LOCUS       NM_022522               3352 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus caspase 2 (Casp2), mRNA.
ACCESSION   NM_022522
VERSION     NM_022522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3352)
  AUTHORS   Huang,J., Huang,Y., Feng,Z., Guo,W., Wang,X. and Liao,Z.
  TITLE     MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2
  JOURNAL   J Recept Signal Transduct Res 41 (1), 6-14 (2021)
   PUBMED   32605511
  REMARK    GeneRIF: MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2.
REFERENCE   2  (bases 1 to 3352)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3352)
  AUTHORS   Zhang,M., Chen,L., Xu,F., Jiang,L., Yan,W., Kunwar,B., Tang,F.,
            Yang,K., Shen,C., Huang,H., Lv,J., Qin,C., Wu,X., Zeng,S., Li,M.,
            Zhong,S. and Chen,Q.
  TITLE     Involvement of Upregulated P53-Induced Death Domain Protein in
            Retinal Ganglion Cells Apoptosis After Optic Nerve Crush
  JOURNAL   Curr Mol Med 20 (1), 51-59 (2019)
   PUBMED   31533600
  REMARK    GeneRIF: Involvement of Upregulated P53-Induced Death Domain
            Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve
            Crush.
REFERENCE   4  (bases 1 to 3352)
  AUTHORS   Thomas,C.N., Thompson,A.M., McCance,E., Berry,M., Logan,A.,
            Blanch,R.J. and Ahmed,Z.
  TITLE     Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After
            Blunt Ocular Injury
  JOURNAL   Invest Ophthalmol Vis Sci 59 (11), 4453-4462 (2018)
   PUBMED   30193318
  REMARK    GeneRIF: Caspase-2 mediates death in a proportion of retinal
            ganglion cell (RGC) but not photoreceptors at the site of blunt
            ocular trauma.
REFERENCE   5  (bases 1 to 3352)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 3352)
  AUTHORS   Kojima,M., Asahi,M., Kikuchi,H., Hashimoto,N., Noda,M. and
            Hoshimaru,M.
  TITLE     Expression of Nedd2/ICH-1 (caspase-2) in the developing rat retina
  JOURNAL   Neurosci Res 31 (3), 211-217 (1998)
   PUBMED   9809666
REFERENCE   7  (bases 1 to 3352)
  AUTHORS   Kaushal,G.P., Singh,A.B. and Shah,S.V.
  TITLE     Identification of gene family of caspases in rat kidney and altered
            expression in ischemia-reperfusion injury
  JOURNAL   Am J Physiol 274 (3), F587-F595 (1998)
   PUBMED   9530276
REFERENCE   8  (bases 1 to 3352)
  AUTHORS   Sato,N., Milligan,C.E., Uchiyama,Y. and Oppenheim,R.W.
  TITLE     Cloning and expression of the cDNA encoding rat caspase-2
  JOURNAL   Gene 202 (1-2), 127-132 (1997)
   PUBMED   9427555
REFERENCE   9  (bases 1 to 3352)
  AUTHORS   Ahmad,M., Srinivasula,S.M., Wang,L., Talanian,R.V., Litwack,G.,
            Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     CRADD, a novel human apoptotic adaptor molecule for caspase-2, and
            FasL/tumor necrosis factor receptor-interacting protein RIP
  JOURNAL   Cancer Res 57 (4), 615-619 (1997)
   PUBMED   9044836
REFERENCE   10 (bases 1 to 3352)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022522.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77933.1, SRR26360176.1435578.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000004.1  72116357-72116436
            81-231              JAXUCZ010000004.1  72118787-72118937
            232-399             JAXUCZ010000004.1  72119191-72119358
            400-481             JAXUCZ010000004.1  72119506-72119587
            482-576             JAXUCZ010000004.1  72120159-72120253
            577-753             JAXUCZ010000004.1  72120573-72120749
            754-882             JAXUCZ010000004.1  72125159-72125287
            883-973             JAXUCZ010000004.1  72128169-72128259
            974-1123            JAXUCZ010000004.1  72131322-72131471
            1124-1233           JAXUCZ010000004.1  72131641-72131750
            1234-3352           JAXUCZ010000004.1  72131905-72134023
FEATURES             Location/Qualifiers
     source          1..3352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3352
                     /gene="Casp2"
                     /note="caspase 2"
                     /db_xref="GeneID:64314"
                     /db_xref="RGD:69274"
     exon            1..80
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1365
                     /gene="Casp2"
                     /EC_number="3.4.22.55"
                     /note="CASP-2; ICH-1 protease; protease ICH-1"
                     /codon_start=1
                     /product="caspase-2"
                     /protein_id="NP_071967.2"
                     /db_xref="GeneID:64314"
                     /db_xref="RGD:69274"
                     /translation="MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNR
                     VVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAF
                     CEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDT
                     MEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHFTGEKDLEF
                     RSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLS
                     HGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDG
                     KNHAQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQ
                     VFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYP
                     PT"
     exon            81..231
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..399
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..481
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..576
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..753
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..882
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..973
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1123
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1233
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..3352
                     /gene="Casp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaaatgg cggcgtcgag cgggaggtct cagtcttccc tgcacaggaa ggggctgatg
       61 gcggctgaca ggaggagcag gattttggca gtgtgtggaa tgcatcctga ccatcaggaa
      121 actctgaaaa agaatcgagt ggtgctggcc aaacagctgc tgctgagcga actgttagaa
      181 catctcctag aaaaggacat tatcactttg gaaatgaggg agctaatcca ggccaaaggg
      241 ggcagtttca gccagaatgt ggaactcctc aacctgctgc caaagagagg accccaggct
      301 tttgatgcct tctgtgaagc cctgcgggag accaggcagg gtcacttgga agacttactg
      361 ctcacaaccc tctctgatat ccagcacata ctcccaccgt tgagctgtga ctatgactca
      421 agtctcccct tctcggtgtg tgagtcctgc cctcctcaca agcagtcccg cctatccaca
      481 gatactatgg aacactcctt agataatggt gatggtcctc cctgtcttca ggtgaagcca
      541 tgcactcctg agttttacca ggcacactac cagctggcct ataggttgca gtctcagcct
      601 cgtggcttgg cactggtgat gagtaatgtg cactttactg gagagaaaga cctggaattt
      661 cgctccggag gggatgtgga ccacactact ctagtcaccc tcttcaagct tttgggctac
      721 aatgtccatg tgctgtatga ccagactgca caggaaatgc aagagaaact tcagaatttt
      781 gcacagttac ctgcacaccg ggtcacagac tcctgcatag tagcactcct ctcacatggt
      841 gtggaaggtg gcatctacgg ggtggatggc aaactgcttc agctccaaga ggtttttcga
      901 ctttttgaca atgctaactg tccaagtcta cagaacaaac caaaaatgtt cttcatccaa
      961 gcatgtcgtg gagatgagac agatagaggg gttgaccagc aagatggaaa gaaccatgca
     1021 caatcccctg gatgtgagga gagtgatgct ggcaaggagg aattaatgaa gatgagactt
     1081 cctactcgct cagacatgat atgtggctat gcttgcctta aaggcaatgc tgccatgcgg
     1141 aataccaaac ggggttcctg gtacattgag gccctcactc aggtgttctc tgagagagct
     1201 tgtgacatgc acgtggccga catgcttgtt aaggtgaatg cccttatcaa ggagcgtgaa
     1261 ggctatgccc ctggtacaga attccaccga tgcaaggaga tgtctgagta ctgtagtact
     1321 ctgtgccagc agctctacct gttcccaggc tacccaccca cgtgatgcca cctgctagtc
     1381 atgctgttgg aggccactgg accacggggc acaatggaga cttctcttca agatgttttt
     1441 gttctgtcta ctccctcagg gatatgagat tctcccaagc ttgtttcctg tcagccatct
     1501 ccgtctttgg gggtgaaact tgaggacagc tcctctggtg tggtgttctc ttcctgtaga
     1561 gccagctatg aatggatctg ttgccagaag cattttggct atagccaatg agactagaaa
     1621 atgacattgt gaacacagta ttattgtggg gagagggcat acggatttct caatgtttgt
     1681 gatatttttg ttcccagggc tcttagggat actttgatta ttgctttttt atatcagtta
     1741 aggactttca gatatcatct cctacttttt ttttcatatc tgcaacctca ttttttccat
     1801 agtgaagatt tggaaaatgt cccaatttaa tgcagttgtt gtcatctgtc atgaagcggc
     1861 aggtgagacc ctgctacttg agcagaagtt tcagaccttt gagttcaggc cttaggtgaa
     1921 ggacagtccc tcagcctttc cattggtttc tttgtgttca ttgtacccag cttttgagca
     1981 gagcctgggg tctgcttgct gtgacactgg aagttatata cgtttccctg gttatgaatt
     2041 gtcactgaaa tgaaccttat tgggcatatc aacataaaaa tgcagtgaca ggtgagtgtg
     2101 ctgtgtctca tactgtcact tgtcaccagg atatctctcc ttccttactg tggtttctgc
     2161 tgtgcagtta aactacttga tggctgacct ccaagaaccc tcttgctttg cattggttcc
     2221 cctccttgac ccattcactg cttctgccac gtctgtgaaa tcttcctttg tagaatgttt
     2281 ctggccactt aagcagtact gcttcagcat aaggtttctt cggttttctg cggcagtgtc
     2341 tccattctca ctgtttctct gttttagtga ggatagtact ataggtgata taacctagaa
     2401 gcacttatct ctgctcttat gaaactttct tattcttaaa aaccttttgc atttccattt
     2461 ttttcctctt ttccagttta ttctccacat gacagagtag ttttgttttt tttttaatat
     2521 ctggtgatgt cactcccttg ttaagaacat tagcttcctg ttacacctca tctaaaattc
     2581 aaattcttac ccagtttatg agatccggct tttacgttcc ctttggatct cattagatgg
     2641 tgatttctct ctgtgttcag cccctcagtt cctcagctca gtgttgcaag tgttctgagc
     2701 tcttctttaa gatagtctct gattcttgag tctggcggag gcctcttgac cgtgatgttg
     2761 atgaagtaag tcttctgtac ctccttagga tggcatcatg ttggtccttg tgcttactgc
     2821 aggttgtaat ggcacatttc acttgctccc tccaaagctg aaggctccaa gagagcagga
     2881 ctgtactcct tacttattgg ctattcagta cggcacttac taggtcttca atgaatgttt
     2941 cctgagtaaa ggaaggagac aagcagctaa ctttagttag agcctatctt ttgcgatttc
     3001 taaattgcta ttatagtact cagtttaatt agtatttgta ctcttgtggg ggtttttttc
     3061 caggtgtttt atttttatcc actgttttgt tgttttttta cattgtttga agatgtatca
     3121 cgtgtgagac aacttctttc acatctccat ggtgccccgc aaatttgagg cctatggtag
     3181 ttgaggtgct caattaatgt ttgtcgtatg aaccaggtgg tttgaagact tgctgccaaa
     3241 ttctgccttt gggtcagtat aggatgcatg agtggtagac tcttcacact tcccactgcc
     3301 aagattttgt attgccatca ggtgccaaat aaatgtcgat acttactact ga
//
