LOCUS       NM_001159594            1865 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calsequestrin 1 (Casq1), mRNA.
ACCESSION   NM_001159594 XM_001057529 XM_001063867
VERSION     NM_001159594.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Ma,J., Pang,X., Wang,T., Ning,M., Liang,Y., Li,X., Tian,X., Mo,Y.,
            Laher,I. and Li,S.
  TITLE     Acute aerobic exercise regulation of myocardial calcium homeostasis
            involves CASQ1, CASQ2, and TRDN
  JOURNAL   J Appl Physiol (1985) 135 (4), 707-716 (2023)
   PUBMED   37589058
  REMARK    GeneRIF: Acute aerobic exercise regulation of myocardial calcium
            homeostasis involves CASQ1, CASQ2, and TRDN.
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Barone,V., Del Re,V., Gamberucci,A., Polverino,V., Galli,L.,
            Rossi,D., Costanzi,E., Toniolo,L., Berti,G., Malandrini,A.,
            Ricci,G., Siciliano,G., Vattemi,G., Tomelleri,G., Pierantozzi,E.,
            Spinozzi,S., Volpi,N., Fulceri,R., Battistutta,R., Reggiani,C. and
            Sorrentino,V.
  TITLE     Identification and characterization of three novel mutations in the
            CASQ1 gene in four patients with tubular aggregate myopathy
  JOURNAL   Hum Mutat 38 (12), 1761-1773 (2017)
   PUBMED   28895244
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Zhang,L., Wang,L., Li,S., Xue,J. and Luo,D.
  TITLE     Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting
            STIM1 Aggregation
  JOURNAL   Cell Physiol Biochem 38 (6), 2183-2193 (2016)
   PUBMED   27185316
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Zheng,Y., Wang,L., Zhu,Z., Yan,X., Zhang,L., Xu,P. and Luo,D.
  TITLE     Altered platelet calsequestrin abundance, Na/Ca(2) exchange and
            Ca(2) signaling responses with the progression of diabetes mellitus
  JOURNAL   Thromb Res 134 (3), 674-681 (2014)
   PUBMED   25084748
  REMARK    GeneRIF: CSQ-1 expression in platelets is gradually downregulated
            as diabetes progresses, causing a progressive disruption of
            internal Ca2+ store recycling, and platelet function.
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Sanchez,E.J., Lewis,K.M., Danna,B.R. and Kang,C.
  TITLE     High-capacity Ca2+ binding of human skeletal calsequestrin
  JOURNAL   J Biol Chem 287 (14), 11592-11601 (2012)
   PUBMED   22337878
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Bataille,N., Schmitt,N., Aumercier-Maes,P., Ollivier,B.,
            Lucas-Heron,B. and Lestienne,P.
  TITLE     Molecular cloning of human calmitine, a mitochondrial calcium
            binding protein, reveals identity with calsequestrine
  JOURNAL   Biochem Biophys Res Commun 203 (3), 1477-1482 (1994)
   PUBMED   7945294
REFERENCE   7  (bases 1 to 1865)
  AUTHORS   Volpe,P., Martini,A., Furlan,S. and Meldolesi,J.
  TITLE     Calsequestrin is a component of smooth muscles: the skeletal- and
            cardiac-muscle isoforms are both present, although in highly
            variable amounts and ratios
  JOURNAL   Biochem J 301 (Pt 2) (Pt 2), 465-469 (1994)
   PUBMED   8042990
REFERENCE   8  (bases 1 to 1865)
  AUTHORS   Hall,D.E., Frazer,K.A., Hann,B.C. and Reichardt,L.F.
  TITLE     Isolation and characterization of a laminin-binding protein from
            rat and chick muscle
  JOURNAL   J Cell Biol 107 (2), 687-697 (1988)
   PUBMED   3417768
REFERENCE   9  (bases 1 to 1865)
  AUTHORS   Jorgensen,A.O., Shen,A.C., Campbell,K.P. and MacLennan,D.H.
  TITLE     Ultrastructural localization of calsequestrin in rat skeletal
            muscle by immunoferritin labeling of ultrathin frozen sections
  JOURNAL   J Cell Biol 97 (5 Pt 1), 1573-1581 (1983)
   PUBMED   6355123
REFERENCE   10 (bases 1 to 1865)
  AUTHORS   Greenway,D.C. and MacLennan,D.H.
  TITLE     Assembly of the sarcoplasmic reticulum. Synthesis of calsequestrin
            and the Ca2+ + Mg2+ -adenosine triphosphatase on membrane-bound
            polyribosomes
  JOURNAL   Can J Biochem 56 (6), 452-456 (1978)
   PUBMED   149586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA334109.1, CB699232.1, FM056035.1 and BE109529.1.
            
            On or before Apr 25, 2009 this sequence version replaced
            XM_001063867.1, XM_001057529.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               CA334109.1         1-603
            604-813             CB699232.1         191-400
            814-1310            FM056035.1         119-615
            1311-1865           BE109529.1         1-555               c
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1865
                     /gene="Casq1"
                     /note="calsequestrin 1"
                     /db_xref="GeneID:686019"
                     /db_xref="RGD:1586677"
     exon            1..442
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1384
                     /gene="Casq1"
                     /note="Aspartactin; Calsequestrin-1; Laminin-binding
                     protein; calsequestrin 1 (fast-twitch, skeletal muscle)"
                     /codon_start=1
                     /product="calsequestrin-1 precursor"
                     /protein_id="NP_001153066.1"
                     /db_xref="GeneID:686019"
                     /db_xref="RGD:1586677"
                     /translation="MRATDRMGARAVSKLRLALLFVLVLGTPRSGVQGEDGLDFPEYD
                     GVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDK
                     GVGFGLVDSEKDAAVAKKLGLTEEDSVYVFKGDEVIEYDGEFSADTLVEFLLDVLEDP
                     VELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAYEDAAEEFHPYIPFFATFDSKV
                     AKKLTLKLNEIDFYEAFMEEPVTIPDKPNSEEEIVSFVEEHRRSTLRKLKPESMYETW
                     EDDLDGIHIVAFAEEADPDGYEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWE
                     KTFDIDLSAPQIGVVNVTDADSIWMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDD
                     DDDDDDDDDDDDDD"
     exon            443..527
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..628
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..740
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..814
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..945
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..991
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1046
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1147
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1222
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1849
                     /gene="Casq1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgctccag gacccagcag tgtccactgt ccactgctct ggcccactct ctaccccacc
       61 cccacccgga gcccctaact caggactctg tatccggggg ctcctcccta ttccagctaa
      121 cctcctctgg accaggagag cagacccagc tcgtactacc tccatgagag ccactgacag
      181 gatgggggcc agggcagtgt ccaagctgcg gctggcactg ctgtttgtac tggtgctagg
      241 gacgcccagg tcaggggtcc agggggagga cgggctggac ttccctgaat acgacggtgt
      301 ggaccgcgtg atcaatgtga acgcaaagaa ctacaagaac gtgtttaaga agtatgaggt
      361 gctagccctc ctctaccatg agccccccga ggacgacaag gcctcccaaa gacaatttga
      421 gatggaggag ctaattctgg agttagcagc ccaagtccta gaagacaagg gtgttggctt
      481 tggcctggtg gactctgaga aagatgcagc tgtggccaag aaactaggcc taactgaaga
      541 ggacagcgtg tatgtgttca aaggagatga agtcatcgag tatgatggcg agttttccgc
      601 agacactttg gtggagtttc tgctcgatgt cctagaagac cctgtcgaat tgattgaagg
      661 tgaacgagag ctgcaggcat ttgagaacat cgaggatgaa atcaaactca ttggctactt
      721 caagagcaaa gactcagagc attacaaagc ctacgaggat gcagctgaag aattccaccc
      781 ctacatccct ttcttcgcta ccttcgacag caaggtggca aagaagctga cgctgaagtt
      841 gaacgagatc gatttctatg aggccttcat ggaagaacct gtgaccatcc cagacaagcc
      901 caacagtgaa gaggagattg tcagcttcgt ggaggagcac aggagatcga ccctgaggaa
      961 actgaagcct gagagtatgt atgagacttg ggaggatgat ctggatggaa tccacattgt
     1021 ggcctttgca gaggaagctg accctgatgg ttatgagttc ttagagactc tcaaggctgt
     1081 ggcccaagac aacactgaga accctgacct cagtatcatc tggattgacc ctgatgactt
     1141 cccactgctg gtcccgtact gggagaagac ctttgacatc gacttgtcag ctccgcaaat
     1201 aggagttgtc aatgttacgg atgcggacag catatggatg gagatggacg acgaggagga
     1261 ccttccttct gctgaggagc tggaggactg gctggaggat gtgctggagg gtgaaatcaa
     1321 cacagaggat gacgacgacg acgacgacga cgacgatgat gacgacgacg acgacgatga
     1381 ctagttgcta tggcaactcc ttaccagccc cccttgctct ttacatgtac cttcctaccg
     1441 cccatgcact gccccgagct ccttgggaca ctaggtcatt ctctactata gggccaactg
     1501 tggtctacat gcagggtgct cgagatcctg gtctccctcg ctggagaaaa ggagctgctt
     1561 tatctccgat accagcccag ttctctcatc tgacttgttt cttatcccgt accttatctg
     1621 tatctactgt ttctcttcta ccactcccca tacttaacga tttgcaaact cttctctgtc
     1681 ccttccatcg gtacagtctc ccattactca aatcttaaac ctttccgact gtcctgaccc
     1741 tggctaggag gaagggaggt actgtgttag gggctatatc ttagccatct cctgttaatg
     1801 tatttgggtc aaatgcaagg ccttaataaa gaaatctggg gcagaatgaa aaaaaaaaaa
     1861 aaaaa
//
