LOCUS       NM_031632               2356 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus caspase 9 (Casp9), mRNA.
ACCESSION   NM_031632
VERSION     NM_031632.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Bai,L., Yang,J., Zhang,H., Liao,W. and Cen,Y.
  TITLE     PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial
            ischemia/hypoxia-reperfusion injury via inactivation of apoptotic
            protease activating factor-1 (APAF-1)/Caspase9 signaling pathway
  JOURNAL   Bioengineered 12 (1), 4385-4396 (2021)
   PUBMED   34304702
  REMARK    GeneRIF: PTB domain and leucine zipper motif 1 (APPL1) inhibits
            myocardial ischemia/hypoxia-reperfusion injury via inactivation of
            apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling
            pathway.
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Martin,S., Harrington,D.A., Ohlander,S., Stupp,S.I., McVary,K.T.
            and Podlasek,C.A.
  TITLE     Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog
            protein to the penis and cavernous nerve suppresses intrinsic and
            extrinsic apoptotic signaling mechanisms, which are an underlying
            cause of erectile dysfunction
  JOURNAL   Nanomedicine 37, 102444 (2021)
   PUBMED   34314869
  REMARK    GeneRIF: Peptide amphiphile nanofiber hydrogel delivery of Sonic
            hedgehog protein to the penis and cavernous nerve suppresses
            intrinsic and extrinsic apoptotic signaling mechanisms, which are
            an underlying cause of erectile dysfunction.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Liu,H., Li,J., Jiang,C., Yuan,T. and Ma,H.
  TITLE     Cellular communication network factor 1 (CCN1) knockdown exerts a
            protective effect for hepatic ischemia/reperfusion injury by
            deactivating the MEK/ERK pathway
  JOURNAL   Clin Res Hepatol Gastroenterol 45 (5), 101737 (2021)
   PUBMED   34144219
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Song,Z., Tian,X. and Shi,Q.
  TITLE     Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced
            fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant
            rat models
  JOURNAL   J Obstet Gynaecol Res 47 (7), 2298-2306 (2021)
   PUBMED   33847039
  REMARK    GeneRIF: Fas, Caspase-8, and Caspase-9 pathway-mediated bile
            acid-induced fetal cardiomyocyte apoptosis in intrahepatic
            cholestasis pregnant rat models.
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Zhuang,C., Ni,S., Yang,Z.C. and Liu,R.P.
  TITLE     Oxidative Stress Induces Chondrocyte Apoptosis through
            Caspase-Dependent and Caspase-Independent Mitochondrial Pathways
            and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide
  JOURNAL   Oxid Med Cell Longev 2020, 3240820 (2020)
   PUBMED   33224431
  REMARK    GeneRIF: Oxidative Stress Induces Chondrocyte Apoptosis through
            Caspase-Dependent and Caspase-Independent Mitochondrial Pathways
            and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Vu,C.C., Bortner,C.D. and Cidlowski,J.A.
  TITLE     Differential involvement of initiator caspases in apoptotic volume
            decrease and potassium efflux during Fas- and UV-induced cell death
  JOURNAL   J Biol Chem 276 (40), 37602-37611 (2001)
   PUBMED   11431480
  REMARK    GeneRIF: The activation of caspase-8, but not caspase-9, is
            necessary for Fas-induced apoptosis. Conversely, caspase-9, but not
            caspase-8, is important for UV-mediated shrunken morphology and
            apoptosis progression.
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Angelastro,J.M., Moon,N.Y., Liu,D.X., Yang,A.S., Greene,L.A. and
            Franke,T.F.
  TITLE     Characterization of a novel isoform of caspase-9 that inhibits
            apoptosis
  JOURNAL   J Biol Chem 276 (15), 12190-12200 (2001)
   PUBMED   11278518
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Zaidi,A.U., D'Sa-Eipper,C., Brenner,J., Kuida,K., Zheng,T.S.,
            Flavell,R.A., Rakic,P. and Roth,K.A.
  TITLE     Bcl-X(L)-caspase-9 interactions in the developing nervous system:
            evidence for multiple death pathways
  JOURNAL   J Neurosci 21 (1), 169-175 (2001)
   PUBMED   11150333
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   D'Sa-Eipper,C., Leonard,J.R., Putcha,G., Zheng,T.S., Flavell,R.A.,
            Rakic,P., Kuida,K. and Roth,K.A.
  TITLE     DNA damage-induced neural precursor cell apoptosis requires p53 and
            caspase 9 but neither Bax nor caspase 3
  JOURNAL   Development 128 (1), 137-146 (2001)
   PUBMED   11092819
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Kermer,P., Ankerhold,R., Klocker,N., Krajewski,S., Reed,J.C. and
            Bahr,M.
  TITLE     Caspase-9: involvement in secondary death of axotomized rat retinal
            ganglion cells in vivo
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 144-150 (2000)
   PUBMED   11146116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_031632.3.
            
            On Nov 30, 2020 this sequence version replaced NM_031632.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF286006.1, AF271996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000005.1  159392074-159392245
            173-572             JAXUCZ010000005.1  159394338-159394737
            573-607             JAXUCZ010000005.1  159397278-159397312
            608-784             JAXUCZ010000005.1  159398840-159399016
            785-874             JAXUCZ010000005.1  159399389-159399478
            875-1022            JAXUCZ010000005.1  159400428-159400575
            1023-1202           JAXUCZ010000005.1  159406720-159406899
            1203-1312           JAXUCZ010000005.1  159407383-159407492
            1313-2356           JAXUCZ010000005.1  159408606-159409649
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2356
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /note="caspase 9"
                     /db_xref="GeneID:58918"
                     /db_xref="RGD:61867"
     exon            1..172
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1405
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /EC_number="3.4.22.62"
                     /note="caspase-9-carboxyl-terminal divergent; 25 kDa
                     caspase-9 dominant negative protein; caspase-9 dominant
                     negative form; apoptotic protease Mch-6; Ice-like
                     apoptotic protease 6; apoptotic protease activating factor
                     3; caspase 9, apoptosis-related cysteine peptidase"
                     /codon_start=1
                     /product="caspase-9"
                     /protein_id="NP_113820.1"
                     /db_xref="GeneID:58918"
                     /db_xref="RGD:61867"
                     /translation="MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQ
                     RAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEA
                     VTPLDHLVPVVLGPMGLKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLT
                     PETPRPVDIGSGRAHDVCTPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTR
                     IGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHG
                     CQASHLQFPGAVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGF
                     EVAFTSSQDKAFDSDSEPDAVPYQEGPRTLDQLDAVSSLPTPSDILVSYSTFPGFVSW
                     RDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVANAVSEKGVYKQIPGCFNFLRKKLF
                     FKTS"
     exon            173..572
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            573..607
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            608..784
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..874
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1022
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1202
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1312
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2356
                     /gene="Casp9"
                     /gene_synonym="Apaf3; Casp-9-CTD; Casp9_v1; Ice-Lap6;
                     Mch6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagcgga cggaaccagg ggtccagcaa tccgctagcc atggaggagg ctgaccggca
       61 actcctgcgg cgatgcaggg tacgccttgt gcgcgaactg caagtcgcgg agctgtggga
      121 cgctctgctg agtcgtgagc tcttcacgcg cgacatgatc gaggatattc agcgggcagg
      181 ctctgggtct cggcgggatc aggccaggca gctggtcata gatcttgaga ctcgagggag
      241 gcaggccctt cctcgcttca tctcctgctt agaggacaca ggccaaggct ctctggcttc
      301 attcttgcaa agcagtgggc aagcagccaa gcaggatcca gaagctgtta cacccctaga
      361 ccacctggtg cctgtggtcc tgggaccaat gggactcaaa tcaaaggagc agaaagtagt
      421 gaagctggac ccatctcagc ctgccttggg aaacctcacc ccagtggtgc tggggccgga
      481 agagctctgg cctactcggc tcaggccaga ggttctcaca ccagaaacac ccaggccggt
      541 ggacattggt tctggcagag ctcatgatgt ctgtactcca gggaagatcg agagacatgc
      601 agatatggca tacaccctgg actcggatcc ctgtggccac tgcctcatca tcaacaacgt
      661 gaacttctgc ccttcctcag ggctcagcac acgcattggc tcccacgtgg actgtgagaa
      721 gcttcagcac cgcttctgct ggctgcgctt catggtggag gtgaagaacg acctgactgc
      781 taagaaaatg gtcacggctt tgatggagat ggcgcaccgc gaccaccgtg ccctggactg
      841 cttcgtggtg gtcatcctct ctcatggctg ccaggccagc cacctccagt tcccgggtgc
      901 tgtctatggc acagatggat gctctgtgtc catcgagaga attgtgaaca tcttcaatgg
      961 gaccggctgc cccagcctgg gagggaagcc caagctgttc ttcatccagg cctgtggtgg
     1021 tgagcagaaa gaccatggct ttgaggtggc cttcacttcc tctcaagaca aggccttcga
     1081 cagtgactct gagccagatg ctgtcccata ccaggaaggc ccaaggacct tggaccagct
     1141 ggacgcagtg tcaagtttgc ccacccccag tgacatcctt gtgtcctact ccaccttccc
     1201 aggttttgtc tcctggagag acaagaagag cggttcctgg tacatcgaga ccttggatgg
     1261 tgtcctggag cagtgggctc gctcggaaga cctgcagtcc ctccttctca gggtcgccaa
     1321 tgctgtttct gagaaagggg tttataagca gattcctggc tgttttaact tcctccggaa
     1381 gaagctgttc tttaaaactt catgagtcag gggctgctct ctgcctcatt tttctcccaa
     1441 aagccttcat ggcctggagt aggccaaggt cagaactgtc ccgtgaagca aggatttcga
     1501 actggggcag gctgctcttc cccgtttccc atgcagacag gctcctagca gcttccaggt
     1561 tggaggagac gtgggacggt gggaggggag gaacagagta ctgtggatgc tgcctggccg
     1621 cttcatctgt ggttagggac tgtggcctgg gacccccagg cctctctaga acagggcttc
     1681 tctgccgatg taccacggac acatgaggtt gtgtaatcct gtcatgggac tgccccgtgt
     1741 gttgtagtgt tttgagctgt ctctggtctc cacctgagca cccctcctga gttctgccaa
     1801 ccagacatgt cttcaggcat tgtcatgtgt gccctggggg acattacagc acccccctcc
     1861 cagggccatc gcccacaggg gtctgtggct gcagacacca gcatcactgc ttcccagacc
     1921 cacagtccag ctggcccagt gtgaatacct ggatctggac tgcgtctcat caaagtttcc
     1981 agaagggtta attcttcctt gagcacagta tttatcctta aacaataaat cttaggcaaa
     2041 aggactgtct tttgcctgta tcatccccac cctcactctg ctcttcctac aatggagact
     2101 agctttttcc tgagtatttc tctgtgttcc aaggtctcgg cctgagccca ggagttgact
     2161 gaggtgggag ccagagtccc cactgatcaa gtctcctgtc tgttggttac cctagtgggg
     2221 acacctggac agtgtctccc agtgtcttcc ttgctaagtg agcctggtcc tccagtggca
     2281 gtgaccgggc aacagtgaca tgttggcctc ccctgggaag ggtaccatcc ccgtctttaa
     2341 agctgttctg acttca
//
