LOCUS       NM_019292                802 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 3 (Car3), mRNA.
ACCESSION   NM_019292
VERSION     NM_019292.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 802)
  AUTHORS   Yamamoto,H., Uramaru,N., Kawashima,A. and Higuchi,T.
  TITLE     Carbonic anhydrase 3 increases during liver adipogenesis even in
            pre-obesity, and its inhibitors reduce liver adipose accumulation
  JOURNAL   FEBS Open Bio 12 (4), 827-834 (2022)
   PUBMED   35108454
  REMARK    GeneRIF: Carbonic anhydrase 3 increases during liver adipogenesis
            even in pre-obesity, and its inhibitors reduce liver adipose
            accumulation.
REFERENCE   2  (bases 1 to 802)
  AUTHORS   Li,H., Liu,Y., Tang,S., Hu,J., Wu,Q., Wei,Y. and Niu,M.
  TITLE     Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and
            Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line
  JOURNAL   Cardiovasc Toxicol 21 (11), 914-926 (2021)
   PUBMED   34387844
  REMARK    GeneRIF: Carbonic Anhydrase III Attenuates Hypoxia-Induced
            Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte
            Cell Line.
REFERENCE   3  (bases 1 to 802)
  AUTHORS   Silagi,E.S., Batista,P., Shapiro,I.M. and Risbud,M.V.
  TITLE     Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic
            Marker, is Hypoxia-responsive and Confers Protection from Oxidative
            Stress-induced Cell Death
  JOURNAL   Sci Rep 8 (1), 4856 (2018)
   PUBMED   29559661
  REMARK    GeneRIF: these data clearly suggests that CAIII serves as an
            important antioxidant critical in protecting NP cells against
            oxidative stress-induced injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 802)
  AUTHORS   Huang,H., Zhao,Y., Shang,X., Liu,X. and Ren,H.
  TITLE     Expression of carbonic anhydrase III and skeletal muscle remodeling
            following selective denervation
  JOURNAL   Mol Med Rep 16 (6), 8289-8294 (2017)
   PUBMED   28983629
  REMARK    GeneRIF: These results indicated that, following denervation,
            changes in the expression of CAIII were associated with myofiber
            remodeling. Specifically, the change in the expression of CAIII
            reflected the conversion to type I myofibers, suggesting the
            importance of CAIII in resistance to fatigue in skeletal muscle.
REFERENCE   5  (bases 1 to 802)
  AUTHORS   Carter,W.G., Vigneswara,V., Newlaczyl,A., Wayne,D., Ahmed,B.,
            Saddington,S., Brewer,C., Raut,N., Gerdes,H.K., Erdozain,A.M.,
            Tooth,D., Bolt,E.L., Osna,N.A., Tuma,D.J. and Kharbanda,K.K.
  TITLE     Isoaspartate, carbamoyl phosphate synthase-1, and carbonic
            anhydrase-III as biomarkers of liver injury
  JOURNAL   Biochem Biophys Res Commun 458 (3), 626-631 (2015)
   PUBMED   25684186
  REMARK    GeneRIF: The results suggest that elevated isoaspartate and CPS-1,
            and reduced CA-III levels could serve as biomarkers of
            hepatocellular injury.
REFERENCE   6  (bases 1 to 802)
  AUTHORS   Milot,J., Cote,C.H. and Tremblay,R.R.
  TITLE     Putative effects of nerve extract on carbonic anhydrase III
            expression in rat muscles
  JOURNAL   Muscle Nerve 17 (12), 1431-1438 (1994)
   PUBMED   7969243
REFERENCE   7  (bases 1 to 802)
  AUTHORS   Askmark,H. and Wistrand,P.J.
  TITLE     Leakage of carbonic anhydrase III from normal and denervated rat
            skeletal muscle following contractile activity
  JOURNAL   Muscle Nerve 15 (6), 643-647 (1992)
   PUBMED   1508229
REFERENCE   8  (bases 1 to 802)
  AUTHORS   Chai,Y.C., Jung,C.H., Lii,C.K., Ashraf,S.S., Hendrich,S., Wolf,B.,
            Sies,H. and Thomas,J.A.
  TITLE     Identification of an abundant S-thiolated rat liver protein as
            carbonic anhydrase III; characterization of S-thiolation and
            dethiolation reactions
  JOURNAL   Arch Biochem Biophys 284 (2), 270-278 (1991)
   PUBMED   1899179
REFERENCE   9  (bases 1 to 802)
  AUTHORS   Kelly,C.D., Carter,N.D., Jeffery,S. and Edwards,Y.H.
  TITLE     Characterisation of cDNA clones for rat muscle carbonic anhydrase
            III
  JOURNAL   Biosci Rep 8 (5), 401-406 (1988)
   PUBMED   2852973
REFERENCE   10 (bases 1 to 802)
  AUTHORS   Fremont,P., Charest,P.M., Cote,C. and Rogers,P.A.
  TITLE     Carbonic anhydrase III in skeletal muscle fibers: an
            immunocytochemical and biochemical study
  JOURNAL   J Histochem Cytochem 36 (7), 775-782 (1988)
   PUBMED   3133407
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB030830.1.
            
            On Jun 10, 2007 this sequence version replaced NM_019292.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030830.1, AB030829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..802
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /note="carbonic anhydrase 3"
                     /db_xref="GeneID:54232"
                     /db_xref="RGD:2241"
     exon            1..44
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..793
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /EC_number="4.2.1.1"
                     /function="carbonic anhydrase"
                     /function="phosphatase"
                     /note="CA-III; carbonic anhydrase III; carbonate
                     dehydratase III"
                     /codon_start=1
                     /product="carbonic anhydrase 3"
                     /protein_id="NP_062165.2"
                     /db_xref="GeneID:54232"
                     /db_xref="RGD:2241"
                     /translation="MAKEWGYASHNGPEHWHELYPIAKGDNQSPIELHTKDIRHDPSL
                     QPWSVSYDPGSAKTILNNGKTCRVVFDDTFDRSMLRGGPLSGPYRLRQFHLHWGSSDD
                     HGSEHTVDGVKYAAELHLVHWNPKYNTFGEALKQPDGIAVVGIFLKIGREKGEFQILL
                     DALDKIKTKGKEAPFNHFDPSCLFPACRDYWTYHGSFTTPPCEECIVWLLLKEPMTVS
                     SDQMAKLRSLFASAENEPPVPLVGNWRPPQPIKGRVVRASFK"
     exon            45..242
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..361
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..454
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..517
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..673
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..802
                     /gene="Car3"
                     /gene_synonym="Ca3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaaggcc atggctaagg agtggggtta cgccagccac aatggtcctg agcactggca
       61 tgaactttat ccaattgcca aaggggacaa ccagtcaccc attgaactgc atactaaaga
      121 catcaggcat gatccttctc tgcagccttg gtcagtatct tatgatcctg gctctgctaa
      181 gaccatcctg aacaatggga agacctgcag agttgtgttt gatgatactt tcgacaggtc
      241 catgctgaga ggtggccctc tctctggacc ctaccgactt cgccaattcc atcttcactg
      301 gggctcctcg gatgaccatg gctctgagca cacagtggat ggagtgaagt atgctgctga
      361 gcttcacctg gttcactgga acccgaagta taacaccttc ggagaggctc tgaagcagcc
      421 cgatgggatt gctgtggttg gcatttttct gaagatagga cgggagaaag gcgagttcca
      481 gattctcctt gatgccctgg acaaaattaa gactaagggc aaggaggctc cttttaatca
      541 cttcgaccca tcgtgcctgt tccctgcttg ccgggactat tggacctacc atggctcctt
      601 caccacgcca ccctgcgagg agtgcattgt gtggctgcta ctgaaagagc ccatgacagt
      661 gagctcagac cagatggcca agctgcgcag cctgttcgcc agtgcagaga atgagccccc
      721 ggtgcctctg gtggggaatt ggcgccctcc tcagccgatc aagggcaggg tggtgagggc
      781 ctccttcaag taaggctctg ga
//
