LOCUS       NM_001024974            1339 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus carnosine N-methyltransferase 1 (Carnmt1), mRNA.
ACCESSION   NM_001024974 XM_219758
VERSION     NM_001024974.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Cao,R., Zhang,X., Liu,X., Li,Y. and Li,H.
  TITLE     Molecular basis for histidine N1 position-specific methylation by
            CARNMT1
  JOURNAL   Cell Res 28 (4), 494-496 (2018)
   PUBMED   29463897
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Drozak,J., Piecuch,M., Poleszak,O., Kozlowski,P., Chrobok,L.,
            Baelde,H.J. and de Heer,E.
  TITLE     UPF0586 Protein C9orf41 Homolog Is Anserine-producing
            Methyltransferase
  JOURNAL   J Biol Chem 290 (28), 17190-17205 (2015)
   PUBMED   26001783
  REMARK    GeneRIF: UPF0586 is mammalian carnosine N-methyltransferase and
            hypothesize that it may also serve as a peptide or protein
            methyltransferase in eukaryotes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091268.1.
            
            On Jun 25, 2005 this sequence version replaced XM_219758.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091268.1, FQ224897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..1339
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /note="carnosine N-methyltransferase 1"
                     /db_xref="GeneID:293871"
                     /db_xref="RGD:1311863"
     exon            1..225
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1225
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /EC_number="2.1.1.22"
                     /note="UPF0586 protein C9orf41 homolog; anserine-producing
                     methyltransferase"
                     /codon_start=1
                     /product="carnosine N-methyltransferase"
                     /protein_id="NP_001020145.1"
                     /db_xref="GeneID:293871"
                     /db_xref="RGD:1311863"
                     /translation="MQRRRRAPPASQPAQDSGHSEEVEVQFSAGRLGSAAPAGPPVRG
                     TAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPDNQQKLLPQFPLHLDK
                     IRKCVDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDW
                     SGTGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQG
                     NEWSFFMLFSSNFVLNRCSEVDKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPP
                     GSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGP
                     LLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECV
                     LFVVRKPQ"
     exon            226..421
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     exon            422..585
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     exon            586..726
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     exon            727..905
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1019
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1123
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1313
                     /gene="Carnmt1"
                     /gene_synonym="RGD1311863"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgccgtgg gccgcggcgg cgatgcagcg acgacggcgc gctccgcccg cgtctcagcc
       61 ggcccaggac agcgggcaca gcgaggaggt ggaggtgcag ttctccgccg ggcgtttggg
      121 ctcggccgcc cctgccgggc ccccagtgcg cggcaccgcc gaggacgagg agcggctgga
      181 gcgcgagcac ttctggaagg tcattaacgc gttccgctac tacggcacca gtatgcacga
      241 acgagtgaac agaacagaaa gacagtttcg atcacttcca gataatcagc agaaactgct
      301 tcctcagttt cctcttcact tggacaagat ccggaaatgc gttgaccata atcaggaaat
      361 actgctgacc attgtgaatg attgcataca tatgtttgaa aataaagaat atggagaaga
      421 tgccaatgga aagattatgc cagcatctac atttgacatg gataagttaa aatctacact
      481 caaacagttt gtaagagact ggagtggaac cggaaaagca gaaagggatg cctgctataa
      541 gccaatcatt aaagagatta tcaaaaattt tccaaaagag agatgggatc cttctaaagt
      601 aaatattctg gtacctggtg ctggactagg aagattggcc tgggaaatag ctatgctagg
      661 ttatgcttgt caaggaaatg aatggagttt ttttatgctc ttttcttcca actttgtact
      721 caacagatgt tctgaagttg acaaatataa actttatccc tggatccatc agtttagcaa
      781 taatcggaga tcagctgatc agattcgacc catttttttc cctgatgttg acccccacag
      841 tcttcctcct ggttctaact tttcgatgac agcaggagac tttcaggaga tttactcaga
      901 atgcaatacc tgggactgta ttgccacctg tttcttcata gacacagctc acaatgtcat
      961 tgattatatt gatacgatat ggagaatact caagccaggt ggaatttgga taaatcttgg
     1021 tcctctactc taccactttg aaaacctggc aaatgaactg tctatagaat tgagctatga
     1081 ggatattaaa aacgttgttc tgcagtatgg attccagcta gaggtggaga aagaatccgt
     1141 actgtcaaca tatactgtga atgacctctc catgatgaag tactactatg agtgtgtttt
     1201 gtttgtggtc cggaagccac aataatggtc ttaagtggta ttacccagaa aacatttaat
     1261 aagcataaat gctgaaataa acaacttaca gtcaactgtc ggtgacaaca ggaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaa
//
