LOCUS       NM_131914               2489 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus caveolin 2 (Cav2), mRNA.
ACCESSION   NM_131914 XM_346689 XM_347374
VERSION     NM_131914.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Bulacio,R.P., Nosetto,E.C., Brandoni,A. and Torres,A.M.
  TITLE     Novel finding of caveolin-2 in apical membranes of proximal tubule
            and first detection of caveolin-2 in urine: A promising biomarker
            of renal disease
  JOURNAL   J Cell Biochem 120 (4), 4966-4974 (2019)
   PUBMED   30269377
  REMARK    GeneRIF: n increase in the urinary abundance of Cav-2 in two models
            of acute kidney injury, and thus we proposed the urinary excretion
            of Cav-2 as a potential biomarker of kidney injury.
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Kwon,H., Lee,J., Jeong,K., Jang,D. and Pak,Y.
  TITLE     Fatty acylated caveolin-2 is a substrate of insulin receptor
            tyrosine kinase for insulin receptor substrate-1-directed signaling
            activation
  JOURNAL   Biochim Biophys Acta 1853 (5), 1022-1034 (2015)
   PUBMED   25667086
  REMARK    GeneRIF: Insulin receptor substrate-1 (IRS-1) is recruited to
            interact with the IR-catalyzed phospho-tyrosine cav-2, which
            facilitates IRS-1 association with and activation by IR to initiate
            IRS-1-mediated downstream signaling.
REFERENCE   3  (bases 1 to 2489)
  AUTHORS   Jeong,K., Kwon,H., Lee,J., Jang,D. and Pak,Y.
  TITLE     Insulin-response epigenetic activation of Egr-1 and JunB genes at
            the nuclear periphery by A-type lamin-associated pY19-Caveolin-2 in
            the inner nuclear membrane
  JOURNAL   Nucleic Acids Res 43 (6), 3114-3127 (2015)
   PUBMED   25753664
  REMARK    GeneRIF: show that Cav-2 is an epigenetic regulator of histone H3
            modifications, and provide novel mechanisms of insulin-response
            epigenetic activation at the nuclear periphery
REFERENCE   4  (bases 1 to 2489)
  AUTHORS   Kipper,S., Hamad,S., Caly,L., Avrahami,D., Bacharach,E., Jans,D.A.,
            Gerber,D. and Bajorek,M.
  TITLE     New host factors important for respiratory syncytial virus (RSV)
            replication revealed by a novel microfluidics screen for
            interactors of matrix (M) protein
  JOURNAL   Mol Cell Proteomics 14 (3), 532-543 (2015)
   PUBMED   25556234
REFERENCE   5  (bases 1 to 2489)
  AUTHORS   Badaut,J., Ajao,D.O., Sorensen,D.W., Fukuda,A.M. and Pellerin,L.
  TITLE     Caveolin expression changes in the neurovascular unit after
            juvenile traumatic brain injury: signs of blood-brain barrier
            healing?
  JOURNAL   Neuroscience 285, 215-226 (2015)
   PUBMED   25450954
  REMARK    GeneRIF: Study suggests that molecular changes involving cav1, cav2
            and cav3 occurring in endothelial cells following juvenile
            traumatic brain injury might participate in blood-brain barrier
            repair while, might serve other undefined roles in astrocytes
REFERENCE   6  (bases 1 to 2489)
  AUTHORS   Gargalovic,P. and Dory,L.
  TITLE     Caveolin-1 and caveolin-2 expression in mouse macrophages. High
            density lipoprotein 3-stimulated secretion and a lack of
            significant subcellular co-localization
  JOURNAL   J Biol Chem 276 (28), 26164-26170 (2001)
   PUBMED   11316799
REFERENCE   7  (bases 1 to 2489)
  AUTHORS   de Marco,M.C., Kremer,L., Albar,J.P., Martinez-Menarguez,J.A.,
            Ballesta,J., Garcia-Lopez,M.A., Marazuela,M., Puertollano,R. and
            Alonso,M.A.
  TITLE     BENE, a novel raft-associated protein of the MAL proteolipid
            family, interacts with caveolin-1 in human endothelial-like ECV304
            cells
  JOURNAL   J Biol Chem 276 (25), 23009-23017 (2001)
   PUBMED   11294831
REFERENCE   8  (bases 1 to 2489)
  AUTHORS   Kiss,A.L., Turi,A., Mullner,N. and Timar,J.
  TITLE     Caveolin isoforms in resident and elicited rat peritoneal
            macrophages
  JOURNAL   Eur J Cell Biol 79 (5), 343-349 (2000)
   PUBMED   10887965
REFERENCE   9  (bases 1 to 2489)
  AUTHORS   Scherer,P.E., Lewis,R.Y., Volonte,D., Engelman,J.A., Galbiati,F.,
            Couet,J., Kohtz,D.S., van Donselaar,E., Peters,P. and Lisanti,M.P.
  TITLE     Cell-type and tissue-specific expression of caveolin-2. Caveolins 1
            and 2 co-localize and form a stable hetero-oligomeric complex in
            vivo
  JOURNAL   J Biol Chem 272 (46), 29337-29346 (1997)
   PUBMED   9361015
REFERENCE   10 (bases 1 to 2489)
  AUTHORS   Scherer,P.E., Okamoto,T., Chun,M., Nishimoto,I., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Identification, sequence, and expression of caveolin-2 defines a
            caveolin gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 131-135 (1996)
   PUBMED   8552590
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_131914.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062059.1, FQ209775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               JAXUCZ010000004.1  46582681-46582953
            274-461             JAXUCZ010000004.1  46583320-46583507
            462-2489            JAXUCZ010000004.1  46588031-46590058
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2489
                     /gene="Cav2"
                     /note="caveolin 2"
                     /db_xref="GeneID:363425"
                     /db_xref="RGD:620348"
     exon            1..273
                     /gene="Cav2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..612
                     /gene="Cav2"
                     /codon_start=1
                     /product="caveolin-2"
                     /protein_id="NP_571989.3"
                     /db_xref="GeneID:363425"
                     /db_xref="RGD:620348"
                     /translation="MGLETEKADVQLFMADDAYSHHSVVDYADPEKYVDSSQDRDPHQ
                     LNSHLKLGFEDLIAEPPTTHSFDKVWICSHALFEISKYVIYKFLTVFLAIPLAFIAGI
                     LFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVVIGPLCTSVGRIFSSVSMQLS
                     HD"
     exon            274..461
                     /gene="Cav2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..2489
                     /gene="Cav2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgggcag ccggaggcta ggcagggcga agccaggcgg ggcggggctg ggagccaagg
       61 gaaggggagg ccgtgctgcc tagggaccga ccgacccgag ccagtctccc aacaccagcc
      121 accatggggc tggagaccga gaaggccgac gtgcagctct tcatggccga tgacgcctac
      181 agccaccaca gtgtcgtcga ctacgcagat cctgagaagt atgttgactc cagtcaggac
      241 cgggatcctc accagctcaa ctctcatctc aagctaggct tcgaggatct gatcgcagaa
      301 cctccgacta cacactcctt tgacaaagtg tggatctgca gccacgcgct ctttgaaatc
      361 agcaaatacg tgatctacaa gttcctgacg gtgtttctag ccatcccctt ggccttcatt
      421 gcgggtatcc tgtttgctac cctcagctgt ctgcacatct ggatcctaat gccttttgtg
      481 aagacctgcc tcatggtcct gccttccgtg cagacgatat ggaagagtgt gacagatgtt
      541 gtcattggcc cattgtgtac aagtgtaggg cgcatcttct cctctgtcag catgcaactg
      601 agccatgact gaacactcag accccaggtc caaatatttg gatactgtac aactctgttg
      661 atgtgacaca aaagcactac tgttctgttc actttccatt tgtcataatt attcttaaga
      721 tgggaccaag gtttatcaat gttcactgtc agatctttag caataatgat tttccccact
      781 aaaagccaag gattccatat ctaattgtgt aacaagggtt ggcaacactc aacgtaagaa
      841 cagacagctt tctgctttca gaaaaaaaca tacatttgta gtgatgattt gataatggtc
      901 aaagggcaac ttcctcagac actagagtaa ttttgtgcat aactgctcat acaagtgtgg
      961 aatttcttat tttcttttac tctaggagta atgtcttaaa gctactttta cagatatgat
     1021 cataaggcta ggtagaggta atatattcaa acattctaga aacttagtgc agtaacagaa
     1081 gcatatactt atgaaaataa ctatcaaata taataagaca gataaatgtg aaaaatgtgt
     1141 tcctttgcaa tattgttagc ttgtaaccct ctttaacaag acgtttcgtt ttgctgtata
     1201 tcttatacct aatgcaatgt tactcaaatg caatcgcttt ggagtgcttt tgcttgcgtt
     1261 tgctatctta ttgatctcat acacaaggta agcagagcta ccatagggta actttctttg
     1321 taagactgtg atgtcatata tgagaagttt tgtagcttct ttgggataca atgtaaaatg
     1381 tgctgtctag gtgacctctc caacttcccc agcaaatgtt ttatgactgg gcttcatctg
     1441 gctgtgacca gaagatatgt agttgttttg tttactagaa gttttcttcc gaataagtag
     1501 aaacttaacc tgtagtctac attcctatga atgcttcact tactgtcaag tacttctggt
     1561 gctagttaat atttttatga taaagactat gtctaagatc taagcacatt actacagtgg
     1621 ctcatgtaga gaaacttaca ggagaattaa cacttgtgag ggcctataaa actaaagtac
     1681 acatgtaaat taaaaactaa cagttacaaa ttttcaagat cttctctagt atgaatcttg
     1741 taacccatga acattatttc cttttcaatt ctagacctat tttaacattt actcatatgg
     1801 ccttttaaat gttggtatat aagaactttc tacattataa ttatacaatt tttcaaattt
     1861 cagagttatt atcaaaacct gaagtatttg cttgaatatt ctcatgggtg tcaaaccttc
     1921 acttagtgaa gataaataat ttttttttca aattttcaat tctggtcaat attaaatgtg
     1981 attgaactgg gattccattg cagaccagat caaaagatta tggttataaa aacccatgtt
     2041 ataaatctca tatcaatttg atggtaatca taaaagaaac gtttcaaaat gtccttacgg
     2101 tatcatacca ttctcagaaa aagaagtcat agctcagtaa tagccacaaa acattgccac
     2161 taatgtgact atgaacattg tatcttatta gtttccaagg tcagtctcaa ggctttatac
     2221 tactatttgt aatttaaaca cttggatata ttgattagtc aaaactttaa caataaagta
     2281 ttagtttacc ttttttaaat agttctgaca gatttaaaag acaaatatgt ataattatat
     2341 gtaaaaacct ttaattgcta atatatatat gtatatgact tcttttttct gaataatatc
     2401 aattactttc aaggaaactt ttactgaaac ttttcatgaa ttattttgtc ttaaaaactc
     2461 aaatcacgaa taaaaagaat caaagttaa
//
