LOCUS       NM_022303               1971 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus caspase recruitment domain family, member 9
            (Card9), mRNA.
ACCESSION   NM_022303 XM_346649
VERSION     NM_022303.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Wang,J., Tian,J., He,Y.H., Yang,Z.W., Wang,L., Lai,Y.X. and Xu,P.
  TITLE     Role of CARD9 in inflammatory signal pathway of peritoneal
            macrophages in severe acute pancreatitis
  JOURNAL   J Cell Mol Med 24 (17), 9774-9785 (2020)
   PUBMED   32790017
  REMARK    GeneRIF: Role of CARD9 in inflammatory signal pathway of peritoneal
            macrophages in severe acute pancreatitis.
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Li,Y., Liang,P., Jiang,B., Tang,Y., Liu,X., Liu,M., Sun,H.,
            Chen,C., Hao,H., Liu,Z. and Xiao,X.
  TITLE     CARD9 promotes autophagy in cardiomyocytes in myocardial
            ischemia/reperfusion injury via interacting with Rubicon directly
  JOURNAL   Basic Res Cardiol 115 (3), 29 (2020)
   PUBMED   32248306
  REMARK    GeneRIF: CARD9 promotes autophagy in cardiomyocytes in myocardial
            ischemia/reperfusion injury via interacting with Rubicon directly.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Li,Y., Liang,P., Jiang,B., Tang,Y., Lv,Q., Hao,H., Liu,Z. and
            Xiao,X.
  TITLE     CARD9 inhibits mitochondria-dependent apoptosis of cardiomyocytes
            under oxidative stress via interacting with Apaf-1
  JOURNAL   Free Radic Biol Med 141, 172-181 (2019)
   PUBMED   31212066
  REMARK    GeneRIF: CARD9 protects cardiomyocytes from apoptosis by
            interacting with Apaf-1 and interfering with apoptosome formation
            following myocardial ischemia/reperfusion injury in vivo and in
            vitro
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Yang,Z.W., Meng,X.X., Zhang,C. and Xu,P.
  TITLE     CARD9 gene silencing with siRNA protects rats against severe acute
            pancreatitis: CARD9-dependent NF-kappaB and P38MAPKs pathway
  JOURNAL   J Cell Mol Med 21 (6), 1085-1093 (2017)
   PUBMED   27957800
  REMARK    GeneRIF: siRNAs showed that the reduction of CARD9 in severe acute
            pancreatitis (SAP)rats down-regulated the expression of
            NF-kappaBp65 and P38MAPK which are involved in the transcription
            and release of a wide variety of inflammatory cytokines
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Gringhuis,S.I., Kaptein,T.M., Wevers,B.A., Theelen,B., van der
            Vlist,M., Boekhout,T. and Geijtenbeek,T.B.
  TITLE     Dectin-1 is an extracellular pathogen sensor for the induction and
            processing of IL-1beta via a noncanonical caspase-8 inflammasome
  JOURNAL   Nat Immunol 13 (3), 246-254 (2012)
   PUBMED   22267217
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Hsu,Y.M., Zhang,Y., You,Y., Wang,D., Li,H., Duramad,O., Qin,X.F.,
            Dong,C. and Lin,X.
  TITLE     The adaptor protein CARD9 is required for innate immune responses
            to intracellular pathogens
  JOURNAL   Nat Immunol 8 (2), 198-205 (2007)
   PUBMED   17187069
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Gross,O., Gewies,A., Finger,K., Schafer,M., Sparwasser,T.,
            Peschel,C., Forster,I. and Ruland,J.
  TITLE     Card9 controls a non-TLR signalling pathway for innate anti-fungal
            immunity
  JOURNAL   Nature 442 (7103), 651-656 (2006)
   PUBMED   16862125
REFERENCE   9  (bases 1 to 1971)
  AUTHORS   Bertin,J., Guo,Y., Wang,L., Srinivasula,S.M., Jacobson,M.D.,
            Poyet,J.L., Merriam,S., Du,M.Q., Dyer,M.J., Robison,K.E.,
            DiStefano,P.S. and Alnemri,E.S.
  TITLE     CARD9 is a novel caspase recruitment domain-containing protein that
            interacts with BCL10/CLAP and activates NF-kappa B
  JOURNAL   J Biol Chem 275 (52), 41082-41086 (2000)
   PUBMED   11053425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022303.4.
            
            On Feb 10, 2021 this sequence version replaced NM_022303.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF311288.1, SRR8487230.96235.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JACYVU010000115.1  2636913-2637131     c
            220-415             JACYVU010000115.1  2635633-2635828     c
            416-553             JACYVU010000115.1  2635111-2635248     c
            554-858             JACYVU010000115.1  2634021-2634325     c
            859-1038            JACYVU010000115.1  2633774-2633953     c
            1039-1182           JACYVU010000115.1  2633495-2633638     c
            1183-1308           JACYVU010000115.1  2633102-2633227     c
            1309-1500           JACYVU010000115.1  2631760-2631951     c
            1501-1542           JACYVU010000115.1  2631255-2631296     c
            1543-1591           JACYVU010000115.1  2630796-2630844     c
            1592-1665           JACYVU010000115.1  2629445-2629518     c
            1666-1742           JACYVU010000115.1  2628949-2629025     c
            1743-1971           JACYVU010000115.1  2628635-2628863     c
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1971
                     /gene="Card9"
                     /note="caspase recruitment domain family, member 9"
                     /db_xref="GeneID:64171"
                     /db_xref="RGD:708370"
     exon            1..219
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            220..415
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1842
                     /gene="Card9"
                     /function="binds to Bcl10/CLAP and activates NF-kB"
                     /note="rCARD9; caspase recruitment domain protein 9"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 9"
                     /protein_id="NP_071639.1"
                     /db_xref="GeneID:64171"
                     /db_xref="RGD:708370"
                     /translation="MSDYENDDECWSALESFRVKLISVIDPSRITPYLRQCKVLNPDD
                     EEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARV
                     FSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQER
                     VQRLKEECELSSAELKRCKDENYDLAMRLAHLSEEKGAALMRNRDLQLEVDQLRHSLM
                     KAEDDCKVERKHTLKLRHAMEQRPSQELLWDLQQERDLLQARVQELEVSVQEGKLHRN
                     SPYIQVLEEDWRQALQEHQEQASTIFSLRKDLRQAEALRTRCMEEKEMFELQCLALRK
                     DAKMYKDRIEAILQQMEEVSIERDQAMTSREELHAQCAQSFQDKDKLRKQVRELDEKA
                     DELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDAQL
                     SDKGVLADRESPEQPFVVLNKKHLSQTHDTVPSSSEPPEKERRRLKESFENYRRKRAL
                     RKMQNSWRQGEGDHGNTTGSDNTDTEGS"
     exon            416..553
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            554..858
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1038
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1182
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1308
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1500
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1542
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1591
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1665
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1742
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1971
                     /gene="Card9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagaaggta gaccagcagg gactgccccc cccccccctc ccagggagga ctggctggct
       61 tgtggcagca accagaacac atcaggaagt gcacagcctc cctcatggct ccacccttct
      121 ccagttaggg agcatctcca cactcccaga ggctcgctcc tggagtgccc atagcccagg
      181 cagcatccag ctggcaggtg gctcccacag gaccctgagc ctacagagga catgtcagac
      241 tatgaaaatg acgacgagtg ctggagtgcc ctggagagct tccgggtgaa gctaatctct
      301 gtcattgacc cctcacgaat cacaccctat ctgcgccagt gcaaagtcct gaaccccgat
      361 gatgaggagc aggtgctcag tgaccccaac ctggtcatcc gcaagcggaa agtgggtgtg
      421 ctcctggaca tcctgcagcg gacaggccac aagggctacg tggcctttct tgagagtctg
      481 gaactctact accctcagtt atacaggaaa gtcactggca aggagccagc gcgtgtcttc
      541 tccatgatca tcgacgcatc aggggagtcg ggcctgacgc agctgctgat gacagaggtc
      601 atgaagctgc agaagaaggt tcaggacctg acggcccttc tgagctccaa ggatgacttc
      661 atcaaggagc tgagggtaaa ggacagcctc ctgcgcaagc accaggagcg ggtgcagcgg
      721 ctcaaggagg agtgtgagct gagcagtgcc gagctgaagc gctgcaagga tgagaactac
      781 gacctggcca tgcgcctggc tcacctgagt gaagagaagg gagcagcact catgcggaac
      841 cgtgacctgc agcttgaggt ggaccagctc aggcacagcc tcatgaaggc agaggatgac
      901 tgcaaggtgg agcgcaaaca cacactgaag ctccggcacg ccatggagca gcggcctagc
      961 caggagctgc tgtgggacct gcagcaggag agggacttgt tgcaggcccg ggtgcaggag
     1021 ctggaggtct ccgtgcagga gggtaagcta cacaggaata gcccatacat ccaggtgctg
     1081 gaggaggact ggcgtcaggc actgcaggaa caccaggagc aggccagcac catcttctcc
     1141 ctacgaaagg acctccgcca ggctgaggcc ctccggaccc ggtgcatgga ggaaaaggag
     1201 atgttcgagc tgcagtgcct ggccttgcgc aaggatgcca agatgtacaa ggaccggatc
     1261 gaggctatcc tgcagcagat ggaggaagtc tccattgagc gggaccaggc tatgacctca
     1321 agggaagagc tgcatgcaca gtgtgcccaa agctttcagg acaaagataa gctgcgaaag
     1381 caggttcgag aactggatga gaaggccgac gagttgcagc tgcagctgtt ccagaccgag
     1441 agccgattac tggccgctga gggcagactc aagcagcagc aattggacat gctcatcctg
     1501 agctctgact tggaagacag ttcccccagg aactcccagg agctttcact gcctcaggac
     1561 ctggaggagg atgcccagct ctcagacaaa ggtgtcctgg cagacaggga gagcccagag
     1621 cagcccttcg tggttctgaa caagaagcat ctttcgcaga cccatgacac ggtgcccagc
     1681 agcagcgagc ccccggagaa ggagcggcgg cgcctcaagg agagcttcga gaactaccgc
     1741 aggaagcggg cgctccgcaa gatgcagaac agctggcgac agggagaagg ggatcacggg
     1801 aatacgacag gcagcgacaa caccgacacc gagggctcct agaggaccac gccgaggctg
     1861 agcgtctgtg taattgtgaa gggatgctgc gggttttttt actgtacgct acacatacgt
     1921 tgtacaagta ttagaaaaaa atgcagccta ataaaatgac ctctgagctg a
//
