LOCUS       NM_001109655            1669 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 14 (Car14), mRNA.
ACCESSION   NM_001109655
VERSION     NM_001109655.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Qin,W., Li,L., Wang,T., Huang,H. and Gao,Y.
  TITLE     Urine Proteome Changes in a TNBS-Induced Colitis Rat Model
  JOURNAL   Proteomics Clin Appl 13 (5), e1800100 (2019)
   PUBMED   31095872
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Zhang,P.B., Xiao,H.Y., Liu,H. and Qin,R.
  TITLE     Regulation of zinc transporter 3 and carbonic anhydrases 2 and 14
            mRNA expression in the retina of rats affected by low dietary zinc
  JOURNAL   Genet Mol Res 13 (1), 963-971 (2014)
   PUBMED   24634117
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Akiba,Y., Ghayouri,S., Takeuchi,T., Mizumori,M., Guth,P.H.,
            Engel,E., Swenson,E.R. and Kaunitz,J.D.
  TITLE     Carbonic anhydrases and mucosal vanilloid receptors help mediate
            the hyperemic response to luminal CO2 in rat duodenum
  JOURNAL   Gastroenterology 131 (1), 142-152 (2006)
   PUBMED   16831598
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   Hermo,L., Chong,D.L., Moffatt,P., Sly,W.S., Waheed,A. and
            Smith,C.E.
  TITLE     Region- and cell-specific differences in the distribution of
            carbonic anhydrases II, III, XII, and XIV in the adult rat
            epididymis
  JOURNAL   J Histochem Cytochem 53 (6), 699-713 (2005)
   PUBMED   15928319
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Whittington,D.A., Grubb,J.H., Waheed,A., Shah,G.N., Sly,W.S. and
            Christianson,D.W.
  TITLE     Expression, assay, and structure of the extracellular domain of
            murine carbonic anhydrase XIV: implications for selective
            inhibition of membrane-associated isozymes
  JOURNAL   J Biol Chem 279 (8), 7223-7228 (2004)
   PUBMED   14660577
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Kyllonen,M.S., Parkkila,S., Rajaniemi,H., Waheed,A., Grubb,J.H.,
            Shah,G.N., Sly,W.S. and Kaunisto,K.
  TITLE     Localization of carbonic anhydrase XII to the basolateral membrane
            of H+-secreting cells of mouse and rat kidney
  JOURNAL   J Histochem Cytochem 51 (9), 1217-1224 (2003)
   PUBMED   12923247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 6, 2022 this sequence version replaced NM_001109655.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214663.1, EF187253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000002.1  186137859-186138164 c
            307-327             JAXUCZ010000002.1  186135661-186135681 c
            328-507             JAXUCZ010000002.1  186134599-186134778 c
            508-650             JAXUCZ010000002.1  186133791-186133933 c
            651-746             JAXUCZ010000002.1  186133481-186133576 c
            747-813             JAXUCZ010000002.1  186133279-186133345 c
            814-971             JAXUCZ010000002.1  186132970-186133127 c
            972-1092            JAXUCZ010000002.1  186132765-186132885 c
            1093-1113           JAXUCZ010000002.1  186132441-186132461 c
            1114-1198           JAXUCZ010000002.1  186132262-186132346 c
            1199-1669           JAXUCZ010000002.1  186131196-186131666 c
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1669
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /note="carbonic anhydrase 14"
                     /db_xref="GeneID:791259"
                     /db_xref="RGD:1599277"
     exon            1..306
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1265
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /EC_number="4.2.1.1"
                     /note="carbonic anhydrase XIV"
                     /codon_start=1
                     /product="carbonic anhydrase 14 precursor"
                     /protein_id="NP_001103125.1"
                     /db_xref="GeneID:791259"
                     /db_xref="RGD:1599277"
                     /translation="MLFFVLLLKVTWILAADGGHHWTYEGPHGQDHWPASYPECGGNA
                     QSPIDIQTDGVIFDPDLPTVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRK
                     YTAAQLHLHWGQKGTLKGSEHQINSEATAAELHVVHYDSESYGSLSEAAQKPQGLAVL
                     GILIEVGETENPAYDHILSHLHEVRYKDQKTSVPPFNVRELLPQQLEQFFRYNGSLTT
                     PPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFA
                     SFIQVGPLYTTGEMLGLGMGISAGCLCLLLTIYFIAQKIRRKRLGNRKSVVFTSARAT
                     TEA"
     exon            307..327
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            328..507
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            508..650
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            651..746
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            747..813
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            814..971
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1092
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1113
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1198
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1669
                     /gene="Car14"
                     /gene_synonym="Ca14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccagttag tcgtgtgaag accacaggag gacttacaga aagggcagag aagaagagaa
       61 acaaagtgag gaagagagaa atttatcctg gggtccagaa gttcgtgtta acctgtgaaa
      121 aaaatcaaat ccctggaagt ctgcagagac agagacaaga agagacggga cgccagaaac
      181 tcctctctct ccccacctct cttttctagc ccccaaattc ctggccccct gttccccatt
      241 gtgaggataa tatgttgttc ttcgttctcc tgttaaaggt gacttggatc ctggctgcag
      301 atgggggtca ccattggaca tatgaaggcc cacacggtca ggaccattgg ccagcctcct
      361 atcctgaatg tggaggcaat gcccagtccc ccatcgatat ccagacagac ggtgtgatat
      421 ttgaccccga tctgcctact gtgcagcccc acggatatga ccagcttggt accgagcctt
      481 tggatctaca caataatggc catacagtgc agctctccct gcccccaacc ctgcaccttg
      541 gtggactgcc ccggaaatac acagcagccc agctccacct gcactggggt cagaagggaa
      601 ccctaaaggg atcagagcac cagatcaaca gtgaagccac agctgcagag ctccacgtgg
      661 tccattatga ctcggagtcc tatggcagct tgagtgaggc agctcagaag cctcagggac
      721 tggctgtcct aggcatccta attgaggtgg gtgagactga gaatccagct tatgatcaca
      781 ttctgagtca tctgcatgaa gtaagataca aagatcagaa gacctccgtg cctcccttca
      841 atgtgaggga gctcctcccc caacagctgg agcagttctt ccgctacaat ggctcgctca
      901 caaccccccc ctgctaccag agtgtgctct ggacagtgtt caacagaagg gcccagattt
      961 caatgggaca gttagaaaag cttcaggaga cactgtcctc tacagaagag gacccatctg
     1021 agccccttgt acaaaactac agagtgcccc agcctctcaa ccagaggacc atctttgctt
     1081 ctttcatcca agtgggacca ctgtatacca caggagagat gctgggtcta ggtatgggaa
     1141 tctcggctgg atgtctctgc cttctgctga ctatttattt catcgctcag aagattagga
     1201 ggaagaggct cggaaacagg aaaagtgtgg ttttcacctc tgctcgggct accacagagg
     1261 catgaactct gtctcgagat gctgcagata tggatgcctt cctctcatac ctgtcaggga
     1321 gcctctctaa gagggtacag gcaccggact accagtcata ggcaggttca ttcaggtata
     1381 gagagatacc acctctctat acacgaatac cagagaagcg aggaccccag ttcttcaaga
     1441 aagggctgag tctttggcct ttcaaagctg tagatcagga gatccctgtt ttagtgttta
     1501 gttatgaaga agctgaggac aagctctgcc gcccttcgcc tcacactgtc atgttccctc
     1561 ccacatatac accttgtagt ttttccctct aggaaaaaag ggctgctaat agggttttaa
     1621 ttattttttg ctcaatatat gtttgaaaat taaaaggttt tgaccttaa
//
