LOCUS       NM_012762               1328 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus caspase 1 (Casp1), mRNA.
ACCESSION   NM_012762
VERSION     NM_012762.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Chen,L., Yu,H., Li,Z., Wang,Y., Jin,S., Yu,M., Zhu,L., Ding,C.,
            Wu,X., Wu,T., Xun,C., Zhou,Y., He,D. and Liu,Y.
  TITLE     Force-induced Caspase-1-dependent pyroptosis regulates orthodontic
            tooth movement
  JOURNAL   Int J Oral Sci 16 (1), 3 (2024)
   PUBMED   38221531
  REMARK    GeneRIF: Force-induced Caspase-1-dependent pyroptosis regulates
            orthodontic tooth movement.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Li,X. and Yang,N.
  TITLE     Exosome miR-223-3p in the bone marrow-derived mesenchymal stem
            cells alleviates the inflammation and airway remodeling through
            NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway
  JOURNAL   Int Immunopharmacol 123, 110746 (2023)
   PUBMED   37549514
  REMARK    GeneRIF: Exosome miR-223-3p in the bone marrow-derived mesenchymal
            stem cells alleviates the inflammation and airway remodeling
            through NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway.
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Zhou,L., Wang,B., Xie,H., Du,C., Tang,J. and Tang,W.
  TITLE     Intrauterine exposure to oxidative stress induces
            caspase-1-dependent enteric nerve cell pyroptosis
  JOURNAL   Pediatr Surg Int 38 (11), 1555-1567 (2022)
   PUBMED   35995981
  REMARK    GeneRIF: Intrauterine exposure to oxidative stress induces
            caspase-1-dependent enteric nerve cell pyroptosis.
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Bai,H., Zhang,Z., Liu,L., Wang,X., Song,X. and Gao,L.
  TITLE     Activation of adenosine A3 receptor attenuates progression of
            osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced
            signalling
  JOURNAL   J Cell Mol Med 26 (15), 4230-4243 (2022)
   PUBMED   35775127
  REMARK    GeneRIF: Activation of adenosine A3 receptor attenuates progression
            of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD
            induced signalling.
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Han,Y., Dong,B., Chen,M. and Yao,C.
  TITLE     LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate
            myocardial infarction in a PBX3/CYP1B1-dependent manner
  JOURNAL   Mol Cell Biochem 476 (3), 1387-1400 (2021)
   PUBMED   33389498
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Winter,R.N., Kramer,A., Borkowski,A. and Kyprianou,N.
  TITLE     Loss of caspase-1 and caspase-3 protein expression in human
            prostate cancer
  JOURNAL   Cancer Res 61 (3), 1227-1232 (2001)
   PUBMED   11221855
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Solle,M., Labasi,J., Perregaux,D.G., Stam,E., Petrushova,N.,
            Koller,B.H., Griffiths,R.J. and Gabel,C.A.
  TITLE     Altered cytokine production in mice lacking P2X(7) receptors
  JOURNAL   J Biol Chem 276 (1), 125-132 (2001)
   PUBMED   11016935
REFERENCE   8  (bases 1 to 1328)
  AUTHORS   Oshikawa,K., Shi,F., Rakhmilevich,A.L., Sondel,P.M., Mahvi,D.M. and
            Yang,N.S.
  TITLE     Synergistic inhibition of tumor growth in a murine mammary
            adenocarcinoma model by combinational gene therapy using IL-12,
            pro-IL-18, and IL-1beta converting enzyme cDNA
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13351-13356 (1999)
   PUBMED   10557324
REFERENCE   9  (bases 1 to 1328)
  AUTHORS   Flaws,J.A., Kugu,K., Trbovich,A.M., DeSanti,A., Tilly,K.I.,
            Hirshfield,A.N. and Tilly,J.L.
  TITLE     Interleukin-1 beta-converting enzyme-related proteases (IRPs) and
            mammalian cell death: dissociation of IRP-induced oligonucleosomal
            endonuclease activity from morphological apoptosis in granulosa
            cells of the ovarian follicle
  JOURNAL   Endocrinology 136 (11), 5042-5053 (1995)
   PUBMED   7588240
REFERENCE   10 (bases 1 to 1328)
  AUTHORS   Keane,K.M., Giegel,D.A., Lipinski,W.J., Callahan,M.J. and
            Shivers,B.D.
  TITLE     Cloning, tissue expression and regulation of rat interleukin 1 beta
            converting enzyme
  JOURNAL   Cytokine 7 (2), 105-110 (1995)
   PUBMED   7780029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 8, 2020 this sequence version replaced NM_012762.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.32330.1,
                                           SRR26643429.29095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                JAXUCZ010000008.1  10872830-10872848
            20-286              JAXUCZ010000008.1  10873399-10873665
            287-349             JAXUCZ010000008.1  10873918-10873980
            350-462             JAXUCZ010000008.1  10876534-10876646
            463-636             JAXUCZ010000008.1  10877089-10877262
            637-871             JAXUCZ010000008.1  10877651-10877885
            872-1012            JAXUCZ010000008.1  10878309-10878449
            1013-1122           JAXUCZ010000008.1  10881056-10881165
            1123-1222           JAXUCZ010000008.1  10881602-10881701
            1223-1328           JAXUCZ010000008.1  10882190-10882295
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..1328
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /note="caspase 1"
                     /db_xref="GeneID:25166"
                     /db_xref="RGD:2274"
     exon            1..19
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1221
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /EC_number="3.4.22.36"
                     /function="interleukin-1beta converting enzyme"
                     /note="Interleukin 1beta converting enzyme; interleukin 1,
                     beta, convertase; IL-1 beta-converting enzyme;
                     interleukin-1 beta-converting enzyme"
                     /codon_start=1
                     /product="caspase-1"
                     /protein_id="NP_036894.3"
                     /db_xref="GeneID:25166"
                     /db_xref="RGD:2274"
                     /translation="MADKILRAKRKQFINSVSVGTINGLLDELLEKRVLNQEEMDTIK
                     LANITVMEKARDLCDHVTKKGPRASQMFITYICNEDCYLAEILELQSGPSAETVFVTE
                     DSKGGHPFSSETKEKLNKEGGAFPGPSGSLKFCPLEIAQKLWKENHSEIYPIMKTPTR
                     TRLALIICNTDFQHLSRRVGADVDLREMKLLLQDLGYTVKVKENLTALEMTKELKEFA
                     ACPEHKTSDSTFLVFMSHGLQEGICGITYSNEVADILKVDTIFQMMNTLKCPSLKDKP
                     KVIIIQACRGEKQGVVLLKDSVGNSEEGFLTDAIFEDDGIKKAHIEKDFIAFCSSTPD
                     NVSWRHPVQGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPDSRLQMPTTERVTL
                     TKRFYLFPGH"
     exon            20..286
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            287..349
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            350..462
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            463..636
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            637..871
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1012
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1122
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1222
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1328
                     /gene="Casp1"
                     /gene_synonym="Ice; Il1bc; p45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagaaacg ccatggctga caagatcctg agggcaaaga ggaagcaatt tatcaactca
       61 gtgagtgtag ggacaataaa tggattgctg gatgaacttt tagagaagag agtcctgaac
      121 caggaagaga tggatacaat caaacttgca aatatcactg ttatggaaaa ggcacgagac
      181 ctgtgcgatc atgtcactaa aaaaggaccc cgggcaagcc agatgtttat cacttacatt
      241 tgtaatgaag actgctacct ggcagaaatt ctggagcttc agtcaggtcc atcagctgaa
      301 actgtttttg ttacagaaga ttctaaggga ggacatcctt tctcctcaga aacaaaagaa
      361 aaactgaaca aagaaggtgg cgcatttcct ggaccgagtg gttccctcaa gttttgccct
      421 ttagaaatag cccagaagtt atggaaagaa aatcattcag agatttatcc aataatgaaa
      481 acacccactc gtacacgtct tgccctcatt atctgcaaca cagactttca acatctttct
      541 cggagagtcg gagctgatgt tgacctcaga gaaatgaagt tgctgctgca ggatctgggg
      601 tatactgtga aagtcaaaga aaatctcaca gctctggaga tgacaaaaga attgaaagaa
      661 tttgctgcct gcccagagca caagacttct gacagtacct tccttgtatt catgtctcat
      721 ggtctccagg agggaatatg tgggatcaca tactctaatg aagttgcaga tattttaaag
      781 gttgacacaa tctttcaaat gatgaacaca ttgaagtgcc caagcttgaa agacaagccc
      841 aaggttatca ttattcaggc atgccgtgga gagaaacaag gagtggtgtt gttaaaagat
      901 tcagtaggga actccgaaga gggattctta acagatgcaa tttttgaaga tgatggcatt
      961 aagaaggccc atatagagaa agattttatt gctttctgct cttcaacacc agataatgtg
     1021 tcctggagac atcctgtcca gggatctctc ttcattgagt cactcatcaa acacatgaaa
     1081 gaatatgcct ggtcttgtga cttggaggac attttcagaa aggttcgatt ttctttcgaa
     1141 caaccagact ctagactaca gatgccaacc actgaaaggg tgaccctgac aaaacgtttc
     1201 tacctcttcc caggacatta aagaatccaa gacttcattc ttatgtacct gtgttgggaa
     1261 tcatgccaat aagaagccaa taatccccaa aatgatacaa taaatttcaa aacaaaacaa
     1321 aaaagcta
//
