LOCUS       NM_022260               2312 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus caspase 7 (Casp7), mRNA.
ACCESSION   NM_022260 XM_008760546
VERSION     NM_022260.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Wiberg,R., Novikova,L.N. and Kingham,P.J.
  TITLE     Evaluation of apoptotic pathways in dorsal root ganglion neurons
            following peripheral nerve injury
  JOURNAL   Neuroreport 29 (9), 779-785 (2018)
   PUBMED   29659443
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Liu,Z.R., Chen,S.Q., Zou,Y.W., Wu,X.Y., Li,H.Y., Wang,X.Q., Shi,Y.
            and Niu,H.X.
  TITLE     Hypochlorite modified albumins promote cell death in the tubule
            interstitium in rats via mitochondrial damage in obstructive
            nephropathy and the protective effects of antioxidant peptides
  JOURNAL   Free Radic Res 52 (5), 616-628 (2018)
   PUBMED   29781318
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Zeng,C., Jiang,W., Zheng,R., He,C., Li,J. and Xing,J.
  TITLE     Cardioprotection of tilianin ameliorates myocardial
            ischemia-reperfusion injury: Role of the apoptotic signaling
            pathway
  JOURNAL   PLoS One 13 (3), e0193845 (2018)
   PUBMED   29538428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Wei,Y., Zheng,D., Guo,X., Zhao,M., Gao,L. and Bai,L.
  TITLE     Transient Receptor Potential Channel, Vanilloid 5, Induces
            Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the
            Mediation of Ca2+ Influx
  JOURNAL   Cell Physiol Biochem 46 (2), 687-698 (2018)
   PUBMED   29621761
REFERENCE   5  (bases 1 to 2312)
  AUTHORS   Maeda,N., Abdullahi,A., Beatty,B., Dhanani,Z. and Adegoke,O.A.J.
  TITLE     Depletion of the mRNA translation initiation inhibitor, programmed
            cell death protein 4 (PDCD4), impairs L6 myotube formation
  JOURNAL   Physiol Rep 5 (17) (2017)
   PUBMED   28899909
REFERENCE   6  (bases 1 to 2312)
  AUTHORS   Larner,S.F., McKinsey,D.M., Hayes,R.L. and W Wang,K.K.
  TITLE     Caspase 7: increased expression and activation after traumatic
            brain injury in rats
  JOURNAL   J Neurochem 94 (1), 97-108 (2005)
   PUBMED   15953353
  REMARK    GeneRIF: Activation of caspase 7 protein after acute brain injury,
            demonstrated by increase of activated caspase 7 in cortex and
            hippocampus, is up-regulated in neurons and astrocytes and may
            contribute to neuronal cell death on a scale not previously
            recognized.
REFERENCE   7  (bases 1 to 2312)
  AUTHORS   Seo,S.Y., Chen,Y.B., Ivanovska,I., Ranger,A.M., Hong,S.J.,
            Dawson,V.L., Korsmeyer,S.J., Bellows,D.S., Fannjiang,Y. and
            Hardwick,J.M.
  TITLE     BAD is a pro-survival factor prior to activation of its
            pro-apoptotic function
  JOURNAL   J Biol Chem 279 (40), 42240-42249 (2004)
   PUBMED   15231831
REFERENCE   8  (bases 1 to 2312)
  AUTHORS   Gamblin,T.C., Chen,F., Zambrano,A., Abraha,A., Lagalwar,S.,
            Guillozet,A.L., Lu,M., Fu,Y., Garcia-Sierra,F., LaPointe,N.,
            Miller,R., Berry,R.W., Binder,L.I. and Cryns,V.L.
  TITLE     Caspase cleavage of tau: linking amyloid and neurofibrillary
            tangles in Alzheimer's disease
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10032-10037 (2003)
   PUBMED   12888622
REFERENCE   9  (bases 1 to 2312)
  AUTHORS   Pompl,P.N., Yemul,S., Xiang,Z., Ho,L., Haroutunian,V., Purohit,D.,
            Mohs,R. and Pasinetti,G.M.
  TITLE     Caspase gene expression in the brain as a function of the clinical
            progression of Alzheimer disease
  JOURNAL   Arch Neurol 60 (3), 369-376 (2003)
   PUBMED   12633148
REFERENCE   10 (bases 1 to 2312)
  AUTHORS   Henshall,D.C., Skradski,S.L., Meller,R., Araki,T., Minami,M.,
            Schindler,C.K., Lan,J.Q., Bonislawski,D.P. and Simon,R.P.
  TITLE     Expression and differential processing of caspases 6 and 7 in
            relation to specific epileptiform EEG patterns following limbic
            seizures
  JOURNAL   Neurobiol Dis 10 (2), 71-87 (2002)
   PUBMED   12127146
  REMARK    GeneRIF: While caspase-7 expression also increased within cortical
            and hippocampal neuronal populations in response to the same
            seizure patterns, caspase-7 was not proteolytically activated.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Nov 16, 2022 this sequence version replaced
            XM_008760546.3, NM_022260.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3156204.1,
                                           SRR22582419.2005816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000001.1  265442647-265442714
            69-178              JAXUCZ010000001.1  265449672-265449781
            179-315             JAXUCZ010000001.1  265472451-265472587
            316-444             JAXUCZ010000001.1  265473032-265473160
            445-620             JAXUCZ010000001.1  265475639-265475814
            621-750             JAXUCZ010000001.1  265476107-265476236
            751-2312            JAXUCZ010000001.1  265480377-265481938
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2312
                     /gene="Casp7"
                     /note="caspase 7"
                     /db_xref="GeneID:64026"
                     /db_xref="RGD:620944"
     exon            1..68
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..980
                     /gene="Casp7"
                     /EC_number="3.4.22.60"
                     /codon_start=1
                     /product="caspase-7"
                     /protein_id="NP_071596.1"
                     /db_xref="GeneID:64026"
                     /db_xref="RGD:620944"
                     /translation="MTDDQDCAAELEMADSSTEDGVDAKPDRSTIISSLLWKKKKNAS
                     MCPVSTTRDRVPTYLYRMDFEKMGKCIIINNKNFDKATGMDVRNGTDKDAEALFKCFR
                     SLGFEVTVYNDCSCAKMQDLLRRASEEDHSNSACFACVLLSHGEENLIYGKDGVTPIK
                     DLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEAD
                     FLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQ
                     SDDPRFNEKKQIPCMVSMLTKELYFGR"
     exon            69..178
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
     exon            179..315
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
     exon            316..444
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
     exon            445..620
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
     exon            621..750
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
     exon            751..2312
                     /gene="Casp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaagctgcc ctcgcccctc gcggaggacg cacgccgtcg tgggctgctg gctgccgctg
       61 tgggaacgat gacagacgat caggactgtg ctgcagagct ggaaatggca gattcttcga
      121 cggaagacgg agttgacgct aagccagacc gctccaccat catctcatcc cttctctgga
      181 agaagaagaa aaatgcctct atgtgccccg tcagtaccac ccgggaccgc gtgcccactt
      241 acctgtaccg tatggacttc gagaagatgg gcaaatgtat catcataaat aacaagaact
      301 tcgacaaagc gacaggtatg gatgtccgga atgggacgga caaagacgca gaggccctct
      361 tcaagtgctt ccgaagcctg ggttttgaag tgaccgtcta taatgactgc tcttgcgcaa
      421 agatgcagga tctgcttaga cgagcctctg aagaggacca cagcaactca gcctgcttcg
      481 cctgcgtcct gctgagccac ggagaagaga atctgattta tgggaaagac ggcgtgacac
      541 cgataaagga tctgacagct cattttaggg gagaccgatg caaaaccctg ctagagaaac
      601 ccaagctctt cttcatccag gcgtgccgag ggacggagct ggatgacggg atccaggctg
      661 actcggggcc tatcaacgac accgacgcta atccccgcta caagatcccg gtggaagctg
      721 actttctctt tgcttactcc acggttccag gctattattc gtggaggaac ccaggaaagg
      781 gctcctggtt tgtgcaggcc ctctgctcca tcctgaatga gcatggcaag gacctggaga
      841 tcatgcagat cctgaccagg gtgaacgaca gggtggccag acacttcgag tcccagtctg
      901 atgacccccg cttcaatgag aagaagcaga ttccatgtat ggtgtccatg ctcaccaaag
      961 agctctactt tggccgttga ccagcctcca actgagaacc tgctgtcatt cactgatgaa
     1021 tccagctttt attttatttt tgttttgatg ctctcaaaat atccagaaat gttaaggaga
     1081 tttaatttca ggaaagtata ttgattcagg gagggagttc tctggtgatg tctgataatt
     1141 ctgggtttcc agattttttt tgtttgttta ataactttgt tcatctgatg acttcacact
     1201 tttcctttaa agttaatttc ctgtttctat tttttttttc cctgtcatct ccttgagcgc
     1261 atactgtgag catggcctct ggagaagaca ttgagacttt ggtgatgaca ggaatggaaa
     1321 gtcagagtct tagttgaact tggcaaagag aattccagct cttgatgaga gaatacggct
     1381 gagacactcg ccagcctcca ttggaaaagg tggctgttga gtggagtgtt tgttttcagt
     1441 ggctttgaac aagttcttaa gcaaaccttc ccaggtagct gagggaagac agttaatact
     1501 ctagtatata ggacccaatc cagaaaacaa gccattctag ggtatcggta cagaagggtc
     1561 gacacaggga attcacttaa gtgggtaatt aagagagcca agcagtaaaa atctgttacc
     1621 tcacctgcca ccatggggct gaagagttca gttcccttgt catcagaaaa aagtgtggca
     1681 gggcagcctt ctagaagcta aaaccataga gggatatggt gattgcagcc atgcccagga
     1741 caagccactg tctgagatgg aaaccaagcc agaactgagt caggcaccaa gataccccca
     1801 gacctcccca ggcctgtgcc catatccacc agcgccttac cattccaggg tgcctgaaag
     1861 ccagctagtg aggccctggg aaccgtgctc ccttgtggtg tagagcagag gaacggatag
     1921 caaggcaggg gtagtggtgg ggggtaaact tggccccaaa tgtgaattaa ataaccatgt
     1981 cctccggcgt gctacaatgt attcattcat tattcactga cttgcccgat catccacaca
     2041 ggtgctgaag agtaacccat cccacgttgt attcagaata atgtttttgt acttcaaata
     2101 catctggaat tctgtcaaat attccaaggt tttttttctg aataatcttc ggttacctct
     2161 ggttctacaa atgacacttt aggcaaaggt cttggcactt tcctcttttc aaggtgtcgt
     2221 tttctttgga attctttcta cattcctgtt ttcccctcct aataagtggt tgacaaatat
     2281 tcctatttat tgattaaaat gtgtttcaga aa
//
