LOCUS       NM_017110                840 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus CART prepropeptide (Cartpt), mRNA.
ACCESSION   NM_017110
VERSION     NM_017110.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 840)
  AUTHORS   Casini,A., Vivacqua,G., Vaccaro,R., Renzi,A., Leone,S.,
            Pannarale,L., Franchitto,A., Onori,P., Mancinelli,R. and Gaudio,E.
  TITLE     Expression and role of cocaine-amphetamine regulated transcript
            (CART) in the proliferation of biliary epithelium
  JOURNAL   Eur J Histochem 67 (4), 3846 (2023)
   PUBMED   37859350
  REMARK    GeneRIF: Expression and role of cocaine-amphetamine regulated
            transcript (CART) in the proliferation of biliary epithelium.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 840)
  AUTHORS   Schuller,J. and Koch,M.
  TITLE     Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats
  JOURNAL   Behav Brain Res 440, 114268 (2023)
   PUBMED   36539163
  REMARK    GeneRIF: Blockade of the orexin 1-receptors and 'cocaine- and
            amphetamine-regulated transcript' in the nucleus accumbens shell
            alters impulse control in rats.
REFERENCE   3  (bases 1 to 840)
  AUTHORS   Samson,W.K., Salvemini,D. and Yosten,G.L.C.
  TITLE     Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise
  JOURNAL   Endocrinology 162 (8) (2021)
   PUBMED   34043767
  REMARK    GeneRIF: Overcoming Stress, Hunger, and Pain: Cocaine- and
            Amphetamine-Regulated Transcript Peptide's Promise.
            Review article
REFERENCE   4  (bases 1 to 840)
  AUTHORS   Drott,C.J., Norman,D. and Espes,D.
  TITLE     CART decreases islet blood flow, but has no effect on total
            pancreatic blood flow and glucose tolerance in anesthetized rats
  JOURNAL   Peptides 135, 170431 (2021)
   PUBMED   33098940
  REMARK    GeneRIF: CART decreases islet blood flow, but has no effect on
            total pancreatic blood flow and glucose tolerance in anesthetized
            rats.
REFERENCE   5  (bases 1 to 840)
  AUTHORS   Walker,L.C., Hand,L.J., Letherby,B., Huckstep,K.L., Campbell,E.J.
            and Lawrence,A.J.
  TITLE     Cocaine and amphetamine regulated transcript (CART) signalling in
            the central nucleus of the amygdala modulates stress-induced
            alcohol seeking
  JOURNAL   Neuropsychopharmacology 46 (2), 325-333 (2021)
   PUBMED   32826981
REFERENCE   6  (bases 1 to 840)
  AUTHORS   Walder,K., Morris,C. and Ravussin,E.
  TITLE     A polymorphism in the gene encoding CART is not associated with
            obesity in Pima Indians
  JOURNAL   Int J Obes Relat Metab Disord 24 (4), 520-521 (2000)
   PUBMED   10805512
REFERENCE   7  (bases 1 to 840)
  AUTHORS   Echwald,S.M., Sorensen,T.I., Andersen,T., Hansen,C., Tommerup,N.
            and Pedersen,O.
  TITLE     Sequence variants in the human cocaine and amphetamine-regulated
            transcript (CART) gene in subjects with early onset obesity
  JOURNAL   Obes Res 7 (6), 532-536 (1999)
   PUBMED   10574510
REFERENCE   8  (bases 1 to 840)
  AUTHORS   Thim,L., Nielsen,P.F., Judge,M.E., Andersen,A.S., Diers,I.,
            Egel-Mitani,M. and Hastrup,S.
  TITLE     Purification and characterisation of a new hypothalamic satiety
            peptide, cocaine and amphetamine regulated transcript (CART),
            produced in yeast
  JOURNAL   FEBS Lett 428 (3), 263-268 (1998)
   PUBMED   9654146
REFERENCE   9  (bases 1 to 840)
  AUTHORS   Kristensen,P., Judge,M.E., Thim,L., Ribel,U., Christjansen,K.N.,
            Wulff,B.S., Clausen,J.T., Jensen,P.B., Madsen,O.D., Vrang,N.,
            Larsen,P.J. and Hastrup,S.
  TITLE     Hypothalamic CART is a new anorectic peptide regulated by leptin
  JOURNAL   Nature 393 (6680), 72-76 (1998)
   PUBMED   9590691
REFERENCE   10 (bases 1 to 840)
  AUTHORS   Douglass,J., McKinzie,A.A. and Couceyro,P.
  TITLE     PCR differential display identifies a rat brain mRNA that is
            transcriptionally regulated by cocaine and amphetamine
  JOURNAL   J Neurosci 15 (3 Pt 2), 2471-2481 (1995)
   PUBMED   7891182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U10071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..840
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="CART prepropeptide"
                     /db_xref="GeneID:29131"
                     /db_xref="RGD:2272"
     exon            1..178
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..409
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /note="cocaine and amphetamine regulated transcript;
                     cocaine- and amphetamine-regulated transcript protein"
                     /codon_start=1
                     /product="cocaine- and amphetamine-regulated transcript
                     protein precursor"
                     /protein_id="NP_058806.1"
                     /db_xref="GeneID:29131"
                     /db_xref="RGD:2272"
                     /translation="MESSRLRLLPVLGAALLLLLPLLGAGAQEDAELQPRALDIYSAV
                     DDASHEKELPRRQLRAPGAVLQIEALQEVLKKLKSKRIPIYEKKYGQVPMCDAGEQCA
                     VRKGARIGKLCDCPRGTSCNSFLLKCL"
     exon            179..301
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
     exon            302..840
                     /gene="Cartpt"
                     /gene_synonym="Cart"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggaag tccagcacca tggagagctc ccgcctgcgg ctgctacccg tcctgggcgc
       61 cgccctactg ctgctgctac ctttgctggg tgccggtgcc caggaggatg ccgagctgca
      121 gccccgagcc ctggacatct actctgccgt ggatgatgcg tcccatgaga aggagctgcc
      181 aaggcggcaa cttcgggctc ccggcgctgt gttgcagatt gaagcgctgc aggaagtcct
      241 gaagaagctc aagagtaaac gcattccgat ctatgagaag aagtacggcc aagtccccat
      301 gtgtgacgct ggagagcagt gcgcagtgcg gaaaggggcc aggatcggga agctgtgtga
      361 ctgtccccga ggaacttctt gcaattcttt cctcttgaag tgcttgtgaa ggggtgacag
      421 cctccttcgg ttcccatatt tcctctttcc cctaaaggag cgctcttttg tccctggagc
      481 cgctttaaca acaataaagt ttgcgttccc cccagagagt ggatgggctc tttccctgct
      541 gcttcaaaat aaaagatttg atgttattgt gtgaaggaca ataccttgaa tggtgttggt
      601 atgtgtgcaa agtattcttc tctcgtttta tccacctgac acattcttgt gacctttctg
      661 ggaagaagag ggactttcgc tttaaaactg tatttttgta tgtggcgggt cacaatgaag
      721 attagaccta gttaattttg gcagatgaca tcataacccg gaaaacaaat caccccaaag
      781 caacacaaat ggaagcatgt gcaaattaca cccaataaag catttttgat aattgctcac
//
