LOCUS       NM_022184               3819 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium/calmodulin dependent serine protein
            kinase (Cask), mRNA.
ACCESSION   NM_022184
VERSION     NM_022184.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3819)
  AUTHORS   Zhang,K., Wang,T., Liu,X., Yuan,Q., Xiao,T., Yuan,X., Zhang,Y.,
            Yuan,L. and Wang,Y.
  TITLE     CASK, APBA1, and STXBP1 collaborate during insulin secretion
  JOURNAL   Mol Cell Endocrinol 520, 111076 (2021)
   PUBMED   33159991
  REMARK    GeneRIF: CASK, APBA1, and STXBP1 collaborate during insulin
            secretion.
REFERENCE   2  (bases 1 to 3819)
  AUTHORS   Wu,X., Cai,Q., Chen,Y., Zhu,S., Mi,J., Wang,J. and Zhang,M.
  TITLE     Structural Basis for the High-Affinity Interaction between CASK and
            Mint1
  JOURNAL   Structure 28 (6), 664-673 (2020)
   PUBMED   32348748
  REMARK    GeneRIF: Structural Basis for the High-Affinity Interaction between
            CASK and Mint1.
REFERENCE   3  (bases 1 to 3819)
  AUTHORS   Wang,Y., Lin,H., Hao,N., Zhu,Z., Wang,D., Li,Y., Chen,H., Zhu,Y.
            and Han,X.
  TITLE     Forkhead box O1 mediates defects in palmitate-induced insulin
            granule exocytosis by downregulation of
            calcium/calmodulin-dependent serine protein kinase expression in
            INS-1 cells
  JOURNAL   Diabetologia 58 (6), 1272-1281 (2015)
   PUBMED   25796372
  REMARK    GeneRIF: induction of beta cell insulin-secretion defects by fatty
            acids is mediated, at least in part, by FOXO1 via downregulation of
            Cask expression
REFERENCE   4  (bases 1 to 3819)
  AUTHORS   Hu,H.T. and Hsueh,Y.P.
  TITLE     Calcium influx and postsynaptic proteins coordinate the dendritic
            filopodium-spine transition
  JOURNAL   Dev Neurobiol 74 (10), 1011-1029 (2014)
   PUBMED   24753440
REFERENCE   5  (bases 1 to 3819)
  AUTHORS   Liu,L., Sun,T., Liu,Z., Chen,X., Zhao,L., Qu,G. and Li,Q.
  TITLE     Traumatic brain injury dysregulates microRNAs to modulate cell
            signaling in rat hippocampus
  JOURNAL   PLoS One 9 (8), e103948 (2014)
   PUBMED   25089700
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3819)
  AUTHORS   Laverty,H.G. and Wilson,J.B.
  TITLE     Murine CASK is disrupted in a sex-linked cleft palate mouse mutant
  JOURNAL   Genomics 53 (1), 29-41 (1998)
   PUBMED   9787075
REFERENCE   7  (bases 1 to 3819)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
REFERENCE   8  (bases 1 to 3819)
  AUTHORS   Dimitratos,S.D., Stathakis,D.G., Nelson,C.A., Woods,D.F. and
            Bryant,P.J.
  TITLE     The location of human CASK at Xp11.4 identifies this gene as a
            candidate for X-linked optic atrophy
  JOURNAL   Genomics 51 (2), 308-309 (1998)
   PUBMED   9722958
REFERENCE   9  (bases 1 to 3819)
  AUTHORS   Hsueh,Y.P., Yang,F.C., Kharazia,V., Naisbitt,S., Cohen,A.R.,
            Weinberg,R.J. and Sheng,M.
  TITLE     Direct interaction of CASK/LIN-2 and syndecan heparan sulfate
            proteoglycan and their overlapping distribution in neuronal
            synapses
  JOURNAL   J Cell Biol 142 (1), 139-151 (1998)
   PUBMED   9660869
REFERENCE   10 (bases 1 to 3819)
  AUTHORS   Hata,Y., Butz,S. and Sudhof,T.C.
  TITLE     CASK: a novel dlg/PSD95 homolog with an N-terminal
            calmodulin-dependent protein kinase domain identified by
            interaction with neurexins
  JOURNAL   J Neurosci 16 (8), 2488-2494 (1996)
   PUBMED   8786425
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U47110.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_022184.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U47110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3819
                     /gene="Cask"
                     /note="calcium/calmodulin dependent serine protein kinase"
                     /db_xref="GeneID:29647"
                     /db_xref="RGD:62004"
     exon            1..416
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..3087
                     /gene="Cask"
                     /EC_number="2.7.11.1"
                     /function="calmodulin binding protein"
                     /note="calcium/calmodulin-dependent serine protein kinase
                     (MAGUK family); peripheral plasma membrane protein
                     CASK-like"
                     /codon_start=1
                     /product="peripheral plasma membrane protein CASK"
                     /protein_id="NP_071520.1"
                     /db_xref="GeneID:29647"
                     /db_xref="RGD:62004"
                     /translation="MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVD
                     VAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFE
                     IVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKL
                     GGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLP
                     FYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
                     KERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSED
                     PTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINT
                     KSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHHVVAHE
                     VYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMN
                     ELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFK
                     IVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQFEYDPAKDDLIPCKEA
                     GIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQ
                     QASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKN
                     TLITKHPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAM
                     YGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFPPFVVFIAAPTITPGLNEDESLQ
                     RLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY"
     exon            417..529
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            530..635
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            636..713
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            714..786
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            787..889
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1065
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1188
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1272
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1372
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1390
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1512
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1590
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1671
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1860
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1939
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2025
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2094
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2163
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2360
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2476
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2542
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2623
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2826
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2910
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3819
                     /gene="Cask"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcccgcgc gggctgacga gcggagagtg cggtgcttcg cggtccccga gggtccgcac
       61 gccccggcag cgcggccgcc agcaaccgcg cgaggagcag cgggcgggcg ggcggcgccg
      121 ggcccgggcc gccctcgctc ccacgccccg gccccgccgc ccgcgccggg gcggcagccg
      181 gcagaggaaa ggcgctgcag tctccgggcc tcgcggcccc ggtcgagctt cctgagcacc
      241 gagggcttgc gggtcctcag gggaggacac gagcccggag ccgggcactg agctcttggg
      301 cgcccccaac ccagttttca gaaccctcca cgctgcggcc gctgtcccct ccggaccatg
      361 gccgacgacg acgtgctgtt cgaggatgtg tacgagctgt gcgaggtgat cggcaagggt
      421 cccttcagtg ttgtacgacg atgcatcaac agagaaactg gacaacaatt tgctgtaaaa
      481 attgttgacg tagccaagtt cacatcaagt ccagggttaa gtacagaaga tctaaagcgg
      541 gaagccagta tctgtcatat gctgaagcat ccacacattg tagagctgtt ggagacatat
      601 agctcagatg ggatgcttta catggttttt gaatttatgg atggagcaga tctgtgtttt
      661 gaaattgtaa agcgagctga tgctggtttt gtatacagtg aagctgtagc cagtcactac
      721 atgagacaga tactggaagc tctacgctac tgtcatgata ataacataat tcacagggat
      781 gtgaagcccc actgtgttct cctcgcctca aaagaaaatt ctgcacctgt taagcttggg
      841 ggctttgggg tagccatcca gttaggagaa tctggacttg ttgctggagg acgcgttgga
      901 acacctcact ttatggcccc agaagtggtc aagagagagc cttatggaaa gcctgtggat
      961 gtctggggct gcggtgtgat tcttttcatc ctgctcagcg gctgtttgcc tttctacgga
     1021 accaaggaaa gattgtttga aggcattatt aaaggaaaat ataagatgaa tccaaggcag
     1081 tggagccata tctctgaaag tgccaaagac ctagtgcgcc gcatgctgat gctggatcct
     1141 gctgaaagga tcactgttta tgaagcactg aatcacccat ggcttaagga gcgggatcgt
     1201 tatgcctaca aaattcatct tccagaaaca gtagaacaac tgaggaaatt caatgcaagg
     1261 agaaaactaa agggtgcagt actagcggct gtgtcaagtc acaaattcaa ttccttctac
     1321 ggggaccctc ctgaagagtt gccagatttc tccgaagacc ctacctcctc aggacttcta
     1381 gcagcagaaa gagccgtctc tcaggtgctg gacagcctgg aagagattca cgcacttaca
     1441 gactgcagtg aaaaggacct agattttcta cacagtgttt tccaggatca gcatcttcac
     1501 acactgctgg atctgtatga caaaattaac acaaagtctt cgccacaaat caggaatcct
     1561 ccaagcgatg cagtacagag agccaaagag gtattggaag aaatttcatg ttaccctgag
     1621 aataatgacg cgaaggaact aaagcgtatt ttaacacaac ctcatttcat ggccttactt
     1681 cagactcacc acgtagtggc acatgaagtt tacagtgatg aagcattaag ggtcacacct
     1741 ccgccgactt ccccgtattt aaacggtgat tctccagaaa gtgcaaatgg agacatggac
     1801 atggagaatg tgaccagagt tcgcctggta cagtttcaaa agaacacaga tgagccaatg
     1861 ggaatcactt tgaaaatgaa tgagctcaat cattgtattg ttgcgagaat catgcatggc
     1921 gggatgattc acaggcaagg tacacttcat gttggtgatg aaatccgaga aatcaatggc
     1981 atcagtgtcg ctaaccaaac agtggaacag ctacaaaaaa tgcttaggga aatgcgaggg
     2041 agtattacct tcaagattgt gccaagctac cgcactcagt cttcgtcatg tgagagagat
     2101 tccccctcca cttccagaca gtcccctgct aatggtcata gcagcactaa caattctgtt
     2161 tcgatctatg taagagcaca atttgaatat gatccagcca aggatgacct catcccctgc
     2221 aaagaagctg gcatccggtt ccgagttggt gacatcatcc agattattag taaggatgac
     2281 cacaactggt ggcagggtaa actggaaaac tccaaaaacg gaactgcagg tctcattcct
     2341 tctcctgaac ttcaggaatg gcgagtagct tgcattgcca tggagaagac caaacaagag
     2401 cagcaggcca gctgtacttg gtttggcaag aaaaagaagc agtacaaaga taaatatttg
     2461 gcaaagcaca atgcagatct tgtcacgtat gaagaagtag tgaaactgcc agcgttcaaa
     2521 aggaaaacat tagtcttatt aggtgcacat ggtgttggga gaagacacat caaaaacacc
     2581 ctcatcacaa agcacccgga gcgcttcgcg taccccattc cgcatacaac cagacctcca
     2641 aagaaagatg aagaaaatgg caagaattat tactttgtat ctcatgacca aatgatgcaa
     2701 gatatctcaa ataatgaata cttggagtac ggcagccatg aggatgcaat gtatgggaca
     2761 aaactggaga ccattcggaa aatccatgag caggggctga ttgcgattct ggacgtggag
     2821 cctcaggcat tgaaggtcct gagaactgca gagtttcccc cttttgttgt cttcattgcg
     2881 gcgccaacta tcactccagg tttaaatgag gatgaatctc ttcagcgcct gcagaaggag
     2941 tccgatgtct tgcagagaac atatgcacac tacttcgatc tcacaattat caacaatgaa
     3001 attgatgaga caatcagaca tctggaggaa gctgtcgagc ttgtgtgcac agccccacag
     3061 tgggtcccgg tctcctgggt ctattaggct tctctgtggc tatctgagta taaaaccagg
     3121 agccacttcc tatgtggaaa agcctctttg ttatcggcct tgtgtcagca ggtcgtggtc
     3181 cctagagact acctagttgt agtgtgacct acatttataa ttattgtcat gtccgaatag
     3241 ataggaggag aaaatcaatt acacactaat ttaaagagac agtatctttt ttaatcagtt
     3301 ctcctaaact ttaataaaat gtatctttaa atgtatgtat tattcaatcc tttggaatgt
     3361 tatatttttg gaaatcatag ctttttattt ccaaggcccc taaaaactgc acaaaataga
     3421 tgctgctttc tataatctat tttaataata ataaacatga ttctgttacc ttgactgggg
     3481 gtggaacact acattctttt tagagtctga ttttatggat tggaatacct ttctttcctt
     3541 tatttatttg aaatgattag tctagtgatt acaaaacagt cataaatttt taaaggcctt
     3601 ttttctctct ctttttttta agtcctttat gtaacatcca gatactgtga tactgtctct
     3661 ttgaagcacc ctgtaaacct tttagagatt tgaagttggg tcttgactct taatgcatgt
     3721 ggacagtcgc gagcgtttat gctgtcggtg tgtctgtgtt ggacaaaaca atctgtaatt
     3781 acagcgaagt acattccgtt cacggggcat accctgggg
//
