LOCUS       NM_019174               1266 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 4 (Car4), mRNA.
ACCESSION   NM_019174
VERSION     NM_019174.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Chuang,C.L., Huang,H.C., Chang,C.C., Lee,F.Y., Wu,J.C., Lee,J.Y.,
            Hsieh,H.G. and Lee,S.D.
  TITLE     Lipopolysaccharide enhanced renal vascular response to endothelin-1
            through ETA overexpression in portal hypertensive rats
  JOURNAL   J Gastroenterol Hepatol 30 (1), 199-207 (2015)
   PUBMED   24989426
  REMARK    GeneRIF: Renal vascular reactivity is associated with up regulation
            of renal endothelin receptors type A.
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1266)
  AUTHORS   Fanjul,M., Alvarez,L. and Hollande,E.
  TITLE     Expression and subcellular localization of a 35-kDa carbonic
            anhydrase IV in a human pancreatic ductal cell line (Capan-1)
  JOURNAL   J Histochem Cytochem 55 (8), 783-794 (2007)
   PUBMED   17409381
REFERENCE   5  (bases 1 to 1266)
  AUTHORS   Essalihi,R., Dao,H.H., Gilbert,L.A., Bouvet,C., Semerjian,Y.,
            McKee,M.D. and Moreau,P.
  TITLE     Regression of medial elastocalcinosis in rat aorta: a new vascular
            function for carbonic anhydrase
  JOURNAL   Circulation 112 (11), 1628-1635 (2005)
   PUBMED   16144999
  REMARK    GeneRIF: Vascular mineral loss induced by blockade of endothelin
            receptors seems dependent on activation of membrane-bound carbonic
            anhydrase IV. Mineral loss may proceed via local changes in pH
            similar to that seen in bone resorption.
REFERENCE   6  (bases 1 to 1266)
  AUTHORS   Decker,B., Sender,S. and Gros,G.
  TITLE     Membrane-associated carbonic anhydrase IV in skeletal muscle:
            subcellular localization
  JOURNAL   Histochem Cell Biol 106 (4), 405-411 (1996)
   PUBMED   8911968
REFERENCE   7  (bases 1 to 1266)
  AUTHORS   Fleming,R.E., Parkkila,S., Parkkila,A.K., Rajaniemi,H., Waheed,A.
            and Sly,W.S.
  TITLE     Carbonic anhydrase IV expression in rat and human gastrointestinal
            tract regional, cellular, and subcellular localization
  JOURNAL   J Clin Invest 96 (6), 2907-2913 (1995)
   PUBMED   8675662
REFERENCE   8  (bases 1 to 1266)
  AUTHORS   Fleming,R.E., Crouch,E.C., Ruzicka,C.A. and Sly,W.S.
  TITLE     Pulmonary carbonic anhydrase IV: developmental regulation and
            cell-specific expression in the capillary endothelium
  JOURNAL   Am J Physiol 265 (6 Pt 1), L627-L635 (1993)
   PUBMED   8279579
REFERENCE   9  (bases 1 to 1266)
  AUTHORS   Waheed,A., Zhu,X.L., Sly,W.S., Wetzel,P. and Gros,G.
  TITLE     Rat skeletal muscle membrane associated carbonic anhydrase is
            39-kDa, glycosylated, GPI-anchored CA IV
  JOURNAL   Arch Biochem Biophys 294 (2), 550-556 (1992)
   PUBMED   1533109
REFERENCE   10 (bases 1 to 1266)
  AUTHORS   Waheed,A., Zhu,X.L. and Sly,W.S.
  TITLE     Membrane-associated carbonic anhydrase from rat lung. Purification,
            characterization, tissue distribution, and comparison with carbonic
            anhydrase IVs of other mammals
  JOURNAL   J Biol Chem 267 (5), 3308-3311 (1992)
   PUBMED   1737787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 4, 2012 this sequence version replaced NM_019174.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097329.1, EV771205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000010.1  70325358-70325522
            166-219             JAXUCZ010000010.1  70330276-70330329
            220-375             JAXUCZ010000010.1  70331156-70331311
            376-521             JAXUCZ010000010.1  70331929-70332074
            522-614             JAXUCZ010000010.1  70332184-70332276
            615-681             JAXUCZ010000010.1  70332390-70332456
            682-845             JAXUCZ010000010.1  70332567-70332730
            846-1266            JAXUCZ010000010.1  70333496-70333916
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1266
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /note="carbonic anhydrase 4"
                     /db_xref="GeneID:29242"
                     /db_xref="RGD:2242"
     exon            1..165
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1040
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /EC_number="4.2.1.1"
                     /note="CA-IV; carbonate dehydratase IV; carbonic anhydrase
                     IV"
                     /codon_start=1
                     /product="carbonic anhydrase 4 precursor"
                     /protein_id="NP_062047.1"
                     /db_xref="GeneID:29242"
                     /db_xref="RGD:2242"
                     /translation="MQLLLALLALAYVAPSTEDSHWCYEIQAKEPNSHCSGPEQWTGD
                     CKKNQQSPINIVTSKTKLNPSLTPFTFVGYDQKKKWEVKNNQHSVEMSLGEDIYIFGG
                     DLPTQYKAIQLHLHWSEESNKGSEHSIDGKHFAMEMHVVHKKMTTGDKVQDSDSKDKI
                     AVLAFMVEVGNEVNEGFQPLVEALSRLSKPFTNSTVSESCLQDMLPEKKKLSAYFRYQ
                     GSLTTPGCDETVIWTVFEEPIKIHKDQFLEFSKKLYYDQEQKLNMKDNVRPLQPLGNR
                     QVFRSHASGRLLSLPLPTLLVPTLTCLVASFLH"
     exon            166..219
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            220..375
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            376..521
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..614
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..681
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..845
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1266
                     /gene="Car4"
                     /gene_synonym="Ca4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttaggtcg tggctctgct ataaagcctc aaccggcatg atcccgaagc ctcgggtggc
       61 ttcgttggtg ctggacccca ggctgggcag cgtctatgcc ctcaagcacc atgcagctcc
      121 ttcttgctct actggcgctg gcttacgtgg ccccctctac tgaagattca cactggtgct
      181 atgagattca agccaaggag cccaacagcc attgctcagg gcctgaacaa tggactggag
      241 actgtaagaa gaaccagcag tctcctatca atattgtcac tagtaagaca aagttgaacc
      301 ccagtctgac acccttcact ttcgttggct atgaccaaaa gaagaagtgg gaagttaaga
      361 acaaccaaca ctcagtggaa atgtcgctgg gggaggacat ctatattttt ggaggagatc
      421 tgcccaccca gtacaaggcc atacagttac acctgcactg gtcagaggag tcgaacaagg
      481 gttcagagca cagtattgat gggaaacatt ttgccatgga gatgcatgtc gtgcataaga
      541 agatgacaac aggcgataag gtgcaggact cggactccaa ggacaagatt gcggtgctgg
      601 cattcatggt tgaggtggga aacgaggtaa acgagggctt ccagcccctg gtggaggcac
      661 tgtccaggct ctccaaaccc tttacaaact ccacagtgag tgagagctgc ctgcaggata
      721 tgcttcctga aaagaagaaa ctgtctgcct acttccgtta ccagggctca ctgactacac
      781 caggctgtga tgagactgtc atctggactg tgttcgagga acctattaag atccataaag
      841 accagttcct ggaattctca aaaaagctct actatgacca agaacagaag ttgaacatga
      901 aggacaatgt gaggcccctg cagccactgg gaaaccgcca ggtgttcagg tctcatgcct
      961 caggacgact gctgtctttg cccctgccca ctctattggt ccccacactc acctgcctgg
     1021 tggccagctt cctccactga tggtcaaatt ctggatatct ggcctctgac ctcaaccttt
     1081 agaggatatg gcttctcttt ctcaatcttt ccaggttgaa ctttggggac tattaaggtg
     1141 tgctgtggtg gtgcacacct ttaatcccag ccctggatgg agagagcaga gacctatgga
     1201 tctctgacct tcccctaacc cctgattaaa ttaaataaaa tatggatatg tttttactct
     1261 ttgcaa
//
