liu,S.P., Zhang,L.L., Xu,Y.N., Mu,P.W.,
            Geng,D.F. and Tan,Z.
  TITLE     Downregulation of Cavin-1 Expression via Increasing Caveolin-1
            Degradation Prompts the Proliferation and Migration of Vascular
            Smooth Muscle Cells in Balloon Injury-Induced Neointimal
            Hyperplasia
  JOURNAL   J Am Heart Assoc 6 (8), e005754 (2017)
   PUBMED   28751541
  REMARK    GeneRIF: Cavin-1 downregulation in neointimal formation promotes
            vascular smooth muscle cell proliferation, migration, and
            synchronously enhancing caveolin-1 lysosomal degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Liu,L. and Pilch,P.F.
  TITLE     PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in
            response to metabolic challenges
  JOURNAL   Elife 5, e17508 (2016)
   PUBMED   27528195
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Madawala,R.J., Poon,C.E., Dowland,S.N. and Murphy,C.R.
  TITLE     PTRF is associated with caveolin 1 at the time of receptivity: but
            SDPR is absent at the same time
  JOURNAL   Histochem Cell Biol 143 (6), 637-644 (2015)
   PUBMED   25618412
  REMARK    GeneRIF: The PTRF and lack of SDPR may contribute not only to the
            morphology of the basal plasma membrane as observed at the time of
            implantation, but also to the maintenance of epithelial polarity
            during early pregnancy.
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Wei,Z., Zou,X., Wang,H., Lei,J., Wu,Y. and Liao,K.
  TITLE     The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential
            and sufficient for its caveolae-association
  JOURNAL   Biochem Biophys Res Commun 456 (3), 750-756 (2015)
   PUBMED   25514038
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Aboulaich,N., Vainonen,J.P., Stralfors,P. and Vener,A.V.
  TITLE     Vectorial proteomics reveal targeting, phosphorylation and specific
            fragmentation of polymerase I and transcript release factor (PTRF)
            at the surface of caveolae in human adipocytes
  JOURNAL   Biochem J 383 (Pt 2), 237-248 (2004)
   PUBMED   15242332
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Voldstedlund,M., Vinten,J. and Tranum-Jensen,J.
  TITLE     cav-p60 expression in rat muscle tissues. Distribution of caveolar
            proteins
  JOURNAL   Cell Tissue Res 306 (2), 265-276 (2001)
   PUBMED   11702238
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Vinten,J., Voldstedlund,M., Clausen,H., Christiansen,K., Carlsen,J.
            and Tranum-Jensen,J.
  TITLE     A 60-kDa protein abundant in adipocyte caveolae
  JOURNAL   Cell Tissue Res 305 (1), 99-106 (2001)
   PUBMED   11512676
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Jansa,P., Burek,C., Sander,E.E. and Grummt,I.
  TITLE     The transcript release factor PTRF augments ribosomal gene
            transcription by facilitating reinitiation of RNA polymerase I
  JOURNAL   Nucleic Acids Res 29 (2), 423-429 (2001)
   PUBMED   11139612
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Jansa,P., Mason,S.W., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Cloning and functional characterization of PTRF, a novel protein
            which induces dissociation of paused ternary transcription
            complexes
  JOURNAL   EMBO J 17 (10), 2855-2864 (1998)
   PUBMED   9582279
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_220982.3, XM_001081467.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ236462.1, CK357571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1393
                     /gene="Cavin1"
                     /note="caveolae associated protein 1"
                     /db_xref="GeneID:287710"
                     /db_xref="RGD:1307685"
     exon            1..583
                     /gene="Cavin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1285
                     /gene="Cavin1"
                     /note="cavin; cav-p60; cavin-1; polymerase I and
                     transcript release factor"
                     /codon_start=1
                     /product="caveolae-associated protein 1"
                     /protein_id="NP_001099311.1"
                     /db_xref="GeneID:287710"
                     /db_xref="RGD:1307685"
                     /translation="MEDVTLHIVERPYSGYPDASSEGPEPTPGEARATEEPSGTGSDE
                     LIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAH
                     ATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQD
                     EVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEEDAAAIELSSDEAVEVEEVIEES
                     RAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRM
                     NKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGE
                     VEVLKATEMVEVGPDDDEVGAERGEATDLLRGSSPDVHTLLEITEESDAVLVDKSDSD
                     "
     exon            584..1393
                     /gene="Cavin1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctccgctc taggctcctg ctcgctttcc cctctctcgc tcctccttct ctccgggtct
       61 cccgctccag ttccaccgag tcggccccgc acggctccgg gaagccatgg aggatgtcac
      121 gctccatatc gtcgagcggc cgtattccgg atatcccgat gcttcctccg agggcccgga
      181 gcccacccca ggggaggcac gggccaccga ggagccgtcg gggaccggtt ccgacgagct
      241 gatcaagtcg gaccaggtaa acggtgtact ggtgctgagc cttctggata aaatcatcgg
      301 cgccgttgac cagatccagc tgacccaagc ccagctggaa gagcgacagg cagagatgga
      361 gggcgctgtg cagagcatcc agggagagct gagcaagctg ggcaaggcgc acgccaccac
      421 cagcaacacc gtgagcaagt tgctggagaa ggtgcgcaag gtcagcgtca acgtgaagac
      481 ggtgcgaggc agcctggagc gccaggctgg ccagataaag aaactggagg tcaacgaggc
      541 ggagctgctg cggcgccgca acttcaaagt catgatctac caggatgaag tcaagctgcc
      601 ggccaaactg agcgtcagca agtctctgaa agagtcggag gcgctgccag agaaggaggg
      661 cgatgagctg ggcgagggcg agcggccgga ggaggacgct gcggcgatcg agctgtcgtc
      721 tgacgaggcg gtggaggtgg aggaggtgat cgaggagtcc cgcgccgagc gcatcaagcg
      781 cagcggcctg cggcgcgtgg acgacttcaa gaaggccttc tccaaggaga agatggagaa
      841 gaccaaggtg cgcacgcgcg agaacctgga gaagacgcgc ctgaagacta aggagaacct
      901 ggagaagacg cggcacacgc tggagaagcg catgaacaag ctgggcacgc gcctggtgcc
      961 cgtggagcga cgcgagaagc tgaagacgtc gcgcgacaag ctgcgcaagt ccttcacgcc
     1021 cgaccacgtg gtgtacgcgc gctccaagac cgcggtctac aaggtgccgc cctttacctt
     1081 ccatgtcaag aagatccgcg agggcgaggt ggaggtgctg aaggccaccg agatggtgga
     1141 ggtgggtcct gatgacgacg aggttggcgc ggagcgcggc gaggccactg acctgctgcg
     1201 cgggagcagc cccgacgtgc acacgctgct ggagatcacc gaggaatcgg acgccgtcct
     1261 ggtggacaag agcgacagcg actgagcagg actcacgggg ctctgccctg gaggccggtg
     1321 cctgatcctg tcctccctga cccccactcc tgcccaccgc ctttctcatt tcaaactttc
     1381 tcttttgcat tct
//
