LOCUS       NM_012520               2564 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus catalase (Cat), mRNA.
ACCESSION   NM_012520
VERSION     NM_012520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Huang,T., Zhou,F., Yuan,X., Yang,T., Liang,X., Wang,Y., Tu,H.,
            Chang,J., Nan,K. and Wei,Y.
  TITLE     Reactive Oxygen Species Are Involved in the Development of Gastric
            Cancer and Gastric Cancer-Related Depression through ABL1-Mediated
            Inflammation Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2019, 5813985 (2019)
   PUBMED   31396300
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Hwang,J.H., Jung,H.W., Kang,S.Y., Kang,A.N., Ma,J.N., Meng,X.L.,
            Hwang,M.S. and Park,Y.K.
  TITLE     Therapeutic effects of acupuncture with MOK, a polyherbal medicine,
            on PTU-induced hypothyroidism in rats
  JOURNAL   Exp Ther Med 16 (1), 310-320 (2018)
   PUBMED   29896255
REFERENCE   3  (bases 1 to 2564)
  AUTHORS   Rai,A., Kumar,U., Raj,V., Singh,A.K., Kumar,P., Keshari,A.K.,
            Kumar,D., Maity,B., De,A., Samanta,A., Nath,S., Prakash,A.,
            Gosipatala,S.B., Chand,G. and Saha,S.
  TITLE     Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3
            signals with potential regulation of oxidative and metabolic stress
            during colorectal cancer
  JOURNAL   Pharmacol Res 132, 188-203 (2018)
   PUBMED   29229353
REFERENCE   4  (bases 1 to 2564)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2564)
  AUTHORS   Pejic,S., Stojikjkovic,V., Todorovic,A., Gavrilovic,L.,
            Pavlovic,I., Popovic,N. and Pajovic,S.B.
  TITLE     Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute,
            Chronic and Combined Stress
  JOURNAL   Folia Biol (Krakow) 64 (3), 189-195 (2016)
   PUBMED   29847079
  REMARK    GeneRIF: These results indicate that stress conditions most
            probably altered the cell redox equilibrium, thus influencing the
            antioxidant response in brain cortex.
REFERENCE   6  (bases 1 to 2564)
  AUTHORS   Reiners,J.J. Jr., Thai,G., Rupp,T. and Cantu,A.R.
  TITLE     Assessment of the antioxidant/prooxidant status of murine skin
            following topical treatment with
            12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of
            skin cancer. Part I: Quantitation of superoxide dismutase,
            catalase, glutathione peroxidase and xanthine oxidase
  JOURNAL   Carcinogenesis 12 (12), 2337-2343 (1991)
   PUBMED   1747937
REFERENCE   7  (bases 1 to 2564)
  AUTHORS   Nakashima,H., Yamamoto,M., Goto,K., Osumi,T., Hashimoto,T. and
            Endo,H.
  TITLE     Isolation and characterization of the rat catalase-encoding gene
  JOURNAL   Gene 89 (2), 295 (1990)
   PUBMED   2373372
REFERENCE   8  (bases 1 to 2564)
  AUTHORS   Wen,J.K., Osumi,T., Hashimoto,T. and Ogata,M.
  TITLE     Molecular analysis of human acatalasemia. Identification of a
            splicing mutation
  JOURNAL   J Mol Biol 211 (2), 383-393 (1990)
   PUBMED   2308162
REFERENCE   9  (bases 1 to 2564)
  AUTHORS   Nakashima,H., Yamamoto,M., Goto,K., Osumi,T., Hashimoto,T. and
            Endo,H.
  TITLE     Isolation and characterization of the rat catalase-encoding gene
  JOURNAL   Gene 79 (2), 279-288 (1989)
   PUBMED   2792765
  REMARK    Erratum:[Gene 1990 May 14;89(2):295]
REFERENCE   10 (bases 1 to 2564)
  AUTHORS   Feinstein,R.N., Fry,R.J. and Staffeldt,E.F.
  TITLE     Carcinogenic and antitumor effects of aminotriazole on acatalasemic
            and normal catalase mice
  JOURNAL   J Natl Cancer Inst 60 (5), 1113-1116 (1978)
   PUBMED   642030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM043772.1 and BC081853.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012520.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081853.1, M11670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               FM043772.1         1-624
            625-2564            BC081853.1         522-2461
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..2564
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /note="catalase"
                     /db_xref="GeneID:24248"
                     /db_xref="RGD:2279"
     exon            1..198
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1716
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /EC_number="1.11.1.6"
                     /codon_start=1
                     /product="catalase"
                     /protein_id="NP_036652.1"
                     /db_xref="GeneID:24248"
                     /db_xref="RGD:2279"
                     /translation="MADSRDPASDQMKQWKEQRAPQKPDVLTTGGGNPIGDKLNIMTA
                     GPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEH
                     IGKRTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAML
                     FPSFIHSQKRNPQTHLKDPDMVWDFWSLCPESLHQVTFLFSDRGIPDGHRHMNGYGSH
                     TFKLVNANGEAVYCKFHYKTDQGIKNLPVEEAGRLAQEDPDYGLRDLFNAIASGNYPS
                     WTFYIQVMTFKEAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPANYFAEVEQMAF
                     DPSNMPPGIEPSPDKMLQGRLFAYPDTHRHRLGPNYLQIPVNCPYRARVANYQRDGPM
                     CMHDNQGGAPNYYPNSFSAPEQQGSALEHHSQCSADVKRFNSANEDNVTQVRTFYTKV
                     LNEEERKRLCENIANHLKDAQLFIQRKAVKNFTDVHPDYGARVQALLDQYNSQKPKNA
                     IHTYVQAGSHIAAKGKANL"
     exon            199..370
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..481
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..612
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..717
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..843
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1035
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1188
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1327
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1458
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1566
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1650
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2541
                     /gene="Cat"
                     /gene_synonym="Cas1; Cat01; Catl; Cs-1; CS1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgattggca gagcctgaag tcaccactcc agcgggcctg actgacgcga ttgcctaccc
       61 cgggtggaga ccgtgctcgt ccggccctct tgcctcacgt tctgcagctc tgcagctccg
      121 caatcctaca ccatggcgga cagccgggac ccagccagcg accagatgaa gcagtggaag
      181 gagcagcggg cccctcagaa acccgatgtc ctgaccaccg gaggcgggaa cccaatagga
      241 gataaactta atatcatgac tgcggggccc cgagggcccc tcctcgttca agatgtggtt
      301 ttcaccgacg agatggcaca ctttgacaga gagcggattc ctgagagagt ggtacatgca
      361 aagggagcag gtgcttttgg atactttgag gtcacccacg atattaccag atactccaag
      421 gcaaaggtgt ttgagcatat tgggaagagg actcctattg ccgtccgatt ctccacagtc
      481 gctggagagt caggctcagc tgacacagtt cgtgaccctc gtgggtttgc agtgaaattc
      541 tacactgaag atggtaactg ggaccttgtg ggaaacaaca cccctatttt cttcatcagg
      601 gatgccatgt tgtttccatc ctttatccat agccagaaga gaaacccaca aactcacctg
      661 aaggaccctg acatggtctg ggacttctgg agtctttgtc cagagtctct ccatcaggtt
      721 actttcttgt tcagcgaccg agggattcca gatggacatc ggcacatgaa tggctatggc
      781 tcacacacct tcaagctggt taatgcgaat ggagaggcag tgtactgcaa gttccattac
      841 aagactgacc agggcatcaa aaacttgcct gttgaagagg caggaagact tgcacaggaa
      901 gacccggatt atggcctccg agatcttttc aatgccatcg ccagtggcaa ttacccatcc
      961 tggacttttt acatccaggt catgactttc aaggaggcag aaaccttccc atttaatcca
     1021 tttgacctga ccaaggtttg gcctcacaag gactaccctc ttataccagt tggcaaactg
     1081 gtcttaaaca gaaatcctgc taattatttt gctgaagttg aacagatggc ttttgaccca
     1141 agcaacatgc cccctggcat tgagcccagc ccggacaaga tgctccaggg ccgccttttt
     1201 gcttacccag acactcaccg ccaccgcctg ggaccaaact atctgcagat acctgtgaac
     1261 tgtccctacc gtgctcgcgt ggccaactac cagcgcgatg gccccatgtg catgcatgac
     1321 aaccagggtg gtgctcccaa ctactacccc aacagcttca gcgcaccaga gcagcagggc
     1381 tcggccctgg agcaccatag ccagtgctct gcagatgtga agcgcttcaa cagtgctaat
     1441 gaagacaacg tcactcaggt gcggacattc tatacgaagg tgttgaatga ggaggagagg
     1501 aaacgcctgt gtgagaacat tgccaaccac ctgaaagatg ctcagctttt cattcagagg
     1561 aaagcggtca agaatttcac tgacgtccac cctgactacg gggcccgagt ccaggctctt
     1621 ctggaccagt acaactccca gaagcctaag aatgcaattc acacctacgt acaggccggc
     1681 tctcacatag ctgccaaggg aaaagctaac ctgtaaagca cgggtgctca gcctcctcag
     1741 cctgcactga ggagatccct catgaagcag ggcacaagcc tcaccagtaa tcatcgctgg
     1801 atggagtctc ccctgctgaa gcgcagactc acgctgacgt ctttaaaacg ataatccaag
     1861 cttctagagt gaatgatagc catgcttttg atggcatttc ccgaggggga aattaaagat
     1921 tagggcttag caatcactta acagaaacat ggatctgctt aggacttctg tttggattat
     1981 tcatttaaaa tgattacaag aaaggttttc tagccagaaa catgatttga ttagatatga
     2041 tatatgataa aatcttggtg attttactat agtcttatgt tacctcacag cctggtatat
     2101 atacaacaca cacacacaca cacacacaca cacacacacc aaaacacaca tacactatac
     2161 acacacacac taaaacacac atacacaaca cacacataca ctacacacac agaacacaca
     2221 acacacacat acacacatag acacacacac acacacacac acacacacac acacacacac
     2281 acacacacat gaatgaaggg attataaaga tggcccaccc agaatttttt ttttattttt
     2341 ctaaggtcct tataagaaaa accatacttg gatcatgtct tccaaaaata actttagcac
     2401 tgttgaaact taatgtttat tcctgtgtag ttgatcggat tccttttccc cttgaaatta
     2461 tgtttatgct gatacacagt gatttcacat agggtgattt gtatttgctt acatttttac
     2521 aataaaatga tcttcatgga aaaaaaaaaa aaaaaaaaaa aaaa
//
