LOCUS       NM_001107956            2073 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus carbonic anhydrase 9 (Car9), mRNA.
ACCESSION   NM_001107956 XM_001069821 XM_233380
VERSION     NM_001107956.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2073)
  AUTHORS   Lee JY, Stevens RP, Kash M, Alexeyev MF, Balczon R, Zhou C, Renema
            P, Koloteva A, Kozhukhar N, Pastukh V, Gwin MS, Voth S, deWeever A,
            Wagener BM, Pittet JF, Eslaamizaad Y, Siddiqui W, Nawaz T, Clarke
            C, Fouty BW, Audia JP, Alvarez DF and Stevens T.
  TITLE     Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial
            Cell Survival during Infection
  JOURNAL   Am J Respir Cell Mol Biol 65 (6), 630-645 (2021)
   PUBMED   34251286
  REMARK    GeneRIF: Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary
            Endothelial Cell Survival during Infection.
REFERENCE   2  (bases 1 to 2073)
  AUTHORS   Nolly MB, Vargas LA, Correa MV, Lofeudo JM, Pinilla AO, Rueda JOV,
            Guerrero-Gimenez ME, Swenson ER, Damiani MT and Alvarez BV.
  TITLE     Carbonic anhydrase IX and hypoxia-inducible factor 1 attenuate
            cardiac dysfunction after myocardial infarction
  JOURNAL   Pflugers Arch 473 (8), 1273-1285 (2021)
   PUBMED   34231059
  REMARK    GeneRIF: Carbonic anhydrase IX and hypoxia-inducible factor 1
            attenuate cardiac dysfunction after myocardial infarction.
REFERENCE   3  (bases 1 to 2073)
  AUTHORS   Fan M, Wang J, Wang S, Li T, Pan H, Liu H, Xu H, Zhernakova DV,
            O'Brien SJ, Feng Z, Chang L, Dai E, Lu J, Xi H, Yu Y, Zhang J, Wang
            B and Zeng Z.
  TITLE     New Gene Variants Associated with the Risk of Chronic HBV Infection
  JOURNAL   Virol Sin 35 (4), 378-387 (2020)
   PUBMED   32297155
REFERENCE   4  (bases 1 to 2073)
  AUTHORS   Lee JY, Alexeyev M, Kozhukhar N, Pastukh V, White R and Stevens T.
  TITLE     Carbonic anhydrase IX is a critical determinant of pulmonary
            microvascular endothelial cell pH regulation and angiogenesis
            during acidosis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 315 (1), L41-L51 (2018)
   PUBMED   29631360
  REMARK    GeneRIF: CA IX may contribute to lung vascular repair during acute
            lung injury that is accompanied by acidosis within the
            microenvironment.
REFERENCE   5  (bases 1 to 2073)
  AUTHORS   Kuchuk O, Tuccitto A, Citterio D, Huber V, Camisaschi C, Milione M,
            Vergani B, Villa A, Alison MR, Carradori S, Supuran CT, Rivoltini
            L, Castelli C and Mazzaferro V.
  TITLE     pH regulators to target the tumor immune microenvironment in human
            hepatocellular carcinoma
  JOURNAL   Oncoimmunology 7 (7), e1445452 (2018)
   PUBMED   29900055
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2073)
  AUTHORS   Zavada J, Zavadova Z, Zat'ovicova M, Hyrsl L and Kawaciuk I.
  TITLE     Soluble form of carbonic anhydrase IX (CA IX) in the serum and
            urine of renal carcinoma patients
  JOURNAL   Br J Cancer 89 (6), 1067-1071 (2003)
   PUBMED   12966427
REFERENCE   7  (bases 1 to 2073)
  AUTHORS   Shimizu K, Uemura H, Yoshikawa M, Yoshida K, Hirao Y, Iwashima K,
            Saga S and Yoshikawa K.
  TITLE     Induction of antigen specific cellular immunity by vaccination with
            peptides from MN/CA IX in renal cell carcinoma
  JOURNAL   Oncol Rep 10 (5), 1307-1311 (2003)
   PUBMED   12883698
REFERENCE   8  (bases 1 to 2073)
  AUTHORS   Chrastina A, Pastorekova S and Pastorek J.
  TITLE     Immunotargeting of human cervical carcinoma xenograft expressing CA
            IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody
  JOURNAL   Neoplasma 50 (1), 13-21 (2003)
   PUBMED   12687273
REFERENCE   9  (bases 1 to 2073)
  AUTHORS   Cho M, Uemura H, Kim SC, Kawada Y, Yoshida K, Hirao Y, Konishi N,
            Saga S and Yoshikawa K.
  TITLE     Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9
            expression in human renal cell carcinoma
  JOURNAL   Br J Cancer 85 (4), 563-567 (2001)
   PUBMED   11506497
REFERENCE   10 (bases 1 to 2073)
  AUTHORS   Pastorekova S, Parkkila S, Parkkila AK, Opavsky R, Zelnik V,
            Saarnio J and Pastorek J.
  TITLE     Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary
            DNA sequence and expression in human and rat alimentary tracts
  JOURNAL   Gastroenterology 112 (2), 398-408 (1997)
   PUBMED   9024293
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233380.4, XM_001069821.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF187254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2073
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /note="carbonic anhydrase 9"
                     /db_xref="GeneID:313495"
                     /db_xref="RGD:1306426"
     exon            1..389
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1363
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /EC_number="4.2.1.1"
                     /note="carbonic anhydrase IX"
                     /codon_start=1
                     /product="carbonic anhydrase 9 precursor"
                     /protein_id="NP_001101426.1"
                     /db_xref="GeneID:313495"
                     /db_xref="RGD:1306426"
                     /translation="MASLGLSPWVPLLTPAPTVQLLLLLLLLVSAHPQSLSGMQGVPS
                     LGESSSGEDDLGVEDLPSEEDTPGEADPPGGEDPPEVNSKARKEDSLALEDLPTPEAP
                     ENRQGSHRDEKGGGHSLWSYGGTLLWPQVSPACAGRFQSPVDIRLELTSFCRTLQPLE
                     LLGYELQSLPELSLCNNGHTVQLTLPPGLKMVLGPGQEYRALQLHLHWGTSDHPGSEH
                     TVNGHRFPAEIHVVHLSTAFSELHEALGRPGGLAVLAAFLQESPEENSAYEQLLSHLE
                     EIAEEGSKIEIPGLDVSALLPSDLSRYYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQ
                     LHTLSVSLWGLRDSRLQLNFRATQPLNGRTIEASFPAVADSSPEPVHVNSCLSAGDIL
                     ALVFGLLFAATSIAFLLQLRRQHRHRSGTKDGVTYSPAEMTETGA"
     exon            390..419
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            420..590
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            591..733
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            734..826
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            827..893
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1051
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1187
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1214
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1296
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2073
                     /gene="Car9"
                     /gene_synonym="Ca9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacgtacag cccgtccaca ccgtgtcctg ggacacccca gtcagctgca tggcttccct
       61 gggcctgagc ccctgggtcc ctttgttgac cccagcccct actgtgcagc tgctgctgtt
      121 actgctgctc ctagtgtccg ctcatcccca gagcctgtcc gggatgcagg gggtgccctc
      181 cttgggagaa agttcatctg gggaggatga tctgggcgtg gaggatctgc ccagcgaaga
      241 ggatacacct ggagaggcgg atccacccgg tggggaggat ccacctgaag ttaattctaa
      301 agccagaaag gaggattccc tcgccttaga ggacctaccg actcctgagg ctcctgagaa
      361 caggcaaggt tcccacaggg atgaaaaagg gggtggccac agtctttgga gctatggagg
      421 caccctactc tggccccagg tgtccccagc ctgtgctggc cgctttcagt cccctgtgga
      481 cattcgtctg gagctcacct cattctgccg cactctgcaa cccctggaac tactgggtta
      541 tgagctccag tctctcccgg aactgagcct gtgcaacaat ggccacactg tacagctgac
      601 tctgccgccc gggctgaaga tggttctggg acctgggcag gaataccggg ccctgcagtt
      661 gcatctacac tggggaactt cagatcaccc aggctcagaa cacacagtca atggccaccg
      721 gttccctgct gagatccatg tggttcacct cagtacagcc ttctcagaac ttcatgaagc
      781 cttgggacgc ccaggaggcc tggcggtttt ggctgccttt ctgcaggaga gtccagaaga
      841 aaacagtgcc tacgaacagt tgctgtccca cttggaagaa atcgcagagg aaggctccaa
      901 gattgagatc ccaggtttgg atgtatctgc actgttgccc tcggacctca gtcgctacta
      961 ccgatatgaa gggtctctga ccacacctcc ctgcagccag ggtgtcatct ggactgtgtt
     1021 caatgagaca gtgaagctga gtgctaagca gctccatacg ctctccgttt ccctgtgggg
     1081 acttcgtgat tctcgactac aactgaactt ccgagccaca caacctttga atgggcgaac
     1141 gattgaggct tccttccctg ctgtagcgga cagcagccct gagccagttc atgtgaattc
     1201 ctgcctctct gctggtgaca tcctagcctt ggtgtttggc cttctctttg ctgccaccag
     1261 catcgccttc ctcctacagc tgaggaggca gcacaggcac agaagtggga ccaaagatgg
     1321 agttacctac agccctgcgg aaatgacaga aactggggcc taatgaggag aagccagcta
     1381 aaggagtctg ggaaccttta tacagcggct tctccgtaac cacgtaacca cgaagaactc
     1441 atttccatct tttttttttt tttctttttt ttctggagct ggggaccgaa cccagggcct
     1501 cgagcttgct aagcaagtgc tctaccgctg agctaaatcc ccaacccctc atttccatct
     1561 ttttaacttt cttcctttcc ttaaacgatg gcgataagaa cttaacagtg aaaacagcca
     1621 agattggact caattctcac tgggttttga ggatttttta agacagagtt tttccgtgta
     1681 gccctggctg tcctcaaact cactctgtag cctaggctgg ctttgaactt gcctgtgcct
     1741 tcttagtgct gggatagagg gtatctacca ctaccaccac cccacaactc ttgctcttac
     1801 tatgctctac cactgaggca tacacacccc ttgatcttaa ctgtggagtc aggctggcct
     1861 tgaactgtgt gtgtctagtg gtggagtttg aacccagggt cttgttccta ctagacaagt
     1921 gctctatcac tgacctaaac ttccagtccc ttccctagag ccctattctc ctgtcccagc
     1981 ctcttgaatg ctgggattac gggcatgcgt catcatgcct ggctcatccc aattatttaa
     2041 agaaatatat atatataaat cttcctaata aaa
//
