LOCUS       XM_003749031            4058 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus carnosine synthase 1 (Carns1),
            transcript variant X1, mRNA.
ACCESSION   XM_003749031
VERSION     XM_003749031.5
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 3, 2024 this sequence was replaced by
            NM_001427792.1.
            
            On Jan 21, 2021 this sequence version replaced XM_003749031.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4058
                     /gene="Carns1"
                     /note="carnosine synthase 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 12
                     ESTs, 4 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 35 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:309150"
                     /db_xref="RGD:1308234"
     CDS             185..3040
                     /gene="Carns1"
                     /codon_start=1
                     /product="carnosine synthase 1 isoform X1"
                     /protein_id="XP_003749079.1"
                     /db_xref="GeneID:309150"
                     /db_xref="RGD:1308234"
                     /translation="MLCLDPLGTEWDHPLGSKDLDGEEEPWKGGAGLPPTDCFPGPWR
                     QDVSLDCKGSPEEAEARAWTVYYYGLLQSCLQQAGLPETQDRSQAPRTGCPGAEVTLC
                     ILGSPSTFLSLLLEGGVQSPGNMLLCLSPAWLMKVASAGQEGEADLLVSKAVSFYPGG
                     LTFLDDFVPPRHATYFLAGLGPEFGHSKEAAELARHLTCPTGGSSELARLLEDRLLMR
                     WLLSQQSGVAVPATLAFTYRPPGLLRGGDTSPGLRLVELSGKEGQETLVKEEVEAFVH
                     SKALGDASQVAVRLSGWRWRGQQVLPLHLQEEPSTVVNTVLGLLEKLEEEESVLVEAM
                     CPPVRLPLPGSPAPGPELAVRICAVVCRIQGDRPLLSKVVCGVGRGDQPVRHHYTLPR
                     SLGVALAQCGLEEEAQVALLEQGIKEAAEAALAAVLALEAGLSVEQRGGRQVHTDFLG
                     VDFVLTVVGRTLTPVVLKLNSGLCLETCGALEGLWAMPRLRRSAEEAAAAPLVETMLR
                     RSGRHLMDGKQLLVIGAGGVSKKFVWEAAQDYGLKLHLVESDPNHFASQLVQTFIHFD
                     VTEHRRDEENARLLAELVRARNLKLDGCFSFWDDCLVLTALLCRELGLPCSPPAAMCL
                     AKQKSRTQLHLLRCQGPPWPSTSLHAVACCPLESEADVERAIYQVPLPGVMKLEFGSG
                     AVGVQLVKDGPQCHEHFSRILHDLQGEADHPGIGLGWGNAMLLMEFVEGTEHDVDLVV
                     FGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVF
                     NVELKMTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLASAMVACGLQPALPAHPRA
                     RGYLVGIMCLVSQHLQLLSSPGSRETLQALHDQGQLRLNLLEEALIPGQYEEPYCNVA
                     CAGASPAEARHRLLGICQGLGIDRPNYPVAHFLSHFK"
ORIGIN      
        1 cctcgcgtga gtctaagcag ccccgccctg ggcatggcca ggctcactat ataaggacaa
       61 gccactggcc acagtgccgt gcctccaccg ctgcagaact cccttgttct ttgctcacct
      121 gcccgcctgc ctagcctgct ccagttgctg ctaccagcag tctctctgct tctctacctc
      181 caagatgctc tgcctggatc cactgggtac agagtgggac catcccctgg gctccaagga
      241 cctggatgga gaggaagaac catggaaagg aggcgctggt ctgccaccca cagactgctt
      301 ccctgggccc tggcgccagg atgttagcct ggattgcaag ggctccccgg aagaggctga
      361 ggctcgggcc tggactgtgt actactacgg tctccttcag agctgtctgc agcaagctgg
      421 ccttcctgag acccaggatc gcagccaggc acctcgtaca ggctgccctg gggcagaggt
      481 gaccttgtgc attctgggtt cccccagcac cttcctgtct ctgttgctgg agggcggggt
      541 ccagagccct ggaaacatgc tcctttgcct gtcccctgcc tggctgatga aggtggcttc
      601 tgcaggccaa gagggagagg cagacctgtt ggtctccaag gctgtgagct tctatccagg
      661 aggcctgaca ttcctggatg attttgttcc ccctcgccat gccacctact tcctggcagg
      721 cctagggcca gaatttggcc acagcaagga ggcggcagag ctggcccggc atctcacttg
      781 ccccactgga ggctcatcgg agctggcacg gctgctggag gaccggctgc tgatgaggtg
      841 gttgctgtcc cagcagagtg gtgtagctgt gccagctacc ctggctttca cttataggcc
      901 tccagggctg cttcggggag gggataccag ccctggacta cggctggtgg agctcagtgg
      961 gaaggagggc caggaaacac tggtgaaaga ggaagtagag gcctttgtgc actccaaggc
     1021 cttgggtgat gcttcacagg tggctgtgag gctcagtggc tggcgctggc ggggacagca
     1081 ggtattgcct ctgcacctgc aggaagagcc atccacagtg gtgaacacag tgctgggatt
     1141 gctggagaag ctggaggagg aggagagtgt ccttgtggag gccatgtgcc cacctgtccg
     1201 gctgccctta ccagggagtc ctgcacctgg ccctgagctg gctgtgcgta tctgtgcagt
     1261 ggtgtgtcgg attcagggtg ataggcccct actgagtaag gtggtgtgtg gcgtgggccg
     1321 aggggatcaa cccgtgcggc accactatac cctgccgagg tcactggggg tggcgctggc
     1381 ccagtgtggc ctggaagaag aggcacaggt ggcgctactg gagcagggca tcaaagaagc
     1441 agctgaggcc gcgttggccg cagtgctggc cctggaggcc ggactgagtg tggagcagcg
     1501 tggtggacgc caagtgcaca ctgacttcct cggcgtggac ttcgttctca cagtggtcgg
     1561 acgcacgctg actcccgtgg tccttaagct gaatagtggc ctgtgcctag agacatgcgg
     1621 cgcgctcgag ggactgtggg ccatgccacg cctgagacgc tcagctgagg aggcagcagc
     1681 cgcaccgctg gtggagacca tgctgcggcg ctcagggcgc cacctcatgg acggaaagca
     1741 gctgctggtg atcggcgccg gcggcgtcag caagaagttc gtgtgggagg cggcgcagga
     1801 ctacggactg aagctgcact tggtggaatc agaccccaac cactttgcat cccagctggt
     1861 ccagaccttc atccactttg atgtgactga gcaccggagg gatgaggaga atgctcggct
     1921 gctggctgag ctggtacggg cacggaacct gaagctagat ggctgtttct ccttctggga
     1981 tgactgcttg gtgcttactg ctctcctctg tcgtgagctg ggtctgccct gcagcccccc
     2041 agctgccatg tgcttggcaa agcagaagag ccgcacccaa ctgcatctgt tgcgatgcca
     2101 gggcccaccc tggccttcga cttccctcca tgccgtggcc tgctgcccac tggagagcga
     2161 ggctgacgta gagagagcca tttaccaggt acctctgccc ggtgtgatga aactggaatt
     2221 tgggtcagga gccgtaggcg tgcagctggt gaaggatggg ccacagtgcc acgagcactt
     2281 ttcccggatc ctccatgact tgcagggtga ggctgaccac ccaggcattg gactgggctg
     2341 gggcaatgcc atgctactga tggagtttgt ggagggcaca gagcatgacg tggacctggt
     2401 ggtgtttggt ggacggctgc tggctgcttt tgtctctgat aatggcccca caaggctgcc
     2461 tggcttcaca gagactgctg cctgcatgcc cactgggcta gcaccagagc aggaggccca
     2521 gatggtgcag gcagcttttc gctgctgcct gggctgtggg ctgctggatg gggttttcaa
     2581 tgtggagctc aagatgactg gggctgggcc gaggctcatt gagatcaacc ctcgaatggg
     2641 agggttctac cttcgagact ggatcctgga actctatggt gtggatttgc ttttggcttc
     2701 tgcaatggtg gcctgtggcc tgcagcctgc cttgcctgcc caccctcgtg cccgtggcta
     2761 cctagtgggc atcatgtgcc tggtgtccca gcacctacag ctgctgagtt cccctggcag
     2821 tcgagagact ctgcaagctc tccatgacca gggtcaatta cgactcaatc tgctggagga
     2881 ggccctgata cctggccagt atgaggagcc ctattgcaat gtggcttgtg ctggggccag
     2941 ccctgctgag gcccgtcacc gcctgctagg catctgtcag ggcttgggca ttgacaggcc
     3001 caactaccca gttgcccatt tcctgtctca tttcaaatag cactggggtc caggagcagc
     3061 aggcatggag tgctaggagg aaggactgtg gtggtctgtt tccctgttcc tctctgtcac
     3121 tctgccccaa acctggttca gcacactccc atgcctcagg tctattccag aacagtagag
     3181 ccattttgac atcaaagtct tctggattca aggaccataa aacaaggatc tggaatttgc
     3241 tgggtcctct tgccttccag aaagcctcca tctagtccca gctatcccca ggactctagc
     3301 cttaaagaac taacaaatat cagcaccaca ctatcagtgc ccagcccagg tgggaatggt
     3361 agaaccctgg ctcctcctct ttcactcctc caaccttcca ggtctgtctc ttcctgtcac
     3421 ctatgcaagg agagaacctc cgctgacccc tagccttgga caaaggccat gaaatctgag
     3481 attagcacac cagtctttat gcaaagtcca ggacagttgt agagcctgct gaaaatgtct
     3541 ggcagtgctt ccccgtgccc gttggcctga gcagtaaaag caaatgtctg tgatcagcaa
     3601 taggcgtaac catttcccct cacacgttca ggcagaccct agtgccccca tgctacagat
     3661 gaggaagcag gcacagagag gaaaaaaccg actgcctcca aggtcctagc tcagtggatg
     3721 tcaacaggat gcagaggcac cttctctgtt tactgtgtta cgtgctctgt cagcctccag
     3781 gtcctctcca ctttctatct tcattcataa gcagcttcag actcctgaac acctcccttc
     3841 cataacacct ccctcccata taccatgcat gttccccacc agtttgttgc tttggcctct
     3901 ggcatacatc cctagtctgg ccctgggact tctgtgtaca aacctttcct cattctggga
     3961 agctagctac tttgaaaact cctgtctctg cccagtacgg gagccatgga cagctcccaa
     4021 aacatgccta cccaaataaa gacttgtgaa ctagtgaa
//
