LOCUS       NM_001100561            6852 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cytosolic arginine sensor for mTORC1 subunit 2
            (Castor2), mRNA.
ACCESSION   NM_001100561 XM_001077942 XM_222092
VERSION     NM_001100561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6852)
  AUTHORS   Hallett,J.E.H. and Manning,B.D.
  TITLE     CASTORing New Light on Amino Acid Sensing
  JOURNAL   Cell 165 (1), 15-17 (2016)
   PUBMED   27015302
REFERENCE   2  (bases 1 to 6852)
  AUTHORS   Chantranupong,L., Scaria,S.M., Saxton,R.A., Gygi,M.P., Shen,K.,
            Wyant,G.A., Wang,T., Harper,J.W., Gygi,S.P. and Sabatini,D.M.
  TITLE     The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
  JOURNAL   Cell 165 (1), 153-164 (2016)
   PUBMED   26972053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Sep 26, 2014 this sequence version replaced NM_001100561.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.50172.1,
                                           SRR26643288.47479.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000012.1  28256422-28256593   c
            173-243             JAXUCZ010000012.1  28230993-28231063   c
            244-437             JAXUCZ010000012.1  28222837-28223030   c
            438-570             JAXUCZ010000012.1  28222454-28222586   c
            571-694             JAXUCZ010000012.1  28221928-28222051   c
            695-805             JAXUCZ010000012.1  28221002-28221112   c
            806-888             JAXUCZ010000012.1  28220529-28220611   c
            889-983             JAXUCZ010000012.1  28219890-28219984   c
            984-6852            JAXUCZ010000012.1  28213927-28219795   c
FEATURES             Location/Qualifiers
     source          1..6852
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..6852
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /note="cytosolic arginine sensor for mTORC1 subunit 2"
                     /db_xref="GeneID:304410"
                     /db_xref="RGD:1304672"
     exon            1..172
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1049
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /note="opposite strand transcription unit to Stag3;
                     GATS-like protein 2; GATS protein-like 2"
                     /codon_start=1
                     /product="cytosolic arginine sensor for mTORC1 subunit 2"
                     /protein_id="NP_001094031.1"
                     /db_xref="GeneID:304410"
                     /db_xref="RGD:1304672"
                     /translation="MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSL
                     TETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKS
                     VIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLS
                     ITNGFVKPKMVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMA
                     SSDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSHLLFTSASGELWKMVRIGGQPLGF
                     DECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENISGVIHALKVSQAGKH"
     exon            173..243
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            244..437
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..570
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..694
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..805
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..888
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..983
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..6852
                     /gene="Castor2"
                     /gene_synonym="Gats; Gatsl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccccccc aactcgggcc accgcggatg atccgccgtg gaggaaccct gggcggacga
       61 tggaactgca cattctggaa caccggctgc aagttgccag cgtcgccaag gagagtatcc
      121 cgctcttcac ctacggcctc atcaaacttg ccttcctgtc ttccaagacc aggtgcaagt
      181 ttttcagtct gacagagacc cctgaggact acaccatcat tgtagatgag gagggcttcc
      241 ttgagctgcc ctcctcagag cacctgagcg tggctgatgc cacctggctg gccctgaatg
      301 tggtgtccgg tggcggcagc ttctccagtt cccagcccat cggtgtgaca aagatcgcca
      361 agtctgtcat cgctccactg gccgaccaga acatctctgt gttcatgctc tctacctacc
      421 agactgactt catcctggtg cgagagcgtg acctgccctt cgtcactcac accttgtcct
      481 cggaattcac catccttcgt gttgtcaatg gagaaacggt agcggctgag aatctcagca
      541 tcaccaatgg ctttgtgaag cctaaaatgg tccagaggcc agtcatccac ccactctcca
      601 gcccaagcaa cagattctgc gtcaccagcc tggaccctga cacgctgccc gccgttgcca
      661 ccctcctcat ggatgtgatg ttctactcca atggagtgaa ggaccccatg gcttccagtg
      721 acgactgtgg ccacatccgc ttcttctctt tctcactcat tgagggttac atctcactgg
      781 tgatggatgt gcagacccag cagaggttcc cgagtcattt actattcacg agtgcatccg
      841 gagagctctg gaagatggtg cgaataggag gacaaccctt gggattcgac gagtgtggga
      901 ttgtagccca gatctccgag cccttggcag ctgcagacat cccagcatat tacatcagta
      961 ctttcaagtt cgaccatgcg ttggttccag aagagaatat cagcggggtt atccatgccc
     1021 tgaaggtcag tcaagcaggg aagcattaga aaagactcgt ctctgggctc ctccctgcca
     1081 cagcccgcct gggcctttcc cccccacgaa ggttattctt gcagtatttc cctatggact
     1141 gaaagctcag ccccaggacc tttaaggaag gggcctctgg gacactcccc tgattcctga
     1201 ctcctccagg cctgggccta aactagggcc accacccccc atcttcctcc tgcctaccag
     1261 agtcccggcc ttttcaatca tgacccagtt tcccatcagt gaggatatgc ccatcttcct
     1321 cccccaggtt ccaccccaga aagtggtctc tgaggcccag ggtacttggg aacagcccaa
     1381 ggcctcacat tcagccggca gcaaacgcca aaggaagctg gcacctcctg tgagacattg
     1441 ggattggggt cctgatgcac ctagggacat cttaggaagt tggtggagca agatcagggg
     1501 ggcagagctg gggaagcccc cgtgaggccc ccgggtttga tggttatggt tgccacttgg
     1561 gagccggctc cctcagaatg gaggccagca ggccaccctc aggtcataat ggccggtgag
     1621 tctcagacag aagcagtggg gtccctaccc ctaagctggg gaggaaaacc aagaccctag
     1681 aaccccacct gctgaccaca cagggcctgt gtcgatttcc tctacaactg ccaagagggg
     1741 acctgggcct aacttccccc caacccccag agcacttgtc cctggagggg atcccaggac
     1801 acctcctctc ccaccagcct agagtgccag cttctatctg tccttcgtcc gctctcccaa
     1861 gacccaacat gggcaaacaa agacttggct tctcccagca acgggcatcc cgacctgccc
     1921 aggcctagag tgccctgggc tatgtcccac ctccccagct gtcacttaga ccagcgtaga
     1981 gaatccccct tcatcctctc tacccacttt taggggacaa aaaggcatca gcctcccctc
     2041 ccccgcagct cataggcctg cccaaaatac acatgcagca gtctgtggtc aaggtgatgc
     2101 ctgggaggca gccatcttgg agcgtttgta gagagaaatt acacttgcgg gtttcttctt
     2161 tgttgtgttt gcatacaggt ggctggggaa agagtggttt tgtttgggag agacggggcc
     2221 tgtttgagtc tcactagggt gcccagggtt cgagtgagac ttagcaccct gtgtgtctcc
     2281 agggacagac accagtgcaa agatgtatct taagaatcgt ggctatgtct tctgaggagg
     2341 gctgttggga gcagagctca ccaggacccc acagcacccc ctacagggca tcccagtgta
     2401 ctgccatctg catgtggcaa tgtggctggg actgaggggt ccaccagact ttgctcttgg
     2461 ggtgttttcc caggcctgta ctacgcagtc tccaacaaca aggtcagagg agggaatgtt
     2521 tatttagccc tgcacagtct tgtaggaact gtttctctcc tcttctagaa ccatgtagaa
     2581 gctcagaacc cagcatgtta atcaaaaatc gcctctggtt ggttttggtg ggtttagttt
     2641 tctttctttc tttcttttta actccttttg cacaaaaccc ttaaaacaac caaattttat
     2701 tgttttcccg tcccaaatgg gaaatggcca agtgggcggg gctttatagt gagtgcccgc
     2761 cccccgccca gtcccctttt tctctccctg gaaggccttg attgtccggg gtgcacctct
     2821 ctgtaacccc ttctgtctcc ttttccagtt atcccttccc accgtataag tgtgctgacc
     2881 ccacgtcccc tgccccatag ttgtgtggcc cctcccctag acttgctagg atgagaccat
     2941 gtattgtaca cacttataaa tacgtgtttt atgtcgatag agatatattc tgtaaatagc
     3001 atatatactt aagcaatata tatgttaata tattctgtgt gcgcaggaca caggcaaggg
     3061 ccccacctca cgtgcgcgca cacggggacg tttttgagcc accgtatatt tttaattcaa
     3121 atatgtaggc aatatgacga ttggaaaagc cctggggtcc tgaggccagc ccaggaggga
     3181 gacagaacca acagcctact gcatgtgggg caggttgaga gggccagtgt ggtctgcttc
     3241 atagctactg tacccccatt tccacagcct atagctgtag atgactttat cttattgggg
     3301 gagggggcat tgatccagag gagggatttc tgttgttgta tttttaacag tggctccttc
     3361 cctcagggtt actccaaaac ctttgtctag tgaccccagc atgtccccgc ctccctcctc
     3421 tccgagtccc ctcctccaca gaaagctgta gacccggcat cttatctgat ttctgtagtt
     3481 attgttctga taatcgtttt ttgttttttt ttgttttttt ttgttttttt ttttgttttt
     3541 ttgttttttt gtttttgttt tttttttggt ttttttgagg cagggtctct ttatatagcc
     3601 ctggctatcc tggaactctc tctgtagccc agactggcct tgaatttata gaaatcagcc
     3661 tgcctctgcc tctgcctctg cctcctgagt gctgggatta aaggtgtgcg ccaccacacc
     3721 tggctaggtt tattttcttt ttaatattat tattatgatt ataataactt caagcttagg
     3781 aatctcaggt tctttttccc tgctctcttc ctaagcctga ctccgtaagg acagaacacc
     3841 acacattccc accattgtgt gtccagagaa gagctgggcc tgggttctgc ctggcggcct
     3901 ttcaagggac cccactgttt agctgcagtg ggtccttgga gtttctgtgt tctgtgggtg
     3961 gatcggcact aggggatgtg acggtcccca ctgaggccct ctattcttgt gtttttagtg
     4021 ccctctctca gcatcttctg gttttatgaa ggatcactcc atcccctgct ggcccagcct
     4081 cagagggaac ccaagtggca cgcctgtcgc cagcaatcag ggttccctag gggattttct
     4141 ttgtattttt ctgcagtgct gaggaatgta ggcagggcct cctgcttgag aggcaagtgg
     4201 ctcaccggga gggtaggaga tcccgctgtt aagagaggta aagtttcagg gaaatagtca
     4261 ggacccctgg atgggactac caaatcctgc actcccgggg ttcgtgtatg tgcctgaaag
     4321 gtacccttaa cagaagagcg tactttggga tttagctcag tggatagtgt gctcctctag
     4381 cattcatgaa gccctgggtt ctgttcttag cgctcggggg atgaaagcaa acagatcaca
     4441 gggtcagcct gggctacgtg aggctctgcc tcaaaaaaga aaaaaaaaga aagtcaaata
     4501 tcacctgtac agactaatga gaccacccaa gatccccact gacaaagcac cccggacccc
     4561 agctatatac tctctccact gggtcctaaa gaccaccccc atccatagag gcatgcagcc
     4621 ctgcccccac aaaaccccct tatctgagac tccgaagcat cagcgttcac cctgtcccac
     4681 cagctgcagg tagcaggtcc ctggtgtggg atggacccag ggacctggct ctgtccgctg
     4741 cccactgggc agtgttgctg ctcaggctgg tgaggtggtc cccccataat ggaaagaact
     4801 gtggaagtaa agagatactc aggcagatga aaacgagcta gcccctgctc acaggcagcc
     4861 cagcccgccc cccagtcatc tggtacgtga tcttcaacga aggtctgagc cctctgtcac
     4921 cagctcctcc tagccacatt tcccaggctg acctttaaaa gtccccagcc acctctgggc
     4981 caccagccag agcctctgga ttggatgtgg ggacaaggcc aggctctgct gaggcaactg
     5041 aagaggggag ccaaagggag gaagtgttca ttttgaccct agggtttaat gggatacagt
     5101 ccatcatggc ggggagaggt gtggcagcag gactgtgaag ccggtcacat tgcatctgca
     5161 gtcatgaagc tgagaggcgg atgctgctgc cccactcact ttctcctgtt tatctgggac
     5221 aagagcctag cctgtggaag gttgccacat tgagggtagg tctcctgggc aggttgactc
     5281 agaggtttgt cttctaggtg gttcttgatc ctgtcaggat gactgttaac catcacagga
     5341 cacccctcac cccgccgtgt tcctctgtgg gataccatag gtggcgtcgg cacttggcgt
     5401 ggtgagggga gcctagatga gaacagggag ggggtatagg gacatagctt ggggttttca
     5461 aatgatgggt gtgctgaaag ttggcgtatg gcctggaagg gtggcagacc tccagtttta
     5521 catccaggag ggaagcaagg ccaacaatgg ccgacagcca gtcagccttg ctttgctatt
     5581 gtgctgttgt gacagtgtac aactcactta atagacctaa cctcagagtt catcccagct
     5641 ccctttttca tgtccgtttt ctaattataa gcagcaaaag gatgcattta accgaccccg
     5701 gggcaacccc agcttgagct ctagcccttc ctctgaaggc aacttgactg gggaagggca
     5761 ggtgctgggc ctgttgctga aggcaccagg agaggcccga ggcctaggct atgactcttg
     5821 caggtatcag tttggtggtg gtgatgtatg gctcttggta gaagagagga agctgggaga
     5881 gtcagacgtg cagggtggcc cagtcccatg tgtcagatga tgctgtttat ttacgtgtgt
     5941 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc atgtgtgttc atgtattagg catgagtgtg
     6001 tgtgcccacg tgcgcagagc tgtgagctat ttgatgcagt gtttggcccc ttagcctaac
     6061 ccattgccac agagttacac agataggggt gcaaggttgg aatgtggggc tgccctgatg
     6121 gttttggctc cttccccatt cgctgcatcc ccaagaaaga ctgctcctca gggagtccgt
     6181 gcaggcagcc tgagctggcc tagtcctccg tggggctctt caaatgcttc agttctaagg
     6241 acagtgtttg cgtggagagg ttggggacaa gaggtgccgc ttgcttccca ggaaagggaa
     6301 agggtccaca aagctataga ctccagcaac gggcaagatt caggtttccg tgggctgagc
     6361 ctagcacggc tttcctttct actgcctcag tttacctgtg tcacaggaag agttagagca
     6421 gggtcagtct ccaaacaggg gagacagaag aacagcggta gtcctcccag ccctcctcct
     6481 gtatgccaaa atcatttccg ttatcctgag gcaggggagc aggtatgggt gccctgtggc
     6541 atttttaagg gaccctgccc tgcccacagc cccagctgac cctcacctgg cgtgtcgtgc
     6601 ccaggtcacc agcaacagtg gtacttcatc agtcccgagg cttgggtgaa gggaggtggg
     6661 gggctggtgt cctactctgt ccgcctccgg ggcccctcat gctttcgttt tccttgtcaa
     6721 agaaacaaaa cccttgaaag ttgtgtactg tatgatgaag agacaaaaaa aagtacctaa
     6781 tgtcccccta aaaaaaaaga cagtatattt tgtactttgt aaagtgttca ttaaaatgaa
     6841 ggggaaaaaa at
//
