LOCUS       NM_001401070            3623 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus caprin family member 2 (Caprin2), mRNA.
ACCESSION   NM_001401070 XM_039108909
VERSION     NM_001401070.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3623)
  AUTHORS   Barez-Lopez,S., Konopacka,A., Cross,S.J., Greenwood,M.,
            Skarveli,M., Murphy,D. and Greenwood,M.P.
  TITLE     Transcriptional and Post-Transcriptional Regulation of Oxytocin and
            Vasopressin Gene Expression by CREB3L1 and CAPRIN2
  JOURNAL   Neuroendocrinology 112 (11), 1058-1077 (2022)
   PUBMED   35051932
  REMARK    GeneRIF: Transcriptional and Post-Transcriptional Regulation of
            Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2.
REFERENCE   2  (bases 1 to 3623)
  AUTHORS   Loh,S.Y., Jahans-Price,T., Greenwood,M.P., Greenwood,M., Hoe,S.Z.,
            Konopacka,A., Campbell,C., Murphy,D. and Hindmarch,C.C.T.
  TITLE     Unsupervised Network Analysis of the Plastic Supraoptic Nucleus
            Transcriptome Predicts Caprin2 Regulatory Interactions
  JOURNAL   eNeuro 4 (6) (2017)
   PUBMED   29279858
  REMARK    GeneRIF: Using the unsupervised graphical lasso (Glasso) algorithm,
            study reconstructed a putative network from 500 plastic supraoptic
            nucleus genes in which genes are the nodes and the edges are the
            inferred interactions. The most active nodal gene identified within
            the network was Caprin2. Overexpressio or knock down Caprin2
            transcripts in PC12 cells had significant opposite effects on the
            levels of putative target mRNAs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3623)
  AUTHORS   Konopacka,A., Greenwood,M., Loh,S.Y., Paton,J. and Murphy,D.
  TITLE     RNA binding protein Caprin-2 is a pivotal regulator of the central
            osmotic defense response
  JOURNAL   Elife 4, e09656 (2015)
   PUBMED   26559902
  REMARK    GeneRIF: Caprin-2 knockdown in the hypothalamus decreases urine
            output and fluid intake, and increases urine osmolality, urine
            sodium concentration, and plasma arginine vasopressin levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3623)
  AUTHORS   Shiina,N. and Tokunaga,M.
  TITLE     RNA granule protein 140 (RNG140), a paralog of RNG105 localized to
            distinct RNA granules in neuronal dendrites in the adult vertebrate
            brain
  JOURNAL   J Biol Chem 285 (31), 24260-24269 (2010)
   PUBMED   20516077
  REMARK    GeneRIF: RNG140 has roles in the maintenance of the dendritic
            structure in the adult vertebrate brain through localizing to a
            kind of RNA granules that are distinct from RNG105-containing
            granules
REFERENCE   5  (bases 1 to 3623)
  AUTHORS   Ding,Y., Xi,Y., Chen,T., Wang,J.Y., Tao,D.L., Wu,Z.L., Li,Y.P.,
            Li,C., Zeng,R. and Li,L.
  TITLE     Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6
            phosphorylation
  JOURNAL   J Cell Biol 182 (5), 865-872 (2008)
   PUBMED   18762581
REFERENCE   6  (bases 1 to 3623)
  AUTHORS   Aerbajinai,W., Lee,Y.T., Wojda,U., Barr,V.A. and Miller,J.L.
  TITLE     Cloning and characterization of a gene expressed during terminal
            differentiation that encodes a novel inhibitor of growth
  JOURNAL   J Biol Chem 279 (3), 1916-1921 (2004)
   PUBMED   14593112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 1, 2022 this sequence version replaced XM_039108909.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.17930.1,
                                           SRR26643289.14570.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000004.1  183591944-183592102 c
            160-366             JAXUCZ010000004.1  183590792-183590998 c
            367-429             JAXUCZ010000004.1  183586977-183587039 c
            430-516             JAXUCZ010000004.1  183579172-183579258 c
            517-755             JAXUCZ010000004.1  183572564-183572802 c
            756-838             JAXUCZ010000004.1  183571455-183571537 c
            839-994             JAXUCZ010000004.1  183568071-183568226 c
            995-1038            JAXUCZ010000004.1  183566107-183566150 c
            1039-1695           JAXUCZ010000004.1  183564399-183565055 c
            1696-1818           JAXUCZ010000004.1  183561466-183561588 c
            1819-1888           JAXUCZ010000004.1  183559144-183559213 c
            1889-1953           JAXUCZ010000004.1  183558018-183558082 c
            1954-2055           JAXUCZ010000004.1  183555054-183555155 c
            2056-2190           JAXUCZ010000004.1  183553219-183553353 c
            2191-2359           JAXUCZ010000004.1  183547072-183547240 c
            2360-2545           JAXUCZ010000004.1  183543255-183543440 c
            2546-2646           JAXUCZ010000004.1  183541707-183541807 c
            2647-2710           JAXUCZ010000004.1  183540769-183540832 c
            2711-3623           JAXUCZ010000004.1  183537935-183538847 c
FEATURES             Location/Qualifiers
     source          1..3623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3623
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /note="caprin family member 2"
                     /db_xref="GeneID:686779"
                     /db_xref="RGD:1593683"
     exon            1..159
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            160..366
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..3279
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /note="cytoplasmic activation/proliferation-associated
                     protein 2; adiponectin r"
                     /codon_start=1
                     /product="caprin-2"
                     /protein_id="NP_001387999.1"
                     /db_xref="GeneID:686779"
                     /db_xref="RGD:1593683"
                     /translation="MKSAKSQVNHTQQGENQRALSPLQSTLSSAASPSQAYETYIDNG
                     LICLKHKIRNIEKKKLKLEDYKDRLKNGEQLNPDQLEAVEKYEEVLHNLEFAKELQKT
                     FSALSQDLLKAQKKAQRREHMLKLEAEKKKLRTILQIQYVLQNLTQEHVQKDFKGGLN
                     GAMYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYK
                     HVKDLLSKLLHSGYFESVPVLRNSKEKTEEMLMQSEKRKQLLKTESIKESESLKELVQ
                     PEIQPQEFLNRRYMTEVNFSRKQENEEQSWEADYARKPGLLKCWNTLPEPDGQEKKKE
                     SVESWESSLKSQEVSKPVVSFEQEKLRPTLQEEQKQQISMAPVSQWKPESPKSKVGSP
                     QEEQNVQETPKPWVVQPQKEQDPKKLPPGSWAVSVQSEQSGSRSWTTPVCREQASVQP
                     GTPVSWENNAENQKHSLVPQSQISLKSWGAASAGLLPNDKVPPRKLNVEPKDVPKPMP
                     QPIDSSSPFPKDPALRKEKLQDLMTQIQGTCNFMQESVLDVDTPSSAIPSSQPPSASP
                     VSAVSAEQNLSNQSDFLQEPSKASSPVTCSSNACLVTTDQASLGSETEFMTSETPEMV
                     APPCKPASALASPNPPLSKGFQLPPASGSSAAISTAPFQAMQTVFNVNAPLPPRKEQA
                     MKESPYSSGYSQSFTSSSTQTVSQCQLPAVHVEQTTQPPETAAGYHPDGTVQVSNGSL
                     AFYPAPTSMFPRPAQPFISSRGALRGCSRGGRLLMNPYRSPGSYKGFDSYRGLPSASS
                     GTYSQLQLQAREYPGTPYSQRDNFQQCYKRSGTSSGLQANSRAGWSDSSQVSSPERDS
                     ETFNSGDSGVGDSRSMTPVDVPVTSPAAAILPVHVYPLPQQMRVAFSAARTSNLAPGT
                     LDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEV
                     LVSAYANDGAPDHETASNHAILQLLQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD"
     exon            367..429
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            430..516
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            517..755
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            756..838
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            839..994
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1038
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1695
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1818
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1888
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1953
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2055
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2190
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2359
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2545
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2646
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2710
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..3623
                     /gene="Caprin2"
                     /gene_synonym="Adir; Rng140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggcgcgag cagcggagtt ggctgggtgc actgtcggcc gcggccgcag gctaagctga
       61 ggagggagga agggacggga ggagaaggga gtgcggggtg gcgtcggccc actttgcagt
      121 gcgctgggct cccgcgcgct ttcggaggca gccggggagt caccctcaga ggaggcaaga
      181 gtgggaaata tgaagtcagc caagtcccaa gtgaaccaca ctcagcaagg ggaaaaccag
      241 cgggctctga gccccctgca gtctactctc agttctgctg catctccttc ccaggcatac
      301 gaaacctata ttgataatgg acttatatgc cttaaacaca aaattaggaa catcgagaag
      361 aagaagctca aactggaaga ttacaaagat cgcctgaaaa atggagagca gcttaaccca
      421 gaccagttgg aagcagtgga aaagtatgaa gaagtacttc ataatttgga atttgccaag
      481 gagcttcaga aaaccttttc tgcactgagc caagatctcc tgaaagcgca gaaaaaggcc
      541 cagagaaggg agcacatgct aaaacttgag gccgagaaga aaaagcttcg aactatactt
      601 caaattcagt atgtattaca gaacttgaca caagaacatg tacagaaaga cttcaaaggg
      661 ggcttgaatg gtgcaatgta tttgccttca aaagaacttg actacctcat taaattctca
      721 aaactgacct gccctgaaag aaatgaaagt ttgagtgttg aagaccagat ggagcagtca
      781 tccttgtact tttgggacct tttggaaggt agtgagaaag cagtggtagg aacaacatac
      841 aaacatgtga aagacctgct gtccaaattg ctgcactcag gttattttga aagtgtccca
      901 gttctcagga attctaagga aaaaacagaa gaaatgttaa tgcagtcaga aaagagaaag
      961 cagttactga agactgagtc tatcaaagag tcagaatctc tgaaggaact tgtacagcca
     1021 gagatacagc cgcaggagtt tcttaacaga cgctatatga cagaagtaaa tttttcaaga
     1081 aaacaagaaa atgaagaaca atcctgggaa gcagattatg ctaggaaacc aggtctcctc
     1141 aaatgctgga atacacttcc agaaccagat ggtcaggaga agaagaagga gtccgtggag
     1201 tcgtgggagt cttctcttaa gtctcaggag gtatccaagc ctgtggtgtc tttcgaacag
     1261 gagaagctca ggccaacatt acaggaagag cagaagcagc agatttccat ggcacctgtc
     1321 agtcaatgga agccagaaag ccctaagtcc aaagtgggca gccctcaaga agagcagaat
     1381 gtacaggaga cgccaaagcc gtgggtggtt cagccacaga aagaacaaga tccaaagaag
     1441 ctacctcctg gatcctgggc agtatctgtg cagagtgaac agagtggcag cagatcctgg
     1501 accactcctg tgtgcagaga acaggcttca gtgcagcctg ggactccagt atcctgggaa
     1561 aacaatgctg agaaccagaa acactcctta gtaccacaat cacagatctc tctgaagtcc
     1621 tggggagcag cttcagcagg cctcttacca aatgacaagg tccctcccag gaagttaaat
     1681 gtagagccca aagatgtgcc taagcccatg cctcagccta tagactcttc ctctcccttt
     1741 ccaaaggatc cagcattgag gaaagaaaaa ctgcaggacc tcatgaccca gattcaagga
     1801 acttgtaact ttatgcaaga gtctgttcta gatgtcgaca caccctcaag tgcaattcca
     1861 tcttctcagc cgccttcagc ttcgccagtc tctgcagtat ctgcagaaca aaacttgtcc
     1921 aaccaaagtg attttcttca agagccatca aaggcttctt ctccagttac ttgtagctcg
     1981 aatgcttgct tggttactac tgatcaggct tctctgggat ctgaaacaga gtttatgacc
     2041 tcagagaccc ctgagatggt ggctcccccc tgcaagccag catctgcact tgcttctcca
     2101 aatcctccac tgtcgaaggg cttccagtta cctcctgcaa gtgggagctc ggcagccatt
     2161 agcacagcac cctttcaggc catgcagaca gtatttaatg ttaatgcacc tctgcctcca
     2221 cggaaagaac aagcaatgaa agaatctcct tattcatctg gctacagtca aagttttact
     2281 tcatcaagta cacagacagt atcccaatgt cagctcccag ctgtacacgt ggagcagaca
     2341 acccaacctc ctgagactgc tgcaggttac catcctgatg gaactgttca agtaagcaat
     2401 gggagccttg ccttttaccc agcacccacg agtatgtttc ccagacctgc tcagccattt
     2461 atcagtagta ggggggctct gagaggatgt tcacgtggag ggaggttact aatgaatcct
     2521 tatcggtctc ctggtagcta caaaggtttt gatagttaca gaggccttcc ctcagcttca
     2581 agtgggactt acagccaact gcagctgcaa gctagagagt atcctgggac accttactct
     2641 cagagggata atttccagca gtgttataaa agatcaggga catctagtgg tcttcaggca
     2701 aattcaagag cagggtggag cgactcctct caggtgagca gcccagagag agacagcgag
     2761 acttttaaca gtggagactc tggggtagga gactcccgga gcatgacccc agtggatgtg
     2821 ccagtgacaa gcccagcagc cgccattctg ccagtacacg tctatcctct gcctcagcaa
     2881 atgcgagttg ccttctcagc tgccagaaca tccaatctgg ctcctggaac tttagaccaa
     2941 cctattgtgt ttgatcttct cctgaacaac ttgggagaga cctttgatct tcaacttggt
     3001 agattcaatt gcccagtaaa tggcacttac gtgttcattt ttcacatgct aaagctggct
     3061 gtgaatgtac cactgtatgt caacctcatg aagaatgagg aggtcttggt gtcagcctat
     3121 gccaatgatg gtgctccaga ccatgagaca gcaagcaacc atgctattct ccagctcctc
     3181 cagggagatc agatatggtt gcgcttacac aggggagcga tttatggaag tagctggaaa
     3241 tactctacat tttcaggcta tcttctttat caagattgaa attcagttca gagaaaacaa
     3301 cggagttttc tctagtggat ctaaggagaa gtagtccttg ccctggtggt tgactggttg
     3361 aggaaagtat ttctgttcct aggaaaagaa ggaggtcctt acttttttgt tttcttttta
     3421 tgtgaagact ttgaagcaga atgataatta gcactaatct ggcactttat aaattgtgat
     3481 gtagccttgc tagtcacaca gcaaatatgt atcgcttgca cttaaccctg aactgtgtta
     3541 atggtcagct tactgaactg aatgcctcaa cttcagacaa gttaccatgc ctcgttgtgc
     3601 ctcaataaaa aatttaaact gca
//
