LOCUS       NM_017131               2478 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus calsequestrin 2 (Casq2), mRNA.
ACCESSION   NM_017131
VERSION     NM_017131.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   de Alba-Aguayo,D.R., Pavon,N., Mercado-Morales,M.,
            Miranda-Saturnino,M., Lopez-Casamichana,M., Guerrero-Hernandez,A.
            and Rueda,A.
  TITLE     Increased calcium leak associated with reduced calsequestrin
            expression in hyperthyroid cardiomyocytes
  JOURNAL   Cell Calcium 62, 29-40 (2017)
   PUBMED   28169003
  REMARK    GeneRIF: The exacerbated diastolic Ca(2+) leak and arrhythmogenic
            activities were related to a diminished expression of calsequestrin
            along with increased SERCA pump activity, which, in effect,
            promoted a gain-of-function in RyRs without alterations in SR
            Ca(2+) load, RyR expression or its Ca(2+) sensitivity.
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Sanchez,E.J., Hayes,R.P., Barr,J.T., Lewis,K.M., Webb,B.N.,
            Subramanian,A.K., Nissen,M.S., Jones,J.P., Shelden,E.A., Sorg,B.A.,
            Fill,M., Schenk,J.O. and Kang,C.
  TITLE     Potential role of cardiac calsequestrin in the lethal arrhythmic
            effects of cocaine
  JOURNAL   Drug Alcohol Depend 133 (2), 344-351 (2013)
   PUBMED   23876860
  REMARK    GeneRIF: We propose that cocaine accumulates in SR through its
            affinity for CASQ2 and affects both sasrcoplasmic reticulum Ca(2+)
            storage and release by altering the normal CASQ2 Ca(2+)-dependent
            polymerization
REFERENCE   3  (bases 1 to 2478)
  AUTHORS   Lee,K.W., Maeng,J.S., Choi,J.Y., Lee,Y.R., Hwang,C.Y., Park,S.S.,
            Park,H.K., Chung,B.H., Lee,S.G., Kim,Y.S., Jeon,H., Eom,S.H.,
            Kang,C., Kim,D.H. and Kwon,K.S.
  TITLE     Role of Junctin protein interactions in cellular dynamics of
            calsequestrin polymer upon calcium perturbation
  JOURNAL   J Biol Chem 287 (3), 1679-1687 (2012)
   PUBMED   22123818
REFERENCE   4  (bases 1 to 2478)
  AUTHORS   Yanni,J., Tellez,J.O., Maczewski,M., Mackiewicz,U., Beresewicz,A.,
            Billeter,R., Dobrzynski,H. and Boyett,M.R.
  TITLE     Changes in ion channel gene expression underlying heart
            failure-induced sinoatrial node dysfunction
  JOURNAL   Circ Heart Fail 4 (4), 496-508 (2011)
   PUBMED   21565973
REFERENCE   5  (bases 1 to 2478)
  AUTHORS   Cheng,Y.S., Dai,D.Z., Ji,H., Zhang,Q. and Dai,Y.
  TITLE     Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by
            suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and
            SERCA2a in rats
  JOURNAL   Acta Pharmacol Sin 32 (4), 441-448 (2011)
   PUBMED   21441944
REFERENCE   6  (bases 1 to 2478)
  AUTHORS   Rodriguez,M.M., Chen,C.H., Smith,B.L. and Mochly-Rosen,D.
  TITLE     Characterization of the binding and phosphorylation of cardiac
            calsequestrin by epsilon protein kinase C
  JOURNAL   FEBS Lett 454 (3), 240-246 (1999)
   PUBMED   10431815
REFERENCE   7  (bases 1 to 2478)
  AUTHORS   Jones,L.R., Suzuki,Y.J., Wang,W., Kobayashi,Y.M., Ramesh,V.,
            Franzini-Armstrong,C., Cleemann,L. and Morad,M.
  TITLE     Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes
            overexpressing calsequestrin
  JOURNAL   J Clin Invest 101 (7), 1385-1393 (1998)
   PUBMED   9525981
REFERENCE   8  (bases 1 to 2478)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   9  (bases 1 to 2478)
  AUTHORS   Volpe,P., Martini,A., Furlan,S. and Meldolesi,J.
  TITLE     Calsequestrin is a component of smooth muscles: the skeletal- and
            cardiac-muscle isoforms are both present, although in highly
            variable amounts and ratios
  JOURNAL   Biochem J 301 (Pt 2) (Pt 2), 465-469 (1994)
   PUBMED   8042990
REFERENCE   10 (bases 1 to 2478)
  AUTHORS   Takahashi,T., Schunkert,H., Isoyama,S., Wei,J.Y., Nadal-Ginard,B.,
            Grossman,W. and Izumo,S.
  TITLE     Age-related differences in the expression of proto-oncogene and
            contractile protein genes in response to pressure overload in the
            rat myocardium
  JOURNAL   J Clin Invest 89 (3), 939-946 (1992)
   PUBMED   1531837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK602439.1, BC072547.1 and CO401252.1.
            
            On Sep 29, 2005 this sequence version replaced NM_017131.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072547.1, U33287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: downstream AUG is associated
                                                  with N-terminal localization
                                                  signal
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CK602439.1         1-13
            14-2444             BC072547.1         1-2431
            2445-2478           CO401252.1         666-699
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2478
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /note="calsequestrin 2"
                     /db_xref="GeneID:29209"
                     /db_xref="RGD:2276"
     exon            1..386
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1394
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /note="SR calcium binding protein; calsequestrin 2
                     (cardiac muscle)"
                     /codon_start=1
                     /product="calsequestrin-2 precursor"
                     /protein_id="NP_058827.3"
                     /db_xref="GeneID:29209"
                     /db_xref="RGD:2276"
                     /translation="MKRIYLLVVGLYLLSFSRAEEGLNFPTYDGKDRVVSLSEKNLKQ
                     VLKRYDLLCLYYHEPVSSDKVAQKQFQLKEIVLELVAQVLEHKNIGFVMVDSRKEAKL
                     AKRLGFSEEGSLYVLKGGRTIEFDGEFAADVLVEFLLDLIEDPVEIVNNKLEVQAFER
                     IEDQIKLLGFFKNEDSEYYKAFQEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVGFYE
                     PFMDEPSVIPNKPYTEEELVEFVKEHQRPTLRRLRPEDMFETWEDDLNGIHIVAFAEK
                     SDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFKPQIGVV
                     NVTDADSVWMEIPDDDDLPTAEELEDWIEDVLSGKINTEDDDNEDEDDDGDNDNDDDD
                     DDDDNSDEDNDDSDDDDDDDE"
     exon            387..471
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            472..572
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            573..684
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            685..758
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            759..889
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            890..935
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            936..990
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1091
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1166
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..2457
                     /gene="Casq2"
                     /gene_synonym="cardCSQ"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgttctga gcccacaact acacagccgc aggaccaagg aggtgagatc agcctctttg
       61 ttccctaacc aagcttagca gcgtctccaa gaaccttcca tctgtcttcc atgatctccg
      121 ttctggggac tgagaaacaa gactcttccc aaatgaagag gatttacctg ctcgtggtgg
      181 ggctttatct gctgtccttt agcagggcag aagaggggct gaacttcccc acgtacgatg
      241 ggaaggaccg agtggtcagc ctttctgaga agaacttgaa gcaagtgttg aagagatacg
      301 atttgctctg tctctactac cacgagcctg tgtcttcaga caaggtcgca cagaagcagt
      361 tccaactgaa ggagatcgta ctggagcttg tggcccaggt tctggaacat aaaaacatag
      421 gctttgtgat ggtggattca aggaaagagg ccaagcttgc caagaggctg ggcttcagtg
      481 aagaaggaag cctgtatgtt ctgaagggtg gtcgcaccat tgagtttgac ggggaatttg
      541 cagcagatgt cttggtggaa tttctcttgg acctcattga ggacccagta gagatcgtga
      601 acaacaagtt ggaagtccaa gcctttgagc gcatcgagga ccagatcaag ctgcttggct
      661 ttttcaagaa tgaggactca gaatattaca aagcgttcca agaggcagct gaacacttcc
      721 agccttacat caagttcttt gccacctttg acaagggggt ggcaaagaag ttgtccttga
      781 agatgaatga agttggcttc tatgagccat ttatggatga acccagtgtc atccctaaca
      841 agccctacac agaagaggag cttgtggagt ttgtgaagga gcatcaaaga cccaccctac
      901 gtcgcttgcg cccagaggac atgtttgaaa catgggaaga cgacttgaat ggaatccaca
      961 ttgtggcatt tgcggagaag agtgacccag atggctatga gttcctggag atcctaaaac
     1021 aggttgcccg ggacaacact gacaaccctg acttgagcat cttgtggatt gacccagacg
     1081 actttcctct gcttgttgct tactgggaga agactttcaa gattgacctg ttcaagccac
     1141 agattggggt ggtgaatgta accgatgctg acagtgtctg gatggagatc ccagatgatg
     1201 acgacctgcc cacagctgag gagctggaag actggattga ggatgtgctt tctggaaaga
     1261 tcaatactga agacgatgac aatgaagatg aagatgatga tggcgataat gacaatgacg
     1321 atgacgatga cgacgatgat aattctgatg aggataatga tgacagtgat gatgacgatg
     1381 atgacgatga ataactccag ccccgggtac ttctgatgag agtgacatca caaccacccc
     1441 gtaccccatt acagacagcc caagggggca gcaagcagtg gtgcccacac ctagtcagct
     1501 cttttccttt ctccagcatc ttttccaagt ccgttcttgg caggagcagt acatttccgt
     1561 gaatgccttt ccaaacccag ctgtcccact ctgcagggac agaaggggga ggggggcggt
     1621 gattcccatg ctgactcctt ttaactattg aggaacaaac agctcttgtt ctttgttaga
     1681 taatcagggg tcatggaatt ctgggagtct gggcacagta tctcctgaca cctctactca
     1741 agtttacttg ttgtttttga ttcagatggt gacagaactg acagcttgct attagttcac
     1801 aagcagagag tggccttcta atcagagccc agaaaggcca catgattatc taattcagct
     1861 cccaaaccca gagcatctgt ggactcagac ccaagccttg gatggctatg ggtactgcca
     1921 tcatttctgg aatattagga tgctgtgtgg gggtcattta gctctataaa catcccatta
     1981 attgccaagc ctcatatatt caccagcagt gaggagagag actgaaggct aaaaggcttt
     2041 tcatttttct gacggagact gttcaggtct gctggctgcc tacagtgcgc tgggaactga
     2101 atgcaccctc tctgtcctgc tagcgagctg tcccattctg agttaaaacc actctatcca
     2161 atggtcaatt aactctcccc attcatcagc actcctgcag ttgaccaggg catcgataat
     2221 ttagagttca cgatgctctg aggaactgag aaaaaaaaaa aaaagaaccc ccaagtgcct
     2281 tttggattgt ctgaaagcag cactgtgctc ggtagtgata gtcgctaagt gttctaattt
     2341 atttttgaaa tctgttaaca tggagaagac tctgtgtggt gttgtttttg aaactggggc
     2401 agtcctttta tggaacagca ataaactaat ggacattaaa ctcatgcttt gaaaggaaaa
     2461 aaaaaaaaaa aaaaaaaa
//
