LOCUS       NM_019293               1260 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 5A (Car5a), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_019293
VERSION     NM_019293.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Lehtonen,J., Shen,B., Vihinen,M., Casini,A., Scozzafava,A.,
            Supuran,C.T., Parkkila,A.K., Saarnio,J., Kivela,A.J., Waheed,A.,
            Sly,W.S. and Parkkila,S.
  TITLE     Characterization of CA XIII, a novel member of the carbonic
            anhydrase isozyme family
  JOURNAL   J Biol Chem 279 (4), 2719-2727 (2004)
   PUBMED   14600151
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Shah,G.N., Hewett-Emmett,D., Grubb,J.H., Migas,M.C., Fleming,R.E.,
            Waheed,A. and Sly,W.S.
  TITLE     Mitochondrial carbonic anhydrase CA VB: differences in tissue
            distribution and pattern of evolution from those of CA VA suggest
            distinct physiological roles
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1677-1682 (2000)
   PUBMED   10677517
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Nagao,Y., Srinivasan,M., Platero,J.S., Svendrowski,M., Waheed,A.
            and Sly,W.S.
  TITLE     Mitochondrial carbonic anhydrase (isozyme V) in mouse and rat: cDNA
            cloning, expression, subcellular localization, processing, and
            tissue distribution
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10330-10334 (1994)
   PUBMED   7937950
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Heck,R.W., Tanhauser,S.M., Manda,R., Tu,C., Laipis,P.J. and
            Silverman,D.N.
  TITLE     Catalytic properties of mouse carbonic anhydrase V
  JOURNAL   J Biol Chem 269 (40), 24742-24746 (1994)
   PUBMED   7929150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088147.1.
            
            On Feb 12, 2015 this sequence version replaced NM_019293.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088147.1, U12268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1260              BC088147.1         1-1260
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1260
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /note="carbonic anhydrase 5A"
                     /db_xref="GeneID:54233"
                     /db_xref="RGD:2243"
     exon            1..191
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..967
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /EC_number="4.2.1.1"
                     /note="CA-VA; carbonate dehydratase VA; carbonic anhydrase
                     5 mitochondrial; carbonic anhydrase Va, mitochondrial;
                     carbonic anhydrase 5a, mitochondrial"
                     /codon_start=1
                     /product="carbonic anhydrase 5A, mitochondrial precursor"
                     /protein_id="NP_062166.1"
                     /db_xref="GeneID:54233"
                     /db_xref="RGD:2243"
                     /translation="MLRAKMLGRGPYKPLAILRHMGPLCATRPQHWRFQHSYAEKHSN
                     CARHPLWTGPVSSPGGTQQSPINIQWTDSVYDPKLAPLRVSYDAASCRYLWNTGYFFQ
                     VEFDDSCEESGISGGPLGNHYRLKQFHFHWGATDEWGSEHMVDGHAYPAELHLVHWNS
                     MKYENYKKATTGENGLAVIGVFLKLGAHHEALQRLVDILPEVRHKDTQVTMGPFDPSC
                     LLPACRDYWTYPGSLTTPPLAESVTWIVHKMPIEVSPSQLSTFRTLLFSGRGEDEEVM
                     VNNFRPLQPLRGRNVRSSFQVPRVGTKS"
     exon            192..389
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
     exon            390..508
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
     exon            509..604
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
     exon            605..667
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
     exon            668..823
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1247
                     /gene="Car5a"
                     /gene_synonym="Ca5; Ca5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgaggtgg ccctgaccaa aacaagggca gacagtgggc caccaccccg ccatgctcag
       61 agccaagatg ctcgggagag gcccctacaa gcccttagcc atcctcaggc acatgggacc
      121 tctctgtgcc acaaggccac agcactggcg cttccagcat tcctacgcag agaaacacag
      181 caactgtgcc cggcaccctc tctggactgg cccagtgtcc tcaccgggag gcacccagca
      241 gtctcccatt aatatccagt ggacggatag tgtctatgac ccgaagctgg caccgctcag
      301 ggtctcctat gatgctgcgt cctgcagata cctctggaac actggttact tcttccaggt
      361 ggagtttgac gattcctgtg aggagtcagg gatcagtggt gggcctctgg gaaaccacta
      421 caggctgaag cagtttcact tccactgggg agcaacagat gaatggggct ctgagcacat
      481 ggtggacggc catgcctacc cggctgagct ccatttggtt cactggaatt ccatgaaata
      541 tgaaaattac aagaaagcca ccacggggga gaatggactg gcggtgattg gagtgtttct
      601 gaagctcggg gcccatcacg aggccctgca gaggctggtg gacatcttgc cggaagtaag
      661 acacaaggac acacaggtga ccatggggcc ctttgaccct tcttgcctgc tgcctgcctg
      721 ccgggattac tggacctacc ctggctccct caccacccca ccactggctg agtcagtcac
      781 ctggattgtg cacaagatgc ccattgaggt gtccccgagc cagctgtcca cattccgtac
      841 actcttgttc tccgggcgag gtgaggacga ggaggtgatg gtgaacaact tccgcccgct
      901 ccaaccactc aggggccgca acgttcgctc ctccttccag gtccccaggg tgggaacaaa
      961 gtcttgatct caggatgagg tctgtaagga taggcagagc ggatggaaaa gggggtgcgc
     1021 atttccaggg tgcgacgcct ggattaaaaa aaaaatggct gcagagatgg ctcaggggtt
     1081 aagagcactg actgctcttc cagaggtcct gagttcagtt cccagtaacc acatggtggc
     1141 tcacaaccat ctgtaatggg atccgatgcc ctcttctggt gtgtctgaag agagcgacac
     1201 tgcactcata tgcattaaat taataaatct ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
