LOCUS       NP_071967                452 aa            linear   ROD 07-APR-2024
DEFINITION  caspase-2 [Rattus norvegicus].
ACCESSION   NP_071967
VERSION     NP_071967.2
DBSOURCE    REFSEQ: accession NM_022522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Huang,J., Huang,Y., Feng,Z., Guo,W., Wang,X. and Liao,Z.
  TITLE     MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2
  JOURNAL   J Recept Signal Transduct Res 41 (1), 6-14 (2021)
   PUBMED   32605511
  REMARK    GeneRIF: MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2.
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Zhang,M., Chen,L., Xu,F., Jiang,L., Yan,W., Kunwar,B., Tang,F.,
            Yang,K., Shen,C., Huang,H., Lv,J., Qin,C., Wu,X., Zeng,S., Li,M.,
            Zhong,S. and Chen,Q.
  TITLE     Involvement of Upregulated P53-Induced Death Domain Protein in
            Retinal Ganglion Cells Apoptosis After Optic Nerve Crush
  JOURNAL   Curr Mol Med 20 (1), 51-59 (2019)
   PUBMED   31533600
  REMARK    GeneRIF: Involvement of Upregulated P53-Induced Death Domain
            Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve
            Crush.
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Thomas,C.N., Thompson,A.M., McCance,E., Berry,M., Logan,A.,
            Blanch,R.J. and Ahmed,Z.
  TITLE     Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After
            Blunt Ocular Injury
  JOURNAL   Invest Ophthalmol Vis Sci 59 (11), 4453-4462 (2018)
   PUBMED   30193318
  REMARK    GeneRIF: Caspase-2 mediates death in a proportion of retinal
            ganglion cell (RGC) but not photoreceptors at the site of blunt
            ocular trauma.
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Kojima,M., Asahi,M., Kikuchi,H., Hashimoto,N., Noda,M. and
            Hoshimaru,M.
  TITLE     Expression of Nedd2/ICH-1 (caspase-2) in the developing rat retina
  JOURNAL   Neurosci Res 31 (3), 211-217 (1998)
   PUBMED   9809666
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Kaushal,G.P., Singh,A.B. and Shah,S.V.
  TITLE     Identification of gene family of caspases in rat kidney and altered
            expression in ischemia-reperfusion injury
  JOURNAL   Am J Physiol 274 (3), F587-F595 (1998)
   PUBMED   9530276
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Sato,N., Milligan,C.E., Uchiyama,Y. and Oppenheim,R.W.
  TITLE     Cloning and expression of the cDNA encoding rat caspase-2
  JOURNAL   Gene 202 (1-2), 127-132 (1997)
   PUBMED   9427555
REFERENCE   9  (residues 1 to 452)
  AUTHORS   Ahmad,M., Srinivasula,S.M., Wang,L., Talanian,R.V., Litwack,G.,
            Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     CRADD, a novel human apoptotic adaptor molecule for caspase-2, and
            FasL/tumor necrosis factor receptor-interacting protein RIP
  JOURNAL   Cancer Res 57 (4), 615-619 (1997)
   PUBMED   9044836
REFERENCE   10 (residues 1 to 452)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 4, 2002 this sequence version replaced NP_071967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77933.1, SRR26360176.1435578.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     Protein         1..452
                     /product="caspase-2"
                     /EC_number="3.4.22.55"
                     /note="CASP-2; ICH-1 protease; protease ICH-1"
                     /calculated_mol_wt=50597
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P42575; propagated from
                     UniProtKB/Swiss-Prot (P55215.3)"
     Region          32..118
                     /region_name="CARD_CASP2"
                     /note="Caspase activation and recruitment domain of
                     Caspase-2; cd08332"
                     /db_xref="CDD:260040"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42575; propagated from
                     UniProtKB/Swiss-Prot (P55215.3)"
     Region          192..447
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; smart00115"
                     /db_xref="CDD:214521"
     Site            order(219,278,318,325,375..380,384..385)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(277,320)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(326,360..361,368,371,374,397,405,411,430,435..436,
                     438,441..442)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(327,359)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     Region          327..349
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P55215.3)"
     Site            340
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42575; propagated from
                     UniProtKB/Swiss-Prot (P55215.3)"
     CDS             1..452
                     /gene="Casp2"
                     /coded_by="NM_022522.3:7..1365"
                     /db_xref="GeneID:64314"
                     /db_xref="RGD:69274"
ORIGIN      
        1 maassgrsqs slhrkglmaa drrsrilavc gmhpdhqetl kknrvvlakq lllsellehl
       61 lekdiitlem reliqakggs fsqnvellnl lpkrgpqafd afcealretr qghledlllt
      121 tlsdiqhilp plscdydssl pfsvcescpp hkqsrlstdt mehsldngdg ppclqvkpct
      181 pefyqahyql ayrlqsqprg lalvmsnvhf tgekdlefrs ggdvdhttlv tlfkllgynv
      241 hvlydqtaqe mqeklqnfaq lpahrvtdsc ivallshgve ggiygvdgkl lqlqevfrlf
      301 dnancpslqn kpkmffiqac rgdetdrgvd qqdgknhaqs pgceesdagk eelmkmrlpt
      361 rsdmicgyac lkgnaamrnt krgswyieal tqvfseracd mhvadmlvkv nalikeregy
      421 apgtefhrck emseycstlc qqlylfpgyp pt
//
