LOCUS       NM_001080756            3723 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus carbonic anhydrase 12 (Car12), mRNA.
ACCESSION   NM_001080756 XM_001074522 XM_001075974 XM_001075999 XM_343416
VERSION     NM_001080756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Zeng,J., Zhang,X., Yang,Q., Peng,J., Wang,F., Tang,J., Xu,Y.,
            Huang,D., Liang,J. and Li,L.
  TITLE     The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis
            in Congenital Pulmonary Airway Malformations
  JOURNAL   Oxid Med Cell Longev 2023, 6428579 (2023)
   PUBMED   36846718
  REMARK    GeneRIF: The Role of the miR-548au-3p/CA12 Axis in Tracheal
            Chondrogenesis in Congenital Pulmonary Airway Malformations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Ai,F., Wang,W., Liu,S., Zhang,D., Yang,Z. and Liu,F.
  TITLE     Integrative Proteo-Genomic Analysis for Recurrent Survival
            Prognosis in Colon Adenocarcinoma
  JOURNAL   Front Oncol 12, 871568 (2022)
   PUBMED   35847888
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Ning,W.R., Jiang,D., Liu,X.C., Huang,Y.F., Peng,Z.P., Jiang,Z.Z.,
            Kang,T., Zhuang,S.M., Wu,Y. and Zheng,L.
  TITLE     Carbonic anhydrase XII mediates the survival and prometastatic
            functions of macrophages in human hepatocellular carcinoma
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35362480
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Gu,X.F., Shi,C.B. and Zhao,W.
  TITLE     Prognostic value of carbonic anhydrase XII (CA XII) overexpression
            in hepatocellular carcinoma
  JOURNAL   Int J Clin Exp Pathol 12 (6), 2173-2183 (2019)
   PUBMED   31934040
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Kuchuk,O., Tuccitto,A., Citterio,D., Huber,V., Camisaschi,C.,
            Milione,M., Vergani,B., Villa,A., Alison,M.R., Carradori,S.,
            Supuran,C.T., Rivoltini,L., Castelli,C. and Mazzaferro,V.
  TITLE     pH regulators to target the tumor immune microenvironment in human
            hepatocellular carcinoma
  JOURNAL   Oncoimmunology 7 (7), e1445452 (2018)
   PUBMED   29900055
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Hermo,L., Chong,D.L., Moffatt,P., Sly,W.S., Waheed,A. and
            Smith,C.E.
  TITLE     Region- and cell-specific differences in the distribution of
            carbonic anhydrases II, III, XII, and XIV in the adult rat
            epididymis
  JOURNAL   J Histochem Cytochem 53 (6), 699-713 (2005)
   PUBMED   15928319
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Kivela,A.J., Parkkila,S., Saarnio,J., Karttunen,T.J., Kivela,J.,
            Parkkila,A.K., Bartosova,M., Mucha,V., Novak,M., Waheed,A.,
            Sly,W.S., Rajaniemi,H., Pastorekova,S. and Pastorek,J.
  TITLE     Expression of von Hippel-Lindau tumor suppressor and
            tumor-associated carbonic anhydrases IX and XII in normal and
            neoplastic colorectal mucosa
  JOURNAL   World J Gastroenterol 11 (17), 2616-2625 (2005)
   PUBMED   15849821
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Whittington,D.A., Grubb,J.H., Waheed,A., Shah,G.N., Sly,W.S. and
            Christianson,D.W.
  TITLE     Expression, assay, and structure of the extracellular domain of
            murine carbonic anhydrase XIV: implications for selective
            inhibition of membrane-associated isozymes
  JOURNAL   J Biol Chem 279 (8), 7223-7228 (2004)
   PUBMED   14660577
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Kyllonen,M.S., Parkkila,S., Rajaniemi,H., Waheed,A., Grubb,J.H.,
            Shah,G.N., Sly,W.S. and Kaunisto,K.
  TITLE     Localization of carbonic anhydrase XII to the basolateral membrane
            of H+-secreting cells of mouse and rat kidney
  JOURNAL   J Histochem Cytochem 51 (9), 1217-1224 (2003)
   PUBMED   12923247
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Kivela,A., Parkkila,S., Saarnio,J., Karttunen,T.J., Kivela,J.,
            Parkkila,A.K., Waheed,A., Sly,W.S., Grubb,J.H., Shah,G., Tureci,O.
            and Rajaniemi,H.
  TITLE     Expression of a novel transmembrane carbonic anhydrase isozyme XII
            in normal human gut and colorectal tumors
  JOURNAL   Am J Pathol 156 (2), 577-584 (2000)
   PUBMED   10666387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 26, 2022 this sequence version replaced NM_001080756.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.928583.1,
                                           SRR26643294.33269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000008.1  76169815-76170030
            217-237             JAXUCZ010000008.1  76173731-76173751
            238-417             JAXUCZ010000008.1  76204687-76204866
            418-563             JAXUCZ010000008.1  76205831-76205976
            564-659             JAXUCZ010000008.1  76209396-76209491
            660-723             JAXUCZ010000008.1  76210393-76210456
            724-881             JAXUCZ010000008.1  76210734-76210891
            882-1008            JAXUCZ010000008.1  76212078-76212204
            1009-1038           JAXUCZ010000008.1  76221213-76221242
            1039-1126           JAXUCZ010000008.1  76222049-76222136
            1127-3723           JAXUCZ010000008.1  76222869-76225465
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3723
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /note="carbonic anhydrase 12"
                     /db_xref="GeneID:363085"
                     /db_xref="RGD:1306612"
     exon            1..216
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1196
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /EC_number="4.2.1.1"
                     /note="membrane-bound carbonic anhydrase 12; carbonic
                     anyhydrase 12"
                     /codon_start=1
                     /product="carbonic anhydrase 12 precursor"
                     /protein_id="NP_001074225.1"
                     /db_xref="GeneID:363085"
                     /db_xref="RGD:1306612"
                     /translation="MPHCSLHATVVLLLVILKEQPSSSAPLNGSKWTYIGPAGEKNWS
                     KKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNS
                     DMYIQGLQPHQYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYSDFGS
                     ASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGE
                     YYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPSPREMVNNFR
                     QVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSVWLFKRKKSKK
                     GDNKGVIYKPAIKKEAEVHA"
     exon            217..237
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            238..417
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            418..563
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            564..659
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            660..723
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            724..881
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1008
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1038
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1126
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..3723
                     /gene="Car12"
                     /gene_synonym="Ca12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacaaccg acgtgcacgc tttggtccca ggctacgtgc acgctgtgct ggtgtgccgc
       61 tgccagctcg gagcggaaca gagcgcccca cagcttagag ccagcggcag ctttgagtcg
      121 ccgggacaaa gatgcctcac tgcagcctgc acgctactgt cgtcctccta ttggtgatcc
      181 ttaaggagca accttccagc tcagccccac tcaacggatc caagtggacc tacattggtc
      241 ctgctgggga aaagaactgg tccaagaagt acccgtcatg tgggggtctc ctgcagtccc
      301 cgatagacct acacagtgac atccttcaat atgatgccag ccttgcacca ctccagttcc
      361 aaggttacaa tgtgtctgtt gaaaagctat tgaacctaac caatgatggc cattcagtga
      421 gactgaatct gaactcagac atgtacatcc agggactcca gcctcaccag tacagagcgg
      481 agcagctgca cttgcactgg gggaaccgca atgaccccca tggctctgaa cacactgtga
      541 gtgggaagca ctttgctgct gagctgcaca tcgtccatta taactcagac ctgtactccg
      601 acttcggcag tgccagtgac aagtcagaag ggctcgctgt ccttgctgtt cttattgaga
      661 taggctctgt caatccgtcc tatgacaaga tctttagtca tcttcaacac gtcaagtata
      721 aaggccaaca agtgctcatc ccaggcttca acattgaaga acttctgcct gagagccctg
      781 gcgagtatta ccgctatgaa gggtccctga ctacacctcc ttgctaccct actgtgctct
      841 ggacagtttt ccgaaaccct gtgcagattt cccaggagca gctgctagct ttggagacag
      901 ctctgtattt cacacacatg gatgatcctt cccccagaga aatggtcaac aacttccggc
      961 aagtccagaa gtttgatgag aggctggtgt atatctcctt ccgacaagga ctgcttaccg
     1021 acacaggact gagtttgggt atcatccttt cagtggccct ggctggtgtc cttgggatct
     1081 ccattgttct ggcagtgtct gtttggctct tcaaaaggaa gaagagcaaa aaaggtgaca
     1141 acaagggagt catttataaa ccagccatca agaaggaggc tgaggtccac gcctgaggtc
     1201 cctggcagtc tcagacatcc aaggaaggac cttgctttgg atactacata ctttggctct
     1261 ctggacactt gaaatacctc aaggtgttct cttgagctca cctgtatccc cttcccccag
     1321 actcttgtga ggcttccagc tgggcctccc ctgttctgct gtcacatcca tcccagaatg
     1381 accagtgagt gggatgaagt gaactagggg gcaggagttt tgagtggact tctccagctg
     1441 tgtgagacgg ctaaagattc tgaattctga gtcacaaaac ctaacttgct ggtggaccat
     1501 tctggtttgg aaaacactag catcctggtt cttcctggta catttccaga gtcctgaagg
     1561 ttattctcca accttccaga ctacaacatg caccctttgc ttaggtgaca cttttgaaac
     1621 tcagcttcct tcctcaggga gcagttgttt tccttggatt tccttctgct ctgacagacc
     1681 caccaacctg acctcgcacc tacagagaag aactgagaca ggaagtacat attatcagaa
     1741 agaaatgaaa accataatat accaggacat ttttacagtc ctatcttttg ggttacagac
     1801 attgaccatg ccttacagca aagcaggctc acgttttatt ccttagtggg gatgaaacgg
     1861 agacagagaa aggagaagca gagggaacgg gaaggcatac attgtccagg agtctgcctt
     1921 tggagccaga actggactca agatacagtg taggggaaaa cagtctatgc tatcacctac
     1981 ttggcctcag gaggacagtt acactttaca ctccactccg ttatttggaa atgaattact
     2041 tcctctgtcc tggaataatc tactctgttt tgaactcagg ggaagcagac agaatcaaga
     2101 ctactggaca gttttgcctc ctttgcccaa atgtccattc taccttgtct gatcttccta
     2161 ctacccactc ggtgtcagga ctgtctactc ctctggctgt ggggaagtct aaataatgtt
     2221 tagtgaaatg tattttcata ttatcaaagc aggaagctat ccgtgtagag ctaaaccagg
     2281 tcttggtatt taagtaccga aaccaataga atgtttctga gattctccct gttcttcccc
     2341 tcagtcccat ggtttctggg aatgcttaat cccttcttca tgttctttcc accgaggtga
     2401 gaaccctgtg gagagcagtc agttcatggc tctaaagaag tctcagccac cagcccctga
     2461 ttgctagttc cttgcagttc atagggagtt ctctgattta gtctcgtttt gacagcatgg
     2521 aatgtcctct tgaagagcag gtttatatat ttttttcttc ttctatcctc cctcctgact
     2581 tgataaaaat ctcttctgct attacagtgt ttcacagtgg cggccctgtg tctttgtagc
     2641 ataattcact gggcaaagtt acaggtgatt agatgggggc tcagctgtgt gtgcagtacc
     2701 tgtgcatgca ctccttggag tctgggtgcc accctagcct tgggaccaac atgcctgatg
     2761 gtgtcatcag agtgagggca agcctcaaga agaagcaacc caatttaggt ggcttcctga
     2821 ccttggtcca ggattgtcct ccagaagcta tcataaagca gtccagggca gcaagtctgt
     2881 cttaaagaag tgtatacact gacaagttat gtgagagtac agcgaggtca tcatggctgg
     2941 cctgaggatt ggtcagaaaa ggagagatgc taggaggcaa aaacagtggc atttctcctt
     3001 cccttttccc cttcagcatg gtccaggcat tcagtcctcg ctcaatcctc atggctgaga
     3061 tgaaacaaag ccagggaggc agaaagagtg ctccaagaat cagcgctgtc aacctttaac
     3121 tcctgaagat gcagctttct tcagattcaa aatcattctg tgggacacct ggccaccact
     3181 gagggaaacc agtgctgtgg tatatgatac acagccttgc actccttaac tctgctgtgt
     3241 gaggtgcaag gtgggtgcct gggagagcct gggctggcac agggctgggc acatagcaag
     3301 tggagatgac ctacacaatt cgtgggtggg cggggggcac acaccaggga cctgaggaag
     3361 gcactggctt ctgtaatatt tcctctgcct ctaacaggaa aacttgagtc tctctgttct
     3421 ttgttagtat ctgtcttcta ttatagcaaa tcctatatcc atggctttaa tggacattct
     3481 aaaatttgct gcactgacag tcttaatatt tctattcctc tccctctcta tactctttga
     3541 agacctcctg attggccctg aggaagtacc aggggtaaca gtatctctgg gtccctgtcc
     3601 ctcagcccat aggccactgt gataattgtc tgcttagcat ttccatattt attgtaccaa
     3661 tgattgtaat gaagatatac actgaaagtt tgagattata ataaaaacat ttttcacatc
     3721 tga
//
