LOCUS       NM_031775               1605 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus caspase 6 (Casp6), transcript variant 1, mRNA.
ACCESSION   NM_031775
VERSION     NM_031775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Wang,C., Li,Q., Jia,Z., Zhang,H., Li,Y., Zhao,Q., Su,L., Yu,Y. and
            Xu,R.
  TITLE     Spinal caspase-6 contributes to remifentanil-induced hyperalgesia
            via regulating CCL21/CXCR3 pathway in rats
  JOURNAL   Neurosci Lett 721, 134802 (2020)
   PUBMED   32014515
  REMARK    GeneRIF: Spinal caspase-6 contributes to remifentanil-induced
            hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Nie,Z.Y., Yao,M., Yang,Z., Yang,L., Liu,X.J., Yu,J., Ma,Y.,
            Zhang,N., Zhang,X.Y., Liu,M.H., Jiang,L.L. and Luo,J.M.
  TITLE     De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis
            suppresses CML cell apoptosis and contributes to Imatinib
            resistance
  JOURNAL   J Exp Clin Cancer Res 39 (1), 17 (2020)
   PUBMED   31952546
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Woo,V., Cheng,C., Duraikannu,A., Chandrasekhar,A., Purdy,K.,
            Martinez,J.A. and Zochodne,D.W.
  TITLE     Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal
            Degeneration
  JOURNAL   Neuroscience 371, 242-253 (2018)
   PUBMED   29229552
  REMARK    GeneRIF: To evaluate an axon autonomous role of Casp6, study
            examined axon integrity following transection ex vivo, and analyzed
            the serial morphological fragmentation of neurofilament expression
            as a structural index of axonal degeneration. Adding a specific
            Casp6 inhibitor to the preparation delayed neurofilament
            fragmentation.
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Wei,Y., Zheng,D., Guo,X., Zhao,M., Gao,L. and Bai,L.
  TITLE     Transient Receptor Potential Channel, Vanilloid 5, Induces
            Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the
            Mediation of Ca2+ Influx
  JOURNAL   Cell Physiol Biochem 46 (2), 687-698 (2018)
   PUBMED   29621761
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Harrison,D.C., Davis,R.P., Bond,B.C., Campbell,C.A., James,M.F.,
            Parsons,A.A. and Philpott,K.L.
  TITLE     Caspase mRNA expression in a rat model of focal cerebral ischemia
  JOURNAL   Brain Res Mol Brain Res 89 (1-2), 133-146 (2001)
   PUBMED   11311984
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Guo,R.F., Huber-Lang,M., Wang,X., Sarma,V., Padgaonkar,V.A.,
            Craig,R.A., Riedemann,N.C., McClintock,S.D., Hlaing,T., Shi,M.M.
            and Ward,P.A.
  TITLE     Protective effects of anti-C5a in sepsis-induced thymocyte
            apoptosis
  JOURNAL   J Clin Invest 106 (10), 1271-1280 (2000)
   PUBMED   11086028
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Ferrer,I.
  TITLE     Role of caspases in ionizing radiation-induced apoptosis in the
            developing cerebellum
  JOURNAL   J Neurobiol 41 (4), 549-558 (1999)
   PUBMED   10590178
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Vakkala,M., Paakko,P. and Soini,Y.
  TITLE     Expression of caspases 3, 6 and 8 is increased in parallel with
            apoptosis and histological aggressiveness of the breast lesion
  JOURNAL   Br J Cancer 81 (4), 592-599 (1999)
   PUBMED   10574243
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Kaushal,G.P., Singh,A.B. and Shah,S.V.
  TITLE     Identification of gene family of caspases in rat kidney and altered
            expression in ischemia-reperfusion injury
  JOURNAL   Am J Physiol 274 (3), F587-F595 (1998)
   PUBMED   9530276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM068086.1 and BC078785.1.
            
            On Dec 19, 2012 this sequence version replaced NM_031775.2.
            
            Transcript Variant: This variant (1) is the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078785.1, AF025670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                FM068086.1         1-35
            36-1605             BC078785.1         1-1570
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1605
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /note="caspase 6"
                     /db_xref="GeneID:83584"
                     /db_xref="RGD:70967"
     exon            1..53
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            54..208
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..250
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1055
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /EC_number="3.4.22.59"
                     /note="CASP-6; apoptotic protease Mch-2"
                     /codon_start=1
                     /product="caspase-6"
                     /protein_id="NP_113963.2"
                     /db_xref="GeneID:83584"
                     /db_xref="RGD:70967"
                     /translation="MTETDGFYRSREVLDPAEQYKMDHKRRGTALIFNHERFFWHLAL
                     PERRGTNADRDNLTRRFSELGFEVKCFNDLRAEELLLKIHEVSTSSHVDADCFLCVFL
                     SHGEGNHIYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPVVPLDV
                     VDHQTDKLDDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEM
                     LARHGSSLEFTELLTLVNRKVSQRRVDFCKDPGAIGKKQVPCFASMLTKKLHFCPKPS
                     K"
     exon            251..400
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..477
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..653
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..813
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1582
                     /gene="Casp6"
                     /gene_synonym="Mch2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggagagc ggaggcctca ggacgagcgc ggacacccgg agctcgtggg cagcctgaaa
       61 agtggggaga agtggcagac cagagctcgg ggcacaggcc tgcaggagcc cagctcaaga
      121 cccctaacca aggccagacc aaggccagac ctgggcaggc acctccatca cagcgccttc
      181 tgcagtcaga acttgttgct gtccacaggg gaaagtaaaa catgacggag acagatggct
      241 tctacagaag tagggaagtg ttggatccag ccgagcagta caagatggac cacaagagga
      301 gaggaactgc cctaatcttc aatcacgaga ggttcttctg gcacctagca ctcccagaga
      361 ggcggggcac caacgcagac agggacaacc tgactcgaag gttctcagag ctaggatttg
      421 aagtgaaatg ctttaacgac ctccgggcag aagaactact gctcaagatt cacgaggtgt
      481 cgacttccag ccacgtagat gccgattgct tcctgtgtgt cttcctgagc cacggggaag
      541 gcaaccacat ttacgcatac gatgccaaaa ttgaaattca gaccttgact ggcttgttca
      601 aaggagacaa gtgtcagagc ctggttggaa aacccaagat attcatcatc caggcctgtc
      661 ggggcagcca gcatgacgtg cccgtggttc ctctggacgt ggtggatcat cagacagaca
      721 agctggacga caacgtgacc caggtggatg ctgcctcggt gtacactctg cctgcggggg
      781 cggacttcct catgtgttac tctgttgcag aagggtatta ctctcaccga gagactgtga
      841 acggctcctg gtacattcag gatttgtgcg agatgctggc caggcacggt agttccctgg
      901 agttcaccga gctgctcacg ctggtgaaca ggaaggtctc tcagcgccgt gtggatttct
      961 gcaaagaccc aggtgcaatt ggcaagaagc aggttccctg ctttgcctca atgctgacca
     1021 aaaagctgca tttctgtccc aaacctagta agtagggccg tccgacttgc tacaaatgtt
     1081 tcacacacat ttcccttcta cacagaggcc agctggccaa agactccgcc caccaacgga
     1141 cactgtttga atttttaagg tgctacagaa aagtaatgtt ttgcctttgt tattattttc
     1201 caatcatgtt ggggatgggg aaagggctaa agaaatcctc aggaaattac tgtgcgcaaa
     1261 tgcccaatac atttattatg tttctggtaa atggcaagat tactaagaat accaactact
     1321 ttgccttacc ttttgtgaca ctatttatat aggctcattg tataatgttt ttaaagatct
     1381 ttgaaactca agaatgagat cgttttcacc taataaaaat gtctaaaact cactaacatt
     1441 ttctaattca tatgcttaca taatgtacag tgggcctgtt ttagtcggtc atgctttcat
     1501 ttattatttt gtttacctgt aatggggcat tttatgtgtg gctttaattc ccattttgga
     1561 aacaataaac ctttcagaac taaaaaaaaa aaaaaaaaaa aaaaa
//
