LOCUS       NM_019291               1459 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 2 (Car2), mRNA.
ACCESSION   NM_019291
VERSION     NM_019291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1459)
  AUTHORS   Khan,I. and Khan,K.
  TITLE     Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in
            Experimental Colitis: A Possible Mechanistic Link with Na-H
            Exchanger
  JOURNAL   Biomolecules 9 (11), 700 (2019)
   PUBMED   31694264
  REMARK    GeneRIF: Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in
            Experimental Colitis: A Possible Mechanistic Link with Na-H
            Exchanger.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1459)
  AUTHORS   Qin,W., Li,L., Wang,T., Huang,H. and Gao,Y.
  TITLE     Urine Proteome Changes in a TNBS-Induced Colitis Rat Model
  JOURNAL   Proteomics Clin Appl 13 (5), e1800100 (2019)
   PUBMED   31095872
REFERENCE   3  (bases 1 to 1459)
  AUTHORS   Liu,T., Zhou,J., Cui,H., Li,P., Li,H., Wang,Y. and Tang,T.
  TITLE     Quantitative proteomic analysis of intracerebral hemorrhage in rats
            with a focus on brain energy metabolism
  JOURNAL   Brain Behav 8 (11), e01130 (2018)
   PUBMED   30307711
REFERENCE   4  (bases 1 to 1459)
  AUTHORS   Tachibana,H., Gi,M., Kato,M., Yamano,S., Fujioka,M., Kakehashi,A.,
            Hirayama,Y., Koyama,Y., Tamada,S., Nakatani,T. and Wanibuchi,H.
  TITLE     Carbonic anhydrase 2 is a novel invasion-associated factor in
            urinary bladder cancers
  JOURNAL   Cancer Sci 108 (3), 331-337 (2017)
   PUBMED   28004470
REFERENCE   5  (bases 1 to 1459)
  AUTHORS   Viikila,P., Kivela,A.J., Mustonen,H., Koskensalo,S., Waheed,A.,
            Sly,W.S., Pastorek,J., Pastorekova,S., Parkkila,S. and Haglund,C.
  TITLE     Carbonic anhydrase enzymes II, VII, IX and XII in colorectal
            carcinomas
  JOURNAL   World J Gastroenterol 22 (36), 8168-8177 (2016)
   PUBMED   27688658
REFERENCE   6  (bases 1 to 1459)
  AUTHORS   Hu,P.Y., Roth,D.E., Skaggs,L.A., Venta,P.J., Tashian,R.E.,
            Guibaud,P. and Sly,W.S.
  TITLE     A splice junction mutation in intron 2 of the carbonic anhydrase II
            gene of osteopetrosis patients from Arabic countries
  JOURNAL   Hum Mutat 1 (4), 288-292 (1992)
   PUBMED   1301935
REFERENCE   7  (bases 1 to 1459)
  AUTHORS   Stolle,C.A., McGowan,M.H., Heim,R.A., Varia,M. and Neubauer,J.A.
  TITLE     Nucleotide sequence of a cDNA encoding rat brain carbonic anhydrase
            II and its deduced amino acid sequence
  JOURNAL   Gene 109 (2), 265-267 (1991)
   PUBMED   1765271
REFERENCE   8  (bases 1 to 1459)
  AUTHORS   Harkonen,P.L., Makela,S.I., Valve,E.M., Karhukorpi,E.K. and
            Vaananen,H.K.
  TITLE     Differential regulation of carbonic anhydrase II by androgen and
            estrogen in dorsal and lateral prostate of the rat
  JOURNAL   Endocrinology 128 (6), 3219-3227 (1991)
   PUBMED   1903702
REFERENCE   9  (bases 1 to 1459)
  AUTHORS   Kumpulainen,T.
  TITLE     Immunohistochemical localization of human carbonic anhydrase
            isoenzyme C
  JOURNAL   Histochemistry 62 (3), 271-280 (1979)
   PUBMED   114507
REFERENCE   10 (bases 1 to 1459)
  AUTHORS   Roussel,G., Delaunoy,J.P., Nussbaum,J.L. and Mandel,P.
  TITLE     Demonstration of a specific localization of carbonic anhydrase C in
            the glial cells of rat CNS by an immunohistochemical method
  JOURNAL   Brain Res 160 (1), 47-55 (1979)
   PUBMED   102414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X58294.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X58294.1, BC065577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680414
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1459
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /note="carbonic anhydrase 2"
                     /db_xref="GeneID:54231"
                     /db_xref="RGD:2240"
     exon            1..42
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..791
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /EC_number="4.2.1.1"
                     /EC_number="4.2.1.69"
                     /note="CA-II; carbonate dehydratase II; carbonic anhydrase
                     II; cyanamide hydratase CA2"
                     /codon_start=1
                     /product="carbonic anhydrase 2"
                     /protein_id="NP_062164.1"
                     /db_xref="GeneID:54231"
                     /db_xref="RGD:2240"
                     /translation="MSHHWGYSKSNGPENWHKEFPIANGDRQSPVDIDTGTAQHDPSL
                     QPLLICYDKVASKSIVNNGHSFNVEFDDSQDFAVLKEGPLSGSYRLIQFHFHWGSSDG
                     QGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQHPDGLAVLGIFLKIGPASQGLQKIT
                     EALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLKEPITVS
                     SEQMSHFRKLNFNSEGEAEELMVDNWRPAQPLKNRKIKASFK"
     exon            43..240
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
     exon            241..359
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..452
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..515
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..671
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1459
                     /gene="Car2"
                     /gene_synonym="Ca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtgactat gtcccaccac tggggataca gcaagagcaa cggaccagag aactggcaca
       61 aggagttccc cattgccaat ggagaccgac agtcccctgt ggacattgac accgggactg
      121 cccagcatga cccttcccta cagcctctgc tcatatgtta cgataaggtt gcttccaaga
      181 gcattgtcaa caatggccat tccttcaacg ttgagtttga tgactcccag gactttgcag
      241 tgctgaaaga gggacccctc agtggctcct acagattgat ccagtttcac tttcactggg
      301 gctcatctga tggccagggc tctgagcaca ccgtgaacaa aaaaaaatat gctgcagagc
      361 ttcacttggt tcactggaac accaaatatg gggattttgg aaaagctgtg cagcacccag
      421 atggactggc tgttttgggt atttttttga agattggacc tgcctcacaa ggccttcaga
      481 aaatcactga agcactgcat tccattaaaa caaaggggaa acgtgcagcc tttgctaact
      541 ttgatccttg ctcccttctt cctggaaact tggactactg gacatatcct ggctctctga
      601 ccactccgcc cctgctggaa tgtgtgacct ggatagtgct caaggaaccc attactgtca
      661 gcagtgagca gatgtctcat ttccgtaaac tgaacttcaa ttcggagggg gaggctgaag
      721 aactgatggt ggacaactgg cgtccagctc agccgctgaa gaacagaaag atcaaggcgt
      781 cctttaaata aaatgaccct gcagctgggg tccaaaaagc acaagtgtgg ctgcctctct
      841 gtagctaagc acagttccgc cttggtgatt cagatcccga ctttgcatct gatattgtag
      901 gcctttttac ctctcaccca ttgtgcttac taataaaatg tgaaaaggaa gacccaggtg
      961 tctcatgtgg tggtagcatg gtggcaggct ggtggttgac ttagggcatc ctttctcagc
     1021 cacaacaatg caatgcaaag aacagatatg gcctcttgct tctccacagc catagaataa
     1081 tgagtactca ggcctgttta ttaaaatgct atttttaaaa ccatataagg tagaatgatt
     1141 gtttacaaat ccacatcatg agacaaactg aggcaattta ggcaaatcag gtaaaacagt
     1201 catagtttta tggttattaa ttagatgaat gttcactatt ccaagatctt atattaaaga
     1261 aaaactttta aaaagcttat atatttgtag caaagttatt cttaaatatg aattatgttg
     1321 taacttagtg acttttgatt tctagaggtg taaatgaaga tgtaaaaatt gatatagttg
     1381 tgatacagag tatatttccc ttcagataac ttaccataac ctaatggata atgtatttta
     1441 gatatattct ctaataaaa
//
