LOCUS       NM_019155               1380 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus caveolin 3 (Cav3), mRNA.
ACCESSION   NM_019155
VERSION     NM_019155.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Wong,A.M., Scott,A.K., Johnson,C.S., Mohr,M.A., Mittelman-Smith,M.
            and Micevych,P.E.
  TITLE     ERalphaDelta4, an ERalpha splice variant missing exon4, interacts
            with caveolin-3 and mGluR2/3
  JOURNAL   J Neuroendocrinol 31 (6), e12725 (2019)
   PUBMED   31050077
  REMARK    GeneRIF: ERalphaDelta4, an ERalpha splice variant missing exon4,
            interacts with caveolin-3 and mGluR2/3.
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Bryant,S.M., Kong,C.H.T., Cannell,M.B., Orchard,C.H. and James,A.F.
  TITLE     Loss of caveolin-3-dependent regulation of ICa in rat ventricular
            myocytes in heart failure
  JOURNAL   Am J Physiol Heart Circ Physiol 314 (3), H521-H529 (2018)
   PUBMED   29101175
  REMARK    GeneRIF: In ventricular myocytes from normal hearts, regulation of
            the L-type Ca(2+) current by beta2-adrenoceptors and the
            constitutive regulation by caveolin-3 is localized to the
            t-tubules. In heart failure, the regulation of L-type Ca(2+)
            current by beta2-adrenoceptors is redistributed to the surface
            membrane, and the constitutive regulation by caveolin-3 is lost.
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Zhou,Q., Peng,X., Liu,X., Chen,L., Xiong,Q., Shen,Y., Xie,J.,
            Xu,Z., Huang,L., Hu,J., Wan,R. and Hong,K.
  TITLE     FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by
            stabilizing caveolin-3
  JOURNAL   J Mol Cell Cardiol 116, 115-124 (2018)
   PUBMED   29438664
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Zhang,L., Yin,H., Jiao,L., Liu,T., Gao,Y., Shao,Y., Zhang,Y.,
            Shan,H., Zhang,Y. and Yang,B.
  TITLE     Abnormal Downregulation of Caveolin-3 Mediates the Pro-Fibrotic
            Action of MicroRNA-22 in a Model of Myocardial Infarction
  JOURNAL   Cell Physiol Biochem 45 (4), 1641-1653 (2018)
   PUBMED   29486470
  REMARK    GeneRIF: Cav3 depletion in cardiac fibroblasts induced an increase
            in collagen content, cell proliferation, and phenotypic conversion
            of fibroblasts to myofibroblasts. Conversely, Cav3 overexpression
            in cardiac fibroblasts was shown to inhibit angiotensin II-mediated
            excessive collagen deposition through protein kinase C-epsilon
            inactivation.
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Nader,M., Alotaibi,S., Alsolme,E., Khalil,B., Abu-Zaid,A.,
            Alsomali,R., Bakheet,D. and Dzimiri,N.
  TITLE     Cardiac striatin interacts with caveolin-3 and calmodulin in a
            calcium sensitive manner and regulates cardiomyocyte spontaneous
            contraction rate
  JOURNAL   Can J Physiol Pharmacol 95 (10), 1306-1312 (2017)
   PUBMED   28825318
  REMARK    GeneRIF: Suggest a novel role for striatin in regulating
            cardiomyocyte spontaneous contraction rate and the dynamics of the
            STRN/caveolin-3/calmodulin complex.
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Minetti,C., Sotgia,F., Bruno,C., Scartezzini,P., Broda,P., Bado,M.,
            Masetti,E., Mazzocco,M., Egeo,A., Donati,M.A., Volonte,D.,
            Galbiati,F., Cordone,G., Bricarelli,F.D., Lisanti,M.P. and Zara,F.
  TITLE     Mutations in the caveolin-3 gene cause autosomal dominant
            limb-girdle muscular dystrophy
  JOURNAL   Nat Genet 18 (4), 365-368 (1998)
   PUBMED   9537420
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Venema,V.J., Ju,H., Zou,R. and Venema,R.C.
  TITLE     Interaction of neuronal nitric-oxide synthase with caveolin-3 in
            skeletal muscle. Identification of a novel caveolin
            scaffolding/inhibitory domain
  JOURNAL   J Biol Chem 272 (45), 28187-28190 (1997)
   PUBMED   9353265
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Parton,R.G., Way,M., Zorzi,N. and Stang,E.
  TITLE     Caveolin-3 associates with developing T-tubules during muscle
            differentiation
  JOURNAL   J Cell Biol 136 (1), 137-154 (1997)
   PUBMED   9008709
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Song,K.S., Scherer,P.E., Tang,Z., Okamoto,T., Li,S., Chafel,M.,
            Chu,C., Kohtz,D.S. and Lisanti,M.P.
  TITLE     Expression of caveolin-3 in skeletal, cardiac, and smooth muscle
            cells. Caveolin-3 is a component of the sarcolemma and
            co-fractionates with dystrophin and dystrophin-associated
            glycoproteins
  JOURNAL   J Biol Chem 271 (25), 15160-15165 (1996)
   PUBMED   8663016
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Tang,Z., Scherer,P.E., Okamoto,T., Song,K., Chu,C., Kohtz,D.S.,
            Nishimoto,I., Lodish,H.F. and Lisanti,M.P.
  TITLE     Molecular cloning of caveolin-3, a novel member of the caveolin
            gene family expressed predominantly in muscle
  JOURNAL   J Biol Chem 271 (4), 2255-2261 (1996)
   PUBMED   8567687
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC084692.1.
            
            On Nov 15, 2004 this sequence version replaced NM_019155.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084692.1, FQ214918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..1380
                     /gene="Cav3"
                     /note="caveolin 3"
                     /db_xref="GeneID:29161"
                     /db_xref="RGD:2281"
     exon            1..249
                     /gene="Cav3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..591
                     /gene="Cav3"
                     /codon_start=1
                     /product="caveolin-3"
                     /protein_id="NP_062028.1"
                     /db_xref="GeneID:29161"
                     /db_xref="RGD:2281"
                     /translation="MMTEEHTDLEARIIKDIHCKEIDLVNRDPKNINEDIVKVDFEDV
                     IAEPEGTYSFDGVWRVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWA
                     VVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLRREG"
     exon            250..1355
                     /gene="Cav3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatgctggg tggggcctat ttagccggca ggggcaccag tctggagacc ctaagcttgg
       61 tctttctgcc ccaggactgt caacaatacc agccacaaga ttctgatctc ctcccgaagg
      121 tgccccagcc tcacaatgat gaccgaagag cacacagatc tggaggcacg gatcatcaag
      181 gacattcact gcaaggagat agacttggtg aacagagacc ccaagaacat caatgaggac
      241 attgtgaagg tggattttga agatgtgatt gcggagcccg agggcactta cagcttcgat
      301 ggcgtgtgga gggtgagcta caccactttc accgtctcca agtactggtg ctaccgcctg
      361 ctgtctacac tgctgggtgt tccactggcc ctgctctggg gattcctgtt tgcctgtatc
      421 tccttctgcc acatctgggc cgtggtgccc tgcattaaga gctacctgat tgagatccag
      481 tgcatcagcc acatctactc actgtgtatc cgcaccttct gcaacccgct ctttgccgca
      541 ctgggccagg tctgcagcaa cattaaggtg gtgctgcgaa gggaaggcta aagccgggct
      601 gggctgtggg gaaggctggg cagggggaat agggccaggt gtacacccat ggctctgctc
      661 cacatgggct gctggcgagc tcatgctttt aagattctcc tcagttccac ctcaaaatgg
      721 gagtacatgg tgcaggggag ccaaaaggaa aagacagccc agtgtggaaa ctgctcagcc
      781 taccatgatc cccagcgacc ctgcctgagc agagggttcc ttaagaggca gctatcacaa
      841 ggctttgcga tcacatgtac tgtaagagca caaaccaaca ccagtcttct agaggggtag
      901 cccgtctcct catgctaggg agagcaagcg gtgactgcca gcatgaggaa ggtgctgcaa
      961 taaagggttt cggctgcacc agggaacact atgctctgtg tctgtaaggt ggttgtgtgt
     1021 ccttttctag ttctgaaacc cagaaacttc agttggtcct ctgcaaattg aaaaccagaa
     1081 ctaagttttg tttccttcag gattctactt gtttgctggg cataaatagg gtttcccata
     1141 tgaggaaatt gtttccaaat gacttctgct gtctctgagg cagctgaggt ggactgaggg
     1201 caggtgagca tccccgggca ctgctgaaaa tgggccccaa cttcagaccc cagaggaatc
     1261 cccgctctgg ctcagacacg gagcgggaaa cacactgggc ctttccatgc agcttgtgcg
     1321 caccaccagc cgtaataaac accatgaatg cagagaaaaa aaaaaaaaaa aaaaaaaaaa
//
