LOCUS       NM_031556               2584 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus caveolin 1 (Cav1), transcript variant 1, mRNA.
ACCESSION   NM_031556 XM_346691 XM_347375
VERSION     NM_031556.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2584)
  AUTHORS   Sakaguchi,R., Takahashi,N., Yoshida,T., Ogawa,N., Ueda,Y.,
            Hamano,S., Yamaguchi,K., Sawamura,S., Yamamoto,S., Hara,Y.,
            Kawamoto,T., Suzuki,R., Nakao,A., Mori,M.X., Furukawa,T.,
            Shimizu,S., Inoue,R. and Mori,Y.
  TITLE     Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein
            assembly potentiates the positive feedback interaction between Ca2+
            and NO signals
  JOURNAL   J Biol Chem 300 (9), 107705 (2024)
   PUBMED   39178948
  REMARK    GeneRIF: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS
            protein assembly potentiates the positive feedback interaction
            between Ca[2+] and NO signals.
REFERENCE   2  (bases 1 to 2584)
  AUTHORS   Jin,H.Q., Jiang,W.F., Zheng,X.T., Li,L., Fang,Y., Yang,Y., Hu,X.W.
            and Chu,L.S.
  TITLE     MiR-199a-5p enhances neuronal differentiation of neural stem cells
            and promotes neurogenesis by targeting Cav-1 after cerebral
            ischemia
  JOURNAL   CNS Neurosci Ther 29 (12), 3967-3979 (2023)
   PUBMED   37349971
  REMARK    GeneRIF: MiR-199a-5p enhances neuronal differentiation of neural
            stem cells and promotes neurogenesis by targeting Cav-1 after
            cerebral ischemia.
REFERENCE   3  (bases 1 to 2584)
  AUTHORS   Li,T., Tao,X., Sun,R., Han,C., Li,X., Zhu,Z., Li,W., Huang,P. and
            Gong,W.
  TITLE     Cognitive-exercise dual-task intervention ameliorates cognitive
            decline in natural aging rats via inhibiting the promotion of
            LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3beta Pathway
  JOURNAL   Brain Res Bull 202, 110761 (2023)
   PUBMED   37714275
  REMARK    GeneRIF: Cognitive-exercise dual-task intervention ameliorates
            cognitive decline in natural aging rats via inhibiting the
            promotion of LncRNA NEAT1/miR-124-3p on
            caveolin-1-PI3K/Akt/GSK3beta Pathway.
REFERENCE   4  (bases 1 to 2584)
  AUTHORS   Cao,D., Li,B., Cao,C., Zhang,J., Li,X., Li,H., Yu,Z., Shen,H. and
            Ye,M.
  TITLE     Caveolin-1 aggravates neurological deficits by activating
            neuroinflammation following experimental intracerebral hemorrhage
            in rats
  JOURNAL   Exp Neurol 368, 114508 (2023)
   PUBMED   37598879
  REMARK    GeneRIF: Caveolin-1 aggravates neurological deficits by activating
            neuroinflammation following experimental intracerebral hemorrhage
            in rats.
REFERENCE   5  (bases 1 to 2584)
  AUTHORS   Tong,F., Shen,W., Zhao,J., Hu,Y., Zhao,Q., Lv,H., Liu,F., Meng,Z.
            and Liu,J.
  TITLE     Silencing information regulator 1 ameliorates
            lipopolysaccharide-induced acute lung injury in rats via the
            upregulation of caveolin-1
  JOURNAL   Biomed Pharmacother 165, 115018 (2023)
   PUBMED   37336147
  REMARK    GeneRIF: Silencing information regulator 1 ameliorates
            lipopolysaccharide-induced acute lung injury in rats via the
            upregulation of caveolin-1.
REFERENCE   6  (bases 1 to 2584)
  AUTHORS   Babitt,J., Trigatti,B., Rigotti,A., Smart,E.J., Anderson,R.G.,
            Xu,S. and Krieger,M.
  TITLE     Murine SR-BI, a high density lipoprotein receptor that mediates
            selective lipid uptake, is N-glycosylated and fatty acylated and
            colocalizes with plasma membrane caveolae
  JOURNAL   J Biol Chem 272 (20), 13242-13249 (1997)
   PUBMED   9148942
REFERENCE   7  (bases 1 to 2584)
  AUTHORS   Parton,R.G., Way,M., Zorzi,N. and Stang,E.
  TITLE     Caveolin-3 associates with developing T-tubules during muscle
            differentiation
  JOURNAL   J Cell Biol 136 (1), 137-154 (1997)
   PUBMED   9008709
REFERENCE   8  (bases 1 to 2584)
  AUTHORS   Scherer,P.E., Okamoto,T., Chun,M., Nishimoto,I., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Identification, sequence, and expression of caveolin-2 defines a
            caveolin gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 131-135 (1996)
   PUBMED   8552590
REFERENCE   9  (bases 1 to 2584)
  AUTHORS   Sargiacomo,M., Scherer,P.E., Tang,Z., Kubler,E., Song,K.S.,
            Sanders,M.C. and Lisanti,M.P.
  TITLE     Oligomeric structure of caveolin: implications for caveolae
            membrane organization
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9407-9411 (1995)
   PUBMED   7568142
REFERENCE   10 (bases 1 to 2584)
  AUTHORS   Dupree,P., Parton,R.G., Raposo,G., Kurzchalia,T.V. and Simons,K.
  TITLE     Caveolae and sorting in the trans-Golgi network of epithelial cells
  JOURNAL   EMBO J 12 (4), 1597-1605 (1993)
   PUBMED   8385608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM039194.1 and BC104689.1.
            
            On Nov 23, 2013 this sequence version replaced NM_031556.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078744.1, FQ224228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               FM039194.1         1-559
            560-2584            BC104689.1         375-2399
FEATURES             Location/Qualifiers
     source          1..2584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2584
                     /gene="Cav1"
                     /gene_synonym="Cav"
                     /note="caveolin 1"
                     /db_xref="GeneID:25404"
                     /db_xref="RGD:2280"
     exon            1..185
                     /gene="Cav1"
                     /gene_synonym="Cav"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..692
                     /gene="Cav1"
                     /gene_synonym="Cav"
                     /note="isoform alpha is encoded by transcript variant 1;
                     caveolin caveolae protein 22 kDa; caveolin 1, caveolae
                     protein; caveolin-like"
                     /codon_start=1
                     /product="caveolin-1 isoform alpha"
                     /protein_id="NP_113744.2"
                     /db_xref="GeneID:25404"
                     /db_xref="RGD:2280"
                     /translation="MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADEVNEKQVYDA
                     HTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRL
                     LSTIFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLF
                     EAIGKIFSNIRISTQKEI"
     exon            186..350
                     /gene="Cav1"
                     /gene_synonym="Cav"
                     /inference="alignment:Splign:2.1.0"
     exon            351..2561
                     /gene="Cav1"
                     /gene_synonym="Cav"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacccctgg ccaacagcca agaggctccc tctcagccac cgccccccgc cagcgccttt
       61 ccccctctat acaatacaag atcttccttc ctcagttctc ttaaatcaca gcccagggaa
      121 acctcctcag agcctgcagc cagccacgcg ccagcatgtc tgggggtaaa tacgtagact
      181 ccgagggaca tctctacact gttcccatcc gggaacaggg caacatctac aagcccaaca
      241 acaaggccat ggcagacgag gtgaatgaga agcaagtgta cgacgcgcac accaaggaga
      301 ttgatctggt caaccgcgac cccaagcatc tcaacgacga cgtggtcaag attgactttg
      361 aagatgtgat tgcggaacca gaagggacac acagtttcga cggcatctgg aaggccagct
      421 tcaccacctt cactgtgaca aaatattggt tttaccgctt gctgtctacc atcttcggca
      481 tccctatggc gctcatctgg ggcatctact ttgccatcct ctctttcctg cacatctggg
      541 cagttgtacc gtgcatcaag agcttcctga ttgagattca gtgcatcagc cgtgtctatt
      601 ccatctacgt ccacaccttc tgtgatccac tctttgaagc gattggcaag atattcagca
      661 atatccgcat cagcacgcag aaagagatat gagtgacatt tcagggatgg aaggcttttc
      721 tcccccttac tattcccttg gtgccaattc caagttgcta tcacagccgt gatttctgaa
      781 tggtttgtct tggtcaagaa caaagaattc attccctcca ttttcatgta tactgcttgt
      841 ctctcctgag ctactgcatc tatttttgac agtctggaat gtttaaaccc attcctgctc
      901 tcccgttcct ttgtggatca ttgtttcatt ggctaaaata taaacatgtt gttgaaagat
      961 actttgagaa aaaataggaa gactgggagg cggaggatga gtgccaacac cctcgactgc
     1021 ctgctctagg cgatgaggtt atagaaaggg aagagtttca ggatatggct gtgtgtgtag
     1081 ggggcatgaa ggcaggttat aaacaaatat atcccagctg cctaaggagt tggttgctgt
     1141 cctcactctt aacaatccag tgggatctag tgatcaacat cagtttggag actctaatct
     1201 tcatgctcat gtattcatcc tgacatttta acttgttatt ctgtgtgacc gaatacttgt
     1261 tatacctaga atacgaccta agtgccttct gatttctcat gatttctttt caaacagggt
     1321 ctaagtcatc tacttgcatt ttgccagaag ctctccggaa aacaaagcat acaaaatcta
     1381 cttgctattt ctctgtactt gtttctgact ctgagacaca gaacctgttg aagttgatct
     1441 ctgcgcttgg ttttgtagcg tctttctcta tactaagccc agtcaacatt aacccagtga
     1501 aatgattcaa agcagacaaa cggggctgag acctccctgg aagaaatagg agccaacttt
     1561 actggccact cagcactgaa tgaggccctc gggtctattc agtttcactt attttcaaga
     1621 ataatcacac attcccgact cttacgctaa cccctcacca ggatggttta gtgaccaacc
     1681 aagatggctt aatgaccaac caggatggtt tagggactca accctgtgct cccttttcag
     1741 ctgatgagtg agccttcagg gaggggtgtc aaaaaacgag tctgccaaag caagattgcc
     1801 aaacctgttg caaacgcaac ccccttctag gcatagcaca agtaatagtc tgtaacgctg
     1861 cgaagcctga cctctccccc tgccaggagc ctttggccta actcaagcac cattttgttc
     1921 agagagaaga tgggggaggg gtggtaacaa aagcttgagg taatgttctt gctggaataa
     1981 gttcaagtct ttctgaaccc aaactgtgga atttcacctg tgtacctgag tctccagaat
     2041 cctgcctgcc tgggacaccc aaaaggcttt tattccccct gctcacatga cagctctgcc
     2101 cttggggata tttttaagac tgcagatagg cctttgtttt cactttcata catttattgg
     2161 aactctgctt gacttgtgta ctccttcagt tttgctgaca ctttaccaac ccgctaccta
     2221 ttttgattgt tcccatttga aacagacact ggcatggcca cagtttgact ttttaaactg
     2281 tgtacataac tgaaaatgta ctagactgta tacctgttta aatgtagaga tatcctttat
     2341 ctttatataa ggaaaatcac ttgggaagtg gttctacgtt tcagtcttta aactgtgttc
     2401 caagacatgt ctgttcttcc tagatactca gtcttatgca agtcaattgc tgatccaaaa
     2461 ggttactgaa attttatatg cttactgata ttttacactt ttttatgctg catgtcctat
     2521 aaagatttca aatctgcaca ataaaattgt ttaacagtaa aaaaaaaaaa aaaaaaaaaa
     2581 aaaa
//
