LOCUS       NP_001258069             690 aa            linear   ROD 27-MAR-2024
DEFINITION  calpain-9 [Rattus norvegicus].
ACCESSION   NP_001258069 XP_341720
VERSION     NP_001258069.1
DBSOURCE    REFSEQ: accession NM_001271140.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 690)
  AUTHORS   Markmann,A., Schafer,S., Linz,W., Lohn,M., Busch,A.E. and
            Wohlfart,P.
  TITLE     Down-regulation of calpain 9 is linked to hypertensive heart and
            kidney disease
  JOURNAL   Cell Physiol Biochem 15 (1-4), 109-116 (2005)
   PUBMED   15665521
  REMARK    GeneRIF: differential regulation of calpain 9 may play a role in
            hypertensive target organ damage
REFERENCE   2  (residues 1 to 690)
  AUTHORS   Yoshikawa,Y., Mukai,H., Hino,F., Asada,K. and Kato,I.
  TITLE     Isolation of two novel genes, down-regulated in gastric cancer
  JOURNAL   Jpn J Cancer Res 91 (5), 459-463 (2000)
   PUBMED   10835488
REFERENCE   3  (residues 1 to 690)
  AUTHORS   Lee,H.J., Sorimachi,H., Jeong,S.Y., Ishiura,S. and Suzuki,K.
  TITLE     Molecular cloning and characterization of a novel tissue-specific
            calpain predominantly expressed in the digestive tract
  JOURNAL   Biol Chem 379 (2), 175-183 (1998)
   PUBMED   9524069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 1, 2012 this sequence version replaced XP_341720.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89514.1, SRR26643288.61964.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..690
                     /product="calpain-9"
                     /EC_number="3.4.22.-"
                     /note="new calpain 4; digestive tract-specific calpain"
                     /calculated_mol_wt=79132
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35920.2)"
     Region          43..335
                     /region_name="Peptidase_C2"
                     /note="Calpain family cysteine protease; pfam00648"
                     /db_xref="CDD:459889"
     Region          338..521
                     /region_name="Domain III"
                     /note="propagated from UniProtKB/Swiss-Prot (O35920.2)"
     Region          347..496
                     /region_name="Calpain_III"
                     /note="Calpain, subdomain III. Calpains are
                     calcium-activated cytoplasmic cysteine proteinases,
                     participate in cytoskeletal remodeling processes, cell
                     differentiation, apoptosis and signal transduction.
                     Catalytic domain and the two calmodulin-like domains
                     are...; cd00214"
                     /db_xref="CDD:238132"
     Site            order(385..387,394)
                     /site_type="other"
                     /note="acidic loop"
                     /db_xref="CDD:238132"
     Region          522..690
                     /region_name="Domain IV"
                     /note="propagated from UniProtKB/Swiss-Prot (O35920.2)"
     Region          522..690
                     /region_name="EFh_PEF"
                     /note="The penta-EF hand (PEF) family; cl25352"
                     /db_xref="CDD:355382"
     Region          522..550
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320054"
     Site            order(534,541,574,576,578,585,604,606,608,615)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320054"
     Site            order(565,567,577,631,634,637..640,650,654,657..658,
                     661..662,665,674..681,683..689)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:320054"
     Region          565..594
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320054"
     Region          595..624
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320054"
     Region          631..659
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320054"
     Region          661..689
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320054"
     CDS             1..690
                     /gene="Capn9"
                     /gene_synonym="Ncl-4"
                     /coded_by="NM_001271140.1:32..2104"
                     /db_xref="GeneID:116694"
                     /db_xref="RGD:70965"
ORIGIN      
        1 mpylhrslrp qpqpvprdar tvhssghsfe qlrqsclqsg tlfedadfpa snsslfyser
       61 pqvpfvwkrp geivenpefi lggatrtdic qgelgdcwll aaiasltlnq kalarvvpqd
      121 qgfgsgyagi fhfqfwqhse wldvviddrl ptfrdrlvfl hsadhnefws allekayakl
      181 ngsyealkgg saieamedft ggvaenfqir eapedfyeil ekalrrgsll gcsidtlnas
      241 eseartplgl ikghaytvtg ldqvnfhgqr iklirvrnpw gqvewngpws dsspewrsms
      301 leeqkrlght alddgefwma fedfkthfdk veicnltpda ledntlhkwe vtihqgswvr
      361 gstaggcrnf ldtfwtnpqi klslterdeg qegctflaal mqkdrrrlkr fganmltigy
      421 aiyqcpdkdg hlnrdffryh aslarsktfi nlrevsgrfq lppgdyilip stfephqead
      481 fclrifsekk avtqdldeni didlpelpkp tpqeeeteee rqfralfrri agedmevsae
      541 eleyvlnavl qkktalkfkr lsllscrnii slmdtsgngk mefeefrvfw dklrywmdlf
      601 lqfdvdksgt mssyelrtal kaagfqlgsh llqlivlrya denlqldfdd ylnclvrlen
      661 asrvfqclsv knkdfihlni nefinltmni
//
