LOCUS       NM_001134841            1375 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 6 (Car6), mRNA.
ACCESSION   NM_001134841 XM_216584
VERSION     NM_001134841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Reibring,C.G., El Shahawy,M., Hallberg,K., Kannius-Janson,M.,
            Nilsson,J., Parkkila,S., Sly,W.S., Waheed,A., Linde,A. and
            Gritli-Linde,A.
  TITLE     Expression patterns and subcellular localization of carbonic
            anhydrases are developmentally regulated during tooth formation
  JOURNAL   PLoS One 9 (5), e96007 (2014)
   PUBMED   24789143
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Morzel,M., Chabanet,C., Schwartz,C., Lucchi,G., Ducoroy,P. and
            Nicklaus,S.
  TITLE     Salivary protein profiles are linked to bitter taste acceptance in
            infants
  JOURNAL   Eur J Pediatr 173 (5), 575-582 (2014)
   PUBMED   24248522
REFERENCE   3  (bases 1 to 1375)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1375)
  AUTHORS   Smith,C.E., Nanci,A. and Moffatt,P.
  TITLE     Evidence by signal peptide trap technology for the expression of
            carbonic anhydrase 6 in rat incisor enamel organs
  JOURNAL   Eur J Oral Sci 114 Suppl 1, 147-53 (2006)
   PUBMED   16674677
REFERENCE   5  (bases 1 to 1375)
  AUTHORS   Moffatt,P., Smith,C.E., Sooknanan,R., St-Arnaud,R. and Nanci,A.
  TITLE     Identification of secreted and membrane proteins in the rat incisor
            enamel organ using a signal-trap screening approach
  JOURNAL   Eur J Oral Sci 114 Suppl 1, 139-46 (2006)
   PUBMED   16674676
REFERENCE   6  (bases 1 to 1375)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 1375)
  AUTHORS   Karhumaa,P., Leinonen,J., Parkkila,S., Kaunisto,K., Tapanainen,J.
            and Rajaniemi,H.
  TITLE     The identification of secreted carbonic anhydrase VI as a
            constitutive glycoprotein of human and rat milk
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11604-11608 (2001)
   PUBMED   11553764
REFERENCE   8  (bases 1 to 1375)
  AUTHORS   Leinonen,J., Parkkila,S., Kaunisto,K., Koivunen,P. and Rajaniemi,H.
  TITLE     Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and
            rat lingual serous von Ebner's glands
  JOURNAL   J Histochem Cytochem 49 (5), 657-662 (2001)
   PUBMED   11304804
REFERENCE   9  (bases 1 to 1375)
  AUTHORS   Sok,J., Wang,X.Z., Batchvarova,N., Kuroda,M., Harding,H. and Ron,D.
  TITLE     CHOP-Dependent stress-inducible expression of a novel form of
            carbonic anhydrase VI
  JOURNAL   Mol Cell Biol 19 (1), 495-504 (1999)
   PUBMED   9858573
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 9, 2008 this sequence version replaced XM_216584.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.926141.1,
                                           SRR23984936.385423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418988 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000005.1  165959468-165959566 c
            100-282             JAXUCZ010000005.1  165956614-165956796 c
            283-431             JAXUCZ010000005.1  165953565-165953713 c
            432-524             JAXUCZ010000005.1  165952154-165952246 c
            525-594             JAXUCZ010000005.1  165948361-165948430 c
            595-752             JAXUCZ010000005.1  165946652-165946809 c
            753-876             JAXUCZ010000005.1  165944986-165945109 c
            877-1375            JAXUCZ010000005.1  165941029-165941527 c
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1375
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /note="carbonic anhydrase 6"
                     /db_xref="GeneID:298657"
                     /db_xref="RGD:70516"
     exon            1..99
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..965
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /EC_number="4.2.1.1"
                     /note="carbonic anhydrase VI; gustin"
                     /codon_start=1
                     /product="carbonic anhydrase 6 precursor"
                     /protein_id="NP_001128313.1"
                     /db_xref="GeneID:298657"
                     /db_xref="RGD:70516"
                     /translation="MRVLVSVVSLFFLGIQALSEWSYSGDDGLEESRWPEKYPSCGGE
                     RQSPIDVKRREVHFSSSLLPLHMVNYEEEGLELSMTNNGHTVQITLPNTMSMRDSDGT
                     VYRTKQMHFHWGGRDSEISGSEHTIDGMRHAIEIHLVHFNEKYETYEKAVDQPDGLAV
                     MAVLVKVEDYTENDYYSTFISELENVKYTGQTTTLRNVNIRNMLPGDIRHYYTYQGSL
                     TTPPCTENVKWFVFQDSATISKAQAERIENAVMDHHNQTIRNGYRRTQPLHNRVVEAN
                     FPYSPDEVSKNHFYMHEKISHGLKLKKIKKKRNHSH"
     exon            100..282
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     exon            283..431
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     exon            432..524
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     exon            525..594
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     exon            595..752
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     exon            753..876
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1375
                     /gene="Car6"
                     /gene_synonym="Ca6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcattcag ggctacagca tctgccatga gggttctggt gagcgtggtg tccttgttct
       61 tcctgggcat ccaggccctc agtgagtgga gctactcagg ggatgacggc ctggaagaga
      121 gtcggtggcc tgagaagtac ccttcctgcg gcggggaaag gcagtcgccc atcgatgtga
      181 agaggaggga ggtgcacttc agtagctcct tgttgcccct gcacatggtc aactatgagg
      241 aggaggggct ggagctctct atgactaaca acggacacac agtacagatc accctgccga
      301 acaccatgtc catgagagac tctgacggca ctgtgtacag gacaaagcag atgcactttc
      361 actggggcgg tcgggactca gaaatcagtg gctctgagca caccatcgat gggatgaggc
      421 acgccataga gattcacctt gttcacttca acgagaagta cgagacctac gagaaagccg
      481 tggaccaacc agacggcttg gcggtgatgg cggtcttggt taaggttgag gattacacag
      541 aaaacgatta ctacagcacc ttcatttctg agctggaaaa cgtcaagtat acaggacaaa
      601 ccacgacact gagaaacgtt aacatccgga acatgttgcc cggggacatc agacactact
      661 acacctacca aggctcgctc accactcccc cctgcacgga gaacgtcaag tggtttgtgt
      721 ttcaggattc cgccaccatc tccaaggccc aggctgagag aatagagaat gcggtaatgg
      781 atcaccacaa ccagaccatt cgaaatggtt accgcaggac gcagcccctc cacaacaggg
      841 tggtggaagc caatttccca tactccccgg atgaagtctc taagaaccac ttttacatgc
      901 acgagaagat ttcacacggt ttgaaactaa agaaaattaa gaagaagaga aaccacagcc
      961 attgaaccgg aaatgagaca cagacaccaa gggctcaccc tgcccctttg ctaaggaatc
     1021 ctggaatgtg ggtctccttg caacctgcag caaggagatc tctgactaac ccagagggag
     1081 ttctcatccc tgagaggaag tggagctgcg tcagccagaa gagaagggat gtgggtgaga
     1141 ccgaatggac ttggatggat gtacaaggaa tcagaccttc cataatcccc tgtcaatcat
     1201 ccacctaaat ttggggtctg cggatgcagc tcatggtaga gaccttgtca tgacattgag
     1261 tttgatcccc ggcaccagaa aaaaaagaaa atctttcact ttgatctacg ttataaatca
     1321 ccccgaacct ccctttttaa tgtaataaag tgattttgga gattttcatt tttaa
//
