LOCUS       NM_053736               1350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus caspase 4 (Casp4), mRNA.
ACCESSION   NM_053736
VERSION     NM_053736.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Li,Z., Cai,Q., Li,B. and Meng,W.
  TITLE     Caspase-11/4 is involved in bacteria-mediated periodontitis by
            promoting the release of interleukin-1 beta and tumor necrosis
            factor-alpha
  JOURNAL   Arch Oral Biol 142, 105517 (2022)
   PUBMED   35988500
  REMARK    GeneRIF: Caspase-11/4 is involved in bacteria-mediated
            periodontitis by promoting the release of interleukin-1 beta and
            tumor necrosis factor-alpha.
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Wang,C., Ma,H., Zhang,B., Hua,T., Wang,H., Wang,L., Han,L., Li,Q.,
            Wu,W., Sun,Y., Yang,H. and Lu,X.
  TITLE     Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through
            ameliorating NLRP3 inflammasome-induced pyroptosis
  JOURNAL   Front Immunol 13, 963582 (2022)
   PUBMED   35990672
  REMARK    GeneRIF: Inhibition of IL1R1 or CASP4 attenuates spinal cord injury
            through ameliorating NLRP3 inflammasome-induced pyroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Zhang,X., Chen,Y., Yu,S., Jin,B. and Liu,W.
  TITLE     Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis
            Affected the Prognosis of UC by Modulating the Pyroptosis and
            Expression of Caspase-11
  JOURNAL   Inflammation 43 (6), 2128-2136 (2020)
   PUBMED   32617860
  REMARK    GeneRIF: Inhibition of C3a/C3aR Axis in Diverse Stages of
            Ulcerative Colitis Affected the Prognosis of UC by Modulating the
            Pyroptosis and Expression of Caspase-11.
            Erratum:[Inflammation. 2021 Jun;44(3):1203-1204. PMID: 33174140]
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Kayagaki,N., Warming,S., Lamkanfi,M., Vande Walle,L., Louie,S.,
            Dong,J., Newton,K., Qu,Y., Liu,J., Heldens,S., Zhang,J., Lee,W.P.,
            Roose-Girma,M. and Dixit,V.M.
  TITLE     Non-canonical inflammasome activation targets caspase-11
  JOURNAL   Nature 479 (7371), 117-121 (2011)
   PUBMED   22002608
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Fradejas,N., Pastor,M.D., Burgos,M., Beyaert,R., Tranque,P. and
            Calvo,S.
  TITLE     Caspase-11 mediates ischemia-induced astrocyte death: involvement
            of endoplasmic reticulum stress and C/EBP homologous protein
  JOURNAL   J Neurosci Res 88 (5), 1094-1105 (2010)
   PUBMED   19890920
  REMARK    GeneRIF: In conclusion, our work contributes to clarifying the
            pathways leading to astrocyte death in response to ischemia by
            defining caspase-11 as a key mediator of the ER stress response
            acting downstream of CHOP.
REFERENCE   6  (bases 1 to 1350)
  AUTHORS   de Rivero Vaccari,J.P., Lotocki,G., Alonso,O.F., Bramlett,H.M.,
            Dietrich,W.D. and Keane,R.W.
  TITLE     Therapeutic neutralization of the NLRP1 inflammasome reduces the
            innate immune response and improves histopathology after traumatic
            brain injury
  JOURNAL   J Cereb Blood Flow Metab 29 (7), 1251-1261 (2009)
   PUBMED   19401709
REFERENCE   7  (bases 1 to 1350)
  AUTHORS   Wang,X., Narayanan,M., Bruey,J.M., Rigamonti,D., Cattaneo,E.,
            Reed,J.C. and Friedlander,R.M.
  TITLE     Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa
            cell death
  JOURNAL   Biochim Biophys Acta 1762 (8), 742-754 (2006)
   PUBMED   16920334
REFERENCE   8  (bases 1 to 1350)
  AUTHORS   Hitomi,J., Katayama,T., Eguchi,Y., Kudo,T., Taniguchi,M.,
            Koyama,Y., Manabe,T., Yamagishi,S., Bando,Y., Imaizumi,K.,
            Tsujimoto,Y. and Tohyama,M.
  TITLE     Involvement of caspase-4 in endoplasmic reticulum stress-induced
            apoptosis and Abeta-induced cell death
  JOURNAL   J Cell Biol 165 (3), 347-356 (2004)
   PUBMED   15123740
REFERENCE   9  (bases 1 to 1350)
  AUTHORS   Hur,J., Kim,S.Y., Kim,H., Cha,S., Lee,M.S. and Suk,K.
  TITLE     Induction of caspase-11 by inflammatory stimuli in rat astrocytes:
            lipopolysaccharide induction through p38 mitogen-activated protein
            kinase pathway
  JOURNAL   FEBS Lett 507 (2), 157-162 (2001)
   PUBMED   11684090
REFERENCE   10 (bases 1 to 1350)
  AUTHORS   Morita,Y., Maravei,D.V., Bergeron,L., Wang,S., Perez,G.I.,
            Tsutsumi,O., Taketani,Y., Asano,M., Horai,R., Korsmeyer,S.J.,
            Iwakura,Y., Yuan,J. and Tilly,J.L.
  TITLE     Caspase-2 deficiency prevents programmed germ cell death resulting
            from cytokine insufficiency but not meiotic defects caused by loss
            of ataxia telangiectasia-mutated (Atm) gene function
  JOURNAL   Cell Death Differ 8 (6), 614-620 (2001)
   PUBMED   11536012
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104720.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_053736.3.
            
            On Sep 25, 2005 this sequence version replaced NM_053736.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104720.1, FQ232279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1350
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /note="caspase 4"
                     /db_xref="GeneID:114555"
                     /db_xref="RGD:621757"
     exon            1..18
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1133
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /note="caspase 11; caspase 4, apoptosis-related cysteine
                     peptidase"
                     /codon_start=1
                     /product="caspase 4"
                     /protein_id="NP_446188.2"
                     /db_xref="GeneID:114555"
                     /db_xref="RGD:621757"
                     /translation="MAENNHPDKPLKVLEELGKEFLTEYLEKLVQSNVLKLKEEEKQK
                     FNNAERSDKRWVFVDVLKRKHNQVGKMLLQTFLNVDSGSHHGEANLEMEEPEESVDTL
                     KLCSSEEFTRLCREKKQEIYPIKETNGRTRKALIICNTEFKHLSLRYGANIDISGMKG
                     LLEELGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLQGLCGTMHS
                     EATPDVLLYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNPGEVWIRESSGAHSYRAV
                     DLPRNMEADAVRMSHVEKDFIALYSTTPHHLSYRDKTRGSYFISKLISCFRIHACSCH
                     LFDIFLKVQQSFEKASINSQMPTIDRATLTRYFYLFPGN"
     exon            19..273
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            274..371
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            372..545
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            546..780
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            781..924
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1034
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1138
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1315
                     /gene="Casp4"
                     /gene_synonym="Casp11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttttcct catggctgaa aacaaccacc ctgataaacc acttaaggtg ttggaagaac
       61 tgggcaaaga gttccttaca gagtacctag aaaaattggt acaaagcaat gtattgaaat
      121 taaaggaaga agagaaacaa aaatttaaca atgctgaacg cagtgacaag cgctgggttt
      181 ttgtagatgt cctgaaaagg aaacacaacc aagtgggcaa aatgcttctc cagacatttc
      241 ttaatgtgga ctcaggcagc caccatggtg aagctaattt ggaaatggag gaaccagaag
      301 aatcagtgga cactctcaag ctttgttcct ccgaggagtt cacaaggctg tgcagagaaa
      361 agaagcaaga aatttaccca ataaaggaga ccaatggccg tactcgaaag gctcttatca
      421 tatgcaatac agagttcaaa catctctccc tgagatatgg ggctaacatt gacattagtg
      481 gcatgaaagg ccttcttgaa gagttgggct atgatgtggt ggtgaaagag gagcttacgg
      541 ctgagggcat ggaatcagaa atgaaagact ttgctgcact ctcagagcac caaacatcag
      601 acagcacatt cctggtgtta atgtctcatg gcacattgca gggcctttgt ggaacaatgc
      661 acagtgaagc aactccagat gtgctattat atgatactat ctatcagata tttaacaatt
      721 gtcactgtcc aggtctacga gacaaaccca aagtcatcat tgtgcaggcc tgcagaggtg
      781 gaaaccctgg ggaagtgtgg atcagagagt cttcaggagc ccactcctac agagctgtag
      841 atctacctag gaatatggaa gctgatgctg tccgcatgag ccatgtggag aaggacttca
      901 ttgccctcta ctctacaaca ccacaccact tgtcctacag agacaaaaca agaggctctt
      961 acttcatctc caaactcatt tcctgcttcc ggatacatgc ctgctcttgt catctatttg
     1021 atatatttct gaaggtgcaa caatcatttg aaaaggcaag tattaattcc cagatgccca
     1081 ccattgatcg ggcaaccttg acaagatatt tctacctctt tcctggcaat tgagaacaaa
     1141 gcagcttgaa gaagtgatct tggccaagga tcatgatata tacctgcaat tccaggatta
     1201 gggaaactga ggaaagaata attatgaatt caagaccagc ctcagcaata ctgtgggatt
     1261 ctgtcacata aacaagcaaa caagcaaaaa taaaacaaac aaacaaaaaa ctttaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
