LOCUS       NM_001109625            3256 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus capping actin protein of muscle Z-line subunit
            alpha 1 (Capza1), mRNA.
ACCESSION   NM_001109625 XM_001077010
VERSION     NM_001109625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3256)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3256)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 3256)
  AUTHORS   Elbediwy,A., Zihni,C., Terry,S.J., Clark,P., Matter,K. and
            Balda,M.S.
  TITLE     Epithelial junction formation requires confinement of Cdc42
            activity by a novel SH3BP1 complex
  JOURNAL   J Cell Biol 198 (4), 677-693 (2012)
   PUBMED   22891260
REFERENCE   4  (bases 1 to 3256)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   5  (bases 1 to 3256)
  AUTHORS   Fan,Y., Tang,X., Vitriol,E., Chen,G. and Zheng,J.Q.
  TITLE     Actin capping protein is required for dendritic spine development
            and synapse formation
  JOURNAL   J Neurosci 31 (28), 10228-10233 (2011)
   PUBMED   21752999
  REMARK    GeneRIF: These findings indicate that capping of actin filaments by
            capping protein represents an essential step for the remodeling of
            the actin architecture underlying spine morphogenesis and synaptic
            formation during development.
REFERENCE   6  (bases 1 to 3256)
  AUTHORS   Fan,Y.M., Pang,C.P., Harvey,A.R. and Cui,Q.
  TITLE     Marked effect of RhoA-specific shRNA-producing plasmids on neurite
            growth in PC12 cells
  JOURNAL   Neurosci Lett 440 (2), 170-175 (2008)
   PUBMED   18556119
  REMARK    GeneRIF: Data show that as a consequence of RhoA knockdown, F-actin
            levels were significantly reduced in PC12 cells.
REFERENCE   7  (bases 1 to 3256)
  AUTHORS   Kuhn,J.R. and Pollard,T.D.
  TITLE     Single molecule kinetic analysis of actin filament capping.
            Polyphosphoinositides do not dissociate capping proteins
  JOURNAL   J Biol Chem 282 (38), 28014-28024 (2007)
   PUBMED   17656356
REFERENCE   8  (bases 1 to 3256)
  AUTHORS   Schroer,T.A.
  TITLE     Dynactin
  JOURNAL   Annu Rev Cell Dev Biol 20, 759-779 (2004)
   PUBMED   15473859
  REMARK    Review article
REFERENCE   9  (bases 1 to 3256)
  AUTHORS   Xiao,H.S., Huang,Q.H., Zhang,F.X., Bao,L., Lu,Y.J., Guo,C.,
            Yang,L., Huang,W.J., Fu,G., Xu,S.H., Cheng,X.P., Yan,Q., Zhu,Z.D.,
            Zhang,X., Chen,Z., Han,Z.G. and Zhang,X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
REFERENCE   10 (bases 1 to 3256)
  AUTHORS   Palmgren,S., Ojala,P.J., Wear,M.A., Cooper,J.A. and Lappalainen,P.
  TITLE     Interactions with PIP2, ADP-actin monomers, and capping protein
            regulate the activity and localization of yeast twinfilin
  JOURNAL   J Cell Biol 155 (2), 251-260 (2001)
   PUBMED   11604420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV765154.1, CB557114.1, EV769947.1, CO563321.1, EX488132.1,
            BG668882.1 and CA505328.1.
            
            On Nov 27, 2007 this sequence version replaced NM_001109625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166464.1, DN937023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-778               EV765154.1         1-778
            779-1196            CB557114.1         248-665
            1197-1852           EV769947.1         120-775
            1853-2266           CO563321.1         308-721
            2267-2749           EX488132.1         54-536              c
            2750-2933           BG668882.1         180-363
            2934-3256           CA505328.1         1-323               c
FEATURES             Location/Qualifiers
     source          1..3256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3256
                     /gene="Capza1"
                     /note="capping actin protein of muscle Z-line subunit
                     alpha 1"
                     /db_xref="GeneID:691149"
                     /db_xref="RGD:1587438"
     exon            1..326
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1148
                     /gene="Capza1"
                     /note="F-actin capping protein alpha-1 subunit; capping
                     protein (actin filament) muscle Z-line, alpha 1; capping
                     actin protein of muscle Z-line alpha subunit 1; capZ
                     alpha-1"
                     /codon_start=1
                     /product="F-actin-capping protein subunit alpha-1"
                     /protein_id="NP_001103095.2"
                     /db_xref="GeneID:691149"
                     /db_xref="RGD:1587438"
                     /translation="MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDN
                     LLREGAAHAFAQYNMDQFTPVKIEGYDDQVLITEHGDLGNSRFLDPRNKISFKFDHLR
                     KEASDPQPEDVDGGLKSWRDSCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIES
                     HQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTV
                     SNEVQTAKEFIKIIESAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILS
                     YKIGKEMQNA"
     exon            327..390
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..442
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..506
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..713
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..793
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..872
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..944
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1007
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..3242
                     /gene="Capza1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcgccat ggacagtcga gacacgccac caagcattcc aggacgaatg ggaaagtgac
       61 tgaaacccag tgagaaagat gttaagactg caaaaccctg aggggaaagt cgacttccta
      121 gagcgctccc accctaagct gtcacgcccg cgcggaactg acatggcgcc ctcttggccg
      181 gagcttccgg gcgggtcctt ctgacggccc cctcggtgat tccaccactc agcttccttc
      241 ccggcttgcc tcgcgccggc ccgccgggct gggccagagc agccaagatg gccgacttcg
      301 aggatcgggt gtcggatgag gagaaggtac gcatagccgc taaattcatc acccatgcac
      361 ccccagggga gttcaatgaa gtattcaatg atgtccggct actgcttaat aatgacaatc
      421 ttctcaggga aggggcagca catgcatttg cccagtataa catggatcag ttcacacctg
      481 tgaagataga aggctacgac gaccaggtct taattacaga gcatggcgac cttggtaaca
      541 gcagattttt agatccaaga aacaaaattt cctttaagtt tgatcattta cggaaagaag
      601 cgagtgaccc gcagccagag gatgtggatg gaggcttgaa gtcttggaga gactcgtgtg
      661 acagtgcact gagagcctat gtgaaagatc attattccaa cggcttctgt actgtttacg
      721 ctaaaaccat agatggacag cagaccatta ttgcatgtat tgaaagccac cagtttcaac
      781 ccaaaaactt ctggaatggt cgttggagat cagagtggaa gttcaccatc acaccaccta
      841 cagcccaggt ggttggagtg ctcaagattc aggttcatta ttatgaagat ggcaatgttc
      901 agctggttag tcataaagat gtgcaggact cagtaactgt ttctaatgaa gtccaaactg
      961 ccaaggagtt tattaaaatc atagagagtg cagaaaatga gtatcagaca gcaattagtg
     1021 aaaattatca aactatgtca gacaccacgt tcaaggcctt gcgccggcag cttccagtta
     1081 cccgcaccaa aatcgactgg aacaagatac tcagttacaa gattggcaaa gaaatgcaga
     1141 atgcttaaag gccgtctgta ggagtctcca gtacatggaa agaaaaggat tcaacacagt
     1201 gtggtcatat gataaataag tgatttataa acaaacaaga gtgatatttt gctagttaac
     1261 aaagttaaca gatcttctag cctcatggaa tactgttgaa cctagagcac tgtcttgatt
     1321 cttttgtgtg tgtgttctct gctttgtaat attctgttat cactttatct acttgtaaat
     1381 ctttttttcc attttgctac atttaatgtc gaagagatat atcctgaagt cgttttactg
     1441 tttagaaaat gtcctagcca tgaagcccca ttactggctt ttgcagtctg ttaagtacct
     1501 tacccctatg ctttaaagca cttccagtac ttccgtggct tttagtgatc caccaatggc
     1561 taaagaggct acgatcccca cgagctgagt ggacaacaca ctcctgtcct actgctttga
     1621 tcatttatag cttctcacaa ctgtagtttt cagacatttg gattggggct ttggggtcca
     1681 tgttgggagg caaaggaagt ttcctggaat ttccatggca gcagctactc tggggacttg
     1741 tttttaatcc aaagacttga accacatccc ctgcacatga atgtttgctt attttcattt
     1801 tctcgttgtc tcctcccatc tagttctgtt gtagccatgg atgtctgtag gaagaacagc
     1861 ttagaaaaag cattaggaaa ccagggttgt caatcacatg cgtctgtttc cttcagtgga
     1921 agggagtgag tgatgcctga tcactagaat gctggagcgg tgtggtcaaa caacctggtg
     1981 atcctcagct cttctgttac gaaagcctcc accttaatct cccccgcccc accccaatat
     2041 tctgagcatt gtttaggccc taatactggc ctttgtctca gtgaatagaa gaacttacgc
     2101 ctatcgtata tccttcctct aggccctagc cctaagttct gtttgtcagt cagtagagtt
     2161 cattcttact gtaaaggtca caggtgcttt actactttgc aagggaatat agatgtagcc
     2221 agccctgaag ctttgttata agaactgtca cacggacact ttcccccaaa gttctactgt
     2281 gtttaaatgt gtagaaaaat taaaacacag gatcagagtc tagaagtctt gatccagact
     2341 gactaagtct ggctatacca agttttcatt cttatctacc ctggatccac ttctcttgcc
     2401 agtggcaata cctgcaggag cccctcagca gatgctggca ttcttaaaag agcgtcgccc
     2461 attagcattg ctcttccaca tttgagaact gctgacgtgc tgtggaggta gtggatataa
     2521 aacttgaaaa cacagacatt gaaggaataa taggtatctg tgctttgtgc tctctggtag
     2581 gattgttcag taagcaggcg aataaacagc tatgtccctc gcaatgctgg aatgaaccaa
     2641 agtgaaaagg agggctccca ggcagtatct gtctgtcata acctggtatt tcagagaatg
     2701 ctagtgcttt cttctaaaca ggatgtaaaa taaaattcat tccaagttac tctttctcca
     2761 tcatcctacc tgcctagaac tcatataact gtgacagagc taccttccca ggtatattgg
     2821 caggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2881 atcttagaac acacaggtaa tgtgatatga cctatgacaa ctggtaacag tggattcatt
     2941 tacattgttt acacttctat gaccaggcct taggggaagg tcagatttta aaacaccaag
     3001 tagtgtcttc ctgcctgtcc ccaaggacaa gttacaacag aaggtgttgg cttcggctct
     3061 gttctctttt tttgctcagt aatacagtca agcaggagtt tgtttgcaaa tgaaagctgt
     3121 gtaagcattt ttgtttattt caaataaaat atatttgtat tatttgtcat tcatattatc
     3181 catccatgcc acactgtctg taccaggtag tccaatagaa atatacctgt tttgttctaa
     3241 aaaaaaaaaa aaaaaa
//
