LOCUS       NM_022277               2003 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Rattus norvegicus caspase 8 (Casp8), mRNA.
ACCESSION   NM_022277
VERSION     NM_022277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Lu,E., Zhuo,Q., Chen,F., Lin,Q. and Wang,X.
  TITLE     [Role of caspase-8 in stem cell transplantation alleviates rat
            cerebral cortex apoptosis after cardiopulmonary resuscitation]
  JOURNAL   Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 34 (12), 1280-1284 (2022)
   PUBMED   36567583
  REMARK    GeneRIF: [Role of caspase-8 in stem cell transplantation alleviates
            rat cerebral cortex apoptosis after cardiopulmonary resuscitation].
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Martin,S., Harrington,D.A., Ohlander,S., Stupp,S.I., McVary,K.T.
            and Podlasek,C.A.
  TITLE     Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog
            protein to the penis and cavernous nerve suppresses intrinsic and
            extrinsic apoptotic signaling mechanisms, which are an underlying
            cause of erectile dysfunction
  JOURNAL   Nanomedicine 37, 102444 (2021)
   PUBMED   34314869
  REMARK    GeneRIF: Peptide amphiphile nanofiber hydrogel delivery of Sonic
            hedgehog protein to the penis and cavernous nerve suppresses
            intrinsic and extrinsic apoptotic signaling mechanisms, which are
            an underlying cause of erectile dysfunction.
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Song,Z., Tian,X. and Shi,Q.
  TITLE     Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced
            fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant
            rat models
  JOURNAL   J Obstet Gynaecol Res 47 (7), 2298-2306 (2021)
   PUBMED   33847039
  REMARK    GeneRIF: Fas, Caspase-8, and Caspase-9 pathway-mediated bile
            acid-induced fetal cardiomyocyte apoptosis in intrahepatic
            cholestasis pregnant rat models.
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   Yang,X., Zeng,Q. and Tezel,G.
  TITLE     Regulation of distinct caspase-8 functions in retinal ganglion
            cells and astroglia in experimental glaucoma
  JOURNAL   Neurobiol Dis 150, 105258 (2021)
   PUBMED   33434617
  REMARK    GeneRIF: Regulation of distinct caspase-8 functions in retinal
            ganglion cells and astroglia in experimental glaucoma.
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Wang,H., Yu,Q., Zhang,Z.L., Ma,H. and Li,X.Q.
  TITLE     Involvement of the miR-137-3p/CAPN-2 Interaction in
            Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation
            of p35 Cleavage and Subsequent Caspase-8 Overactivation
  JOURNAL   Oxid Med Cell Longev 2020, 2616871 (2020)
   PUBMED   33456665
  REMARK    GeneRIF: Involvement of the miR-137-3p/CAPN-2 Interaction in
            Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation
            of p35 Cleavage and Subsequent Caspase-8 Overactivation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Nakagawa,T., Zhu,H., Morishima,N., Li,E., Xu,J., Yankner,B.A. and
            Yuan,J.
  TITLE     Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and
            cytotoxicity by amyloid-beta
  JOURNAL   Nature 403 (6765), 98-103 (2000)
   PUBMED   10638761
REFERENCE   7  (bases 1 to 2003)
  AUTHORS   Estelles,A., Charlton,C.A. and Blau,H.M.
  TITLE     The phosphoprotein protein PEA-15 inhibits Fas- but increases
            TNF-R1-mediated caspase-8 activity and apoptosis
  JOURNAL   Dev Biol 216 (1), 16-28 (1999)
   PUBMED   10588860
REFERENCE   8  (bases 1 to 2003)
  AUTHORS   Lin,Y., Devin,A., Rodriguez,Y. and Liu,Z.G.
  TITLE     Cleavage of the death domain kinase RIP by caspase-8 prompts
            TNF-induced apoptosis
  JOURNAL   Genes Dev 13 (19), 2514-2526 (1999)
   PUBMED   10521396
REFERENCE   9  (bases 1 to 2003)
  AUTHORS   Sanchez,I., Xu,C.J., Juo,P., Kakizaka,A., Blenis,J. and Yuan,J.
  TITLE     Caspase-8 is required for cell death induced by expanded
            polyglutamine repeats
  JOURNAL   Neuron 22 (3), 623-633 (1999)
   PUBMED   10197541
REFERENCE   10 (bases 1 to 2003)
  AUTHORS   Sakamaki,K., Tsukumo,S. and Yonehara,S.
  TITLE     Molecular cloning and characterization of mouse caspase-8
  JOURNAL   Eur J Biochem 253 (2), 399-405 (1998)
   PUBMED   9654089
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF279308.1.
            
            [WARNING] On Mar 18, 2024 this sequence was replaced by
            NM_022277.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279308.1, FQ226407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132280
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2003
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /note="caspase 8"
                     /db_xref="GeneID:64044"
                     /db_xref="RGD:620945"
     exon            1..289
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            290..622
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1766
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /EC_number="3.4.22.61"
                     /codon_start=1
                     /product="caspase-8"
                     /protein_id="NP_071613.1"
                     /db_xref="GeneID:64044"
                     /db_xref="RGD:620945"
                     /translation="MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVL
                     FQRLQEEGMLEEDNLSFLKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAYR
                     VMLFKLSEDMDKEDLKSFKFLLITEIPKCKLQDNSSLLDIFVEMEKRTILAENNLVTL
                     KSICFRVNRSLLGRIDDYERSSTERRMSTEGGEELPVSVLDEVTIKMQDMWDSPGEQE
                     SESLNSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTF
                     KELHFEIVSFSDCTASQIHEVLVSYQSKDHKGKDCFICCILSHGDKGIVYGTDGKEAS
                     IYELTSYFTGSKCPSLAGKPKIFFIQACQGNNFQKAVPVPDETGLEQEHVLEEDSSSY
                     KNYIPDEADFLLGMATVKNCVSYRDPTRGTWYIQSLCQSLRERCPRGEDILSILTGVN
                     YDVSNKDNPRNMGKQMPQPIFTLRKKLFFPPN"
     exon            623..728
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            729..867
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            868..921
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            922..983
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1125
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1630
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2003
                     /gene="Casp8"
                     /gene_synonym="CASP-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaactggc gggcgctcct aaggcgggca gagagaagca gcctatgcca cctagtgatt
       61 atcagaaatt agtcatttct gctccttagt tctctcagtt gcctttctcc tccctctgac
      121 ctccggtgtt ttatagttcc gcttctttga atccatagta aactttggcg gactggccag
      181 ggaacaggaa gtgagcccgg ctagcggcag ccggaggcgg agagcgtctc ccaggggttg
      241 ctcgcccgag aggggagctg tgactggcgg ggcagggact cggcgacagg ttacagctct
      301 cctacccctt ggtaagaatg gatttccaca gttgtcttta cgatattgct gaacgtctgg
      361 gcaacgaaga actggctgcc ctcaagttcc tgtgcttgga ccacatcccg cagaagaagc
      421 aggagtccat caatgatgtc ctggtgctat ttcagaggct gcaggaagag gggatgttgg
      481 aggaagacaa tttgtccttc ctgaaggagc tgcttttcca tatcagtcgg cgggatctgc
      541 tgagcagagt cctaaaaagc agcccagagg aaatggtgag ggagctgcag gttctgggca
      601 aagcccaggt ttctgcctac agggttatgc tctttaagct ctcagaagac atggacaagg
      661 aggatttgaa atcttttaag ttccttttga tcactgagat ccctaaatgt aaactgcaag
      721 acaactcgag cctgcttgat attttcgtag agatggagaa gaggactatc ctggcagaaa
      781 acaacttggt taccctaaaa tcaatctgtt tccgggtcaa caggagcttg ctgggaagga
      841 tcgacgatta cgaacgatca agcacagaga gaagaatgag cactgaagga ggggaagagc
      901 tgccagtttc tgttttggat gaggtgacca tcaaaatgca ggacatgtgg gactcgccag
      961 gagagcaaga gagtgagtca ctaaattcag acaacgttta ccaaatgaag agcaaacctc
     1021 gggggtactg tctgatcttc aacaataata atttcagcaa agcacgggag gacataccca
     1081 aactcagcaa catgcgggac agaaaaggaa ccaactatga tgaagaggct ctgagtaaga
     1141 cctttaagga gcttcatttt gagatcgtgt ccttcagtga ttgcacagca agtcaaatcc
     1201 atgaggttct agtatcctat caaagcaagg accacaaggg caaagactgc ttcatctgct
     1261 gcatcctatc acatggggac aagggcatcg tctacggaac ggatgggaag gaagcctcta
     1321 tctatgagct gacatcttac ttcactggct caaagtgccc ttccctggct ggaaaaccca
     1381 aaatcttttt tattcaagct tgtcaaggaa ataacttcca gaaagcggtg cctgtgcctg
     1441 atgagacagg cttagaacag gagcacgttt tagaagagga ttcatcatct tacaagaact
     1501 atatcccaga tgaggcagac tttctgctgg ggatggctac tgtgaaaaac tgtgtttcct
     1561 accgagatcc cacgcgtggg acctggtata tccagtcact ttgccagagc ctgagggaaa
     1621 gatgtcctcg aggtgaggat attctcagca tcctgactgg cgtgaactat gatgtgagca
     1681 ataaagacaa cccgaggaac atgggaaagc agatgccaca gcccatcttc acactacgga
     1741 agaagctctt cttccctcct aactgatgtg tgctctctac agttcacatg ggttatctgt
     1801 gcacttttgt gtgtcctaac tgatgtgtgc tctctacagt tcacatgggt tatctgtgca
     1861 cttttgtgtg aaggagagaa tcttatttat tttttttacc atttcttttg tttttgagtt
     1921 tacatttatg tcatttccgt tttctctctt caaatcttcc tatgtaatct tccagtttca
     1981 aatacatgac ctcttttgtc atc
//
