LOCUS       NM_001419863            4187 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus caspase recruitment domain family, member 11
            (Card11), mRNA.
ACCESSION   NM_001419863 XM_039089958
VERSION     NM_001419863.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4187)
  AUTHORS   Ma,C.A., Stinson,J.R., Zhang,Y., Abbott,J.K., Weinreich,M.A.,
            Hauk,P.J., Reynolds,P.R., Lyons,J.J., Nelson,C.G., Ruffo,E.,
            Dorjbal,B., Glauzy,S., Yamakawa,N., Arjunaraja,S., Voss,K.,
            Stoddard,J., Niemela,J., Zhang,Y., Rosenzweig,S.D., McElwee,J.J.,
            DiMaggio,T., Matthews,H.F., Jones,N., Stone,K.D., Palma,A.,
            Oleastro,M., Prieto,E., Bernasconi,A.R., Dubra,G., Danielian,S.,
            Zaiat,J., Marti,M.A., Kim,B., Cooper,M.A., Romberg,N., Meffre,E.,
            Gelfand,E.W., Snow,A.L. and Milner,J.D.
  TITLE     Germline hypomorphic CARD11 mutations in severe atopic disease
  JOURNAL   Nat Genet 49 (8), 1192-1201 (2017)
   PUBMED   28628108
  REMARK    Erratum:[Nat Genet. 2017 Oct 27;49(11):1661. PMID: 29074947]
REFERENCE   2  (bases 1 to 4187)
  AUTHORS   Ma,Y., Liao,Z., Xu,Y., Zhong,Z., Wang,X., Zhang,F., Chen,S.,
            Yang,L., Luo,G., Huang,X., Huang,S., Wu,X. and Li,Y.
  TITLE     Characteristics of CARMA1-BCL10-MALT1-A20-NF-kappaB expression in T
            cell-acute lymphocytic leukemia
  JOURNAL   Eur J Med Res 19 (1), 62 (2014)
   PUBMED   25384343
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4187)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 4187)
  AUTHORS   Snow,A.L., Xiao,W., Stinson,J.R., Lu,W., Chaigne-Delalande,B.,
            Zheng,L., Pittaluga,S., Matthews,H.F., Schmitz,R., Jhavar,S.,
            Kuchen,S., Kardava,L., Wang,W., Lamborn,I.T., Jing,H., Raffeld,M.,
            Moir,S., Fleisher,T.A., Staudt,L.M., Su,H.C. and Lenardo,M.J.
  TITLE     Congenital B cell lymphocytosis explained by novel germline CARD11
            mutations
  JOURNAL   J Exp Med 209 (12), 2247-2261 (2012)
   PUBMED   23129749
REFERENCE   5  (bases 1 to 4187)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 4187)
  AUTHORS   Egawa,T., Albrecht,B., Favier,B., Sunshine,M.J., Mirchandani,K.,
            O'Brien,W., Thome,M. and Littman,D.R.
  TITLE     Requirement for CARMA1 in antigen receptor-induced NF-kappa B
            activation and lymphocyte proliferation
  JOURNAL   Curr Biol 13 (14), 1252-1258 (2003)
   PUBMED   12867038
REFERENCE   7  (bases 1 to 4187)
  AUTHORS   Hara,H., Wada,T., Bakal,C., Kozieradzki,I., Suzuki,S., Suzuki,N.,
            Nghiem,M., Griffiths,E.K., Krawczyk,C., Bauer,B., D'Acquisto,F.,
            Ghosh,S., Yeh,W.C., Baier,G., Rottapel,R. and Penninger,J.M.
  TITLE     The MAGUK family protein CARD11 is essential for lymphocyte
            activation
  JOURNAL   Immunity 18 (6), 763-775 (2003)
   PUBMED   12818158
REFERENCE   8  (bases 1 to 4187)
  AUTHORS   Pomerantz,J.L., Denny,E.M. and Baltimore,D.
  TITLE     CARD11 mediates factor-specific activation of NF-kappaB by the T
            cell receptor complex
  JOURNAL   EMBO J 21 (19), 5184-5194 (2002)
   PUBMED   12356734
REFERENCE   9  (bases 1 to 4187)
  AUTHORS   Gaide,O., Favier,B., Legler,D.F., Bonnet,D., Brissoni,B.,
            Valitutti,S., Bron,C., Tschopp,J. and Thome,M.
  TITLE     CARMA1 is a critical lipid raft-associated regulator of TCR-induced
            NF-kappa B activation
  JOURNAL   Nat Immunol 3 (9), 836-843 (2002)
   PUBMED   12154360
REFERENCE   10 (bases 1 to 4187)
  AUTHORS   Bertin,J., Wang,L., Guo,Y., Jacobson,M.D., Poyet,J.L.,
            Srinivasula,S.M., Merriam,S., DiStefano,P.S. and Alnemri,E.S.
  TITLE     CARD11 and CARD14 are novel caspase recruitment domain
            (CARD)/membrane-associated guanylate kinase (MAGUK) family members
            that interact with BCL10 and activate NF-kappa B
  JOURNAL   J Biol Chem 276 (15), 11877-11882 (2001)
   PUBMED   11278692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 20, 2023 this sequence version replaced XM_039089958.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1046884.1,
                                           SRR26643292.47165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000012.1  18735088-18735339
            253-390             JAXUCZ010000012.1  18808265-18808402
            391-603             JAXUCZ010000012.1  18830163-18830375
            604-741             JAXUCZ010000012.1  18834443-18834580
            742-1067            JAXUCZ010000012.1  18836193-18836518
            1068-1247           JAXUCZ010000012.1  18839951-18840130
            1248-1400           JAXUCZ010000012.1  18841823-18841975
            1401-1526           JAXUCZ010000012.1  18843165-18843290
            1527-1724           JAXUCZ010000012.1  18845319-18845516
            1725-1901           JAXUCZ010000012.1  18848027-18848203
            1902-1953           JAXUCZ010000012.1  18849875-18849926
            1954-2036           JAXUCZ010000012.1  18852016-18852098
            2037-2137           JAXUCZ010000012.1  18853010-18853110
            2138-2190           JAXUCZ010000012.1  18853907-18853959
            2191-2323           JAXUCZ010000012.1  18856187-18856319
            2324-2525           JAXUCZ010000012.1  18857213-18857414
            2526-2652           JAXUCZ010000012.1  18857599-18857725
            2653-2893           JAXUCZ010000012.1  18859467-18859707
            2894-2990           JAXUCZ010000012.1  18860890-18860986
            2991-3086           JAXUCZ010000012.1  18861833-18861928
            3087-3222           JAXUCZ010000012.1  18863477-18863612
            3223-3402           JAXUCZ010000012.1  18865892-18866071
            3403-3527           JAXUCZ010000012.1  18867836-18867960
            3528-3643           JAXUCZ010000012.1  18870732-18870847
            3644-4187           JAXUCZ010000012.1  18871502-18872045
FEATURES             Location/Qualifiers
     source          1..4187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..4187
                     /gene="Card11"
                     /note="caspase recruitment domain family, member 11"
                     /db_xref="GeneID:100363332"
                     /db_xref="RGD:2323211"
     exon            1..252
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            253..390
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..3848
                     /gene="Card11"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein
                     11"
                     /protein_id="NP_001406792.1"
                     /db_xref="GeneID:100363332"
                     /db_xref="RGD:2323211"
                     /translation="MPGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTP
                     YLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPEL
                     YKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLE
                     DEKKQLNLIRVELLTFQERYYKMKEERDSHNDELVKVKDDNYNLAMRYAQLSEEKNMA
                     VMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEML
                     KTKIQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNKIYNLQEEVRQAE
                     ELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQ
                     YSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDSGSLDQSLP
                     RHLPATIISQSLGDTSPRTNGQEADDSSTSEESPEDSKYFLPYHPPRRRMNLKGIQLQ
                     RAKSPISMKQASEFQVKGHEEDFTDGSPSSSRSLPVTSSFSKMQPHRSRSSIMSITAE
                     PPGNDSIVRRCKEDAPHRSTVEEDNDSCGFDVLDLDDENHERYSFGPPSIHSSSSSHQ
                     SEGLDAYDLEQVNLMFRKFSLERPFRPSVTSGGHVRGTSPLVQHTTLNGDGLITQLTL
                     LGGNAHGSFIHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVPLDACTKEEARWTI
                     QRCSGPVTLHYKVNHEGYRRLLKEMEDGLITSGDSFYIRLNLNISSQLDACSMSLKCD
                     DVVHVLDTMYQDRHEWLCARVDPFTDQDLDMGTIPSYSRAQQLLLVKLQRLVHRGTRE
                     EADSAHHTLRSLRNTLQPEEPLSASDPRVSPRLSRASFFFGQLLQFVSRSENKYKRMN
                     SNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPENELSRNLTLIPYSLVRAFHCE
                     RRRPVLFTPTMLAKTLVQKLLNSGGAMEFTICKSDIVTRDEYLRKQKTETIIYSREKN
                     PNTFECIVPANIEAVAAKNKHCLLEAGISCVRDLIKCKVYPIVLLIRVSEKNIKRFRK
                     LLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEELLRVLKDKIVEEQRKT
                     IWVDEDQL"
     exon            391..603
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            604..741
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1067
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1247
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1400
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1526
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1724
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1901
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1953
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2036
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2137
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2190
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2323
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2525
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2652
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2893
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2990
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3086
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3222
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3402
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3527
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3643
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..4187
                     /gene="Card11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacacttt ctctctgtct cttccctctc tctcttcctt ctctctctct ctctcccacc
       61 cacttctctc tccctgcttt gagttctctg atctctggac tcctggcacc tggcacccct
      121 acaggtctcc aaggcctagg gagggcggca gcctcgggca ggtgcatgct ggagaccaga
      181 gcccagggct ggaggaagtt ggcggccagc gtggaggaag caccctgagc ctgtggagca
      241 tgaatacccc agattctgcc cagattcact ccagatccaa catcagactg gcccaaagga
      301 ggacagcggg cagccagaaa gtgtgacggt cacatctgga taacagttcc acgtctcttg
      361 tttatagagc accaaccgac cgtatgccag gaggagggcc agctatggat gactacatgg
      421 agacgctgaa ggatgaagag gaagccctgt gggataacgt ggaatgcaat cggcacatgc
      481 tgagccgcta catcaacccc gccaagctca ccccctacct gcgccagtgc aaggtcatcg
      541 acgagcaaga tgaagacgag gtgctcaatg cgcccatgct gccgtccaag atcaaccggg
      601 caggccgatt gttggacatt cttcacacca agggacaaag gggctatgtg gtcttcctgg
      661 aaagcctgga gttttactac ccagaacttt acaagctggt gactggaaag gaacccaccc
      721 gaagattctc caccattgtg gtggaggaag gccatgaggg cctcacgcac ttcctgatga
      781 atgaggtcat caaactgcag cagcaggtga aagccaagga ccttcagcgc tgtgagctgc
      841 tggccaagtc ccggcagctg gaggatgaga agaagcaact gaacctgata cgggtggagc
      901 tcctaacctt ccaggaacgg tactacaaga tgaaggaaga gcgggacagc cacaacgatg
      961 agctggtcaa ggtcaaggac gacaactaca acttagccat gcgctacgcc cagctcagtg
     1021 aggagaaaaa catggcggtg atgaggagcc gcgatctcca actcgagatc gaccaactca
     1081 aacaccgact gaacaaaatg gaggaggaat gcaaactaga gagaaatcag tccctcaagc
     1141 tcaagaatga cattgagaat cggcccaaga aggagcaggt cctggaactg gagcgggaga
     1201 atgagatgct gaagaccaaa atccaggagc tgcagtccat catccaggct ggcaagcgca
     1261 gcctccctga ctcagacaag gccatcttgg acatcctgga acacgaccgg aaggaggcgc
     1321 tagaggaccg gcaggaactg gtcaacaaaa tttacaacct acaagaggaa gtccgccagg
     1381 ctgaggagct gcgggacaag tacctggaag agaaggaaga cctggagctc aagtgctcaa
     1441 ccctggggaa ggactgtgaa atgtacaagc accgcatgaa cacagttatg ctgcagctgg
     1501 aggaggtgga gcgggagcga gaccaggcct tccactcccg cgatgaggca cagactcagt
     1561 actcacagtg cttaatcgag aaggacaagt accggaagca gatccgtgag ctggaggaga
     1621 agaatgatga gatgcgtatc gagatggtgc ggagggaggc ctgcattgtc aacctggaga
     1681 gcaagctccg gcgcctgtct aaggacagcg gcagtctcga ccagagtctg cctagacacc
     1741 ttccagccac catcatctca cagagccttg gagacaccag ccccaggacc aatggccaag
     1801 aagctgatga ttcttcaacc tcagaagagt ctccggaaga cagcaagtac tttctgccct
     1861 accatccacc ccggcgccgg atgaacctaa aaggcatcca gctgcagaga gccaaatccc
     1921 ccatcagcat gaagcaagca tctgagtttc aagtcaaggg gcacgaagag gatttcacag
     1981 acggcagccc cagttcctcc cgctccctgc ctgtcaccag ctctttctcc aagatgcaac
     2041 cccatcggag ccgcagcagt atcatgtcaa tcaccgcaga gcccccggga aatgactcca
     2101 tagtcagacg ctgcaaggaa gacgcgccac atcgtagcac ggtggaagaa gacaacgata
     2161 gctgtgggtt tgatgtctta gaccttgacg atgaaaatca cgaacgttac tcctttggac
     2221 cgccctccat ccactcctcc tcctcctctc accagtcaga aggactggat gcctacgacc
     2281 tggagcaggt caacctcatg ttccggaagt tctctttaga aaggcccttc cggccatcag
     2341 tcacatctgg gggtcacgtg aggggcacca gccccttggt gcagcacaca actctgaatg
     2401 gcgatggact catcacccag ctcaccctgc tgggcggcaa tgcacacgga agcttcattc
     2461 actctgtgaa gcctggctcg ttggctgaga aggccggact tcgtgagggc caccaactcc
     2521 tgctgttgga aggttgcatc cgaggcgaaa ggcagagcgt tccactggat gcgtgcacca
     2581 aggaagaggc ccgttggacc atccagaggt gcagtggccc cgtcaccctg cactacaagg
     2641 tcaaccatga aggataccgg aggctgctga aggagatgga ggatggtctg atcacgtcag
     2701 gggactcttt ctatatccgc ctgaacctga acatctccag ccagctggat gcctgctcca
     2761 tgtccctgaa gtgtgatgat gtggtgcatg tcctagatac catgtaccag gacaggcatg
     2821 aatggctgtg tgcacgagtc gaccccttca cggaccaaga cctagacatg ggcaccatcc
     2881 ccagctacag ccgagctcaa cagcttctcc tggtgaagct ccagcgactg gttcacagag
     2941 gcactcggga agaggcagac agcgctcacc acaccctgcg tagcctccgg aacaccctgc
     3001 agccggaaga gccgctttcg gccagcgacc cccgggtcag tccccgcctc tccagagcaa
     3061 gtttcttctt cggtcagctc ctgcagtttg tcagtcggtc agaaaacaag tacaaaagaa
     3121 tgaacagcaa tgagcgcgtg agaatcatct ctgggagtcc cctggggagc ctctcccggt
     3181 cctcgctgga tgccaccaaa ctcctgaccg agaagcatga agaactggac cctgagaacg
     3241 agctcagccg gaacctcacc ctgatcccct acagcctggt gcgcgccttc cactgcgagc
     3301 gccgcaggcc tgtgctgttc acgcccacca tgctggccaa gacgctggtg cagaagctgc
     3361 tcaactcagg gggtgccatg gagttcacca tctgcaagtc agatattgtc acaagagatg
     3421 agtacctccg gaaacagaag acggagacca tcatctactc ccgagaaaag aaccccaaca
     3481 cctttgagtg catcgtccct gccaacattg aggctgtggc agccaagaat aaacactgcc
     3541 tgctggaggc cgggatcagc tgcgtgcgcg acctgatcaa gtgcaaggtg taccccatag
     3601 tgctgctcat ccgggtgagc gagaagaaca tcaaacggtt caggaagctg ctaccaaggc
     3661 cagagacaga agaggaattc ctgcgtgtgt gcaggctcaa agagaaggag ctggaggctc
     3721 tgccctgcct ctacgccacg gtggaagctg aaatgtggag cagcgtggag gagctgctgc
     3781 gcgtcctcaa agacaagatt gtggaggaac agcgcaagac catctgggtg gacgaggacc
     3841 agctgtgagc atgtctgagt ctgaccagca ggacacaggc acgcagggct cctgagcctc
     3901 tggcaacaaa gttgccagaa gccacctggt ggaaggtcag actctgctga tgtgaaccga
     3961 gaggagcagt cacagagcct ggggcccaag gctctccgag cagcatttga atgtaaaccc
     4021 cacgggacag ggactggtga cgacctacag gcctccaaca gccatagtgg ctcctagccc
     4081 tagaggaagc gcaaagcaca cgccccaggc aggctgggtc tagggagaca ggactcctac
     4141 tactcgcagt tctttttctt gcattaaaat gtctccagtt ctccatc
//
