LOCUS       NM_001009180            2306 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            alpha 2 (Capza2), mRNA.
ACCESSION   NM_001009180 XM_347256
VERSION     NM_001009180.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Davis,D.A., Wilson,M.H., Giraud,J., Xie,Z., Tseng,H.C., England,C.,
            Herscovitz,H., Tsai,L.H. and Delalle,I.
  TITLE     Capzb2 interacts with beta-tubulin to regulate growth cone
            morphology and neurite outgrowth
  JOURNAL   PLoS Biol 7 (10), e1000208 (2009)
   PUBMED   19806181
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Robledo,R.F., Ciciotte,S.L., Gwynn,B., Sahr,K.E., Gilligan,D.M.,
            Mohandas,N. and Peters,L.L.
  TITLE     Targeted deletion of alpha-adducin results in absent beta- and
            gamma-adducin, compensated hemolytic anemia, and lethal
            hydrocephalus in mice
  JOURNAL   Blood 112 (10), 4298-4307 (2008)
   PUBMED   18723693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001009180.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101867.1, SRR22399489.3897433.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000004.1  46944040-46944135
            97-160              JAXUCZ010000004.1  46954948-46955011
            161-212             JAXUCZ010000004.1  46956497-46956548
            213-276             JAXUCZ010000004.1  46960534-46960597
            277-483             JAXUCZ010000004.1  46962881-46963087
            484-563             JAXUCZ010000004.1  46963819-46963898
            564-642             JAXUCZ010000004.1  46966669-46966747
            643-714             JAXUCZ010000004.1  46969127-46969198
            715-777             JAXUCZ010000004.1  46978164-46978226
            778-2306            JAXUCZ010000004.1  46978402-46979930
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2306
                     /gene="Capza2"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 2"
                     /db_xref="GeneID:493810"
                     /db_xref="RGD:1549770"
     exon            1..96
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..918
                     /gene="Capza2"
                     /note="capZ alpha-2; capping actin protein of muscle
                     Z-line alpha subunit 2; capping protein (actin filament)
                     muscle Z-line, alpha 2"
                     /codon_start=1
                     /product="F-actin-capping protein subunit alpha-2"
                     /protein_id="NP_001009180.1"
                     /db_xref="GeneID:493810"
                     /db_xref="RGD:1549770"
                     /translation="MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDN
                     LLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLR
                     KEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIES
                     HQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTV
                     SNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILS
                     YKIGKEMQNA"
     exon            97..160
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            161..212
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..276
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..483
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..563
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..642
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..714
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..777
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..2306
                     /gene="Capza2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaagtca ggtggccgct gctgccacca gcgccacggt ttgtcgccag aaggaagatg
       61 gcggatctgg aggagcagtt gtccgatgag gagaaggtac gtatagcagc aaaattcatc
      121 attcatgccc ctcctggaga atttaatgag gtttttaatg atgttcgatt attgcttaat
      181 aatgataatc ttctcaggga aggagcagca catgcatttg cacagtataa cctggaccag
      241 tttacaccag taaaaattga aggctatgaa gatcaggtct tgataacaga acatggagac
      301 ttgggaaatg gaaaattttt ggatccaaaa aacagaatct gtttcaaatt tgatcattta
      361 agaaaagaag caactgatcc aaggccctat gaagcagaaa atgccattga atcctggaga
      421 acttcagtag aaactgcact gcgagcttat gtaaaagagc attatcccaa tggggtctgc
      481 actgtgtatg gcaaaaaagt agatgggcag caaaccatta ttgcatgcat cgaaagccat
      541 cagtttcaag caaaaaactt ttggaatggt cgttggaggt cagagtggaa gtttacagtc
      601 actccttcca ccacccaggt ggttggcatt ttgaaaattc aggttcatta ttatgaagat
      661 ggtaatgttc agctagtgag tcataaagat atacaagatt ccctcacagt atctaatgag
      721 gtgcaaacag caaaagaatt tataaagatt gtagaagctg cagaaaatga ataccagact
      781 gccatcagtg agaactatca gacaatgtcg gacactacct tcaaagcctt acgtcgacag
      841 ttgccagtga cacgtactaa gatcgactgg aacaagatcc ttagctacaa gattggcaaa
      901 gagatgcaga atgcataaat gaaaattgca tgagcagatt gttttagtgt cttcgcgtta
      961 caaaaattat tgcaaaagta ttctgagctg tcagctgccc agtgaggtgg gctgttgcat
     1021 ctaagatcac tgtaattaag tagtgtggtt agagcacaga gcttagctaa taaccttgtt
     1081 ccatttcctt tgttcagagg gttggacatg agtttagatc agtatcttac tctgttcctc
     1141 ctttccaagt atctctcttt ctctctttct ctctctctct ctctctctgt tccttttcct
     1201 acagtgaaga ggtgatccct ctgggtcatg tctaaaggat tttaaatatc tcaaaagtat
     1261 cttatttact gtaaccctga aattgtctct ggcctgtaaa aagggcaact tctgatgtga
     1321 ccacaggtat ttttagtgga gtcagtagtg gacactctag ttaaggtggt tgatggactt
     1381 agccatacat gctgctaaag aaattgtcta ccttttcctt tcacctcttc tggcgtggga
     1441 gatggagact agagggcgag cattttctac accagtcacg tttaaacctt ctcagtaagg
     1501 ttatttagct agcttagtgt ctaactaaac ttttttaaaa caaggccaag gtctgttgct
     1561 gttttgagat tctgaaatta aatgagaata cttatttcag aaatgcattt aatgcttttt
     1621 tcttgtgaca gttatgcaaa ttagcttgaa ttccatatgt tcctgagtta tttttatcac
     1681 aaagccacaa gtgtattata aggcagattg taatatatat ataatcctga actcatgaac
     1741 atgtctcagc tgattctccc tccccttgga ttgaaaactg aattttattg tgacattaaa
     1801 atggcaaaat ttggtattta tttgagtaaa aaaaaaatca tcagtgaatc atacactatt
     1861 ttaaaatact ttctttgtat attgtcattc ttaacaagtt gtaaattaga aaatttggga
     1921 gtccacatgg tatgcaactg catcttttgt tttccatttt cctatgcatc gtaagcatgt
     1981 gtgtaatacg ttaaatatat ctcctgacac cacaggaatt cgagcctcgg tgaacgtcgg
     2041 catttactat aaaggagttg gtggatttgt ggtttcattc agtagttttg ctgcttatgc
     2101 tcgagtggaa tccatttctc acatactcct gcagacatct gggcctggaa ttttttttta
     2161 aacaccactt ttactatgta taataaaata tttcattagc ttgaattgta tagattttta
     2221 aaaattcaat gagagcatgt tgtttaattt ctttttaaaa tcactgttgg gctttgaaag
     2281 cattgcaaat atatgacatt gtgaca
//
