LOCUS       NP_113744                178 aa            linear   ROD 24-OCT-2024
DEFINITION  caveolin-1 isoform alpha [Rattus norvegicus].
ACCESSION   NP_113744 XP_346692 XP_347376
VERSION     NP_113744.2
DBSOURCE    REFSEQ: accession NM_031556.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 178)
  AUTHORS   Sakaguchi,R., Takahashi,N., Yoshida,T., Ogawa,N., Ueda,Y.,
            Hamano,S., Yamaguchi,K., Sawamura,S., Yamamoto,S., Hara,Y.,
            Kawamoto,T., Suzuki,R., Nakao,A., Mori,M.X., Furukawa,T.,
            Shimizu,S., Inoue,R. and Mori,Y.
  TITLE     Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein
            assembly potentiates the positive feedback interaction between Ca2+
            and NO signals
  JOURNAL   J Biol Chem 300 (9), 107705 (2024)
   PUBMED   39178948
  REMARK    GeneRIF: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS
            protein assembly potentiates the positive feedback interaction
            between Ca[2+] and NO signals.
REFERENCE   2  (residues 1 to 178)
  AUTHORS   Jin,H.Q., Jiang,W.F., Zheng,X.T., Li,L., Fang,Y., Yang,Y., Hu,X.W.
            and Chu,L.S.
  TITLE     MiR-199a-5p enhances neuronal differentiation of neural stem cells
            and promotes neurogenesis by targeting Cav-1 after cerebral
            ischemia
  JOURNAL   CNS Neurosci Ther 29 (12), 3967-3979 (2023)
   PUBMED   37349971
  REMARK    GeneRIF: MiR-199a-5p enhances neuronal differentiation of neural
            stem cells and promotes neurogenesis by targeting Cav-1 after
            cerebral ischemia.
REFERENCE   3  (residues 1 to 178)
  AUTHORS   Li,T., Tao,X., Sun,R., Han,C., Li,X., Zhu,Z., Li,W., Huang,P. and
            Gong,W.
  TITLE     Cognitive-exercise dual-task intervention ameliorates cognitive
            decline in natural aging rats via inhibiting the promotion of
            LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3beta Pathway
  JOURNAL   Brain Res Bull 202, 110761 (2023)
   PUBMED   37714275
  REMARK    GeneRIF: Cognitive-exercise dual-task intervention ameliorates
            cognitive decline in natural aging rats via inhibiting the
            promotion of LncRNA NEAT1/miR-124-3p on
            caveolin-1-PI3K/Akt/GSK3beta Pathway.
REFERENCE   4  (residues 1 to 178)
  AUTHORS   Cao,D., Li,B., Cao,C., Zhang,J., Li,X., Li,H., Yu,Z., Shen,H. and
            Ye,M.
  TITLE     Caveolin-1 aggravates neurological deficits by activating
            neuroinflammation following experimental intracerebral hemorrhage
            in rats
  JOURNAL   Exp Neurol 368, 114508 (2023)
   PUBMED   37598879
  REMARK    GeneRIF: Caveolin-1 aggravates neurological deficits by activating
            neuroinflammation following experimental intracerebral hemorrhage
            in rats.
REFERENCE   5  (residues 1 to 178)
  AUTHORS   Tong,F., Shen,W., Zhao,J., Hu,Y., Zhao,Q., Lv,H., Liu,F., Meng,Z.
            and Liu,J.
  TITLE     Silencing information regulator 1 ameliorates
            lipopolysaccharide-induced acute lung injury in rats via the
            upregulation of caveolin-1
  JOURNAL   Biomed Pharmacother 165, 115018 (2023)
   PUBMED   37336147
  REMARK    GeneRIF: Silencing information regulator 1 ameliorates
            lipopolysaccharide-induced acute lung injury in rats via the
            upregulation of caveolin-1.
REFERENCE   6  (residues 1 to 178)
  AUTHORS   Babitt,J., Trigatti,B., Rigotti,A., Smart,E.J., Anderson,R.G.,
            Xu,S. and Krieger,M.
  TITLE     Murine SR-BI, a high density lipoprotein receptor that mediates
            selective lipid uptake, is N-glycosylated and fatty acylated and
            colocalizes with plasma membrane caveolae
  JOURNAL   J Biol Chem 272 (20), 13242-13249 (1997)
   PUBMED   9148942
REFERENCE   7  (residues 1 to 178)
  AUTHORS   Parton,R.G., Way,M., Zorzi,N. and Stang,E.
  TITLE     Caveolin-3 associates with developing T-tubules during muscle
            differentiation
  JOURNAL   J Cell Biol 136 (1), 137-154 (1997)
   PUBMED   9008709
REFERENCE   8  (residues 1 to 178)
  AUTHORS   Scherer,P.E., Okamoto,T., Chun,M., Nishimoto,I., Lodish,H.F. and
            Lisanti,M.P.
  TITLE     Identification, sequence, and expression of caveolin-2 defines a
            caveolin gene family
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 131-135 (1996)
   PUBMED   8552590
REFERENCE   9  (residues 1 to 178)
  AUTHORS   Sargiacomo,M., Scherer,P.E., Tang,Z., Kubler,E., Song,K.S.,
            Sanders,M.C. and Lisanti,M.P.
  TITLE     Oligomeric structure of caveolin: implications for caveolae
            membrane organization
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9407-9411 (1995)
   PUBMED   7568142
REFERENCE   10 (residues 1 to 178)
  AUTHORS   Dupree,P., Parton,R.G., Raposo,G., Kurzchalia,T.V. and Simons,K.
  TITLE     Caveolae and sorting in the trans-Golgi network of epithelial cells
  JOURNAL   EMBO J 12 (4), 1597-1605 (1993)
   PUBMED   8385608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM039194.1 and BC104689.1.
            
            On May 24, 2008 this sequence version replaced NP_113744.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078744.1, FQ224228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..178
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     Protein         1..178
                     /product="caveolin-1 isoform alpha"
                     /note="caveolin caveolae protein 22 kDa; caveolin 1,
                     caveolae protein; caveolin-like"
                     /calculated_mol_wt=20421
     Region          2..94
                     /region_name="Required for homooligomerization.
                     /evidence=ECO:0000250|UniProtKB:Q03135"
                     /note="propagated from UniProtKB/Swiss-Prot (P41350.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q03135; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Site            5
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q03135; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q03135; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by ABL1.
                     /evidence=ECO:0000250|UniProtKB:P49817; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q03135; propagated from
                     UniProtKB/Swiss-Prot (P41350.3)"
     Region          43..174
                     /region_name="Caveolin"
                     /note="pfam01146"
                     /db_xref="CDD:460081"
     Region          82..94
                     /region_name="Interaction with CAVIN3.
                     /evidence=ECO:0000250|UniProtKB:Q03135"
                     /note="propagated from UniProtKB/Swiss-Prot (P41350.3)"
     Region          131..142
                     /region_name="Interacts with SPRY1, SPRY2, SPRY3 and
                     SPRY4. /evidence=ECO:0000250|UniProtKB:P49817"
                     /note="propagated from UniProtKB/Swiss-Prot (P41350.3)"
     Region          149..160
                     /region_name="Interacts with SPRY1, SPRY2, and SPRY4.
                     /evidence=ECO:0000250|UniProtKB:P49817"
                     /note="propagated from UniProtKB/Swiss-Prot (P41350.3)"
     Region          167..178
                     /region_name="Interacts with SPRY1, SPRY2, SPRY3 and
                     SPRY4. /evidence=ECO:0000250|UniProtKB:P49817"
                     /note="propagated from UniProtKB/Swiss-Prot (P41350.3)"
     CDS             1..178
                     /gene="Cav1"
                     /gene_synonym="Cav"
                     /coded_by="NM_031556.3:156..692"
                     /note="isoform alpha is encoded by transcript variant 1"
                     /db_xref="GeneID:25404"
                     /db_xref="RGD:2280"
ORIGIN      
        1 msggkyvdse ghlytvpire qgniykpnnk amadevnekq vydahtkeid lvnrdpkhln
       61 ddvvkidfed viaepegths fdgiwkasft tftvtkywfy rllstifgip maliwgiyfa
      121 ilsflhiwav vpciksflie iqcisrvysi yvhtfcdplf eaigkifsni ristqkei
//
