LOCUS       NM_001030041            3200 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus coactivator-associated arginine methyltransferase
            1 (Carm1), transcript variant 1, mRNA.
ACCESSION   NM_001030041 XM_343356
VERSION     NM_001030041.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Hsieh,M.C., Ho,Y.C., Lai,C.Y., Wang,H.H., Yang,P.S., Cheng,J.K.,
            Chen,G.D., Ng,S.C., Lee,A.S., Tseng,K.W., Lin,T.B. and Peng,H.Y.
  TITLE     Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing
            Pathway as a Strategy for Neuropathic Pain Relief
  JOURNAL   Neurotherapeutics 18 (2), 1295-1315 (2021)
   PUBMED   33415686
  REMARK    GeneRIF: Blocking the Spinal Fbxo3/CARM1/K(+) Channel Epigenetic
            Silencing Pathway as a Strategy for Neuropathic Pain Relief.
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Wang,Y., Ju,C., Hu,J., Huang,K. and Yang,L.
  TITLE     PRMT4 overexpression aggravates cardiac remodeling following
            myocardial infarction by promoting cardiomyocyte apoptosis
  JOURNAL   Biochem Biophys Res Commun 520 (3), 645-650 (2019)
   PUBMED   31627895
  REMARK    GeneRIF: Mechanistically, PRMT4 overexpression promoted
            hypoxia-induced cardiomyocytes apoptosis, while its inhibition
            abolished these effects.
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Lim,C.S. and Alkon,D.L.
  TITLE     Inhibition of coactivator-associated arginine methyltransferase 1
            modulates dendritic arborization and spine maturation of cultured
            hippocampal neurons
  JOURNAL   J Biol Chem 292 (15), 6402-6413 (2017)
   PUBMED   28264928
  REMARK    GeneRIF: These results suggest that CARM1 is a post-synaptic
            protein that plays roles in dendritic maturation and synaptic
            formation and that spatiotemporal regulation of CARM1 activity
            modulates neuronal connectivity and improves synaptic dysfunction.
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Kim,D.I., Park,M.J., Lim,S.K., Choi,J.H., Kim,J.C., Han,H.J.,
            Kundu,T.K., Park,J.I., Yoon,K.C., Park,S.W., Park,J.S., Heo,Y.R.
            and Park,S.H.
  TITLE     High-glucose-induced CARM1 expression regulates apoptosis of human
            retinal pigment epithelial cells via histone 3 arginine 17
            dimethylation: role in diabetic retinopathy
  JOURNAL   Arch Biochem Biophys 560, 36-43 (2014)
   PUBMED   25072916
  REMARK    GeneRIF: high-glucose-induced CARM1 expression increases RPE cell
            apoptosis via H3R17 asymmetric dimethylation
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Kim,D., Lim,S., Park,M., Choi,J., Kim,J., Han,H., Yoon,K., Kim,K.,
            Lim,J. and Park,S.
  TITLE     Ubiquitination-dependent CARM1 degradation facilitates
            Notch1-mediated podocyte apoptosis in diabetic nephropathy
  JOURNAL   Cell Signal 26 (9), 1774-1782 (2014)
   PUBMED   24726896
  REMARK    GeneRIF: The silencing of CARM1 using siRNA increased Notch1
            expression, the transcriptional activity of Hes, and podocyte
            apoptosis.
REFERENCE   6  (bases 1 to 3200)
  AUTHORS   Kim,J.H., Li,H. and Stallcup,M.R.
  TITLE     CoCoA, a nuclear receptor coactivator which acts through an
            N-terminal activation domain of p160 coactivators
  JOURNAL   Mol Cell 12 (6), 1537-1549 (2003)
   PUBMED   14690606
REFERENCE   7  (bases 1 to 3200)
  AUTHORS   Yadav,N., Lee,J., Kim,J., Shen,J., Hu,M.C., Aldaz,C.M. and
            Bedford,M.T.
  TITLE     Specific protein methylation defects and gene expression
            perturbations in coactivator-associated arginine methyltransferase
            1-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (11), 6464-6468 (2003)
   PUBMED   12756295
REFERENCE   8  (bases 1 to 3200)
  AUTHORS   Teyssier,C., Chen,D. and Stallcup,M.R.
  TITLE     Requirement for multiple domains of the protein arginine
            methyltransferase CARM1 in its transcriptional coactivator function
  JOURNAL   J Biol Chem 277 (48), 46066-46072 (2002)
   PUBMED   12351636
REFERENCE   9  (bases 1 to 3200)
  AUTHORS   Schurter,B.T., Koh,S.S., Chen,D., Bunick,G.J., Harp,J.M.,
            Hanson,B.L., Henschen-Edman,A., Mackay,D.R., Stallcup,M.R. and
            Aswad,D.W.
  TITLE     Methylation of histone H3 by coactivator-associated arginine
            methyltransferase 1
  JOURNAL   Biochemistry 40 (19), 5747-5756 (2001)
   PUBMED   11341840
REFERENCE   10 (bases 1 to 3200)
  AUTHORS   Chen,D., Ma,H., Hong,H., Koh,S.S., Huang,S.M., Schurter,B.T.,
            Aswad,D.W. and Stallcup,M.R.
  TITLE     Regulation of transcription by a protein methyltransferase
  JOURNAL   Science 284 (5423), 2174-2177 (1999)
   PUBMED   10381882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001030041.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB201114.1, SRR26360172.912923.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               JAXUCZ010000008.1  28373370-28373669
            301-426             JAXUCZ010000008.1  28396326-28396451
            427-533             JAXUCZ010000008.1  28401179-28401285
            534-638             JAXUCZ010000008.1  28402113-28402217
            639-749             JAXUCZ010000008.1  28406195-28406305
            750-927             JAXUCZ010000008.1  28407129-28407306
            928-1018            JAXUCZ010000008.1  28409911-28410001
            1019-1100           JAXUCZ010000008.1  28410220-28410301
            1101-1186           JAXUCZ010000008.1  28414756-28414841
            1187-1276           JAXUCZ010000008.1  28415031-28415120
            1277-1414           JAXUCZ010000008.1  28415464-28415601
            1415-1504           JAXUCZ010000008.1  28415687-28415776
            1505-1617           JAXUCZ010000008.1  28415849-28415961
            1618-1695           JAXUCZ010000008.1  28416067-28416144
            1696-1764           JAXUCZ010000008.1  28416423-28416491
            1765-3200           JAXUCZ010000008.1  28416621-28418056
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3200
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /note="coactivator-associated arginine methyltransferase
                     1"
                     /db_xref="GeneID:363026"
                     /db_xref="RGD:1305879"
     exon            1..300
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1904
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /EC_number="2.1.1.319"
                     /note="isoform a is encoded by transcript variant 1;
                     histone-arginine methyltransferase CARM1; protein arginine
                     N-methyltransferase 4"
                     /codon_start=1
                     /product="histone-arginine methyltransferase CARM1 isoform
                     a"
                     /protein_id="NP_001025212.1"
                     /db_xref="GeneID:363026"
                     /db_xref="RGD:1305879"
                     /translation="MAAAAATAVGPGAGSAGVAGPGGAGPCATVSVFPGARLLTIGDA
                     NGEIQRHAEQQALRLEVRAGPDAAGIALYSHEDVCVFKCSVSRETECSRVGRQSFIIT
                     LGCNSVLIQFATPHDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQ
                     QNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEAST
                     MAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHA
                     KKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE
                     YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWF
                     DVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYD
                     ISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSS
                     GVAVAGMPTAYDLSSVIAGGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSG
                     AQGGGGSSSAHYAVNNQFTMGGPAISMASPMSIPTNTMHYGS"
     exon            301..426
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            427..533
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            534..638
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            639..749
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            750..927
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1018
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1100
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1186
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1276
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1414
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1504
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1617
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1695
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1764
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..3200
                     /gene="Carm1"
                     /gene_synonym="Prmt4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgg cggcctgggc ccgggtgcgg cggtggcggt ggcggtggtg gcagcggggc
       61 ctggagccgg acctaagatg gcagcggcgg cagcgacggc ggtggggccg ggtgcgggga
      121 gcgctggggt ggcgggcccg ggcggcgcgg ggccctgcgc gacagtgtcg gtgttccccg
      181 gcgcccgcct cctcactatc ggcgacgcga acggcgagat ccagcggcac gcggagcagc
      241 aggcgctgcg cctcgaggtg cgcgccggac cagacgcggc gggcatcgcc ctctacagcc
      301 atgaagatgt gtgtgtgttc aagtgctcag tgtcccgaga gacagagtgc agccgtgtgg
      361 gcaggcagtc cttcatcatc acactgggct gcaacagcgt cctcatccag ttcgccacac
      421 cccacgattt ctgttctttc tacaacatcc tgaaaacctg ccggggccac acactggagc
      481 gctctgtgtt cagtgagcga acagaggagt cctcagctgt gcagtacttc cagttttatg
      541 gctacctgtc ccagcagcag aacatgatgc aggactatgt gcgaacaggc acctaccagc
      601 gtgcaatcct gcagaaccac accgacttca aggacaagat cgttctagat gtgggctgtg
      661 gctctgggat cctgtcattc tttgctgctc aagcaggagc caggaaaatt tacgcagtgg
      721 aagccagcac catggctcag catgccgagg tcctggtgaa gagtaacaat ctgacagacc
      781 gcatcgtggt catccctggc aaagtagagg aggtctcatt gcctgagcaa gtggacatta
      841 tcatctcaga gcccatgggc tacatgctct tcaacgaacg tatgcttgag agctacctcc
      901 atgccaaaaa gtacctgaag cccagcggca acatgttccc caccattggt gatgttcacc
      961 ttgcaccctt cactgatgaa cagctctaca tggaacagtt caccaaagcc aacttctggt
     1021 accagccatc cttccatgga gtggacctgt cagccctccg aggtgccgct gtggatgagt
     1081 acttccggca acctgtggtg gacacatttg acatccggat cctgatggcc aaatctgtca
     1141 agtacacagt gaacttccta gaagccaaag aaggcgattt gcacaggata gaaatcccat
     1201 tcaaattcca catgctgcat tcagggctgg tccacggctt ggccttctgg ttcgatgttg
     1261 ctttcattgg ctccataatg accgtgtggc tctccacagc cccaacagag cccctgaccc
     1321 actggtacca ggtccggtgc ctcttccagt caccgttgtt tgccaaggcc ggggacacgc
     1381 tctcagggac atgtctgctt attgccaaca aaagacagag ctatgacatc agtattgtgg
     1441 cacaggtgga ccagacaggc tccaaatcca gtaacctgct ggatctaaag aaccccttct
     1501 tcaggtacac aggtacaacc ccatcacccc cgcctggctc acactacacg tctccctcgg
     1561 agaatatgtg gaatacggga agcacctaca atctcagcag cggggtggct gtggctggaa
     1621 tgcctactgc ctacgacctg agcagtgtta ttgctggcgg ctccagcgtg ggtcacaaca
     1681 acctgattcc cttagccaac acagggattg tcaatcacac ccactcccgg atgggctcca
     1741 taatgagcac gggcattgtc caaggctcct caggtgccca gggaggcggc ggtagctcca
     1801 gtgcccacta tgcagtcaac aaccagttca ccatgggtgg ccctgccatc tctatggcct
     1861 cgcccatgtc catcccgacc aacaccatgc actatgggag ttaggtgcct ccagccgcga
     1921 cagcactgcg cactgacagc accaggaaac caaatgaagt ccaggcccgg cacagccggt
     1981 ggctgtcccc cttgttctgg agaagcgtga acacccggtc acagccctct ttgctatggg
     2041 aacttggaca cttttgtaca cgatgtcgcc gctgccctca agtaccccca gcccaatctt
     2101 tggtcccgag cgagtgttgc tgccatactt tacatgagat cctgttgggg cagccctcat
     2161 cctgttctgt atctccactc tgacctggct ttgacatctg ctggaagagg caaatcccac
     2221 ccccacccca cagctgcacc tgaccaggca ggaggaggcc agcagctgcc accacagacc
     2281 tggcagcacc caccccacaa cccgtccttg cacctcccct cacctggggt ggcagcacag
     2341 ccagctggac ctctccttca actaccaggc cacatggtca ccatgggcgt gacatgctgc
     2401 tttttttaat tttatttttt tacgaaaaga accagtgtca acccacagac cctctgagaa
     2461 acccggctgg ccgggccaag ccagcagccc tgtccctagg cccagaggtt ctaggtgagg
     2521 ggtggccctg ccgagccttc agggtgggcg aagccccctc ccaccaaagg gttcacctca
     2581 aacttgaatg tacaaaccac ccagctgtcc aaaggcctag cccctgcttt ctgctactgt
     2641 cctgtcctga gccttgaagg tcccctccgt caaaagctgg aacaggcagc tcagagtgag
     2701 taaccctggg ctactgtggc aaacaagaga cctcaaagat ctatcacaag gaaggcattc
     2761 tgtcctgata gctagcatag gcctgtgtgt tccctccaca ttcatgttcc actcaactcc
     2821 tctcaagaca gcatccctgg gaaggggcct agcagggacc tctccccaga cgaaaataaa
     2881 agcaaacaag gaagggtgac taataagcac aggcagtttc cagtctcttc ccctgtcccc
     2941 ttgccctaga gtccccacct taatggccac agctcaagct gggctcctgc ccaccacagg
     3001 taccctctgg caaaggctgg agctgctctg tgccaccctc ctgacctgtc agggaatcaa
     3061 agggccctca ggcgactggg aaaccaggct ctctcctgtc catcagtaat actccctgct
     3121 tggctgcccc tccccacctt tatataaatt ctctggatca cctttgcata gaaaataaaa
     3181 gtgtttgctt tgtaagaaaa
//
