LOCUS       NM_001107921            6781 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus caspase 8 associated protein 2 (Casp8ap2), mRNA.
ACCESSION   NM_001107921 XM_001063464 XM_232860
VERSION     NM_001107921.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6781)
  AUTHORS   Wu,T.Y., Leng,Q. and Tian,L.Q.
  TITLE     The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced
            Myocardial Injury by Regulating Apoptosis and Autophagy
  JOURNAL   Cytogenet Genome Res 161 (3-4), 132-142 (2021)
   PUBMED   33882492
  REMARK    GeneRIF: The microRNA-210/Casp8ap2 Axis Alleviates Hypoxia-Induced
            Myocardial Injury by Regulating Apoptosis and Autophagy.
REFERENCE   2  (bases 1 to 6781)
  AUTHORS   Li,K., Pan,J., Li,Q., Li,S., Li,K., Cheng,Y., Chai,L., Li,C.,
            Li,J., Fu,Z., Wang,D. and Bai,Y.
  TITLE     The MicroRNA-210/Casp8ap2 Pathway Alleviates Hypoxia-Induced Injury
            in Myocardial Cells by Regulating Apoptosis and Autophagy
  JOURNAL   Heart Surg Forum 23 (6), E797-E802 (2020)
   PUBMED   33234216
  REMARK    GeneRIF: The MicroRNA-210/Casp8ap2 Pathway Alleviates
            Hypoxia-Induced Injury in Myocardial Cells by Regulating Apoptosis
            and Autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6781)
  AUTHORS   Li,T., Song,X., Zhang,J., Zhao,L., Shi,Y., Li,Z., Liu,J., Liu,N.,
            Yan,Y., Xiao,Y., Tian,X., Sun,W., Guan,Y. and Liu,B.
  TITLE     Protection of Human Umbilical Vein Endothelial Cells against
            Oxidative Stress by MicroRNA-210
  JOURNAL   Oxid Med Cell Longev 2017, 3565613 (2017)
   PUBMED   28367268
REFERENCE   4  (bases 1 to 6781)
  AUTHORS   Sun,H. and Hunter,T.
  TITLE     Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins
            identified through a string search
  JOURNAL   J Biol Chem 287 (50), 42071-42083 (2012)
   PUBMED   23086935
REFERENCE   5  (bases 1 to 6781)
  AUTHORS   Kim,H.W., Mallick,F., Durrani,S., Ashraf,M., Jiang,S. and
            Haider,K.H.
  TITLE     Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2
            and their role in cytoprotection during ischemic preconditioning of
            stem cells
  JOURNAL   Antioxid Redox Signal 17 (8), 1053-1065 (2012)
   PUBMED   22482882
  REMARK    GeneRIF: The ischemic preconditioning (IPC) enhances stem cell
            survival via the combined participation of hypoxia responsive miRs
            miR-107 and miR-210 via their respective putative target genes
            Pdcd10 and Casp8ap2.
REFERENCE   6  (bases 1 to 6781)
  AUTHORS   Kim,H.W., Haider,H.K., Jiang,S. and Ashraf,M.
  TITLE     Ischemic preconditioning augments survival of stem cells via
            miR-210 expression by targeting caspase-8-associated protein 2
  JOURNAL   J Biol Chem 284 (48), 33161-33168 (2009)
   PUBMED   19721136
  REMARK    GeneRIF: Data identified FLICE-associated huge protein
            (FLASH)/caspase-8-associated protein-2 (Casp8ap2) in (PC)MSCs as
            the target gene of miR-210.
REFERENCE   7  (bases 1 to 6781)
  AUTHORS   Smith,A.J., Karpova,Y., D'Agostino,R. Jr., Willingham,M. and
            Kulik,G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6781)
  AUTHORS   Milovic-Holm,K., Krieghoff,E., Jensen,K., Will,H. and Hofmann,T.G.
  TITLE     FLASH links the CD95 signaling pathway to the cell nucleus and
            nuclear bodies
  JOURNAL   EMBO J 26 (2), 391-401 (2007)
   PUBMED   17245429
REFERENCE   9  (bases 1 to 6781)
  AUTHORS   Kino,T. and Chrousos,G.P.
  TITLE     Tumor necrosis factor alpha receptor- and Fas-associated FLASH
            inhibit transcriptional activity of the glucocorticoid receptor by
            binding to and interfering with its interaction with p160 type
            nuclear receptor coactivators
  JOURNAL   J Biol Chem 278 (5), 3023-3029 (2003)
   PUBMED   12477726
REFERENCE   10 (bases 1 to 6781)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            [WARNING] On Mar 20, 2025 this sequence was replaced by
            NM_001107921.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063464.1, XM_232860.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132307,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..6781
                     /gene="Casp8ap2"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:313128"
                     /db_xref="RGD:1305771"
     exon            1..227
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..310
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..6144
                     /gene="Casp8ap2"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_001101391.1"
                     /db_xref="GeneID:313128"
                     /db_xref="RGD:1305771"
                     /translation="MAADDDNGDGTGLFDVCPASPLKNNDEGSLDIYAGLDSTVSDST
                     ARSCVSFRNCLDLYEEILTEEGTAKEATYSDLQIEYGKCQQQMKDLMKRFKEIQTQNL
                     NLKNENQSLKKNISALIKTARVEINRKDEEINHLHQRLSEFPHFRNNHKTARTKDSRS
                     KSPHLDNCSKTDHGVKSDVQKDIHPNTSQPNLEKEGKSHSEAQNSLHLSTGIEKHCTN
                     NVWSRSPYQVSEGNSNEDNRRGRNGVRHSQGSRGTDRTQKDLNSSCNDGEPRDKEAAS
                     RLHGNPEKHGSSEARAENKISEIKSSTGLGNKSERSASSWEKETSRERPHTRVEPQND
                     KNLERQNERLQNTHRKELQSQDKAERKGDVKFKPAGEEQGHRGRVDRALPPHSKNDMK
                     YYGFNKYHPEERRGREDGKRDRGMSSHGFQDRRCSSSLSSNRNSKYPHSKEVSVAHQW
                     ENTPFKAERHRTEDRRKRERENKEESRHVKSDKKSPPEHLQRTHKDTKKSTANGKRQT
                     EQKHGKGPVSTSELSKGTDNRECTMKVENGPNEAKGKDLKLSFMEKLNLTLSPAKKQP
                     VCQDNEHQIIGVPKPSGVCDSQSLEKTETVACLPSVSEQDREEPKSELPEPKEALSAT
                     SQPRTSIPENKVKEENRLLFKSVENTVPCELLACGTEISFPAPVEIEQARCLVQSMEV
                     EETCAGARAAASVVMRVLPEHASEDFSQELGTKRHDDINSCDISEGGKKKVVLSPKAA
                     AASESHLEPVVEEPSISPVNCSGDNNPKLEPSLEERPKVENKSSPLEPCLPKEMFVPS
                     PQKTELIDHKIDTGESNSVYQDDDNSVLSIDFNNLRPIPEPISPLNSPVRPVSKVLSM
                     ESSCTIPLYDSSHKDEFPSNSTLSTFKSQSDLNKENEKPVPKLDKCSEAESCKNLSVD
                     ELEEGEIRSDDEESVAQKRLEKSARPRTSTEVPPGKISPGSRRSTVHVHKDNGRTVVK
                     LPRDRITWSQRSNESRPSNTERKSKTMSISSLEKILPLILAPSSVWEVMHMLRLLGKH
                     VRKNYMKFKIKFSLTQFHRIIESAILSFTSLIRYLDLSKICKSVSTLQKSLCDVIESN
                     LKQVKKNGIVDRLFEQQQTDMKKKLWKFVDEQLDYLFEKLKKILLKFCDSVKHENDSS
                     EGKLGKKYKERAQHSNCQKKKMDNKEIRREKVLKSENTVNFKSSLGCEKFEEKHQDQN
                     KTNTTTVKHDVKRTFSTCTDNNTKNSECKEQFLGMNCPSTPRPGETEGNVEEGTPAAQ
                     HACVKSERGFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDTGGTEKAEWELK
                     TPEKQLLESLKCESAPACTTEELVSEAASLCPKVISDDNWSLLSSEKGPSLSSGLSLP
                     VHPDVLDENCMFEVSSNLALSKDNVYSSEKSKPCISSILLEDLAVSLTVPSPLKSDGH
                     LSFLKPEVLSTSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSWTS
                     RSVASGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSPGLKHGMVAEESLTPLPRT
                     GKEADGAAEKEPTLFQSTVLNPVQDLENSDKSIDKSKPTHEDQNSIVQTQVPDIYEFL
                     KDASNKVVHCDQVVDDCFKLHQVWEPKVSESLQELPSMEKNAHSVDDHLPNTHIDLTK
                     DPATETKSLELMDVTVLDIDHLEHSKPNLDQDAQITCTSLQHDAVDAFIDLTHDVSNE
                     SKNESNEPVLTVEGVGCQVICIDDDNHKEGKVGKVNSSLECTVEETCIDLTSESAGSF
                     EVKRHTLKSEPPSKSDCLELPETLGNGHKKRKNSPAVSHSSQKKQRKDMDLSSEKTKR
                     LSPNSDRTGDAHRKHGSKKREPAVSDTSLSSEVNPEVKGSTAPLATFPGSLSAKNVIK
                     KKGEIIVSWTRNDDREILLECQKRMPSLKTFTHLAVKLNKNPNQVSERFQQLKKLFEK
                     SKCR"
     exon            311..379
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..480
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..555
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..671
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..2866
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..5987
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5988..6087
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6088..6173
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            6174..6781
                     /gene="Casp8ap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggggctg ctggggagag gcagcggggt gccgcctggg atggcttgcg ccgtgggcga
       61 agggttgtgc ctggctgggc ctcaaggagc cagctgctgt cctcggggac cgccctttgg
      121 agagtctcga ggggctctgg ggcgagcaca cggagcatcg cccggtctac actgcgcccc
      181 tcccctcccc cacccgtgtc tcctaggtcc ctacttccga gcttttgatg gcacctatga
      241 aaaggatata ggaccatggc agcagatgat gacaatggtg atggaacggg tttgtttgat
      301 gtctgtcctg cctctcctct taaaaataat gatgaaggct cattggacat atatgctggg
      361 ttggacagta ctgtttctga cagtactgct aggtcctgcg tgtcgttcag aaactgtctg
      421 gatttgtatg aagagatcct gactgaagaa ggaactgcaa aggaggcaac atacagtgac
      481 ttgcagatag aatatgggaa atgtcagcag caaatgaaag atctgatgaa aagatttaag
      541 gaaatacaga cacagaactt gaacttaaaa aatgaaaacc agtctcttaa gaagaatatc
      601 tcagcactta tcaaaactgc cagagtggag ataaaccgta aggatgaaga gataaatcat
      661 cttcaccaaa gattgtctga gtttccacat tttcgaaata accataaaac tgcaagaaca
      721 aaagattcac gatccaaatc tccccatttg gacaattgtt caaagactga tcatggagtt
      781 aaaagtgatg ttcagaaaga tatacatcct aacacttcac aaccaaactt ggaaaaggaa
      841 gggaaatcac attctgaagc acagaattct ttgcacttgt ctacgggtat tgagaaacat
      901 tgtacaaaca atgtctggtc acgttctcct taccaggtta gtgaaggtaa ctcaaatgaa
      961 gataatagaa gaggaaggaa tggcgtcaga catagccaag gtagcagagg aactgacaga
     1021 acacagaaag acttgaatag cagctgtaat gatggcgagc caagggacaa agaggctgct
     1081 tccagactac acggaaaccc tgagaaacat ggaagcagtg aagcaagggc tgagaacaaa
     1141 atttcagaga ttaaaagtag cactggtttg ggaaataaaa gcgagcgcag tgcctcttct
     1201 tgggaaaaag aaacttccag agaaaggcca catactcgag tggaacctca aaatgacaaa
     1261 aatctagaga gacaaaatga aagattacaa aatacacaca gaaaagagct tcagtctcag
     1321 gacaaagcag aaagaaaagg tgatgtgaag tttaaaccag caggagagga gcaggggcat
     1381 cggggaagag tggaccgtgc attacctcct cattccaaga atgacatgaa atattatggc
     1441 ttcaataagt atcatccaga agagagaagg ggaagggaag atggtaaacg agacagaggc
     1501 atgagcagtc atggctttca agatagaaga tgttcatctt ctctttcaag caacagaaat
     1561 agcaaatacc cacactccaa ggaagtcagt gttgcacacc agtgggaaaa tacacctttc
     1621 aaagcagaaa gacatagaac tgaggacagg aggaaaagag aacgagaaaa caaagaagaa
     1681 agtagacatg tgaaaagtga caaaaaatca cctccagaac acttgcaaag gactcataaa
     1741 gacactaaga aaagtactgc taatggaaag agacagacgg agcagaaaca cggtaaaggt
     1801 ccagtctcta ccagcgagct ttctaaaggg acagacaata gagagtgtac aatgaaagtg
     1861 gagaatgggc caaatgaagc aaagggcaag gacttaaagt taagcttcat ggagaagctg
     1921 aacttaactc tttctcctgc taaaaagcag cctgtttgtc aagataacga gcatcaaata
     1981 attggtgttc ccaagcccag tggcgtgtgt gactcacagt ccttggagaa gactgaaaca
     2041 gtggcatgtc ttccttctgt cagtgaacaa gatagagagg aacccaaatc agagttacca
     2101 gagccaaagg aggctctttc agcaacatct caacccagga ccagcattcc agaaaataaa
     2161 gtgaaggaag aaaatagatt gttatttaaa tctgttgaga atactgtgcc ttgtgaactg
     2221 cttgcttgtg gcacggaaat ttccttccca gcacctgtag aaattgagca agcaagatgt
     2281 ttggtccaat caatggaagt ggaagagaca tgtgctggtg caagggcagc tgcttctgtg
     2341 gtgatgcgtg tattaccaga acatgcttct gaagacttca gccaagaatt gggcaccaaa
     2401 agacatgatg atataaattc gtgtgatatt tctgaaggtg ggaaaaaaaa ggtggttctt
     2461 tcaccaaaag cagcagcagc cagtgagagc catctggagc ctgtggttga agaacctagc
     2521 atttcaccag taaactgttc gggagacaat aatcctaaac ttgaaccttc tcttgaagag
     2581 agacctaagg ttgagaataa atcttctcct ttggagcctt gtttacctaa agagatgttt
     2641 gtaccttcac cacagaagac tgagttgatt gaccacaaaa tagatactgg agaatcaaac
     2701 tcggtatatc aagatgatga taactcagtt ttgagtattg actttaataa tttgagacct
     2761 attccagaac ccatcagccc tctgaatagt ccagtgagac cggtatccaa agttcttagc
     2821 atggagagct catgtacaat tccactgtat gatagcagcc ataaagatga gtttccatcc
     2881 aattcaactc tttctacctt caagagtcag tctgatctaa ataaggaaaa tgaaaaacca
     2941 gttcccaaat tggacaaatg ttcagaagca gaatcctgta agaatttgtc tgtagatgaa
     3001 ttagaagaag gggaaattag aagtgatgat gaagaatctg tagcacaaaa gcgtttggaa
     3061 aagagtgcaa gacccagaac ttctactgaa gtgccgccag gtaaaatcag cccaggaagc
     3121 aggaggagca ctgtgcatgt gcataaggat aacgggagga cagttgtaaa actccctcgg
     3181 gacagaatca catggagcca aagatcaaat gaatctagac cctcaaacac cgaaaggaaa
     3241 agtaaaacaa tgagcatctc cagcttggaa aaaatacttc cgcttattct tgcaccctcc
     3301 tccgtatggg aagttatgca tatgttacgg ttgctaggaa aacatgtaag gaaaaattac
     3361 atgaaattca agataaaatt ttcattgaca caatttcata gaattattga atcggcaatt
     3421 ttgagtttca catcactaat tagatacctt gatttgtcta agatctgtaa atcagtaagt
     3481 actttacaga agagtctttg tgacgttata gaatctaacc ttaaacaagt gaagaagaat
     3541 ggcatagttg accgtttatt tgaacaacaa caaacagata tgaaaaaaaa attgtggaag
     3601 tttgtggatg aacaacttga ttatttgttt gaaaaactta aaaaaatcct actaaagttt
     3661 tgtgattctg taaagcatga aaatgacagt agtgaaggaa aacttggaaa aaaatataaa
     3721 gagagagccc aacattcaaa ttgtcagaag aagaaaatgg acaacaaaga aatacggaga
     3781 gaaaaagtgc taaaatcaga aaatactgtg aattttaaat cttcactggg gtgtgaaaaa
     3841 tttgaagaaa aacatcaaga ccaaaataaa accaatacta ctacagtaaa gcatgatgtg
     3901 aaaagaactt ttagcacttg cactgataat aatacaaaga actctgaatg taaagagcag
     3961 tttctgggaa tgaactgccc gagtaccccc aggccaggag aaactgaagg caatgtggag
     4021 gaggggacac cggcggcaca gcacgcctgc gttaagtcag agcggggctt tgagatcctc
     4081 accgagcagc aggcgtccag ccttactttt aacttagtga gtgacgcaca gatgggtgag
     4141 atatttaaaa gtttgctaca aggttctgat ctgttggaca caggtggcac tgaaaaagcg
     4201 gagtgggaat taaagactcc agagaaacag ctgctagaga gcctcaagtg tgagtctgca
     4261 ccagcttgta caacagaaga gctagtttca gaggcggctt ctctctgtcc aaaggtgatc
     4321 agtgatgata attggtcttt attatcatct gaaaagggcc catctctatc ttcagggctt
     4381 tcactgccag ttcatcctga tgtgttagat gaaaattgta tgtttgaagt atcttctaac
     4441 cttgctttaa gtaaagataa tgtatacagc tcagaaaaga gtaagccctg catttcttcc
     4501 atactcttag aagatcttgc ggtctcttta acagtaccgt cacctctgaa gtcagatggc
     4561 catttgagtt tcttaaagcc tgaagttttg tcaacttcaa ctcctgaaga agttattagt
     4621 gcacatttta gtgaggatgc tttgcttgag gaagaggatg catctgaaca ggacattcac
     4681 ttagctctag agtctgataa ctcaagcagt aagtcaagct gttcctcatg gacaagccgg
     4741 tctgttgctt caggctttca gtaccaccct aatcttccca tgcatgctgt cattatggaa
     4801 aagtccaatg atcatttcat tgtgaaaata cggcgtgcaa caccatctac ctcccctggc
     4861 cttaaacatg gtatggtagc tgaggagtcg ttgacacctt tgcctagaac tggaaaagaa
     4921 gctgatgggg cagcagagaa agaacctacc ctgtttcaga gtacagtttt aaaccctgtc
     4981 caagacttgg aaaattccga caaaagtatt gataagagca aaccaactca tgaagatcag
     5041 aactctatag tacaaacaca ggttccagat atatacgaat ttcttaaaga tgcttcaaat
     5101 aaggtggttc attgtgatca agtggttgat gattgcttca agttgcatca agtatgggaa
     5161 ccaaaagttt ctgagagcct tcaagaattg ccttcaatgg aaaaaaatgc acactctgtt
     5221 gatgatcatc ttcctaatac acacatagat ctaacaaaag atccagctac tgagactaaa
     5281 agcttggagc taatggatgt aacagtttta gatatcgatc acttggaaca ttctaaaccc
     5341 aacttagatc aagatgcaca gataacgtgt acttcgttac agcatgatgc tgtagatgct
     5401 tttattgatt tgacacatga tgtttcaaat gagagtaaaa acgaaagtaa tgaacctgtg
     5461 ttaactgttg aaggtgtggg atgccaggta atatgtatag atgacgataa ccacaaagaa
     5521 ggaaaagtgg ggaaggtaaa cagttcctta gaatgtactg ttgaggaaac ctgtattgac
     5581 ttgacctcag agtctgctgg ctcctttgaa gtaaagagac acactttaaa gtcagagcct
     5641 ccatcaaagt cggattgttt agagttgcct gagactctgg ggaatggtca caagaagaga
     5701 aagaacagtc ctgctgtgag tcactcttct cagaaaaagc aaagaaagga catggactta
     5761 agtagtgaaa agaccaagag acttagtcct aattctgata gaactggtga tgctcacaga
     5821 aagcatggca gcaagaagag ggaacctgca gtaagtgaca catccttgtc atcagaggtc
     5881 aacccagagg tgaagggctc aacagcacca cttgctactt ttccaggaag cctttctgca
     5941 aaaaatgtta tcaaaaagaa aggagaaatt atagtttcat ggacaagaaa tgacgacagg
     6001 gaaattttac tggaatgtca gaaaagaatg ccgtccctga aaacatttac ccacttggct
     6061 gtcaaactga ataaaaatcc aaatcaggtt tcagagaggt tccagcaact gaaaaagctt
     6121 tttgagaagt caaaatgcag gtagtagtgg gtccatcgca ggatgctaat gctatgagtt
     6181 gctggatttc atggtgcctc actgataatt cttctacaaa gaagcttcga ttcctcgtgt
     6241 tttaaatggg gaactaggtg gaggttttgt ctcagttttg gtgactagat gatcatctac
     6301 ctttttttta ctttcctggt cattgtgctt ggcttattca gatcaacagt ctgattcact
     6361 ttcctgttat tggtcagaat atttattttt aatcattaaa agttgttatc aaatgaaaga
     6421 ataaaagcaa cctcaatgta atactgaaac cttagttttg atattggatg aaataacttc
     6481 tttagatttt aaaaaacaat tttgtagcat tttaaatgta atgactattt agttcacctt
     6541 tctattcatt tttgttttta taattgcctc attttggaaa attgtgaaat aatttaaata
     6601 gtatatttgt atatatgtat aattattgta atgtaaaata ctatgactgt atgtgtcttg
     6661 agtgtatgta tgcacatgaa tggctttgct agccaaaggg tttttttatc tatataaaat
     6721 attttgtata aactttcctt tcagttagtc atgtataata aaaacatgta aagtcctttt
     6781 t
//
