LOCUS       NM_012922               2484 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus caspase 3 (Casp3), mRNA.
ACCESSION   NM_012922
VERSION     NM_012922.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Niedermeyer,S., Yun,X., Trujillo,M., Jiang,H., Andrade,M.R.,
            Kolb,T.M., Suresh,K., Damarla,M. and Shimoda,L.A.
  TITLE     A novel interaction between aquaporin 1 and caspase-3 in pulmonary
            arterial smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L638-L645 (2024)
   PUBMED   38375595
  REMARK    GeneRIF: A novel interaction between aquaporin 1 and caspase-3 in
            pulmonary arterial smooth muscle cells.
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Holota,R., Decmanova,V., Alexovic Matiasova,A., Kosuth,J.,
            Slovinska,L., Pacut,L., Tomori,Z., Daxnerova,Z. and Sevc,J.
  TITLE     Cleaved caspase-3 is present in the majority of glial cells in the
            intact rat spinal cord during postnatal life
  JOURNAL   Histochem Cell Biol 161 (3), 269-286 (2024)
   PUBMED   37938347
  REMARK    GeneRIF: Cleaved caspase-3 is present in the majority of glial
            cells in the intact rat spinal cord during postnatal life.
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Tan,W., Li,Y., Ma,L., Fu,X., Long,Q., Yan,F., Li,W., Liu,X.,
            Ding,H., Wang,Y. and Zhang,W.
  TITLE     Exosomes of endothelial progenitor cells repair injured vascular
            endothelial cells through the Bcl2/Bax/Caspase-3 pathway
  JOURNAL   Sci Rep 14 (1), 4465 (2024)
   PUBMED   38396011
  REMARK    GeneRIF: Exosomes of endothelial progenitor cells repair injured
            vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Galichanin,K. and Yu,Z.
  TITLE     Expression of active caspase 3 in the rat lens after in vivo
            exposure to subthreshold dose of UVR-B
  JOURNAL   BMC Ophthalmol 24 (1), 29 (2024)
   PUBMED   38254051
  REMARK    GeneRIF: Expression of active caspase 3 in the rat lens after in
            vivo exposure to subthreshold dose of UVR-B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Li,C., Zhang,H., Mo,J., Zuo,J. and Ye,L.
  TITLE     Caspase-3/GSDME dependent pyroptosis contributes to offspring lung
            injury induced by gestational PFOS exposure via PERK/ATF4 signaling
  JOURNAL   Arch Toxicol 98 (1), 207-221 (2024)
   PUBMED   37955688
  REMARK    GeneRIF: Caspase-3/GSDME dependent pyroptosis contributes to
            offspring lung injury induced by gestational PFOS exposure via
            PERK/ATF4 signaling.
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Vito,P., Ghayur,T. and D'Adamio,L.
  TITLE     Generation of anti-apoptotic presenilin-2 polypeptides by
            alternative transcription, proteolysis, and caspase-3 cleavage
  JOURNAL   J Biol Chem 272 (45), 28315-28320 (1997)
   PUBMED   9353287
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Ni,B., Wu,X., Du,Y., Su,Y., Hamilton-Byrd,E., Rockey,P.K.,
            Rosteck,P. Jr., Poirier,G.G. and Paul,S.M.
  TITLE     Cloning and expression of a rat brain interleukin-1beta-converting
            enzyme (ICE)-related protease (IRP) and its possible role in
            apoptosis of cultured cerebellar granule neurons
  JOURNAL   J Neurosci 17 (5), 1561-1569 (1997)
   PUBMED   9030616
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   Juan,T.S., McNiece,I.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Fletcher,F.A.
  TITLE     Molecular characterization of mouse and rat CPP32 beta gene
            encoding a cysteine protease resembling interleukin-1 beta
            converting enzyme and CED-3
  JOURNAL   Oncogene 13 (4), 749-755 (1996)
   PUBMED   8761296
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   Liu,X., Kim,C.N., Yang,J., Jemmerson,R. and Wang,X.
  TITLE     Induction of apoptotic program in cell-free extracts: requirement
            for dATP and cytochrome c
  JOURNAL   Cell 86 (1), 147-157 (1996)
   PUBMED   8689682
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081854.1.
            
            On Sep 16, 2004 this sequence version replaced NM_012922.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081854.1, CK357386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2484
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /note="caspase 3"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
     exon            1..41
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            42..109
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..890
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /EC_number="3.4.22.56"
                     /note="IRP; SCA-1; CASP-3; CPP-32; apopain; cysteine
                     protease CPP32; SREBP cleavage activity 1; protein Yama;
                     Caspase 3, apoptosis related cysteine protease (ICE-like
                     cysteine protease); CPP32beta; cysteine protease p32-beta"
                     /codon_start=1
                     /product="caspase-3"
                     /protein_id="NP_037054.1"
                     /db_xref="GeneID:25402"
                     /db_xref="RGD:2275"
                     /translation="MDNNETSVDSKSINNFETKTIHGSKSMDSGIYLDSSYKMDYPEM
                     GLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDS
                     VSKEDHSKRSSFVCVILSHGDEGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLFII
                     QACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQS
                     LCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFY
                     H"
     exon            110..234
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            235..363
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            364..539
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            540..660
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
     exon            661..2461
                     /gene="Casp3"
                     /gene_synonym="CPP32-beta; Lice; Yama"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatcaaag cttagtgtcc tgaggtgcgg agcttggaac gcgaagaaaa gtgaccatgg
       61 acaacaacga aacctccgtg gattcaaaat ccattaataa ttttgaaaca aagactatcc
      121 atggaagcaa gtcgatggac tctggaatat atctggacag cagttacaaa atggattacc
      181 ctgaaatggg cttgtgtata ataattaata ataagaactt ccataaaagc actggaatgt
      241 cagctcgcaa tggtaccgat gtcgatgcag ctaacctcag agagacattc atggccctga
      301 aatacgaagt caggaataaa aatgacctta ctcgtgaaga aattatggaa ttgatggata
      361 gtgtttctaa ggaagatcac agcaaaagga gcagttttgt gtgtgtgatt ctaagtcatg
      421 gagatgaagg agtaattttt ggaacgaacg gacctgtgga cctgaaaaaa ctaactagtt
      481 tcttcagagg cgactactgc cggagtctga ctggaaagcc gaaactcttc atcattcagg
      541 cctgccgagg tacagagctg gactgcggta ttgagacaga cagtggaact gacgatgata
      601 tggcatgcca gaagatacca gtggaggccg acttcctgta tgcttactct accgcacccg
      661 gttactattc ctggagaaat tcaagggacg ggtcatggtt catccagtca ctttgcgcca
      721 tgctgaaact gtacgcgcac aagctggaat tcatgcacat cctcactcgt gttaaccgga
      781 aggtggccac ggaatttgag tccttctccc tggacgccac tttccatgca aagaaacaga
      841 tcccgtgtat tgtgtcaatg ctcacaaaag aactgtactt ttatcactaa aggaatgact
      901 gggagtgggg taggggcatg tttctgtttt ggtttttttt tttggttttt gttttttgtt
      961 tttttttttt tatttgaatg ccaaatgaga aaactgtcag ggagactttt tttttcccct
     1021 ctcatttaaa tcaaatccga tgttccaggt cgtcattgaa caataccact gcctgcaatg
     1081 cagccacaat acaatacctc agctttgata tcaggtagtt gaaatgaaat ttaattagga
     1141 acaaataaat gtcaataatg gtacaaccat catagaagaa attggaaagt cacactttgg
     1201 taattagaga gatttggtgc cactatgaat ttgaaattac gaagcagtga tgatcttata
     1261 ccccctcctc acatctagaa tgtcacttta gttttcgtta agcataggaa cgataatgtc
     1321 aagtggtatg tcttagaact tgaatccacg agcagagtca aaggctggtt ttggaactga
     1381 tctgtggaaa tgaagagttg gagcactgta gcacacatta tagctactgg ttttgtgaca
     1441 gttgaccagg tcacatattt attatttaag acaaaagtcg tgttttatta ttggaacaaa
     1501 aataacttta tatgagagga aaaccatgtg tgaacttggt tggcttgttg aaggctacca
     1561 tccttcagtg gtggacatga cgacagggtg ctacgatcca ccagcatttg tttcttactt
     1621 attcttatgc aaatcagcct aattttacag accagcaaaa tatctaaaga gcgattatgc
     1681 agcagcctca aattgttgac tattagaatg gaataaagga attctacagg aacagaccat
     1741 aataccagct gtcagtcaga gcgtaaggaa aggagaggtg gcatctcctg tgattggaga
     1801 gaagatggtt tgagccggag cagagccatg ggcacgtctt cagaaaaggc ctgctagttg
     1861 gacccacctt gtgagcactg gtctgtgtgg atgatgtcca agttaccaca tgagactgaa
     1921 ccagatcaga agctcctgca aaaaggcttt cccagagtgc tgagcatctc aagaaagttc
     1981 actggactcc atgtacagag tctgtagcat gctgactttt ctgttgaagt ttacaatgaa
     2041 aggaaaatga tggtgatatt tgtaccgtca ctagaaatga agggccctgg cacacgggac
     2101 ttggaaagca tccagcaata ggccctgcag cccatgtgga ggagctgcag actggagtcc
     2161 acccctcctc cccatcaggg cgtctgtgct ccaggcttcc ttaatcatgg aggtgctgag
     2221 tcatcgctgg ctctccctgt gggtccagca tttcccataa gcctccttat tgcacaaaga
     2281 aaggaaggaa ctcacattat aactgatagt aggttcttgt ttagactgga tttactgtta
     2341 actcttttct aagtaaatac agcatgtggt ggtattttaa aatgtgttcc catgtgacaa
     2401 ttttataaaa gtcagatatc ttgcattttt atttcaaaac ataaattcag atttaaaatt
     2461 aaaaaaaaaa aaaaaaaaaa aaaa
//
