LOCUS       NM_130422               1302 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus caspase 12 (Casp12), mRNA.
ACCESSION   NM_130422
VERSION     NM_130422.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Yang,H., Wen,Y., Zhang,M., Liu,Q., Zhang,H., Zhang,J., Lu,L.,
            Ye,T., Bai,X., Xiao,G. and Wang,M.
  TITLE     MTORC1 coordinates the autophagy and apoptosis signaling in
            articular chondrocytes in osteoarthritic temporomandibular joint
  JOURNAL   Autophagy 16 (2), 271-288 (2020)
   PUBMED   31007149
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Lu,J.F., Zhang,Q.J., Li,X.H., Liu,G.Q., Liu,Y.C. and Gu,Z.Y.
  TITLE     Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat
            Lung Tissues
  JOURNAL   Fa Yi Xue Za Zhi 34 (4), 347-351 (2018)
   PUBMED   30465396
REFERENCE   3  (bases 1 to 1302)
  AUTHORS   Wiberg,R., Novikova,L.N. and Kingham,P.J.
  TITLE     Evaluation of apoptotic pathways in dorsal root ganglion neurons
            following peripheral nerve injury
  JOURNAL   Neuroreport 29 (9), 779-785 (2018)
   PUBMED   29659443
REFERENCE   4  (bases 1 to 1302)
  AUTHORS   Liu,X.R., Li,T., Cao,L., Yu,Y.Y., Chen,L.L., Fan,X.H., Yang,B.B.
            and Tan,X.Q.
  TITLE     Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes
            apoptosis through mitochondria- and ER-medicated oxidative stress
            pathways
  JOURNAL   Mol Med Rep 17 (5), 7258-7264 (2018)
   PUBMED   29568958
REFERENCE   5  (bases 1 to 1302)
  AUTHORS   Li,J.H., Jia,J.J., Shen,W., Chen,S.S., Jiang,L., Xie,H.Y., Zhou,L.
            and Zheng,S.S.
  TITLE     Optimized postconditioning algorithm protects liver graft after
            liver transplantation in rats
  JOURNAL   Hepatobiliary Pancreat Dis Int 17 (1), 32-38 (2018)
   PUBMED   29428101
REFERENCE   6  (bases 1 to 1302)
  AUTHORS   Mouw,G., Zechel,J.L., Gamboa,J., Lust,W.D., Selman,W.R. and
            Ratcheson,R.A.
  TITLE     Activation of caspase-12, an endoplasmic reticulum resident
            caspase, after permanent focal ischemia in rat
  JOURNAL   Neuroreport 14 (2), 183-186 (2003)
   PUBMED   12598725
  REMARK    GeneRIF: Immunohistochemical analysis reveals diffuse positive
            immunostaining of caspase-12 throughout the striatum and cerebral
            cortex in animals that undergo ischemia, with more intense
            caspase-12 staining in post-ischemic striatum than in post-ischemic
            cortex.
REFERENCE   7  (bases 1 to 1302)
  AUTHORS   Morishima,N., Nakanishi,K., Takenouchi,H., Shibata,T. and
            Yasuhiko,Y.
  TITLE     An endoplasmic reticulum stress-specific caspase cascade in
            apoptosis. Cytochrome c-independent activation of caspase-9 by
            caspase-12
  JOURNAL   J Biol Chem 277 (37), 34287-34294 (2002)
   PUBMED   12097332
REFERENCE   8  (bases 1 to 1302)
  AUTHORS   Diaz-Horta,O., Kamagate,A., Herchuelz,A. and Van Eylen,F.
  TITLE     Na/Ca exchanger overexpression induces endoplasmic
            reticulum-related apoptosis and caspase-12 activation in
            insulin-releasing BRIN-BD11 cells
  JOURNAL   Diabetes 51 (6), 1815-1824 (2002)
   PUBMED   12031969
  REMARK    GeneRIF: Na/Ca exchanger overexpression, by depleting ER Ca(2+)
            stores, triggers the activation of caspase-12 and increases
            apoptotic cell death
REFERENCE   9  (bases 1 to 1302)
  AUTHORS   Harding,H.P., Zhang,Y., Bertolotti,A., Zeng,H. and Ron,D.
  TITLE     Perk is essential for translational regulation and cell survival
            during the unfolded protein response
  JOURNAL   Mol Cell 5 (5), 897-904 (2000)
   PUBMED   10882126
REFERENCE   10 (bases 1 to 1302)
  AUTHORS   Nakagawa,T., Zhu,H., Morishima,N., Li,E., Xu,J., Yankner,B.A. and
            Yuan,J.
  TITLE     Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and
            cytotoxicity by amyloid-beta
  JOURNAL   Nature 403 (6765), 98-103 (2000)
   PUBMED   10638761
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF317633.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_130422.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF317633.1, SRR8487231.178901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1302
                     /gene="Casp12"
                     /note="caspase 12"
                     /db_xref="GeneID:156117"
                     /db_xref="RGD:621758"
     CDS             16..1278
                     /gene="Casp12"
                     /note="CASP-12"
                     /codon_start=1
                     /product="caspase-12"
                     /protein_id="NP_569106.1"
                     /db_xref="GeneID:156117"
                     /db_xref="RGD:621758"
                     /translation="MAAKRTHERDPIYKIKGLAKDMLDGVFDDLMDKNVLNGDELLKI
                     GEGASLILSKAENLVESFFEKTEMAGKIFAGHIANSDKQLSLQFPSDDEEDELQKMFT
                     PSSASESRGKVEDEEMEVNVGVAHASHLMLTVPQGIQSTEVQDSLKLCSRDWFCTMKT
                     ERAEEIYPVMEKEGRTRLALIICNKKFDYLFDRDDAETDILNMKELLQNLGYSVVIKE
                     NLTAQEMETELMKFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIF
                     TIFNNSNCPSLRNKPKILIMQACRGRHTGTIWVSTSKGIATADTDEECVLSHRWNNSI
                     TKAHVETDFIAFKSSTPHNISWKVGKSGSLFISKLIDCFKKYCWCYHLEEIFRKVQYS
                     FEVPGELTQMPTIERVSMTRYFYLFPGN"
ORIGIN      
        1 ccgggcaggt ctgccatggc tgccaagaga acacatgaaa gggatccaat ctacaagatc
       61 aaaggtttgg ccaaggacat gctggatgga gtttttgatg acctgatgga caaaaatgtt
      121 ttaaatggcg atgagttact caaaatcgga gaaggagcga gcttaatcct gagcaaagct
      181 gagaacctgg ttgaaagttt ctttgagaaa acagaaatgg caggaaaaat atttgcaggt
      241 cacattgcca attccgacaa acagctgagt ttacaatttc cttctgatga tgaagaggat
      301 gaacttcaga aaatgtttac accatcttct gcatcagaat ccaggggaaa agtagaagat
      361 gaagaaatgg aggtaaatgt tggagtggcc catgcatcac atctaatgct tacagttcct
      421 cagggaatcc agagcacaga agtacaggat tcactgaagc tatgttctcg tgattggttt
      481 tgtacgatga agacagaaag ggcagaagag atatatccag tgatggagaa ggaaggccga
      541 acccgcctgg ccctcatcat ctgcaacaaa aagtttgact atctttttga tagagatgat
      601 gctgagactg acattttgaa catgaaagaa ctacttcaaa atcttggata ctcagtggtg
      661 ataaaggaaa accttacagc tcaggaaatg gagacagaat taatgaagtt tgctggccgt
      721 ccagagcacc agtcctccga cagcacattc ctggtcttta tgtcccacgg catcctggaa
      781 ggaatctgtg gggtgaagca cagaaacaaa aagccagatg ttcttcatga tgacactatc
      841 ttcaccattt tcaacaattc taactgtccg agtctgagaa acaaacccaa gattctcatc
      901 atgcaagcct gcagaggcag acatactggt actatttggg tatccacaag caaagggata
      961 gccactgctg atacagatga ggaatgtgtg ttgagccata gatggaataa tagtataaca
     1021 aaggcccatg tggagacaga tttcattgct ttcaaatctt ctaccccaca taacatttct
     1081 tggaaggtag gcaagagtgg ctctctcttc atttccaaac tcattgactg cttcaaaaag
     1141 tattgttggt gttatcattt ggaagaaatt ttccgaaagg ttcaatactc atttgaggtc
     1201 ccaggtgaac tgacccagat gcccaccatt gagagagtat ctatgacacg ctacttctac
     1261 cttttccctg gaaattaaca cagcctactc ttgcaaataa at
//
