LOCUS       NM_001106915            2781 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium responsive transcription factor (Carf),
            mRNA.
ACCESSION   NM_001106915 XM_001069949 XM_217411
VERSION     NM_001106915.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Zheng,F., Zhou,X., Luo,Y., Xiao,H., Wayman,G. and Wang,H.
  TITLE     Regulation of brain-derived neurotrophic factor exon IV
            transcription through calcium responsive elements in cortical
            neurons
  JOURNAL   PLoS One 6 (12), e28441 (2011)
   PUBMED   22174809
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Hasan,M.K., Yaguchi,T., Sugihara,T., Kumar,P.K., Taira,K.,
            Reddel,R.R., Kaul,S.C. and Wadhwa,R.
  TITLE     CARF is a novel protein that cooperates with mouse p19ARF (human
            p14ARF) in activating p53
  JOURNAL   J Biol Chem 277 (40), 37765-37770 (2002)
   PUBMED   12154087
REFERENCE   3  (bases 1 to 2781)
  AUTHORS   Tao,X., West,A.E., Chen,W.G., Corfas,G. and Greenberg,M.E.
  TITLE     A calcium-responsive transcription factor, CaRF, that regulates
            neuronal activity-dependent expression of BDNF
  JOURNAL   Neuron 33 (3), 383-395 (2002)
   PUBMED   11832226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217411.4, XM_001069949.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760384, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2781
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="calcium responsive transcription factor"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
     exon            1..62
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            63..221
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            222..336
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            337..451
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            452..574
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            575..635
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            636..702
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             678..2441
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /note="amyotrophic lateral sclerosis 2 (juvenile)
                     chromosome region, candidate 8; calcium-response factor;
                     amyotrophic lateral sclerosis 2 chromosomal region
                     candidate gene 8 protein"
                     /codon_start=1
                     /product="calcium-responsive transcription factor"
                     /protein_id="NP_001100385.1"
                     /db_xref="GeneID:301446"
                     /db_xref="RGD:1306822"
                     /translation="MLASSQMTSVSEEKPIGGSLPAVSTDALEDSASSYSLHSQASLV
                     GPRKSGTRTLEEPLLAPLQPLSCNTPMWACRLRSCEKIGDSYRGYCVSETELESVLTF
                     HKQQTQTVWGTRQSPSPAKPATRLMWKSQYVPYDGIPFVNAGSRAVVMECQYGPRRKG
                     FQLKKISEQESRSCHLYKATCPARIYIKKVQKFPDYRVPTDPQIDRKTIRMEQEKAFT
                     MLKKNLVDAGGVLRWYVQLPTQQAHQYHEPETPGVPLSPSPFPMSPLEEEEAIIRDEN
                     CVLPSRLHPQVAHKIQELVSQGVGQVYAVRKQLRKFVERELFKPDEVPERHNLSFFPT
                     VNDIKNHIHEVQKSLQTGDVVYNSEIIPATLQWTTDSGNILRETVTVTFAEGNLLKEP
                     ITSKMGTSQTQTSLSPEPLPLLSPLSSFQPKIFTHLQALKLQPRLSSPDGSQALVSVN
                     SHPSSSPPGLDTAGNAEANNHSLLLGQSQNLGTDTCLPENSSTASPMGSLPESVQNLV
                     AVDQLVGGEDAEDAGNLEGNVKRTLLGDAHTIPIHILDSHPALVEEDTLSMNQVKQEP
                     NEPTLSTEAKTLLDCKNVSAT"
     exon            703..832
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            833..917
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1107
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1228
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1372
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1606
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1769
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1833
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1964
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2331
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2781
                     /gene="Carf"
                     /gene_synonym="Als2cr8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggagagtt gcgcctgcgc attgtggtgg tctccacggc ggggcctcgg agccaagacg
       61 agaacatgct acagtgaaga cagagtcaca gcttccatac aaataagctg gcctgcttag
      121 aattcagtgc tccaagggaa gaccaccaat gaatgccaga aaaggcattt ctgaggcaaa
      181 ataacaggaa tctggacttg aacttgagcc actgcctgga ggtatggtga gaccaacaga
      241 cgaagagacg attgccattg ggaagacagc ccatttttca cagttctcga aaggagtggg
      301 catgctgtac caccaagtgc caacaataac accaagccat tagccaatca gagaaaatgg
      361 gactgactga gaagccagca tggagccacg tcactcagta ggaggcacct gtggtgatgg
      421 tgagacagaa agagacaccc caggactcga gaatatacca gagacactga ctgacacaca
      481 ggcccttcat gaagagcaat ttcatctttt ggaccaaaat gggcagccta ttcaatatga
      541 ccttcagtct ttgggaaatt ctactgcaca aatgacaggg atggagcaag tggttatacc
      601 tcaggagtcg tttgcagacg tgtgtagtcc tccaggttat ctgtctattt cattttggga
      661 ttttatgaag ctggctgatg cttgcttcct cccaaatgac cagtgtctct gaagagaagc
      721 ccattggtgg gagtttgcca gctgtaagca cagatgctct agaagacagc gccagtagct
      781 acagtcttca ctcacaagca tccctcgtgg gacccagaaa gtcagggacc agaactcttg
      841 aagaaccttt gctggcccct ctccagccac tttcttgtaa cacacccatg tgggcctgcc
      901 gtcttaggag ttgtgagaaa attggagatt cctaccgtgg ctactgtgta agtgagactg
      961 aattagaaag cgtcctaact tttcacaagc agcaaacaca gactgtctgg ggcactcgcc
     1021 aatctccaag cccagccaaa cctgccacac gcttgatgtg gaagtctcag tatgtcccct
     1081 atgacggcat cccgtttgtc aatgcaggaa gtcgagctgt tgtaatggag tgtcagtatg
     1141 gaccaaggag aaaaggtttt cagttaaaaa aaatcagcga gcaagaaagt aggtcttgtc
     1201 atctctacaa agctacttgt ccagccagga tatacattaa aaaggtacag aaatttcctg
     1261 actatagagt acctactgac ccccagattg ataggaagac aatccggatg gagcaggaga
     1321 aagccttcac tatgctgaag aagaacctgg tggacgcggg cggtgtcctt cggtggtatg
     1381 tgcagttacc tacgcagcaa gctcaccagt atcatgaacc agagactccc ggtgtccctt
     1441 tgtcaccgtc acctttccct atgtctcctc ttgaggaaga ggaggctata atcagagatg
     1501 agaactgtgt gttgccctct cgtctccacc cgcaagtagc gcataagatc caggagttag
     1561 tgtcccaggg agtggggcaa gtgtatgcag tgaggaagca gctaagaaaa tttgtggaaa
     1621 gagaactgtt caaacctgat gaggtacctg aaagacataa tttatctttt tttccaactg
     1681 taaatgatat caaaaatcat atccacgagg tacagaaatc cttgcagact ggagatgtgg
     1741 tatataactc agagattatt ccagcaacgc ttcagtggac tacagatagt ggaaatatcc
     1801 tcagagagac tgtaacagtt acatttgcag aaggaaattt actaaaagag ccgattacca
     1861 gcaaaatggg gacaagtcag acacaaactt ctttgtctcc agaaccactt cccttgctct
     1921 ccccactttc ttcatttcag cccaaaatat ttacacattt acaggctttg aagttgcagc
     1981 caagactctc ctctcctgat ggatcccagg ctttggtgtc agtaaatagc catccatcct
     2041 ccagtccccc cggccttgat acggcaggaa atgctgaagc caataaccac tctctactgc
     2101 ttggccagag tcaaaacctt ggaacagaca cttgcctacc cgagaacagc agcacggcct
     2161 ctcccatggg cagtcttccg gagtcagttc agaacctagt tgcagtggat cagctggtgg
     2221 gaggtgagga tgctgaggat gctgggaatc tggaaggaaa tgtaaagagg actctgttgg
     2281 gagatgcaca caccattcca atacacatcc tagacagcca tccagctctt gttgaagaag
     2341 atactctgtc catgaaccaa gttaaacaag aacccaatga gccaacactg tctacagaag
     2401 caaagacttt gctggactgt aaaaacgtgt ctgctacata aatatttcaa gtttttcaga
     2461 atttacagat ctggcccctt ctgatgtctt agaaggtgaa gattgtcagg gcatggtata
     2521 tcactggacc agagtggatg atgggcagtt ttgacttaaa attcaaatat ttgttgcaaa
     2581 ttctatattt gtatttccct taagaaatat tttactttat tttgtattcc tacaattttt
     2641 ttattattca gtaaggcaag tattttaaaa gatcatctat ctgaagttat acatagtaat
     2701 ttagtgtgaa cgtaaatagt tatatccagt tttggttctt acaagacaga aaagaccaac
     2761 aataaagcag tatgtgagtg c
//
