LOCUS       NM_016996               4180 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus calcium-sensing receptor (Casr), transcript
            variant 1, mRNA.
ACCESSION   NM_016996
VERSION     NM_016996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Carlton-Carew,S.R.E., Greenberg,H.Z.E., Connor,E.J., Zadeh,P.,
            Greenwood,I.A. and Albert,A.P.
  TITLE     Stimulation of the calcium-sensing receptor induces relaxations of
            rat mesenteric arteries by endothelium-dependent and -independent
            pathways via BKCa and KATP channels
  JOURNAL   Physiol Rep 12 (2), e15926 (2024)
   PUBMED   38281732
  REMARK    GeneRIF: Stimulation of the calcium-sensing receptor induces
            relaxations of rat mesenteric arteries by endothelium-dependent and
            -independent pathways via BKCa and KATP channels.
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Li,R.J.W., Barros,D.R., Kuah,R., Lim,Y.M., Gao,A., Beaudry,J.L.,
            Zhang,S.Y. and Lam,T.K.T.
  TITLE     Small intestinal CaSR-dependent and CaSR-independent protein
            sensing regulates feeding and glucose tolerance in rats
  JOURNAL   Nat Metab 6 (1), 39-49 (2024)
   PUBMED   38167726
  REMARK    GeneRIF: Small intestinal CaSR-dependent and CaSR-independent
            protein sensing regulates feeding and glucose tolerance in rats.
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Liu,B., Wei,Y.P., Fan,X., Hu,X., Chen,Z., Liu,X., Xu,Y., Wang,L.,
            Wang,T., Ruiz,M., Dupuis,J., Yuan,P., Liu,J., Huang,S., Zhu,L.,
            Jing,Z.C. and Hu,Q.
  TITLE     Calcium Sensing Receptor Variants Increase Pulmonary Hypertension
            Susceptibility
  JOURNAL   Hypertension 79 (7), 1348-1360 (2022)
   PUBMED   35477244
  REMARK    GeneRIF: Calcium Sensing Receptor Variants Increase Pulmonary
            Hypertension Susceptibility.
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Mary,A., Objois,T., Brazier,M., Bennis,Y., Boudot,C., Lenglet,G.,
            Paccou,J., Bugnicourt,J.M., Choukroun,G., Drueke,T.B., Massy,Z.A.,
            Kamel,S., Six,I. and Mentaverri,R.
  TITLE     Decreased monocyte calcium sensing receptor expression in patients
            with chronic kidney disease is associated with impaired monocyte
            ability to reduce vascular calcification
  JOURNAL   Kidney Int 99 (6), 1382-1391 (2021)
   PUBMED   33647324
  REMARK    GeneRIF: Decreased monocyte calcium sensing receptor expression in
            patients with chronic kidney disease is associated with impaired
            monocyte ability to reduce vascular calcification.
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Du,S.J., Zhang,Y., Zhao,Y.M., Dong,Y.J., Tang,J.L., Zhou,X.H. and
            Gao,W.J.
  TITLE     Astragaloside IV attenuates cerebral ischemia-reperfusion injury in
            rats through the inhibition of calcium-sensing receptor-mediated
            apoptosis
  JOURNAL   Int J Mol Med 47 (1), 302-314 (2021)
   PUBMED   33416112
  REMARK    GeneRIF: Astragaloside IV attenuates cerebral ischemiareperfusion
            injury in rats through the inhibition of calciumsensing
            receptormediated apoptosis.
REFERENCE   6  (bases 1 to 4180)
  AUTHORS   Ho,C., Conner,D.A., Pollak,M.R., Ladd,D.J., Kifor,O., Warren,H.B.,
            Brown,E.M., Seidman,J.G. and Seidman,C.E.
  TITLE     A mouse model of human familial hypocalciuric hypercalcemia and
            neonatal severe hyperparathyroidism
  JOURNAL   Nat Genet 11 (4), 389-394 (1995)
   PUBMED   7493018
REFERENCE   7  (bases 1 to 4180)
  AUTHORS   Chou,Y.H., Pollak,M.R., Brandi,M.L., Toss,G., Arnqvist,H.,
            Atkinson,A.B., Papapoulos,S.E., Marx,S., Brown,E.M., Seidman,J.G.
            et al.
  TITLE     Mutations in the human Ca(2+)-sensing-receptor gene that cause
            familial hypocalciuric hypercalcemia
  JOURNAL   Am J Hum Genet 56 (5), 1075-1079 (1995)
   PUBMED   7726161
REFERENCE   8  (bases 1 to 4180)
  AUTHORS   Ruat,M., Molliver,M.E., Snowman,A.M. and Snyder,S.H.
  TITLE     Calcium sensing receptor: molecular cloning in rat and localization
            to nerve terminals
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3161-3165 (1995)
   PUBMED   7724534
REFERENCE   9  (bases 1 to 4180)
  AUTHORS   Riccardi,D., Park,J., Lee,W.S., Gamba,G., Brown,E.M. and
            Hebert,S.C.
  TITLE     Cloning and functional expression of a rat kidney extracellular
            calcium/polyvalent cation-sensing receptor
  JOURNAL   Proc Natl Acad Sci U S A 92 (1), 131-135 (1995)
   PUBMED   7816802
REFERENCE   10 (bases 1 to 4180)
  AUTHORS   Pollak,M.R., Brown,E.M., Estep,H.L., McLaine,P.N., Kifor,O.,
            Park,J., Hebert,S.C., Seidman,C.E. and Seidman,J.G.
  TITLE     Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing
            receptor gene mutation
  JOURNAL   Nat Genet 8 (3), 303-307 (1994)
   PUBMED   7874174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 11, 2015 this sequence version replaced NM_016996.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10354.1, SRR26643287.27034.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418986, SAMN17050767
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               JAXUCZ010000011.1  77740614-77740945
            333-758             JAXUCZ010000011.1  77784489-77784914
            759-1065            JAXUCZ010000011.1  77787536-77787842
            1066-1950           JAXUCZ010000011.1  77791948-77792832
            1951-2181           JAXUCZ010000011.1  77803206-77803436
            2182-2305           JAXUCZ010000011.1  77805678-77805801
            2306-4180           JAXUCZ010000011.1  77808293-77810167
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4180
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /note="calcium-sensing receptor"
                     /db_xref="GeneID:24247"
                     /db_xref="RGD:2277"
     exon            1..332
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
     exon            333..758
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..3813
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /note="extracellular calcium-sensing receptor; parathyroid
                     Cell calcium-sensing receptor; Calcium-sensing receptor
                     (hypocalciuric hypercalcemia 1, severe neonatal
                     hyperparathyroidism)"
                     /codon_start=1
                     /product="extracellular calcium-sensing receptor
                     precursor"
                     /protein_id="NP_058692.1"
                     /db_xref="GeneID:24247"
                     /db_xref="RGD:2277"
                     /translation="MASYSCCLALLALAWHSSAYGPDQRAQKKGDIILGGLFPIHFGV
                     AAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCN
                     TVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLF
                     YIPQVSYASSSRLLSNKNQYKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDY
                     GRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDL
                     EPLIKEIVRRNITGRIWLASEAWASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFL
                     QKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFR
                     PLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCA
                     DIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEV
                     GYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCQAGTRKGIIEGEPTCCFECV
                     ECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLAWTEPFGIALTLFAVLGI
                     FLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQP
                     AFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQILICI
                     IWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLP
                     ENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNK
                     VYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSSSLGGSTGSIPSSSI
                     SSKSNSEDRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQQPQQPRCKQKVIFGSG
                     TVTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCADADSEMTIQE
                     TGLQGPMVGDHQPEMESSDEMSPALVMSTSRSFVISGGGSSVTENVLHS"
     exon            759..1065
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1950
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2181
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2305
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..4180
                     /gene="Casr"
                     /gene_synonym="PCaR1; RaKCaR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggactctc caggccggct caggcaccgg actgtaggtg tatttggagg gatttggagg
       61 ctggagaccc caggaagcac gcaggcggga gcaggcaagg ggcggagccc cgggcccggc
      121 caaggtggcc gtcagagggt ctgcggggag gcagtagctt gacccaaggc gaccagggaa
      181 cttcagacgg tagcacgcca ctcaaacaaa ttaacttgac atcgcaagct gggcgggctg
      241 gtacgacatc ctgacttcag catccagctg ttcctgggca gacagagggc caacaggtgt
      301 tcctgtggaa gaagccagga caaggactcc agaaaacatc tcgggcagcc tctacatgat
      361 gtcacttctc aggactcgag gaccagccac cctacacctc tactacagag aaggcagaaa
      421 tggagaccca aaggccatca ctcctgctct gtcactaacc actctgtaat catgtctccc
      481 caccagaagg tgtgaaccgc accagggccg tggagttctc gggctcccaa tccactgaca
      541 cctttacctg tcccctgaag agaaggcaac gctatggcat cgtacagctg ctgtttggcc
      601 ctcttggctc ttgcctggca ctcctctgcc tatgggcctg accagcgagc ccaaaagaag
      661 ggggacatta tcctaggagg tctctttcct atccattttg gagtagcagc caaagatcaa
      721 gatctgaagt caagaccaga gtctgtggag tgcattaggt ataacttccg tggattccga
      781 tggttacaag ccatgatatt cgccatagag gagataaaca gcagcccctc ccttcttccc
      841 aacatgacac tgggatatag gatatttgac acctgtaaca ccgtctccaa ggcgctggaa
      901 gccaccttga gttttgttgc ccagaacaaa atcgattctt tgaacctgga cgagttctgc
      961 aactgctctg agcacatccc ttcgaccatt gccgtggtgg gagccaccgg ctccggtgtc
     1021 tccacggcgg tagccaacct gctgggactt ttctacatcc cccaggtgag ctacgcctcc
     1081 tccagcaggc tcctcagcaa taagaaccag tacaaatcct tcctccgcac cattcccaat
     1141 gacgaacacc aggcaaccgc gatggccgac atcatcgagt acttccgctg gaactgggtg
     1201 ggcacaattg cagctgatga cgactatggc agacctggca ttgagaagtt ccgagaggaa
     1261 gccgaagaga gggatatctg cattgatttt agcgagctca tctcccagta ctctgacgag
     1321 gaagagatcc agcaggtggt cgaagtgatc caaaactcta cggccaaggt cattgtcgtt
     1381 ttctccagcg gcccggacct agaacctctc atcaaggaga ttgtgcggcg taacatcaca
     1441 ggcaggatct ggctggctag cgaggcctgg gccagttcct cgctgattgc tatgcctgag
     1501 tatttccatg tagtcggggg caccattggg ttcggtctga aggctgggca gattccaggc
     1561 ttccgagaat tcctacagaa agttcatcct aggaagtctg tccacaatgg ttttgccaaa
     1621 gagttttggg aagaaacttt taattgccac ctccaagaag gcgcaaaagg acctttacct
     1681 gtggacacct tcgtgagaag tcacgaagaa ggtggcaaca ggttactcaa tagctctact
     1741 gccttccgac ccctctgcac aggggatgag aacatcaaca gtgtggagac cccttacatg
     1801 gattacgaac atttacggat atcctacaat gtgtacttag ccgtctactc cattgcgcat
     1861 gccctacaag atatatacac ctgcttaccc ggaagagggc ttttcaccaa cgggtcctgt
     1921 gcagacatca agaaggttga ggcctggcag gtcttgaagc acctacggca cctgaacttc
     1981 accaacaaca tgggggagca ggtgaccttc gatgagtgtg gtgatctggt ggggaactat
     2041 tctatcatca actggcacct ctccccagag gacggctcca ttgtgttcaa ggaagttggg
     2101 tactacaatg tgtatgccaa gaagggagaa agactcttca tcaatgagga gaagatcttg
     2161 tggagtgggt tctccagaga ggtgcctttc tccaattgca gccgggactg tcaggcaggg
     2221 accaggaagg ggatcatcga gggagagccc acctgctgct ttgagtgtgt ggagtgtcct
     2281 gatggagagt acagtggaga gacagatgcg agtgcctgtg acaagtgccc ggatgacttc
     2341 tggtccaatg agaaccacac ttcttgcatt gccaaggaga ttgagtttct ggcgtggacc
     2401 gagccctttg gaatcgctct cactctcttt gcggtgctgg gcattttcct gaccgccttt
     2461 gtgctgggtg tcttcatcaa gttccgaaac acacctatcg tcaaggccac caaccgagaa
     2521 ctgtcctacc tcctgctctt ctccctactc tgctgcttct ccagctcctt gttcttcatt
     2581 ggggagcccc aggactggac gtgccgcctg cgacagcctg ctttcggcat cagctttgtg
     2641 ctctgtatct cgtgcatctt ggtgaagacc aatcgcgtcc tcctggtatt tgaagccaag
     2701 atacccacca gcttccaccg gaagtggtgg gggctcaacc tgcagttcct gctggttttc
     2761 ctctgcacct tcatgcagat cctcatctgc atcatctggc tctacacggc gcccccctct
     2821 agctaccgca accatgagct ggaagacgaa atcatcttca tcacgtgcca tgagggctca
     2881 ctcatggcac ttggctccct gatcggctat acctgcctgc tggctgccat ctgcttcttc
     2941 tttgccttca agtccaggaa gttaccagag aacttcaacg aagccaagtt cattaccttc
     3001 agcatgctca tcttcttcat cgtctggatc tccttcattc cagcctatgc cagcacctac
     3061 ggcaagtttg tctctgccgt agaggtgatc gccattttgg cagccagctt tggcttacta
     3121 gcctgcatct tcttcaacaa ggtctacatt atcctcttca agccttcccg gaacaccatt
     3181 gaggaagtcc gctccagcac cgcagcacat gctttcaaag tagcagcccg cgccactcta
     3241 cgccgtccca acatctcccg gaagcggtcc agcagccttg gaggctccac cggctccatt
     3301 ccctcctcct ccatcagcag caaaagcaac agcgaagacc ggttcccgca gccagagagg
     3361 cagaagcaac agcaaccgct gtccctgacc cagcaagaac agcagcagca gcccctgacc
     3421 ctccacccac agcaacagca gcagccacag cagccgagat gcaaacagaa ggtcatcttc
     3481 ggcagtggta cggtcacctt ctctctgagt tttgacgagc ctcagaagaa tgccatggcc
     3541 cacaggaact ccatgcgtca gaactccctg gaggcccaga ggagcaacga caccttgggc
     3601 agacaccagg ccctgcttcc cctacagtgt gcagatgcgg actcagaaat gaccattcag
     3661 gaaacgggcc tgcaagggcc catggtgggg gaccaccagc cagaaatgga aagctcagat
     3721 gaaatgtccc cagcgctggt catgtccacc tctcggagct tcgtcattag tggtggaggt
     3781 agctctgtga cggaaaacgt attacactcc taatggaggg aaaggctatc cagttgagag
     3841 gttttcttag agccctgagc aaaaggatgg gtccttcctt tcttcccagg aagccaggga
     3901 gagtaggtac gtcaaagcct gtactcagtt gcactgcttt gaatgacagt gaactgactg
     3961 gtgtgctctt tagagttaaa agaagagcca tgttttgggg tcgttttcca gagctcagta
     4021 tcacacctgg gtttgctgaa gtcttttcct ctgctctatc caccatcagt tcagacgaaa
     4081 gcaaggctct aagctaccca tctgcttccc tcaaaaaaaa aaaaaaaaaa aaaaaatgct
     4141 tgcatccaga aatgcctgcc ccaagataca gaaaacatat
//
