LOCUS       NM_001005903            1662 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            beta (Capzb), mRNA.
ACCESSION   NM_001005903 XM_216562
VERSION     NM_001005903.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1662)
  AUTHORS   Rainger,J., Williamson,K.A., Soares,D.C., Truch,J., Kurian,D.,
            Gillessen-Kaesbach,G., Seawright,A., Prendergast,J., Halachev,M.,
            Wheeler,A., McTeir,L., Gill,A.C., van Heyningen,V., Davey,M.G. and
            FitzPatrick,D.R.
  CONSRTM   UK10K
  TITLE     A recurrent de novo mutation in ACTG1 causes isolated ocular
            coloboma
  JOURNAL   Hum Mutat 38 (8), 942-946 (2017)
   PUBMED   28493397
REFERENCE   3  (bases 1 to 1662)
  AUTHORS   Lin,Y.H., Warren,C.M., Li,J., McKinsey,T.A. and Russell,B.
  TITLE     Myofibril growth during cardiac hypertrophy is regulated through
            dual phosphorylation and acetylation of the actin capping protein
            CapZ
  JOURNAL   Cell Signal 28 (8), 1015-1024 (2016)
   PUBMED   27185186
  REMARK    GeneRIF: The goal of this study was to test the hypothesis that
            actin filament assembly during cardiomyocyte growth is regulated by
            post-translational modifications (PTMs) of CapZbeta1.
REFERENCE   4  (bases 1 to 1662)
  AUTHORS   Lin,Y.H., Swanson,E.R., Li,J., Mkrtschjan,M.A. and Russell,B.
  TITLE     Cyclic mechanical strain of myocytes modifies CapZbeta1 post
            translationally via PKCepsilon
  JOURNAL   J Muscle Res Cell Motil 36 (4-5), 329-337 (2015)
   PUBMED   26429793
  REMARK    GeneRIF: with strain there was significant PKCepsilon translocation
            to the Z-disc and co-localization with CapZbeta1 or alpha-actinin,
            which was quantified on confocal images.
REFERENCE   5  (bases 1 to 1662)
  AUTHORS   Mi,N., Chen,Y., Wang,S., Chen,M., Zhao,M., Yang,G., Ma,M., Su,Q.,
            Luo,S., Shi,J., Xu,J., Guo,Q., Gao,N., Sun,Y., Chen,Z. and Yu,L.
  TITLE     CapZ regulates autophagosomal membrane shaping by promoting actin
            assembly inside the isolation membrane
  JOURNAL   Nat Cell Biol 17 (9), 1112-1123 (2015)
   PUBMED   26237647
  REMARK    GeneRIF: Binding of CapZ to PtdIns(3)P, which is enriched in
            omegasomes, stimulates actin polymerization.
REFERENCE   6  (bases 1 to 1662)
  AUTHORS   Kitazawa,M., Yamakuni,T., Song,S.Y., Kato,C., Tsuchiya,R.,
            Ishida,M., Suzuki,N., Adachi,E., Iwashita,S., Ueno,S.,
            Yanagihara,N., Taoka,M., Isobe,T. and Ohizumi,Y.
  TITLE     Intracellular cAMP controls a physical association of V-1 with CapZ
            in cultured mammalian endocrine cells
  JOURNAL   Biochem Biophys Res Commun 331 (1), 181-186 (2005)
   PUBMED   15845376
REFERENCE   7  (bases 1 to 1662)
  AUTHORS   Mejillano,M.R., Kojima,S., Applewhite,D.A., Gertler,F.B.,
            Svitkina,T.M. and Borisy,G.G.
  TITLE     Lamellipodial versus filopodial mode of the actin nanomachinery:
            pivotal role of the filament barbed end
  JOURNAL   Cell 118 (3), 363-373 (2004)
   PUBMED   15294161
REFERENCE   8  (bases 1 to 1662)
  AUTHORS   Pyle,W.G., Hart,M.C., Cooper,J.A., Sumandea,M.P., de Tombe,P.P. and
            Solaro,R.J.
  TITLE     Actin capping protein: an essential element in protein kinase
            signaling to the myofilaments
  JOURNAL   Circ Res 90 (12), 1299-1306 (2002)
   PUBMED   12089068
REFERENCE   9  (bases 1 to 1662)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
REFERENCE   10 (bases 1 to 1662)
  AUTHORS   Hart,M.C. and Cooper,J.A.
  TITLE     Vertebrate isoforms of actin capping protein beta have distinct
            functions In vivo
  JOURNAL   J Cell Biol 147 (6), 1287-1298 (1999)
   PUBMED   10601341
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083861.1.
            
            [WARNING] On Mar 20, 2025 this sequence was replaced by
            NM_001005903.2.
            
            On Oct 23, 2004 this sequence version replaced XM_216562.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083861.1, FQ218507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1662
                     /gene="Capzb"
                     /note="capping actin protein of muscle Z-line subunit
                     beta"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
     exon            1..85
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..901
                     /gene="Capzb"
                     /note="capZ beta; F-actin capping protein beta subunit;
                     capping protein (actin filament) muscle Z-line, beta;
                     capping actin protein of muscle Z-line beta subunit"
                     /codon_start=1
                     /product="F-actin-capping protein subunit beta"
                     /protein_id="NP_001005903.1"
                     /db_xref="GeneID:298584"
                     /db_xref="RGD:1359099"
                     /translation="MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVD
                     QPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANN
                     AFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKS
                     SGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE
                     DMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC"
     exon            86..175
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            176..297
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            298..411
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            412..553
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            554..670
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            671..736
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            737..813
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1626
                     /gene="Capzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggaagtg gaagcgccgg gccctgctgc gggggggaga gccacagacg ccgggactgg
       61 gaccgtcgcc gccgccgcca ccatgagcga tcagcagctg gactgcgcct tggacctgat
      121 gaggcgcctg cctccacagc agattgagaa aaacctcagc gatctgatcg acctggtccc
      181 cagtctgtgt gaagatctcc tgtcttctgt tgaccagccc ctgaaaattg ccagagacaa
      241 ggtggtgggc aaggactacc ttttgtgtga ctacaacaga gacggggact cctataggtc
      301 accatggagt aacaagtatg accctccttt ggaagatggg gccatgccat ctgctcggct
      361 cagaaagctg gaggtagagg ccaacaatgc cttcgaccaa taccgagacc tgtattttga
      421 aggtggtgtc tcatcagtct acctctggga tctcgatcat ggctttgctg gagtgatcct
      481 cataaagaag gctggggatg gatcaaagaa gatcaaaggc tgctgggatt ccatccacgt
      541 ggtggaagtg caggagaagt ccagtggccg tactgcccat tacaagttga cctccacagt
      601 gatgctatgg ctgcaaacca acaaatccgg ctcaggcacc atgaacctgg gaggcagcct
      661 aaccagacag atggagaagg acgaaactgt gagtgactgt tccccacaca tagccaacat
      721 tgggcgcctg gtggaggaca tggaaaacaa aatcagaagc acgctgaatg agatctactt
      781 tggaaaaaca aaggacatcg tcaacgggct gaggtctgtg cagacgtttg cagacaaatc
      841 aaagcaggaa gcccttaaga atgacctggt ggaagccttg aagagaaagc agcagtgtta
      901 aagacctgct tcacgctaac cggacacgcc atgcactcgt taggttcctt tctttagaaa
      961 actcgttttc tgctcctttt ccctcttcct ttccctccct gacggtcaca taacagtttg
     1021 catcgaccac gcagcgccat ctctccccca aaataaagtc caataaccac cctctggctc
     1081 caaggcctgc ttcccacgac gtttccatag agaccgtgtg gctttgttcg cctgtcccct
     1141 tccttccctt gcccgtttgt aggcacaggc gcactgtctg acatcctccc tccgtctttt
     1201 tgttacattg gtgtaaaaaa tgtaaaacaa aaaaatttta tgaactaact ggtgtgtgaa
     1261 agaagggaaa ctggagctct gatccgtgtg tgtttggggg ttgcttggag ccgggggccg
     1321 ggggacaggg gacagctatg gaggaaggag acatgtcctc agcactgtcc tgcgcagagc
     1381 aggtgtgccc ttgtcccaag gagaccgcgg tgggggtggg ggcggggctg gcgaccgctg
     1441 ctctctggcc aggtgctttt ctgtcaaatt tttatggaat gcaaaaggag ttttttgttt
     1501 tattttgttt tttgtaaagc ttaaacagac aaaaaaaatc tacatcttct acttgagcct
     1561 ccatacttaa aaaaaaaaaa ggaaaaaaag aacaaaaaaa ataaataaaa agaaactggg
     1621 acacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
