LOCUS       NM_001271140            2434 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus calpain 9 (Capn9), mRNA.
ACCESSION   NM_001271140 XM_341719
VERSION     NM_001271140.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Markmann,A., Schafer,S., Linz,W., Lohn,M., Busch,A.E. and
            Wohlfart,P.
  TITLE     Down-regulation of calpain 9 is linked to hypertensive heart and
            kidney disease
  JOURNAL   Cell Physiol Biochem 15 (1-4), 109-116 (2005)
   PUBMED   15665521
  REMARK    GeneRIF: differential regulation of calpain 9 may play a role in
            hypertensive target organ damage
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Yoshikawa,Y., Mukai,H., Hino,F., Asada,K. and Kato,I.
  TITLE     Isolation of two novel genes, down-regulated in gastric cancer
  JOURNAL   Jpn J Cancer Res 91 (5), 459-463 (2000)
   PUBMED   10835488
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Lee,H.J., Sorimachi,H., Jeong,S.Y., Ishiura,S. and Suzuki,K.
  TITLE     Molecular cloning and characterization of a novel tissue-specific
            calpain predominantly expressed in the digestive tract
  JOURNAL   Biol Chem 379 (2), 175-183 (1998)
   PUBMED   9524069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 1, 2012 this sequence version replaced XM_341719.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89514.1, SRR26643288.61964.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000019.1  69446847-69447090
            245-314             JAXUCZ010000019.1  69454326-69454395
            315-433             JAXUCZ010000019.1  69456456-69456574
            434-567             JAXUCZ010000019.1  69458790-69458923
            568-736             JAXUCZ010000019.1  69460926-69461094
            737-820             JAXUCZ010000019.1  69462212-69462295
            821-906             JAXUCZ010000019.1  69463707-69463792
            907-984             JAXUCZ010000019.1  69467009-69467086
            985-1145            JAXUCZ010000019.1  69467309-69467469
            1146-1303           JAXUCZ010000019.1  69468862-69469019
            1304-1512           JAXUCZ010000019.1  69469166-69469374
            1513-1549           JAXUCZ010000019.1  69471910-69471946
            1550-1630           JAXUCZ010000019.1  69473773-69473853
            1631-1688           JAXUCZ010000019.1  69474986-69475043
            1689-1753           JAXUCZ010000019.1  69477378-69477442
            1754-1822           JAXUCZ010000019.1  69477856-69477924
            1823-1901           JAXUCZ010000019.1  69478937-69479015
            1902-2018           JAXUCZ010000019.1  69481023-69481139
            2019-2077           JAXUCZ010000019.1  69482428-69482486
            2078-2434           JAXUCZ010000019.1  69483454-69483810
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2434
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /note="calpain 9"
                     /db_xref="GeneID:116694"
                     /db_xref="RGD:70965"
     exon            1..244
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2104
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /EC_number="3.4.22.-"
                     /note="new calpain 4; digestive tract-specific calpain"
                     /codon_start=1
                     /product="calpain-9"
                     /protein_id="NP_001258069.1"
                     /db_xref="GeneID:116694"
                     /db_xref="RGD:70965"
                     /translation="MPYLHRSLRPQPQPVPRDARTVHSSGHSFEQLRQSCLQSGTLFE
                     DADFPASNSSLFYSERPQVPFVWKRPGEIVENPEFILGGATRTDICQGELGDCWLLAA
                     IASLTLNQKALARVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFL
                     HSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIREAPEDFYE
                     ILEKALRRGSLLGCSIDTLNASESEARTPLGLIKGHAYTVTGLDQVNFHGQRIKLIRV
                     RNPWGQVEWNGPWSDSSPEWRSMSLEEQKRLGHTALDDGEFWMAFEDFKTHFDKVEIC
                     NLTPDALEDNTLHKWEVTIHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTERDEGQE
                     GCTFLAALMQKDRRRLKRFGANMLTIGYAIYQCPDKDGHLNRDFFRYHASLARSKTFI
                     NLREVSGRFQLPPGDYILIPSTFEPHQEADFCLRIFSEKKAVTQDLDENIDIDLPELP
                     KPTPQEEETEEERQFRALFRRIAGEDMEVSAEELEYVLNAVLQKKTALKFKRLSLLSC
                     RNIISLMDTSGNGKMEFEEFRVFWDKLRYWMDLFLQFDVDKSGTMSSYELRTALKAAG
                     FQLGSHLLQLIVLRYADENLQLDFDDYLNCLVRLENASRVFQCLSVKNKDFIHLNINE
                     FINLTMNI"
     exon            245..314
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            315..433
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            434..567
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            568..736
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..820
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            821..906
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            907..984
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1145
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1303
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1512
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1549
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1630
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1688
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1753
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1822
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1901
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2018
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2077
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2434
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttcctctg ctaggctgtg gagaagtagt catgccttac ctgcatcggt ccctgagacc
       61 ccagccacag ccagtcccca gggatgccag gactgtccac tcctcgggcc acagctttga
      121 gcagctgagg caaagctgtc tgcagtcggg caccttgttt gaggatgctg acttccctgc
      181 cagcaatagt tcactgttct acagcgagag gccccaggtc ccctttgtgt ggaagcggcc
      241 aggggaaatt gtggaaaacc cagaattcat tctgggaggg gccaccagga ccgacatctg
      301 ccaaggggaa ctgggagact gctggctcct ggccgccatt gcctccctaa ccctcaatca
      361 gaaagcactg gccagagtgg taccccagga ccaaggattt ggttctggct atgctgggat
      421 atttcacttc cagttctggc agcacagtga gtggctggac gtggtgattg atgaccgcct
      481 gcctaccttt cgggatcgcc tggtcttcct ccactctgcc gaccacaatg agttctggag
      541 cgcactgctg gagaaagcct atgccaagct gaacgggagt tacgaggcac tgaagggggg
      601 cagcgccatc gaagccatgg aggacttcac cgggggtgtg gctgagaact tccaaatccg
      661 agaggcacca gaggatttct acgagattct ggagaaggcc ctgcggcgtg gttccttgct
      721 gggctgctcc atagataccc tgaatgcctc agaatctgaa gcccgcacac ctttgggcct
      781 cattaagggc catgcctaca ctgtgactgg actcgaccag gtaaacttcc acggccagag
      841 aatcaagctc atcagagtcc gtaacccttg gggccaggtg gaatggaacg ggccatggag
      901 cgacagctct cctgagtggc gctccatgag cctggaggag cagaagcgcc taggtcacac
      961 cgcccttgac gatggagaat tctggatggc atttgaggac ttcaagaccc attttgacaa
     1021 agtggagatc tgcaacctca cgcctgatgc cctggaggac aacaccctcc acaagtggga
     1081 ggtgaccatc caccaaggaa gctgggttcg tggctccacc gccggcggct gccgcaactt
     1141 cctggacacc ttctggacca acccacagat aaagctgtct ctgacagaga gggatgaggg
     1201 ccaggagggc tgcactttcc tagcagcctt gatgcagaaa gaccgcagga ggctcaagag
     1261 gtttggtgcc aacatgctga ccattggcta tgccatttac cagtgcccag acaaggacgg
     1321 acacctgaat agggactttt tcaggtacca tgcctctctg gcccgaagta agacattcat
     1381 caacttgaga gaagtctcag gccgcttcca gctgcccccg ggagactata tcctcatccc
     1441 cagcaccttt gagccacacc aggaggctga cttctgcctg agaatcttct ctgagaagaa
     1501 agctgttact caggacctgg atgagaacat agacattgac cttcctgagc ttccaaagcc
     1561 gacaccacag gaggaggaaa ccgaagagga gcggcagttc cgggccctgt tccgtcgaat
     1621 tgctggtgag gacatggagg tgtcagcaga agagcttgaa tatgttctaa atgctgttct
     1681 gcaaaagaaa acagccctca agttcaagag gctgagcctg ctttcctgca gaaacattat
     1741 ctccctgatg gacaccagcg gcaacgggaa gatggagttc gaagagttcc gggtgttctg
     1801 ggacaagctg aggtactgga tggacctgtt tctccagttc gatgtggaca agtccggcac
     1861 catgtcttcc tatgagttgc ggacagcact gaaagctgca ggctttcagc tgggtagcca
     1921 tctcctgcag ctgatcgtcc tcaggtatgc agacgagaac ctccagctgg atttcgatga
     1981 ctacctcaac tgcctggtgc ggctggagaa tgcgagccgg gtgttccagt gtctcagtgt
     2041 gaagaacaag gacttcatcc atctcaacat aaacgagttc atcaacttga ccatgaacat
     2101 ctgagcttgc actgacctga tgccgtctgc ccctctgata ctcagctgct ggaccatgaa
     2161 cctcagaatt tttattggag ggccatcccg cccattgctc tctccccact ccacaccacc
     2221 ctccttccct ccctgtcgag atttaaatca aaaagggatt ggccatgttc tccgattcag
     2281 tgatacttct tctaagatca ttgctccaca ggaactcatg gcactgcctg tgtctgtgct
     2341 caggcctggg gttgctgtat gctcctccct ccactgcccc tcctccacca accggagtcc
     2401 tggcttctga gtgctccaat catgctatca agac
//
