LOCUS       NM_001130554            3124 bp    mRNA    linear   ROD 19-FEB-2025
DEFINITION  Rattus norvegicus caspase recruitment domain family, member 10
            (Card10), transcript variant 2, mRNA.
ACCESSION   NM_001130554 XM_001076142 XM_243622
VERSION     NM_001130554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3124)
  AUTHORS   Rau,C.S., Yang,J.C., Chen,Y.C., Wu,C.J., Lu,T.H., Tzeng,S.L.,
            Wu,Y.C. and Hsieh,C.H.
  TITLE     Lipopolysaccharide-induced microRNA-146a targets CARD10 and
            regulates angiogenesis in human umbilical vein endothelial cells
  JOURNAL   Toxicol Sci 140 (2), 315-326 (2014)
   PUBMED   24863965
REFERENCE   2  (bases 1 to 3124)
  AUTHORS   Wang,L., Guo,Y., Huang,W.J., Ke,X., Poyet,J.L., Manji,G.A.,
            Merriam,S., Glucksmann,M.A., DiStefano,P.S., Alnemri,E.S. and
            Bertin,J.
  TITLE     Card10 is a novel caspase recruitment domain/membrane-associated
            guanylate kinase family member that interacts with BCL10 and
            activates NF-kappa B
  JOURNAL   J Biol Chem 276 (24), 21405-21409 (2001)
   PUBMED   11259443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_243622.4, XM_001076142.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3124
                     /gene="Card10"
                     /note="caspase recruitment domain family, member 10"
                     /db_xref="GeneID:315120"
                     /db_xref="RGD:1304949"
     exon            1..41
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            42..293
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..3124
                     /gene="Card10"
                     /note="isoform 1 is encoded by transcript variant 2;
                     caspase recruitment domain-containing protein 10"
                     /codon_start=1
                     /product="caspase recruitment domain-containing protein 10
                     isoform 1"
                     /protein_id="NP_001124026.1"
                     /db_xref="GeneID:315120"
                     /db_xref="RGD:1304949"
                     /translation="MQGRADAAEADEEAGAGSGSEAEEDALWERIEGVRHRLTRALNP
                     AKLTPYLRQCRVLDEQDEEEVLSTYRFPCRANRTGRLIDILRCRGKRGFEAFLEALEF
                     YYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLHREQQLQAR
                     GRALEEERAGLEQRLREQQAAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSE
                     EKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRGRGPPPGAEEKEKEPDGVDLLSE
                     LRAENQRLTASLQELQEGLQQEMSRPGAAGSERILLDILEHDWREAQDSRQELCQKLH
                     AVQGELQWAEELRDKYLQEMEDLRLKHRTLLKDCDLYKHRMATVLAQLEEIEKERDQA
                     IQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTVTSLEGTKAMLEAQLQRTQG
                     GSSLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGETGGSEPHTSEEATDSEKEIN
                     RLSILPFPPSAGSILRRQREEDPEPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSV
                     WPLGKPEGLLARGCGLDFLNRSLAIRVSGWSPSGGLDPQDKSPDSLPILGDRWSGAVV
                     RRVLSGPGSARTEQKEPRAEGSGLEGTGLEAEVQQRTLPWNQSSTLPFLLDSKACQSF
                     HEALDVWAKGPGAEPFYIRANFSLPERADPHALCVKAQEILRLVDPAYKRRQEWFCTR
                     VDTLTLRDLDRGTVPNYQRAQQLLEVQEKYLISSRHRSPRSNLKKRALGLVRPKPAGG
                     TAGDSAEQLPADPCSELERSLKPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPS
                     SRLDFQVCSAESLSGEEQCTSSAPGAPKAWPASAGLGSRIRAIQESVGKKHCLLELGA
                     RGVRELVHSEVYPIVIHVEVTEKNVREIRSLLGRPGWRDSELLRQCRGSEQWLWGLPC
                     SWVQVPAHAWGHAEELAKVVRGRILQEQARLVWVERGSSRGGSGSSSEA"
     exon            294..431
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            432..757
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            758..949
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1105
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1231
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1423
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1549
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1665
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1694
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1818
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1978
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2090
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2334
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2404
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2498
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2657
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2773
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2886
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3124
                     /gene="Card10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaccgag cccggagccc agggcagctg cagcgcccgt gactccgagg acgcggccat
       61 gcagggccgg gcggacgcgg ccgaggccga cgaggaggct ggggcgggct ccgggtcgga
      121 ggccgaagag gacgcgctat gggagcggat cgagggcgtc cggcaccggc tgacccgcgc
      181 cctgaacccg gccaagctca cgccttatct gcgccagtgc cgcgtcttgg acgagcaaga
      241 cgaggaggag gtgctcagca cctaccgttt tccgtgccgc gctaaccgta ccgggcgtct
      301 catagacatt ttacgctgcc ggggcaagag gggcttcgag gccttcctgg aagcgctgga
      361 attctactac ccagaacact tcacgctgct cactggccag gaacctgccc agcgctgctc
      421 catgatactt gatgaggagg ggccagaggg cctgactcag ttcttgatga ctgaagtccg
      481 gaggcttcgg gaagctcgaa agagccagct gcaccgagaa cagcaactgc aggcccgggg
      541 ccgggcactg gaggaggagc gggcagggtt agagcagcgg cttcgggagc agcaggcggc
      601 acaggaacgc tgccagcggc tgagggagga ctgggaggcg ggcagcctgg agctgctgcg
      661 cctcaaggat gagaactaca tgattgccat gcgcctggct cagctcagcg aggagaagaa
      721 ctcggctgtg ctgcgtagcc gagacctgca gcttgcggta gatcagctca agctcaaagt
      781 cagccgattg gaggaagagt gtgcgctact gaggaggggc aggggcccac cgcctggggc
      841 tgaagagaag gagaaggagc cagacggtgt ggatcttctc tcagagcttc gggcagagaa
      901 ccagcgactg acagcttcac tgcaggagct ccaggaaggt cttcagcagg aaatgagccg
      961 gccaggagct gcaggctctg aacgcattct gctggacatc ctggagcatg actggaggga
     1021 ggcacaggac agcaggcagg agctgtgtca gaagcttcac gctgtgcagg gcgagctaca
     1081 gtgggcagaa gaactgcggg acaagtacct gcaggagatg gaggatctga ggctcaaaca
     1141 tcgaacgctg ctgaaggact gtgacctcta taagcaccgc atggccactg tgttggccca
     1201 gctggaggag attgagaaag agcgggacca ggcaatccag agccgagacc ggatccagtt
     1261 gcagtactct cagagcctca ttgagaagga tcagtaccgc aagcaggtgc ggggactaga
     1321 ggcggaacgc gatgagctgc tcaccacagt caccagcctg gaggggacca aggccatgct
     1381 ggaggcacag ctacagcgga cacagggggg ttccagtctc aaggcttgtg cctcctccca
     1441 ctccctgtgc tccaacctca gcagcacctg gagcctcagc gagttcccat caccactggg
     1501 aggcccagaa gctacaggag aaaccggggg atctgagccc cacacctcgg aggaagccac
     1561 agacagtgag aaggagatca accggctctc tatcctgccc tttccaccca gtgctggctc
     1621 catactccgc cggcagcgtg aggaagaccc ggagccccct aagaggtctt ttagcagcat
     1681 gtcggatatc acagggagtg tgacccttaa gccctggtcg cccggcctct cttcatcatc
     1741 gtcatctgac agtgtgtggc ctttgggaaa gccggaaggc ctcctggccc ggggttgtgg
     1801 cctggacttc ctcaataggt ctctggccat ccgagtgtcc ggctggagtc cctctggggg
     1861 cctggacccc caggataaga gtccagatag cctgccgatc cttggggaca gatggtctgg
     1921 ggcagtggtg cgaagggtgt tgtcggggcc tggttccgcc aggacagaac agaaagagcc
     1981 aagggcagaa ggcagtggcc tggaggggac aggcctggaa gctgaggtcc agcagaggac
     2041 tttaccttgg aaccagagct ccaccctccc cttcctgctg gactcaaagg cctgtcagtc
     2101 cttccatgag gccttggatg tctgggcaaa agggccaggt gcagaaccct tctacattcg
     2161 agccaacttc tccttgcctg agcgggcaga tccgcatgcc ctctgtgtga aagcccaaga
     2221 gatcctgcgg ttggtggacc cagcctacaa gcggaggcag gagtggttct gcactcgagt
     2281 ggacaccctt accttacggg acctggaccg gggcactgtg cccaattatc agagagctca
     2341 gcaacttcta gaagtccagg aaaaatacct gatctccagc agacaccgaa gtcctcgaag
     2401 caatctgaag aagcgagccc tggggctggt gaggcccaag cctgcagggg gcactgcagg
     2461 agactcagcg gaacagctac ctgcagaccc ctgctcagag ctagagcgaa gcctaaaacc
     2521 ctacagcctg gtgcggccac tgttggtgtc tgctctgagg cctgtggtgc tcctgcctga
     2581 gtgcctggca cctcgcctta tccgcaatct gctggatctg cccagctcca ggctggattt
     2641 ccaagtgtgc tctgcggaaa gtctctctgg agaggagcag tgtacatcct cggctcccgg
     2701 agcccccaaa gcctggcctg ccagtgctgg gctgggtagc aggatccgtg ccatccagga
     2761 gtctgttggg aagaagcact gtctgctgga gctgggtgca cggggagtac gggagttggt
     2821 gcacagcgag gtctacccca ttgtcatcca tgtggaggtg actgagaaga atgtccgtga
     2881 gatcaggagc ctgttgggca ggccaggctg gcgggattca gagctgctcc gtcagtgccg
     2941 gggctcagaa cagtggctct ggggactgcc gtgttcctgg gtgcaggtgc ctgcccatgc
     3001 gtggggccat gcagaggagc tggccaaggt ggttcgtggc cgaatcttgc aggaacaggc
     3061 tcgccttgtg tgggtggaac gaggcagcag cagagggggc agtggcagca gcagtgaggc
     3121 ctga
//
