LOCUS       NM_001012220            2234 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cation channel, sperm associated 2 (Catsper2),
            mRNA.
ACCESSION   NM_001012220 XM_345425 XM_347327
VERSION     NM_001012220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Ameli,M., Moghimian,M., Saeb,F., Bashtani,E., Shokoohi,M.,
            Salimnejad,R. and Abtahi,H.
  TITLE     The effect of clomiphene citrate and human chorionic gonadotropin
            on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as
            well as the structural changes in testicular tissue of adult rats
  JOURNAL   Mol Reprod Dev 86 (6), 738-748 (2019)
   PUBMED   31041823
  REMARK    GeneRIF: The effect of clomiphene citrate and human chorionic
            gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and
            SF1 genes, as well as the structural changes in testicular tissue
            of adult rats.
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Zhang,Z., Wang,G.L., Li,H.X., Li,L., Cui,Q.W., Wei,C.B. and Zhou,F.
  TITLE     Regulation of fertilization in male rats by CatSper2 knockdown
  JOURNAL   Asian J Androl 14 (2), 301-309 (2012)
   PUBMED   22002435
  REMARK    GeneRIF: It is feasible to achieve male contraception by silencing
            the expression of CatSper2, the key protein involved in sperm
            hyperactivation.
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Chung,J.J., Navarro,B., Krapivinsky,G., Krapivinsky,L. and
            Clapham,D.E.
  TITLE     A novel gene required for male fertility and functional CATSPER
            channel formation in spermatozoa
  JOURNAL   Nat Commun 2, 153 (2011)
   PUBMED   21224844
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Marquez,B., Ignotz,G. and Suarez,S.S.
  TITLE     Contributions of extracellular and intracellular Ca2+ to regulation
            of sperm motility: Release of intracellular stores can
            hyperactivate CatSper1 and CatSper2 null sperm
  JOURNAL   Dev Biol 303 (1), 214-221 (2007)
   PUBMED   17174296
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Qi,H., Moran,M.M., Navarro,B., Chong,J.A., Krapivinsky,G.,
            Krapivinsky,L., Kirichok,Y., Ramsey,I.S., Quill,T.A. and
            Clapham,D.E.
  TITLE     All four CatSper ion channel proteins are required for male
            fertility and sperm cell hyperactivated motility
  JOURNAL   Proc Natl Acad Sci U S A 104 (4), 1219-1223 (2007)
   PUBMED   17227845
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Quill,T.A., Sugden,S.A., Rossi,K.L., Doolittle,L.K., Hammer,R.E.
            and Garbers,D.L.
  TITLE     Hyperactivated sperm motility driven by CatSper2 is required for
            fertilization
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14869-14874 (2003)
   PUBMED   14657366
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Quill,T.A., Ren,D., Clapham,D.E. and Garbers,D.L.
  TITLE     A voltage-gated ion channel expressed specifically in spermatozoa
  JOURNAL   Proc Natl Acad Sci U S A 98 (22), 12527-12531 (2001)
   PUBMED   11675491
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079422.1.
            
            On or before Feb 11, 2005 this sequence version replaced
            XM_345425.1, XM_347327.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2234
                     /gene="Catsper2"
                     /note="cation channel, sperm associated 2"
                     /db_xref="GeneID:366174"
                     /db_xref="RGD:1307620"
     exon            1..350
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..491
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2107
                     /gene="Catsper2"
                     /codon_start=1
                     /product="cation channel sperm-associated protein 2"
                     /protein_id="NP_001012220.1"
                     /db_xref="GeneID:366174"
                     /db_xref="RGD:1307620"
                     /translation="MAHERGHLQLPRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLRE
                     ILDPACQKKLMLGDQEQLVRFSIRARRMGHITHAQRLLSRLRVRCGGRPPLSLWAGWV
                     LDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVTDWFILLSFIVEIL
                     LMWLASFFLFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSLKL
                     FARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFKEYSRSTIENLEYNM
                     FFSDLLNSLVTVFILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNII
                     VAMMVTNFQNIRNELHEEMTHLEVQYKADIFKRRIIQRRQQSESLRGTSQGKVSEDIT
                     ETSEATDEEKSEAEESEEEKSEEEKSDVEKSDEEKNDEEKSDEEENDEEKSDVEKSDE
                     EKNDEEKGYTEKVYSGRTFVERSYAERSFAGKAENEKVQKELKEKAYPGSPPNSSSHD
                     EAFAADDTYLENLDWETLVHENLPGLMDMDQDDRVVWPRDSLFRYFELLESLQYNLEE
                     RKRLQEFAVQALMNFEDK"
     exon            492..665
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..734
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..907
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1063
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1188
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1367
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1467
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1491
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1907
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2075
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2210
                     /gene="Catsper2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggggtcgg cgggaagtgg gggcttagcg aagccggagc ggccctgagc tccgcccgct
       61 gaggaggagt gaagctcagg gcgccggcgc ggaaggcgga ggggtgaagt cagggctgag
      121 tgggcggaag tgcgctggag ctgaagtgag gcccctgagc cctgagcggg ctggagggga
      181 gcttgagctg tccgcctccc tccctccagg gctttggggc gcgcacactt tagcacaaag
      241 cgacacgttt tccaaatgtc aggctgttgc tttgtccaat tatagggcgt agtaagccta
      301 catcctgctg ctgccctacc tcgtatcctg ctttgtcagg tccacgtgag acatggcaca
      361 tgaacgagga catttacagc tgcccagagc tgatgctatc cgttcaaagc tcattgacac
      421 tttctcgctc atagagcatt tgcagggctt gagccaagct gtaccaaggc acactctccg
      481 ggagatactt gatccggctt gtcagaagaa actcatgtta ggagatcagg agcagctagt
      541 gcgcttctcc ataagggcgc ggcgtatggg gcacattacg catgcccagc ggttgctgag
      601 cagacttcga gtgcggtgcg gtggaagacc acctctttcc ttgtgggctg gatgggttct
      661 tgacagttct atcttctcga atttcatcat ctccctcatc tttctgaata cctttgtgct
      721 gatggtcgaa atagaattga tgaactccac aaatacgagt ctgtggccat tgaagctggc
      781 tttggaggtg acagattggt ttatcttgct tagcttcatt gtagagatcc ttctaatgtg
      841 gttggccagc ttttttctct tctggaagaa tgcctggagt gtctttgact ttgtggttac
      901 catgttgtct ctgcttcctg agtttgtggt gctgataggc gtctctgcgg actctgtgtg
      961 gctccaactg ctaagggtct ctcgggtgct gaggtctctc aaactgtttg cacgattccc
     1021 tcaaattaaa gttattcttt tggctctcgt cagggccctg aagagcatga cattcctgtt
     1081 gatgttgctg cttatcttct tctacgtctt cgctgtggcc ggtgtctact tcttcaaaga
     1141 atattcccgt tcaactatcg agaatctgga gtacaacatg ttcttctcgg acctactaaa
     1201 ttccctggtg acagtgttca tcctcttcac cttggatcat tggtatgcag tacttcagga
     1261 cgtctggaag gtgccagaag ctagccgtgt ctttagcagc atctatgtga tcctttggtt
     1321 gttgcttggt tccattatct ttcgaaacat catagtagcc atgatggtta ctaactttca
     1381 gaatatccga aatgagctgc atgaggagat gactcacctg gaggttcagt ataaggctga
     1441 catattcaag cgacggatta tccagaggag acaacaatct gagtcactaa gaggaaccag
     1501 tcaaggaaag gtctccgaag acataacaga aacttccgag gccactgatg aggaaaaaag
     1561 cgaagctgag gaaagcgagg aagagaaaag cgaggaagag aaaagtgatg tagagaaaag
     1621 cgatgaagag aaaaacgatg aagagaaaag tgatgaagag gaaaacgatg aagagaaaag
     1681 tgatgtagag aaaagcgatg aagagaaaaa cgatgaagag aaagggtata ccgagaaagt
     1741 gtattccgga agaacctttg tggagagaag ttatgctgag agaagctttg ctggaaaggc
     1801 tgaaaatgaa aaagtacaaa aagagttgaa agaaaaggcc tacccgggtt ctcctcccaa
     1861 ctcttcatcc catgatgaag cctttgcagc cgatgatact taccttgaaa acctggactg
     1921 ggagactctt gtgcatgaga acctgcctgg gctaatggat atggatcagg atgaccgtgt
     1981 tgtttggccc agagattcgc ttttccgata ttttgagtta ctggaaagcc ttcagtataa
     2041 cctagaggag cgcaagaggt tgcaagaatt tgcagttcaa gcactgatga attttgaaga
     2101 caagtgaagg cacagtgtat gacacctgtg tctttggagc cagcaaaagc taatgatgaa
     2161 aataattaga atttaaaata taaatatcta ataaatactg ctaatgaata aaaaaaaaaa
     2221 aaaaaaaaaa aaaa
//
